Effect of PSC 833 on the efficacy of doxorubicin in vitro in a medullary thyroid carcinoma cell line.

abstract：BACKGROUND/AIM:4-methylumbelliferone (4-MU) has received considerable attention due to its potential for cancer treatment since it inhibits cell proliferation, migration and invasion. An increasing body of evidence suggests that extracellular matrix (e.g. hyaluronan) and nutrients (e.g. glucose) in the tumor microenvir...

journal_title：Anticancer research

authors： Wang R,Zhou W,Wang J,Liu Y,Chen Y,Jiang S,Luo X,Stupack DG,Luo N

更新日期：2015-09-01 00:00:00

abstract：:The recent meeting of the AGMIF (Working Group for Mistletoe Therapy and Immunological Research) held in Herdecke, Germany, on October, 3rd, 1997, covered recent developments in the field of immunological and biological properties of Viscum album L., the European mistletoe, which is used for adjuvant cancer treatment....

journal_title：Anticancer research

authors： Stein GM,Schietzel M,Büssing A

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND/AIM:Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a novel clinical approach to the treatment of peritoneal carcinomatosis. A well-established, not anatomic ex vivo PIPAC model was used to investigate the influence of changes in internal pressure, distance of the Micropump(©) (MIP) to the distri...

journal_title：Anticancer research

authors： Khosrawipour V,Khosrawipour T,Falkenstein TA,Diaz-Carballo D,Förster E,Osma A,Adamietz IA,Zieren J,Fakhrian K

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND/AIM:ANRIL is a long noncoding RNA located on INK4 locus, which encodes p15 and p16 that cause G1 phase arrest in the cell cycle. ANRIL positively regulates proliferation of several kinds of cancer cells such as lung and gastric cancers. This study, examined the effect of ANRIL in head and neck squamous cell ...

journal_title：Anticancer research

authors： Matsunaga N,Wakasaki T,Yasumatsu R,Kotake Y

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:The aim of this study was to assess the metallothionein (MT), maintenance protein 2 (Mcm-2) and Ki-67 expressions in adrenocortical adenomas and carcinomas in comparison to normal tissue and evaluate the correlations between these markers of proliferation and between these markers and tumor diameter. MATERI...

journal_title：Anticancer research

authors： Szajerka A,Dziegiel P,Szajerka T,Zabel M,Winowski J,Grzebieniak Z

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Since the anti-HER2 monoclonal antibody trastuzumab made its triumphant advance into breast cancer therapy, new selective agents, including pan-HER inhibitors are entering clinical practice. MATERIALS AND METHODS:This study investigates the expression of the four HER-family members, HER1-4, in 48 primary br...

journal_title：Anticancer research

authors： Fuchs IB,Siemer I,Bühler H,Schmider A,Henrich W,Lichtenegger W,Schaller G,Kuemmel S

更新日期：2006-11-01 00:00:00

abstract：:Constitutive activation of estrogen receptor alpha (ER-alpha) expression is an early event in breast cancer tumorigenesis. However, the mechanism whereby ER-alpha is constitutively activated during transformation of normal mammary cells has not been well established. Previously, we reported that haploinsufficiency of ...

journal_title：Anticancer research

authors： Zhang X,Shen P,Coleman M,Zou W,Loggie BW,Smith LM,Wang Z

更新日期：2005-01-01 00:00:00

abstract：:The radical modulation activity of hot water and NaOH extracts of the thorn apple of Crataegus Cuneata Sieb. et. Zucc. was investigated, using ESR spectroscopy. The radical intensity of sodium ascorbate was slightly reduced at lower concentrations of the extracts, but it was synergistically enhanced at higher concentr...

journal_title：Anticancer research

authors： Satoh K,Anzai S,Sakagami H

更新日期：1998-07-01 00:00:00

abstract：:The influence of cytostatically active alkyllysophospholipid analogs with different chemical structure on IP3 (inositol-1,4,5-trisphosphate) formation and intracellular Ca++ concentration was studied in human mammary epithelial cells before and after transfection with v-erb B oncogene DNA. Transformed cells showed an ...

journal_title：Anticancer research

authors： Junghahn I,Bergmann J,Langen P,Thun I,Vollgraf C,Brachwitz H

更新日期：1995-03-01 00:00:00

abstract：:Metastatic pancreatic malignant melanoma is considered to be a highly aggressive neoplasm, and only few metastasectomies for lesions originating from the skin or the ocular region have been reported. We report a case of resection of pancreatic metastasis of malignant melanoma originating from the nasal cavity. An isol...

journal_title：Anticancer research

authors： Sugimoto M,Gotohda N,Kato Y,Takahashi S,Kinoshita T,Shibasaki H,Kojima M,Ochiai A,Zenda S,Akimoto T,Konishi M

更新日期：2013-02-01 00:00:00

abstract：:Many retrospective trials have demonstrated a survival benefit for elective lymph node dissection (ELND) in the treatment of clinical stage I malignant melanoma, but two randomized trials have found none. The relevant medical literature was reviewed with special attention devoted to the tumor burden of nodal disease. ...

journal_title：Anticancer research

authors： Evans RA

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:Human carcinomas not only consist of neoplastic epithelial cells but also of tumor stroma, which may play an important role in tumor-progression. Whereas the tumor surrounding stroma is generally believed to represent a reactive component induced by tumor cell derived factors, a contribution of neoplastic ce...

journal_title：Anticancer research

authors： Wernert N,Löcherbach C,Wellmann A,Behrens P,Hügel A

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:DMXAA (5,6-dimethylxanthenone-4-acetic acid; AS1404), a vascular disrupting agent currently in clinical trials, induces tumour endothelial cell apoptosis in vivo in mice and in cancer patients. DMXAA activates NF-kappaB in many different cell types. In this study, whether DMXAA-induced endothelial cell apopt...

journal_title：Anticancer research

authors： Woon ST,Hung SS,Wu DC,Schooltink MA,Sutherland R,Baguley BC,Chen Q,Chamley LW,Ching LM

更新日期：2007-01-01 00:00:00

abstract：:TPS was determined by immunohistochemistry in 44 different tissues (normal and pathological) from various organs such as cervix, endometrium, breast, stomach, bowel and bladder. TPS was expressed in several physiologic situations: in different phases of the endometrial cycle and in cervical metaplasia. In other organs...

journal_title：Anticancer research

authors： Giovagnoli MR,Valli C,Vecchione A,Vecchione A

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND:Preclinical studies have shown that paclitaxel and doxifluridine can act synergistically without overlapping toxicity for the treatment of advanced gastric cancer. The objectives of this study were to determine the maximum tolerated dose (MTD), the dose-limiting toxicity and the recommended Phase II dose for...

journal_title：Anticancer research

authors： Takeyoshi I,Makita F,Tanahashi Y,Yokomori T,Iwazaki S,Kawashima Y,Iwanami K,Yamada T,Kawate S,Hamada K,Sunose Y,Yoshida M,Horiguchi J,Iesato H,Kobayashi M,Morishita Y

更新日期：2005-03-01 00:00:00

abstract：AIM:We investigated the relationship between a new index considering the estimated working space and difficulty of robot-assisted radical prostatectomy (RARP) using our database. PATIENTS AND METHODS:Working height was calculated by the obstetric conjugate diameter minus the bladder and rectal wall thicknesses minus t...

journal_title：Anticancer research

authors： Kadono Y,Ueno S,Makino T,Ofude M,Izumi K,Gabata T,Namiki M

更新日期：2014-10-01 00:00:00

abstract：:We have previously shown that transfection of NIH 3T3 cells with the T24 H-ras oncogene converts the cells to a tumorigenic and metastatic phenotype, in proportion to levels of ras expression. We hypothesize that ras-induced increases in malignancy occur via altered expression of various genes. We have identified OPN ...

journal_title：Anticancer research

authors： Chambers AF,Behrend EI,Wilson SM,Denhardt DT

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Estramustine is an anti-mitotic cytostatic drug that also enhances the effect of radiotherapy. The mechanism of radiosensitization is not thoroughly known. Since both radiotherapy and estramustine induce apoptosis in prostate cancer cells, we conducted an experiment to show whether radiosensitization is medi...

journal_title：Anticancer research

authors： Ståhlberg K,Kairemo K,Erkkilä K,Pentikäinen V,Sorvari P,Taari K,Dunkel L,Rannikko S

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Drug resistance to 5-fluorouracil (5-FU) is a major obstacle in colonic cancer treatment. Activation of nuclear factor-kappa B (NFκB), mitogen-activated protein kinase kinase kinase 8 (MAP3K8) and protein kinase B (AKT) is thought to protect cancer cells against therapy-induced cytotoxicity. MATERIALS AND M...

journal_title：Anticancer research

authors： Körber MI,Staribacher A,Ratzenböck I,Steger G,Mader RM

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND/AIM:Vanek's tumor is an inflammatory fibroid polyp (IFP) of very low incidence, which originates in the submucosa of the stomach, duodenum, jejunum and ileum. The etiology of this tumor is still unknown. Histologically, IFP is characterized by submucosal spindle cell proliferation in fibromyxoid stroma with ...

journal_title：Anticancer research

authors： Jukic Z,Ferencic Z,Radulovic P,Mijic A,Fucic A

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND/AIM:As a result of activation of transcription factors engaged in epithelial-mesenchymal transition (EMT), such as Twist, inhibition of epithelial markers and an increased expression of mesenchymal markers are observed. One of the specific markers of cancer-associated fibroblasts is podoplanin (PDPN) - a muc...

journal_title：Anticancer research

authors： Grzegrzolka J,Wojtyra P,Biala M,Piotrowska A,Gomulkiewicz A,Rys J,Podhorska-Okolow M,Dziegiel P

更新日期：2017-10-01 00:00:00

abstract：:Transcatheter embolization is considered to be less effective for early-stage hepatocellular carcinomas (HCCs) without a hypervascular arterial supply. In the present case report, a 65-year-old male with hepatitis type C and non-hypervascular HCC located in the hepatic hilum was successfully treated by bland transarte...

journal_title：Anticancer research

authors： Tanaka T,Maeda S,Nishiofuku H,Masada T,Sato T,Anai H,Sakaguchi H,Kichikawa K

更新日期：2014-04-01 00:00:00

abstract：:Malignant cells appear to possess a special aptitude for survival. We attempted to prove this in vitro by acute nutritional and energy deprivation as a survival threat. A phosphate-buffered saline (PBS) survival test in cell culture allowed static observations. These were supplemented by classic and quantitative phase...

journal_title：Anticancer research

authors： Janeckova H,Vesely P,Chmelik R

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:Although p21 is an important component that regulates cell-cycle progression, no consensus has been reached about its clinicopathological significance in esophageal squamous cell carcinoma (ESCC). In the present study, we investigated its prognostic significance and correlation with cyclin-D1 (CCND1) express...

journal_title：Anticancer research

authors： Shiozaki A,Nakashima S,Ichikawa D,Fujiwara H,Konishi H,Komatsu S,Kubota T,Okamoto K,Iitaka D,Shimizu H,Nako Y,Takemoto K,Kishimoto M,Otsuji E

更新日期：2013-10-01 00:00:00

abstract：:A brief review summarizing the relationships that exist between the DEK protein and gene regulation, oncogenesis and AIDS. ...

journal_title：Anticancer research

authors： Sitwala KV,Mor-Vaknin N,Markovitz DM

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND/AIM:To predict pCR during neoadjuvant chemotherapy is still difficult. The aim of this study was to evaluate the optimal tumor reduction rate and modalities for predicting pCR after two cycles of docetaxel. PATIENTS AND METHODS:We analyzed 52 patients with HER2-positive or triple-negative breast cancer. The...

journal_title：Anticancer research

authors： Kuba S,Maeda S,Matsumoto M,Yamanouchi K,Iwata T,Morita M,Sakimura C,Otsubo R,Yano H,Sato S,Kanetaka K,Nagayasu T,Eguchi S

更新日期：2020-04-01 00:00:00

abstract：:The expression of the HMG-CoA-reductase and LDL-receptor genes was examined in primary human embryonic tumours and in normal human first trimester foetal tissues. All embryonic and extra-embryonic tissues examined contained RNA that hybridized with the HMG-CoA-reductase and LDL-receptor cDNA-probes. However, the trans...

journal_title：Anticancer research

authors： Engström W,Schofield PN

更新日期：1987-05-01 00:00:00

abstract：:In a prospective study comprising 447 women with endometrial carcinoma stages I-II, the prognostic significance of clinical and flow cytometric variables was evaluated in univariate and multivariate analyses. The parameters studied included age, uterine cavity depth, clinical stage, histopathologic grade, myometrial i...

journal_title：Anticancer research

authors： Wagenius G,Bergström R,Strang P,Gerdes U,Rogo K,Tribukait B,Stendahl U

更新日期：1992-05-01 00:00:00

abstract：:Studies on taurine transport in MDR (multidrug resistant) and non-MDR KB cancer cells show that both cell types contain Na(+)- and Cl(-)-dependent high-affinity and low-affinity transport systems selective for beta-amino acids and a taurine diffusion component. Good buffers, such as HEPES or MOPS, interfered with taur...

journal_title：Anticancer research

authors： Wersinger C,Rebel G,Lelong-Rebel IH

更新日期：2001-09-01 00:00:00

abstract：:Among the limiting side-effects of anticancer drugs, hematological toxicity is the most frequent. Hematological analysis focuses on nucleated blood cells from mouse peripheral blood or hematopoietic organs (bone marrow, spleen, thymus). We have developed an automated method called A.H.E.A.D. (Automated Hematotoxicolog...

journal_title：Anticancer research

authors： Saint-Dizier D,Sancier M,Cudennec CA

更新日期：1990-05-01 00:00:00