Clinical utility of CA 72-4 serum marker in the staging and immediate post-surgical management of gastric cancer patients.

abstract：BACKGROUND:Tissue polypeptide antigen (TPA) is a circulating complex of polypeptide fragments from cytokeratins 8, 18 and 19. It is a tumour-related protein. TPA is an indicator of higher cell proliferation. One function of TP53 is the suppression of apoptosis. TP53 mutations are frequently correlated with tumour devel...

journal_title：Anticancer research

authors： Ecke TH,Lenk SV,Schlechte HH,Loening SA

更新日期：2003-03-01 00:00:00

abstract：:We studied a consecutive series of 54 cases of lower lip squamous cell carcinoma (LLSCC) in order to identify any variables which might predict the development of lymph node metastases. The cases were divided into 38 tumors without metastases (group I) and 16 tumors with lymph node metastases (group II). The following...

journal_title：Anticancer research

authors： Rodolico V,Daniele E,Leonardi V,Marra G,Luciani A,Settineri G,Tralongo V

更新日期：1998-03-01 00:00:00

abstract：:Cancer cells are known to shed extracellular membrane vesicles both in vitro and in vivo. To analyse their possible involvement in the metastatic behaviour of tumours, we measured the Matrigel invasion capability and amounts of vesicles shed by four human tumour cell lines (8701-BC, MCF-7, MDA-MB-231 and HT-1080), and...

journal_title：Anticancer research

authors： Ginestra A,La Placa MD,Saladino F,Cassarà D,Nagase H,Vittorelli ML

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Carbohydrate antigen 15-3 (CA15-3), Kerbs von den Lungen (KL-6) and breast cancer antigen 225 (BCA225) are widely used tumor markers for breast and lung cancer respectively. PATIENTS AND METHODS:We analyzed 460 Japanese volunteers for 99 items on blood examination including 27 serum tumor markers. Correlati...

journal_title：Anticancer research

authors： Ri G,Ohno S,Yamamoto T,Ito E,Furutani M,Furutani Y,Umeda Y,Tsukahara T,Hagita N,Matsuoka R

更新日期：2009-10-01 00:00:00

abstract：:Brain tumors were induced in inbred Fischer rats (F344) by administration of methylnitrosourea in the drinking water. One of the induced tumors, a pleomorphic glioma (78-219), was established in vitro and propagated as 78FR-G-219 permanent cell line. The tumorigenicity of the established line was investigated by intra...

journal_title：Anticancer research

authors： Stavrou D,Bilzer T,Anzil AP,Hultén M,Kaldrymidou E

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Activating mutations of the BRAF gene have recently been reported in thyroid carcinomas. In particular, V600E mutation is highly prevalent in papillary thyroid carcinoma (PTC). PATIENTS AND METHODS:In this study, the BRAF (V600E) mutation in 54 PTCs was investigated and the relationship between the BRAF mut...

journal_title：Anticancer research

authors： Nakayama H,Yoshida A,Nakamura Y,Hayashi H,Miyagi Y,Wada N,Rino Y,Masuda M,Imada T

更新日期：2007-09-01 00:00:00

abstract：:It is generally agreed that most malignancies, particularly those that arise "spontaneously", are caused by randomly occurring mutations at specific sites of the genome. Hence oncogenesis of these spontaneous tumors can be described by stochastic mathematical models. In this paper we offer a mathematical approach to o...

journal_title：Anticancer research

authors： Derkinderen DJ,Boxma OJ,Koten JW,Den Otter W

更新日期：1990-03-01 00:00:00

abstract：AIM:Apocrine breast carcinoma often lacks estrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor type-2 (HER2) expression. Accordingly, development of a new treatment strategy is important for this type of cancer. The growth stimulus through the androgen receptor (AR) can be a c...

journal_title：Anticancer research

authors： Sasahara M,Matsui A,Ichimura Y,Hirakata Y,Murata Y,Marui E

更新日期：2014-03-01 00:00:00

abstract：AIM:We investigated the relationship between a new index considering the estimated working space and difficulty of robot-assisted radical prostatectomy (RARP) using our database. PATIENTS AND METHODS:Working height was calculated by the obstetric conjugate diameter minus the bladder and rectal wall thicknesses minus t...

journal_title：Anticancer research

authors： Kadono Y,Ueno S,Makino T,Ofude M,Izumi K,Gabata T,Namiki M

更新日期：2014-10-01 00:00:00

abstract：:Immunocytochemical assays were performed on frozen sections of inflammatory breast carcinomas (n = 22) using the following monoclonal antibodies (MoAb): anti-pHER2/neu, cathepsin, pS2, ER, PR and MoAb Ki67. The distribution of these proteins, known as prognostic indicators, was evaluated with an image analysis system ...

journal_title：Anticancer research

authors： Charpin C,Bonnier P,Khouzami A,Vacheret H,Andrac L,Lavaut MN,Allasia C,Piana L

更新日期：1992-05-01 00:00:00

abstract：UNLABELLED:Adenomatous polyps are precursor lesions for colorectal carcinoma. The risk of cancer development has been associated with age and size, amount of villous component and high-grade dysplasia of adenomas. The subject-related and adenoma-related risk factors for severely dysplastic lesions were further investig...

journal_title：Anticancer research

authors： Giuliani A,Caporale A,Corona M,Ricciardulli T,Di Bari M,Demoro M,Scarpini M,Angelico F

更新日期：2006-09-01 00:00:00

abstract：:The radical modulation activity of hot water and NaOH extracts of the thorn apple of Crataegus Cuneata Sieb. et. Zucc. was investigated, using ESR spectroscopy. The radical intensity of sodium ascorbate was slightly reduced at lower concentrations of the extracts, but it was synergistically enhanced at higher concentr...

journal_title：Anticancer research

authors： Satoh K,Anzai S,Sakagami H

更新日期：1998-07-01 00:00:00

abstract：AIM:To determine the predictive value of HIF-1α and VEGF-C in primary neuroendocrine breast cancers (NEBC) and their correlation with other clinico-pathological characteristics of NEBC. MATERIALS AND METHODS:HIF-1α and VEGF-C were determined immunohistochemically in tissue samples from 31 cases of NEBC. RESULTS:The H...

journal_title：Anticancer research

authors： Marton I,Knezevic F,Ramic S,Milosevic M,Tomas D

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:Matrix metalloproteinase-2 (MMP-2) and its tissue inhibitor (TIMP-2) are important regulators of cancer invasion and metastasis. Their associations to high-risk (HR) human papillomavirus (HPV) in cervical intra-epithelial neoplasia (CIN) and cervical cancer (CC) are unexplored and their prognostic significanc...

journal_title：Anticancer research

authors： Branca M,Ciotti M,Giorgi C,Santini D,Di Bonito L,Costa S,Benedetto A,Bonifacio D,Di Bonito P,Paba P,Accardi L,Syrjänen S,Favalli C,Syrjänen K,HPV-PathogenISS Study Group.

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND/AIM:Intensity-modulated radiation therapy (IMRT) is a form of radiation therapy that allows accurate irradiation with reduced damage to surrounding tissues. Here, we analyzed borderline-resectable pancreatic cancer (BRPC) with arterial abutment (BR-A) patients with IMRT as neoadjuvant therapy and performed c...

journal_title：Anticancer research

authors： Masui T,Takaori K,Anazawa T,Sato A,Nakano K,Uchida Y,Yogo A,Goto Y,Matsumoto S,Kodama Y,Kanai M,Isoda H,Mizumoto M,Kawaguchi Y,Shibuya K,Itasaka S,Uemoto S

更新日期：2017-12-01 00:00:00

abstract：:Cells cultured as spheroids present an heterogeneity similar to that of tumours in vivo. In the spheroid peripheral layers, cells are proliferating, deeper cells are non-cycling, when in the aggregate centre, cells form often a necrotic core. A multicellular resistance is related on the cell contact to other cells or ...

journal_title：Anticancer research

authors： Desoize B,Gimonet D,Jardiller JC

更新日期：1998-11-01 00:00:00

abstract：:To evaluate the association and interaction of genotypic polymorphism the gene for DNA-apurinic/apyrimidinic endonuclease (APEX1) with personal smoking habit and lung cancer risk in Taiwan, the polymorphic variants of APEX1, Asp(148)Glu (rs1130409), were analyzed in association with lung cancer risk, and their joint e...

journal_title：Anticancer research

authors： Chen WC,Tsai CW,Hsia TC,Chang WS,Lin LY,Liang SJ,Tu CY,Cheng WE,Chen HJ,Wang SM,Bau dT

更新日期：2013-06-01 00:00:00

abstract：:We report a case with unexpected toxicity after low-dose docetaxel chemotherapy. The patient had a history of clinically latent HCV-positive hepatic cirrhosis when she presented with inoperable pulmonary adenocarcinoma. She was recruited in a protocol combining standard radiotherapy (RT) with docetaxel (30 mg/m2 week)...

journal_title：Anticancer research

authors： Koukourakis MI,Kapsoritakis A,Maltezos E,Potamiano S,Mouzas I,Kouroumalis H

更新日期：2002-07-01 00:00:00

abstract：:Macrophages in varying states of activation differ in their ability to perform antibody-dependent cellular cytotoxicity (ADCC). To define further the activation requirements for macrophages to perform cytolytic functions, we stimulated peptone-elicited peritoneal macrophages, which exhibit only a low level of ADCC, wi...

journal_title：Anticancer research

authors： Fehr HG,Fan S,Lötzerich H,Appell HJ

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND:Sweet's syndrome (SS) is a febrile neutrophilic dermatosis that has been clinically linked to hematological malignancies, particularly myelodysplastic syndrome (MDS), in a number of case series. Many epigenetic changes underlying MDS have been identified, such as a mutation in the isocitrate dehydrogenase 1 ...

journal_title：Anticancer research

authors： Snyder R,Libby T,Raciti P,Amin B,Jacobson M,Rakheja D,Fleming K,Bartenstein M,Zhu C,Goel S,Verma AK,Shastri A

更新日期：2018-04-01 00:00:00

abstract：UNLABELLED:The present study evaluated the frequency of the polymorphism of Interleukin-6 (IL6) in women positive for E6/E7 Human Papillomavirus (HPV) (n=152) and women negative for HPV (n=238), 390 women in total. Material for analysis was obtained at the Federal University of São Paulo. Interleukin-6 polymorphism was...

journal_title：Anticancer research

authors： Porto CR,De Oliveira Kleine JP,Longatto Filho A,Da Silva ID

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Concurrent chemoradiotherapy with gemcitabine improves median survival for patients with unresectable pancreatic cancer. Recently, hyperfractionated accelerated radiotherapy (HART) has been used to treat these patients; however, the safety and efficacy are not well defined. PATIENTS AND METHODS:The standard...

journal_title：Anticancer research

authors： Maemura K,Shinchi H,Noma H,Mataki Y,Kurahara H,Maeda S,Hiraki Y,Nakajo M,Natsugoe S,Takao S

更新日期：2008-07-01 00:00:00

abstract：AIM:To evaluate the role of low mechanical index (MI) contrast-enhanced sonography (CEUS) for the characterization of small hepatocellular carcinomas (HCC) in cirrhotic patients by comparing the results to ultrafast dynamic gadolinium-enhanced magnetic resonance imaging (MRI) studies. MATERIALS AND METHODS:Between Sep...

journal_title：Anticancer research

authors： Giorgio A,De Stefano G,Coppola C,Ferraioli G,Esposito V,Di Sarno A,Giorgio V,De Stefano M,Sangiovanni V,Liorre G,Del Viscovo L

更新日期：2007-11-01 00:00:00

abstract：:Currently, feeder cells are γ-irradiated immediately before use for the ex vivo expansion of natural killer (NK) cells from human peripheral blood. Storing irradiated feeder cells by cryopreserving them in multiple vials would be more convenient than irradiating cells each time they are needed. We compared NK cell exp...

journal_title：Anticancer research

authors： Baek HJ,Kim JS,Yoon M,Lee JJ,Shin MG,Ryang DW,Kook H,Kim SK,Cho D

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND/AIM:In this study we aimed to determine if advanced age represents a risk factor for negative perioperative and long-term outcome in patients undergoing curative surgery ductal pancreatic adenocarcinoma surgery. PATIENTS AND METHODS:Two-hundred-twenty-one consecutive patients, twelve (6%) patients ≥80 years...

journal_title：Anticancer research

authors： Marsoner K,Kornprat P,Sodeck G,Schagerl J,Langeder R,Csengeri D,Wagner D,Mischinger HJ,Haybaeck J

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND/AIM:Matrix metalloproteinases (MMPs) are a family of proteins which are involved in breakdown of the extracellular matrix in embryonic development, tissue remodeling and in some diseases. MMP8 has both cancer-promoting and anticancer properties. However, the contribution of MMP8 to laryngeal squamous cell ca...

journal_title：Anticancer research

authors： Insodaite R,Liutkevicius V,Uloza V,Solovejute R,Smalinskiene A

更新日期：2020-04-01 00:00:00

abstract：:5-Fluorouracil (5FU) increases the rate of incorporation of tritiated thymidine (3HTdR) and iododeoxyuridine (125 IUdR) into the cell and its DNA. 5FU has differential effect on metabolism of DNA through its specific action on thymidylate synthetase. Effects of 5FU on the incorporation of other metabolic precursors we...

journal_title：Anticancer research

authors： Vercammen-Grandjean AF,Arnould R,Libert A,Lejeune FJ

更新日期：1982-05-01 00:00:00

abstract：:Overexpression of acyl-coenzyme A:cholesterol acyltransferase (ACAT) results in increased cholesteryl ester levels and has been involved in a variety of cancer types. As a consequence, cholesterol metabolism has raised interest as a potential target for cancer treatment. Inhibition of ACAT results in suppression of pr...

journal_title：Anticancer research

authors： Zabielska J,Sledzinski T,Stelmanska E

更新日期：2019-07-01 00:00:00

abstract：UNLABELLED:Inhibins (INH) are dimeric glycoproteins composed of an alpha-subunit (INH-alpha) and one of two possible beta-subunits (INH-betaA or -betaB), with substantial roles in human reproduction and in endocrine-responsive tumours. The aim of the present study was the determination of the frequency and tissue distr...

journal_title：Anticancer research

authors： Vogl J,Höing A,Schulze S,Kuhn C,Wiest I,Shabani N,Jeschke U,Mylonas I,Friese K

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:NSC697923, a ubiquitin-conjugating enzyme E2 (UBE2) inhibitor, was suggested as an agent to degrade hypoxia-inducible factor 1 alpha subunit (HIF1α), a key factor in radiation resistance. We attempted to clarify whether NSC697923 could overcome radiation resistance. MATERIALS AND METHODS:Radiation resistanc...

journal_title：Anticancer research

authors： Gombodorj N,Yokobori T,Yoshiyama S,Kawabata-Iwakawa R,Rokudai S,Horikoshi I,Nishiyama M,Nakano T

更新日期：2017-05-01 00:00:00