Myelodysplastic Syndrome and Sweet's Syndrome Are Associated with a Mutation in Isocitrate Dehydrogenase 1.

abstract：:Bcl-2 oncoprotein, a member of a new category of oncogenes associated with the regulation of programmed cell death (apoptosis), has been considered to be involved in biological processes such as tumorigenesis and tumor development. To determine the role of bcl-2 oncoprotein in lung cancer, we preliminarily examined th...

journal_title：Anticancer research

authors： Higashiyama M,Doi O,Kodama K,Yokouchi H,Tateishi R

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:Oral squamous cell carcinoma (OSCC) is a multifactorial neoplasm related to tobacco smoke, alcohol consumption and molecular genetic changes such as p53 mutations. The human tumor suppressor gene TP53 contains single nucleotide polymorphism that encodes either arginin (Arg) or proline (Pro) at amino acid cod...

journal_title：Anticancer research

authors： Drummond SN,De Marco L,Pordeus Ide A,Barbosa AA,Gomez RS

更新日期：2002-11-01 00:00:00

abstract：:Adrenocortical Carcinoma (ACC) is rare with an annual incidence of 0.5-2 cases per million worldwide. Some ACC tumors over express N-cadherin, which correlates with metastatic potential. ADH-1 (Exherin™) is a competitive inhibitor of N-cadherin, resulting in rapid onset of tumor vascular angiolysis and apoptosis in pr...

journal_title：Anticancer research

authors： Yarom N,Stewart D,Avruch L,Malik R,Wells J,Jonker DJ

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:To investigate the differences between two rat yolk sac tumor cell lines with different radiosensitivities and p53 status in sensitivity to high-LET heavy-ion beam and in sensitizing effect of etoposide or cisplatin in combination with heavy-ion beam. MATERIALS AND METHODS:NMT-1 (wild-type p53 cell) is a pa...

journal_title：Anticancer research

authors： Takahashi T,Fukawa T,Hirayama R,Yoshida Y,Musha A,Furusawa Y,Ando K,Nakano T

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:The chronomodulated infusion of 5-FU, FA and oxaliplatin allows a significant increase in dose intensity and antitumor efficacy in patients with metastatic colorectal cancer. Here we investigated if substitution of oxaliplatin with cisplatin produced a similar antitumor activity in previously untreated patie...

journal_title：Anticancer research

authors： Natoli C,Scognamiglio MT,Martino MT,Irtelli L,De Tursi M,Cianchetti E,Mascitelli E,Tinari N,Iacobelli S

更新日期：2000-03-01 00:00:00

abstract：:Urachal cancer is a rare malignancy and the standard treatment is surgical resection. The prognosis of recurrent and metastatic urachal cancer is extremely poor because there is no established chemotherapy regimen. Here, the response of one patient with recurrent urachal cancer to combination chemotherapy of gemcitabi...

journal_title：Anticancer research

authors： Miyata Y,Sagara Y,Matsuo T,Ohba K,Takahashi H,Sakai H,Kanetake H

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Green tea polyphenols (GTPs) have been proposed as promising candidates for chemoprevention. However, GTPs levels are maintained relatively low in the blood and are chemically-unstable. Lipid-soluble tea polyphenols (LTPs) are products of modified GTPs with ester linkage with fatty acids. LTPs are lipophilic...

journal_title：Anticancer research

authors： Shen T,Khor SC,Zhou F,Duan T,Xu YY,Zheng YF,Hsu S,DE Stefano J,Yang J,Xu LH,Zhu XQ

更新日期：2014-02-01 00:00:00

abstract：:Neurotrophins are a family of growth factors that are vital to the proper development of the central nervous system. Their effects on cells are governed by the expression and activation of the tyrosine kinase receptors TrkA, TrkB and TrkC. TrkB has been immensely implicated in mediating neuronal migration, development...

journal_title：Anticancer research

authors： Radin DP,Patel P

更新日期：2017-08-01 00:00:00

abstract：:A high-throughput 32D(L858R/T790M) cell-based assay to identify inhibitors of the L858R/T790M mutant epidermal growth factor receptor (EGFR) pathway was established. After screening, ten hits from among 60,000 compounds in our in-house compound library were initially identified. In the secondary assays, one hit, 1-[2-...

journal_title：Anticancer research

authors： Lin WH,Song JS,Lien TW,Chang CY,Wu SH,Huang YW,Chang TY,Fang MY,Yen KJ,Chen CH,Chu CY,Hsieh HP,Chen YR,Chao YS,Hsu JT

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:Malignant gliomas still present a medical challenge, despite decades of continuous extensive research with optimization of surgical techniques, radiotherapy and systemic treatments. PATIENTS AND METHODS:From 1999 to 2004, 104 patients with WHO grade III and IVgliomas underwent surgery and received concomita...

journal_title：Anticancer research

authors： Eberlein KH,Nagel B,Franz K,Imhoff D,Seifert V,Boettcher HD,Mose S

更新日期：2006-11-01 00:00:00

abstract：:Megakaryocyte polyploidization responds to platelet demand and results from the lack of cytoplasmic separation while the nucleus keeps dividing. In normal telophase, the plane of the actin constriction ring is determined by the tubulin spindle. In order to investigate the role of tubulin in the megakaryocyte polyploid...

journal_title：Anticancer research

authors： Baatout S,Chatelain B,Staquet P,Symann M,Chatelain C

更新日期：1998-05-01 00:00:00

abstract：BACKGROUND:We conducted a phase II study of topotecan (Tp) with cisplatin (CDDP) in previously untreated Japanese patients with extensive-disease small cell lung cancer (ED-SCLC). PATIENTS AND METHODS:In stage 1, a total of 30 patients were allocated to Tp 0.65 mg/m(2) with CDDP 60 mg/m(2) day 1 or Tp 1.00 mg/m(2) wit...

journal_title：Anticancer research

authors： Hosomi Y,Shibuya M,Niho S,Ichinose Y,Kiura K,Sakai H,Takeda K,Kudo S,Eguchi K,Matsui K,Masuda N,Ando M,Watanabe K

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Activating mutations of the BRAF gene have recently been reported in thyroid carcinomas. In particular, V600E mutation is highly prevalent in papillary thyroid carcinoma (PTC). PATIENTS AND METHODS:In this study, the BRAF (V600E) mutation in 54 PTCs was investigated and the relationship between the BRAF mut...

journal_title：Anticancer research

authors： Nakayama H,Yoshida A,Nakamura Y,Hayashi H,Miyagi Y,Wada N,Rino Y,Masuda M,Imada T

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:We investigated the influence of age on short-term complications in women undergoing intraoperative radiotherapy (IORT) for early breast cancer. PATIENTS AND METHODS:We retrospectively analyzed data of 188 women who underwent IORT during breast-conserving surgery (BCS). The study group consisted of 54 patie...

journal_title：Anticancer research

authors： Tuschy B,Berlit S,Romero S,Sperk E,Wenz F,Kehl S,Sütterlin M

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND/AIM:ANRIL is a long noncoding RNA located on INK4 locus, which encodes p15 and p16 that cause G1 phase arrest in the cell cycle. ANRIL positively regulates proliferation of several kinds of cancer cells such as lung and gastric cancers. This study, examined the effect of ANRIL in head and neck squamous cell ...

journal_title：Anticancer research

authors： Matsunaga N,Wakasaki T,Yasumatsu R,Kotake Y

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Plasmacytoid dendritic cells (PDCs) infiltrating solid tumor tissues and draining lymph nodes of head and neck squamous cell carcinoma (HNSCC) show an impaired immune response. Immunosuppressive cytokines secreted by HNSCC have been recognized to account for reduced interferon-alpha (IFN-alpha) production, w...

journal_title：Anticancer research

authors： Thiel A,Pries R,Jeske S,Trenkle T,Wollenberg B

更新日期：2009-08-01 00:00:00

abstract：:Our recent study has demonstrated that B16 melanoma-induced cachexia in mice is inhibited by ponalrestat, an aldose reductase inhibitor, which has the ability to activate lipoprotein lipase (LPL) activity both in vitro and in vivo. In this study, the effect of bezafibrate and NO-1886, LPL activators, on B16 melanoma-i...

journal_title：Anticancer research

authors： Kawamura I,Yamamoto N,Sakai F,Yamazaki H,Goto T

更新日期：1999-09-01 00:00:00

abstract：:Upper gastrointestinal malignancies are associated with a high disease burden worldwide, and esophageal and gastric cancers represent the most common entities. Given a lack of early characteristic symptoms and potent screening instruments, the majority of patients present with advanced disease at the time of diagnosis...

journal_title：Anticancer research

authors： Bolm L,Käsmann L,Paysen A,Karapetis C,Rades D,Wellner UF,Keck T,Watson DI,Hummel R,Hussey DJ

更新日期：2018-06-01 00:00:00

abstract：:Squamous cell carcinomas (SCC) make up 96% of all oral cancers. Most laboratory SCC studies grow cells as a monolayer, which does not accurately represent the disease in vivo. We used a more relevant multicellular spheroid (MCS) model to study this disease. The SCC9β6KDFyn cell line, which expresses full-length β6 and...

journal_title：Anticancer research

authors： Lee C,Lee C,Atakilit A,Siu A,Ramos DM

更新日期：2014-12-01 00:00:00

abstract：AIM:Metastasis of unknown primary (MUP) is commonly treated with radiation therapy (RT) to the entire mucosal surfaces and bilateral neck nodes (LN). We report outcomes of oropharynx-targeted RT, retropharyngeal nodes (RPN) and bilateral LN in this context. PATIENTS AND METHODS:Single-Institution retrospective study o...

journal_title：Anticancer research

authors： Mourad WF,Hu KS,Shasha D,Concert C,Ishihara D,Lin W,Shourbaji RA,Ryniak M,Gamez ME,Lukens JN,Li Z,Culliney BE,Khorsandi AS,Tran T,Jacobson A,Manolidis S,Schantz S,Urken M,Persky MS,Harrison LB

更新日期：2014-01-01 00:00:00

abstract：:The option to treat patients presenting with HER-2 overexpressed invasive breast carcinoma with Herceptin requires quantitative determination of the HER-2 status. The aim of this study was to retrospectively evaluate the HER-2 mRNA expression levels using quantitative real-time RT-PCR (Q-RT-PCR) in tissue samples from...

journal_title：Anticancer research

authors： Bossard C,Bieche I,Le Doussal V,Lidereau R,Sabourin JC

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND/AIM:Gemcitabine is a drug commonly used to treat pancreatic cancer but chemoresistance to it is a common clinical issue. KML001 (sodium meta-arsenite) has demonstrated certain antitumor activity. The objective of the study was to evaluate the influence of KML001 on the anticancer activity of gemcitabine agai...

journal_title：Anticancer research

authors： Yang MH,Lee KT,Yang S,Lee JK,Lee KH,Rhee JC

更新日期：2015-01-01 00:00:00

abstract：:The compound 317615 x 2HCl, a selective protein kinase Cbeta inhibitor, was not very cytotoxic toward human CaKi1 renal cell carcinoma cells or human HT-29 colon carcinoma cells in monolayer culture. Isobologram analysis was used to determine additivity or synergy of the combination regimens. Exposure of CaKi1 cells t...

journal_title：Anticancer research

authors： Teicher BA,Menon K,Alvarez E,Galbreath E,Shih C,Faul MM

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND/AIM:Chest radiotherapy (RT) doubles late cardiac mortality. This study aimed to evaluate the evolution of cardiac changes in speckle tracking echocardiography during a three-year follow-up. MATERIALS AND METHODS:This prospective study included 81 chemotherapy-naïve early-stage breast cancer patients who wer...

journal_title：Anticancer research

authors： Tuohinen SS,Skytta T,Huhtala H,Virtanen V,Kellokumpu-Lehtinen PL,Raatikainen P

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:In the present study, 3 cytotoxic agents were combined as front-line chemotherapy in advanced non-small cell lung cancer (NSCLC) patients. All 3 drugs have been used in other 2-agent combinations and have been shown to be effective as first-line therapy. PATIENTS AND METHODS:Sixty-one (53 male, 8 female, me...

journal_title：Anticancer research

authors： Dimitroulis J,Toubis M,Antoniou D,Marosis C,Armenaki U,Stathopoulos GP,Giamboudakis P,Veslemes M,Michalopoulou P,Christou F,Georgatou N,Grigoratou T,Karaindros D,Katis K,SOLCA Study Group.

更新日期：2006-03-01 00:00:00

abstract：:The association of anaemia and other predictors of fatigue was studied in cancer patients on palliative treatment. A cohort of 128 consecutive patients (61 men and 67 women, mean age 63.6 years; range 36-85) was interviewed using the Edmonton Symptom Assessment System (ESAS) questionnaire, with 11 items describing can...

journal_title：Anticancer research

authors： Latvala A,Syrjänen K,Salmenoja H,Salminen E

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:The determination of dihydropyrimidine dehydrogenase (DPD) deficiency is important in avoiding severe 5-fluorouracil (FU) toxicity. The dihydrouracil (UH2)-uracil (Ura) ratio (UH2/Ura) in plasma might be an important indicator of the risk of 5-FU catabolic deficiency. In order to clarify this possibility, th...

journal_title：Anticancer research

authors： Nakayama Y,Matsumoto K,Inoue Y,Katsuki T,Kadowaki K,Shibao K,Tsurudome Y,Hirata K,Sako T,Nagata N,Itoh H

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND/AIM:FAM92A1-289 is recognized as one of the newly-discovered putative oncogenes. This study was performed to reveal its oncogenic functions in human cervical carcinoma cells. MATERIALS AND METHODS:The FAM92A1-289+ cell line was established with knock-in technique and selected by puromycin-resistance screeni...

journal_title：Anticancer research

authors： Gui H,Guo XR,Fang J,Ma SN,Wu G,Shen JH,Tu HJ,Li DS,Dai LJ,Ruan XZ

更新日期：2016-10-01 00:00:00

abstract：:Induction of apoptosis by green tea polyphenols has been observed in various tumor cell systems, but whether green tea polyphenol-induced apoptosis requires caspase 3 for execution has not been confirmed. We previously reported that green tea polyphenol-induced apoptosis involved Apaf-1 accumulation and caspase 3 acti...

journal_title：Anticancer research

authors： Hsu S,Lewis J,Singh B,Schoenlein P,Osaki T,Athar M,Porter AG,Schuster G

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND/AIM:Intensity-modulated radiation therapy (IMRT) is a form of radiation therapy that allows accurate irradiation with reduced damage to surrounding tissues. Here, we analyzed borderline-resectable pancreatic cancer (BRPC) with arterial abutment (BR-A) patients with IMRT as neoadjuvant therapy and performed c...

journal_title：Anticancer research

authors： Masui T,Takaori K,Anazawa T,Sato A,Nakano K,Uchida Y,Yogo A,Goto Y,Matsumoto S,Kodama Y,Kanai M,Isoda H,Mizumoto M,Kawaguchi Y,Shibuya K,Itasaka S,Uemoto S

更新日期：2017-12-01 00:00:00