Human Mesenchymal Stem Cells Protect Dorsal Root Ganglia from the Neurotoxic Effect of Cisplatin.

abstract：CASE REPORT:This case study reports on a patient who relapsed with thymoma (mixed type) nine years after tumor resection. After four courses of rescue chemotherapy (docetaxel and cisplatinum), the patient was further diagnosed with pure red cell aplasia. It was noticed that cyclosporin A (CsA), which was administered t...

journal_title：Anticancer research

authors： Li P,Du F,Gong Z,Hu B,Chi C,Chu H,Chen J

更新日期：2017-08-01 00:00:00

abstract：:Considerable progress has recently been achieved in understanding the pathogenesis of human immunodeficiency virus type 1 (HIV-1), and in improving the efficacy of antiretroviral therapies for the treatment of patients with the acquired immunodeficiency syndrome (AIDS). The pharmacological properties of new drugs are ...

journal_title：Anticancer research

authors： Romano G,Massi D,Giordano A

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND/AIM:For cases of musculoskeletal sarcoma of the knee presenting to our institute, we prioritize joint preservation whenever possible. To investigate patient satisfaction and desire for joint preservation, a questionnaire survey was performed. PATIENTS AND METHODS:Surveys were mailed to 62 patients with musc...

journal_title：Anticancer research

authors： Abe K,Yamamoto N,Hayashi K,Takeuchi A,Kato S,Miwa S,Igarashi K,Inatani H,Aoki YU,Higuchi T,Taniguchi Y,Tsuchiya H

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Oxi4503 has been shown to inhibit tumor growth and improve survival in an animal model of colorectal (CRC) liver metastases. This agent appears to selectively target the endothelial cytoskeleton with resultant vessel occlusion and tumor necrosis. MATERIALS AND METHODS:This study evaluated the pattern of tum...

journal_title：Anticancer research

authors： Chan LS,Malcontenti-Wilson C,Muralidharan V,Christophi C

更新日期：2007-07-01 00:00:00

abstract：AIM:To report the outcomes of salvage robot-assisted radical prostatectomy (S-RaRP). PATIENTS AND METHODS:Fourteen patients underwent S-RaRP. The mean initial prostatic-specific antigen level was 14.3 ng/ml and mean Gleason score was 6.93. Initial definitive treatment was external irradiation in 11 cases, cyberknife i...

journal_title：Anticancer research

authors： Ou YC,Hung SC,Hwang LH,Yang CK,Hung SW,Tung MC

更新日期：2017-04-01 00:00:00

abstract：:"Poly-plat", SSP, and SAP are second generation analogs of cisplatin (CDDP) with higher efficacy and potency. In order to understand the mechanism of action of these compounds, isolated murine peritoneal macrophages were treated with "poly-plat", SSP, or SAP (5 micrograms/ml) for 2 h. Treated macrophages demonstrated ...

journal_title：Anticancer research

authors： Muenchen HJ,Aggarwal SK

更新日期：1998-07-01 00:00:00

abstract：:In a previous study we determined that the fine needle aspiration (FNA) biopsy of thyroid produces 16% of false-negative cases (FNC). In order to determine the value of quantitative cytology (QC) as a tool for predicting the FNC result, thirty-seven cases, 18 of which were operated (histologically benign: 13; malignan...

journal_title：Anticancer research

authors： Liautaud-Roger F,Dufer J,Pluot M,Delisle MJ,Coninx P

更新日期：1989-01-01 00:00:00

abstract：:We have recently found that sodium fluoride (NaF) induced apoptotic cell death in tumor cell lines. We investigated here whether 6 popular antitumor compounds modify the cytotoxic activity of NaF against human squamous cell carcinoma (HSC-2) and human promyelocytic leukemia (HL-60) cell lines. Cytotoxic concentrations...

journal_title：Anticancer research

authors： Morshed SR,Tokunaga T,Otsuki S,Takayama F,Satoh T,Hashimoto K,Yasui T,Okamura M,Shimada J,Kashimata M,Sakagami H

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND/AIM:N6-Methyladenosine (m6A), the most abundant internal modification of RNA, plays a critical role in cancer development. However, the clinical implications of m6A in hepatocellular carcinoma (HCC) remain unclear. MATERIALS AND METHODS:We analyzed 177 HCC and paired noncancerous liver tissues from patients...

journal_title：Anticancer research

authors： Nakagawa N,Tanaka K,Sonohara F,Kandimalla R,Sunagawa Y,Inokawa Y,Takami H,Hayashi M,Yamada S,Kanda M,Tanaka C,Nakayama G,Koike M,Kodera Y

更新日期：2020-12-01 00:00:00

abstract：AIM:To evaluate the tolerability and efficacy of oxaliplatin-based chemotherapy (OBC) in patients ≥ 75 years old with metastatic colorectal cancer (CRC). PATIENTS AND METHODS:We reviewed the medical records of 126 patients with unresectable stage IV CRC in terms of OBC administered as first-line chemotherapy whenever ...

journal_title：Anticancer research

authors： Fukuchi M,Ishibashi K,Tajima Y,Okada N,Yokoyama M,Chika N,Hatano S,Matsuzawa T,Kumamoto K,Kumagai Y,Baba H,Mochiki E,Ishida H

更新日期：2013-10-01 00:00:00

abstract：:A new cell line, CC3/CUHK3, was established from a squamous carcinoma of the uterine cervix from a Chinese patient. Light microscopy of the cell line revealed keratin and electron microscopy demonstrated tonofilaments and desmosomes, thereby confirming its epithelial nature. The population doubling time of CC3/CUHK3, ...

journal_title：Anticancer research

authors： Chew EC,Ho TH,Yeung SO,Hou HJ,Li RS,Huang DP,Wong FW

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND/AIM:Detection of circulating tumor cells in the perioperative period predicts poor prognosis in patients with colorectal cancer. There is only one Food and Drug Administration-approved method for such detection, CellSearch, for which results have been inconsistent. A new immunological method, CytoTrack, has ...

journal_title：Anticancer research

authors： Gogenur M,Hillig T,Gogenur I

更新日期：2017-06-01 00:00:00

abstract：UNLABELLED:The aim of this study was to determine whether modulation of expression of cell adhesion molecules may occur in neoplastic transformation of endometrial epithelium. MATERIALS AND METHODS:E-Cadherin and α-catenin protein expression were evaluated by immunohistochemistry in 124 biopsies representative of norm...

journal_title：Anticancer research

authors： Carico E,Atlante M,Giarnieri E,Raffa S,Bucci B,Giovagnoli MR,Vecchione A

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND/AIM:Due to their unique composition of health-promoting compounds, the consumption of hazelnuts may contribute to the prevention of colon cancer. MATERIALS AND METHODS:Since hazelnuts are often consumed roasted, the impact of different roasting conditions (RC1=140.6°C/25 min, RC2=155.1°C/20 min and RC3=180....

journal_title：Anticancer research

authors： Glei M,Fischer S,Lamberty J,Ludwig D,Lorkowski S,Schlörmann W

更新日期：2018-01-01 00:00:00

abstract：:In-111 pentetreotide is a new radiolabelled [OctreoScan 111, Mallinckrodt Medical BV, Petten] somatostatin analog with high affinity to somatostatin receptors (SR). introduced for the in vivo imaging of SR positive tissues. In an attempt to evaluate its clinical usefulness for tissue characterization in malignancies w...

journal_title：Anticancer research

authors： Limouris GS,Rassidakis A,Kondi-Paphiti A,Triantafyllou N,Manetou A,Giannakopoulos V,Toubanakis N,Psyhojios I,Stavraka A,Vlahos L

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) is one of the most important factors for angiogenesis in various tumors. However, its clinical significance in extrahepatic biliary tract carcinoma remains unclear. MATERIALS AND METHODS:To clarify the association of VEGF expression with the clinicopathological feat...

journal_title：Anticancer research

authors： Hida Y,Morita T,Fujita M,Miyasaka Y,Horita S,Fujioka Y,Nagashima K,Katoh H

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Malignant glioma is one of the most intractable diseases in the human body. Rho-kinase (ROCK) is overexpressed and has been proposed as the main cause for the refractoriness of the disease. Since efficacious treatment is required, this study investigated the effect of inhibition of ROCK isoforms. MATERIALS ...

journal_title：Anticancer research

authors： Inaba N,Ishizawa S,Kimura M,Fujioka K,Watanabe M,Shibasaki T,Manome Y

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND/AIM:Our original hypothesis was that the rectus sheath block (RSB) analgesia could enhance patient satisfaction and decrease pain following midline laparotomy. PATIENTS AND METHODS:Initially, 56 patients were randomized into four groups; control group (n=12), single-dose (n=16), repeated-dose (n=12) and con...

journal_title：Anticancer research

authors： Kuosmanen V,Ruottinen M,Rahkola D,Saimanen I,Kaaronen V,Selander T,Purdy M,Kokki H,Kokki M,Eskelinen M

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Infiltrates of lymphocytes are found in both autoimmune thyroid disease and papillary cancer and are responsible for thyroid destruction in autoimmune disease. Their role in neoplastic transformation is not yet clear. MATERIALS AND METHODS:Phenotypic studies and the capacity to undergo apoptosis were assess...

journal_title：Anticancer research

authors： Mardente S,Lenti L,Lococo E,Consorti F,Della Rocca C,Romeo S,Misasi R,Antonaci A

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Since tumor markers can be increased in the course of many benign diseases, the aim of this study was to verify if this also occurs in the course of rheumatic diseases. MATERIALS AND METHODS:We investigated the incidence and characteristics of Tumor M2-PK in the EDTA-plasma of 137 patients suffering from rh...

journal_title：Anticancer research

authors： Oremek GM,Müller R,Sapoutzis N,Wigand R

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND/AIM:Primary brain tumors are unique tumors due to their different pathobiological behavior, while they rarely metastasize outside the central nervous system. Regarding the oncogenesis of primary brain tumors, it was shown that changes in functions of p16 and mouse double minute 2 homolog (MDM2) are related t...

journal_title：Anticancer research

authors： Kafadar A,Küçükhüseyin Ö,Turan S,Yenilmez EN,Tunoglu S,Zeybek U,Kaynar MY,Kemerdere R,Yaylim I

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND/AIM:To evaluate the impact of DEPDC1 expression on patient prognosis after hepatic resection for hepatocellular carcinoma (HCC). PATIENTS AND METHODS:We reviewed data from 75 patients who underwent hepatic resection for HCC between 2004 and 2013. Recurrence at 2 years following resection, which mainly inclu...

journal_title：Anticancer research

authors： Amisaki M,Yagyu T,Uchinaka EI,Morimoto M,Hanaki T,Watanabe J,Tokuyasu N,Sakamoto T,Honjo S,Fujiwara Y

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Human carcinomas not only consist of neoplastic epithelial cells but also of tumor stroma, which may play an important role in tumor-progression. Whereas the tumor surrounding stroma is generally believed to represent a reactive component induced by tumor cell derived factors, a contribution of neoplastic ce...

journal_title：Anticancer research

authors： Wernert N,Löcherbach C,Wellmann A,Behrens P,Hügel A

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND/AIM:The Glasgow Prognostic Score (GPS), an inflammation-based prognostic score, has been shown to predict the clinical outcomes of a variety of cancer types. The aim of this study was to determine whether the GPS predicts clinical outcomes of patients with pancreatic cancer treated with adjuvant chemotherapy...

journal_title：Anticancer research

authors： Morinaga S,Murakawa M,Katayama Y,Yamaoku K,Aoyama T,Kanazawa A,Higuchi A,Shiozawa M,Kobayashi S,Ueno M,Morimoto M

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND/AIM:The main objective of the present study was to evaluate the significance of apoptosis in the Fletcher's risk classification for gastrointestinal stromal tumors (GISTs). MATERIALS AND METHODS:Apoptotic cells were identified by immunostaining for single-stranded DNA (ssDNA). We assigned each GIST to one o...

journal_title：Anticancer research

authors： Mochizuki K,Kondo T,Oishi N,Tahara I,Inoue T,Kasai K,Nakazawa T,Katoh R

更新日期：2018-05-01 00:00:00

abstract：:Two monoclonal antibodies, KM227 (IgM) and KM432 (IgG1), were established by immunizing mice with the crude membrane fraction of lung squamous cell carcinoma and the high-molecular-weight antigen in pleural perfusion from patients with lung adenocarcinoma, respectively. They were found to recognize the carbohydrate ep...

journal_title：Anticancer research

authors： Shitara K,Hanai N,Yoshida H

更新日期：1993-05-01 00:00:00

abstract：AIM:To evaluate whether the congested area that develops in associating liver partition with portal vein ligation for staged hepatectomy (ALPPS) contributes to rapid future liver remnant (FLR) hypertrophy. PATIENTS AND METHODS:Eight patients undergoing liver partition and right portal vein (RPV) ligation within the FL...

journal_title：Anticancer research

authors： Kawaguchi D,Hiroshima Y,Matsuo K,Endo I,Koda K,Tanaka K

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:CYP3A4 is the most abundant xenobiotic-metabolizing cytochrome P450 isoform. We examined the structural features of the CYP3A4 molecule with regard to ligand access. MATERIALS AND METHODS:The deleted amino acid sequences of X-ray data sets of CYP3A4s were complemented by molecular modeling techniques. Molec...

journal_title：Anticancer research

authors： Ohkura K,Kawaguchi Y,Watanabe Y,Masubuchi Y,Shinohara Y,Hori H

更新日期：2009-03-01 00:00:00

abstract：:Vascular endothelial growth factor A (VEGF) is one of the major regulators of angiogenesis. It plays an important role during the process of physiological and pathological neovascularization. Variant VEGF isoforms are generated as a result of alternative pre-mRNA splicing. To determine the expression of VEGF isoforms ...

journal_title：Anticancer research

authors： Cai C,Böttcher MC,Werner JA,Mandic R

更新日期：2010-03-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) represent the most common mesenchymal tumor entity of the gastrointestinal tract. In fewer than 5% of cases, primary GISTs are located in the duodenum. Surgery represents the treatment of choice for localized tumor disease and remains challenging in GISTs located at the duodenum...

journal_title：Anticancer research

authors： Mrak K,Liegl-Atzwanger B,Haybaeck J,Petritsch W,Mischinger HJ,Kornprat P

更新日期：2015-11-01 00:00:00