Abstract:
:Induction of apoptosis by green tea polyphenols has been observed in various tumor cell systems, but whether green tea polyphenol-induced apoptosis requires caspase 3 for execution has not been confirmed. We previously reported that green tea polyphenol-induced apoptosis involved Apaf-1 accumulation and caspase 3 activation in the cytosol. In the current study, tumor cells either with deleted caspase 3 gene or expressing wild-type caspase 3 were treated with increasing concentrations of green tea polyphenol(s), followed by morphological analysis and caspase 3 activity assay. The caspase 3 null parental cell line was further examined in comparison with a well-characterized, caspase 3 wild type oral carcinoma cell line by MTT assay and BrdU incorporation assay. The results demonstrated that, while the mitochondrial function gradually declined to insignificant levels, caspase 3 null cells did not undergo apoptosis, which suggested that green tea polyphenol-induced apoptosis is a mitochondria-targeted, caspase 3-executed mechanism.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Hsu S,Lewis J,Singh B,Schoenlein P,Osaki T,Athar M,Porter AG,Schuster Gsubject
Has Abstractpub_date
2003-03-01 00:00:00pages
1533-9issue
2Beissn
0250-7005issn
1791-7530journal_volume
23pub_type
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journal_title:Anticancer research
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pub_type: 杂志文章,评审
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