Abstract:
BACKGROUND:UNC5C, one of the Netrin-1 receptors, belongs to the functional dependence receptor family, members of which share the ability to induce apoptosis in the absence of their ligands. Recently, two reports indicated that UNC5C methylation was closely associated with loss of gene expression in colorectal cancer. MATERIALS AND METHODS:The methylation status of the UNC5C gene was examined in primary carcinomas and the corresponding normal tissues derived from 49 patients with colorectal cancer using quantitative methylation-specific polymerase chain reaction (qMSP) and the correlation between the methylation status and the clinicopathological findings was evaluated. RESULTS:Aberrant methylation of the UNC5C gene was detected in 34 out of the 49 (69%) primary colon carcinomas, suggesting that the aberrant methylation of UNC5C was frequent in colorectal cancer. The clinicopathological data were then tested for correlation with this result. A significantly greater proportion of cases with methylated UNC5C was found in Dukes' stage C (p = 0.0380) than in earlier stages. CONCLUSION:UNC5C might act as a tumor suppressor and UNC5C methylation might present a malignant potential in colorectal cancer.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Hibi K,Mizukami H,Shirahata A,Goto T,Sakata M,Saito M,Ishibashi K,Kigawa G,Nemoto H,Sanada Ysubject
Has Abstractpub_date
2009-01-01 00:00:00pages
271-3issue
1eissn
0250-7005issn
1791-7530journal_volume
29pub_type
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journal_title:Anticancer research
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journal_title:Anticancer research
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pub_type: 杂志文章,收录出版
doi:
更新日期:2006-03-01 00:00:00
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doi:
更新日期:2016-04-01 00:00:00
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journal_title:Anticancer research
pub_type: 临床试验,杂志文章
doi:
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pub_type: 杂志文章,评审
doi:
更新日期:2013-08-01 00:00:00
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更新日期:2013-12-01 00:00:00
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journal_title:Anticancer research
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