Prognostic role of angiogenesis in colorectal cancer.

Abstract:

:The need for dependable prognostic markers in colorectal cancer, both in the advanced as well the as adjuvant setting, is greater than ever. The introduction of new chemotherapeutic agents in the clinic, with different mechanisms of action as well as different side-effect profiles, has made this even more important. Angiogenesis, the formation of new vessels, is essential for tumour growth and metastasis. The adverse impact of tumour angiogenesis in the context of colorectal cancer on relapse and prognosis has been evaluated in numerous retrospective studies. Most of these studies have tended to be relatively small in terms of patient numbers and sometimes have reached conflicting conclusions. A number of different angiogenic factors, including vascular endothelial growth factor (VEGF), thymidine phosphorylase (TP) and intratumoural microvessel density (IMD), have been assessed to varying extents. This article highlights some of the important developments in this rapidly expanding field.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Papamichael D

subject

Has Abstract

pub_date

2001-11-01 00:00:00

pages

4349-53

issue

6B

eissn

0250-7005

issn

1791-7530

journal_volume

21

pub_type

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