Abstract:
BACKGROUND/AIM:To evaluate the impact of DEPDC1 expression on patient prognosis after hepatic resection for hepatocellular carcinoma (HCC). PATIENTS AND METHODS:We reviewed data from 75 patients who underwent hepatic resection for HCC between 2004 and 2013. Recurrence at 2 years following resection, which mainly included metastatic recurrence, was defined as late recurrence. RESULTS:DEPDC1 was up-regulated in HCC tissue and in non-tumor tissue of patients with HCC compared to normal liver (p<0.01 and p<0.01, respectively). High expression of DEPDC1 was associated with poor overall, disease-specific, and disease-free survival (p=0.02, p<0.01, and p<0.01, respectively). High DEPDC1 expression was an independent predictor of death and recurrence (p=0.03 and p<0.01, respectively). High expression of DEPDC1 in non-tumor liver was an independent risk factor for late recurrence (p=0.04). CONCLUSION:High expression of DEPDC1 in tumor tissue appears to be associated with tumor progression and poor prognosis.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Amisaki M,Yagyu T,Uchinaka EI,Morimoto M,Hanaki T,Watanabe J,Tokuyasu N,Sakamoto T,Honjo S,Fujiwara Ydoi
10.21873/anticanres.13614subject
Has Abstractpub_date
2019-08-01 00:00:00pages
4423-4430issue
8eissn
0250-7005issn
1791-7530pii
39/8/4423journal_volume
39pub_type
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