Abstract:
BACKGROUND:Large adrenal tumors (LATs, ≥6 cm) are uncommon and associated with malignancy in 25% of cases. Their surgical management remains debatable. The aim of the present report was to evaluate the current incidence, nature and management of LAT. PATIENTS AND METHODS:We carried out a retrospective review of LATs managed in a tertiary referral center (2002-2011). RESULTS:Eighty-one patients were included (out of a total of 750 with adrenal tumors, 11%). Nine patients had no surgical intervention (11%). Fifty-two LATs were malignant (64%): adrenocortical carcinoma (44%), metastasis (27%) and pheochromocytoma (21%). Patients with malignant tumors exhibited a poorer 5-year overall survival than those with benign tumors (53.4% versus 96.3%, p=0.001). Disease-related mortality was approximately 60%, 29% and 0% for those with metastasis, adrenal carcinoma and malignant pheochromocytoma, respectively. The recurrence rate was the same for the three malignant sub-groups (30%). CONCLUSION:LATs are rare and more frequently malignant than previously reported. Some are benign and do not require for surgical intervention. Surgical indication and approach should be tailored for each patient.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Mege D,Taieb D,Lowery A,Loundou A,DE Micco C,Castinetti F,Morange I,Henry JF,Sebag Fsubject
Has Abstractpub_date
2014-05-01 00:00:00pages
2581-8issue
5eissn
0250-7005issn
1791-7530pii
34/5/2581journal_volume
34pub_type
杂志文章,评审abstract:BACKGROUND:Resveratrol (RES) inhibits cell growth, induces apoptosis and augments chemotherapeutics in multiple cancer types, although its effects on drug-resistant cancer cells are unknown. MATERIALS AND METHODS:To study the effects of resveratrol in triple-negative breast cancer cells that are resistant to the commo...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2014-10-01 00:00:00
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journal_title:Anticancer research
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journal_title:Anticancer research
pub_type: 临床试验,杂志文章
doi:
更新日期:2003-07-01 00:00:00
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journal_title:Anticancer research
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2012-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2001-11-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1986-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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更新日期:2005-07-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章,评审
doi:
更新日期:2007-07-01 00:00:00
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journal_title:Anticancer research
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更新日期:2016-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-11-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2004-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2001-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1986-07-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1999-05-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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更新日期:2017-08-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1998-07-01 00:00:00
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更新日期:2005-07-01 00:00:00
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更新日期:2018-06-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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更新日期:2010-06-01 00:00:00
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更新日期:2007-11-01 00:00:00
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journal_title:Anticancer research
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更新日期:2011-11-01 00:00:00
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pub_type: 杂志文章
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