Overexpression of androgen receptor and forkhead-box A1 protein in apocrine breast carcinoma.

Abstract:

AIM:Apocrine breast carcinoma often lacks estrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor type-2 (HER2) expression. Accordingly, development of a new treatment strategy is important for this type of cancer. The growth stimulus through the androgen receptor (AR) can be a candidate for targeted treatment. Therefore, we examined the factors related to AR transcription. MATERIALS AND METHODS:We immunohistochemically evaluated 54 apocrine cancer lesions for ER, PgR, AR, HER2, Ki-67, forkhead-box protein A1 (FOXA1), and prostate-specific antigen (PSA) expression. RESULTS:ER, PgR, and HER2 were expressed at a low level, thus 44 out of 54 (81.4%) cases were of triple-negative breast cancer. AR, PSA and FOXA1 were expressed in 100% (54/54), 48% (26/54) and 93% (50/54) of cases, respectively. CONCLUSION:Most of apocrine breast carcinomas were immunohistochemically-positive for AR and FOXA1. Anti-androgenic therapies can potentially serve as a cancer-targeting therapy for apocrine breast carcinoma.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Sasahara M,Matsui A,Ichimura Y,Hirakata Y,Murata Y,Marui E

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

1261-7

issue

3

eissn

0250-7005

issn

1791-7530

pii

34/3/1261

journal_volume

34

pub_type

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