Prognostic significance of apoptosis related proteins Bcl-2 and Bax in node-negative breast cancer patients.

abstract：BACKGROUND/AIM:The clinicopathological significance and prognostic value of insulin-like growth factor binding protein 1 (IGFBP1) in gastric cancer have not been investigated to date. This study aimed to investigate the relationship of IGFBP1 expression with clinicopathological variables and prognosis. MATERIALS AND M...

journal_title：Anticancer research

authors： Sato Y,Inokuchi M,Takagi Y,Kojima K

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND/AIM:No standard treatment has been established for poorly-differentiated neuroendocrine carcinomas (PDNEC). The aim of this study is to evaluate the response to the combination of three drugs. MATERIAL AND METHODS:We reviewed 21 PDNEC patients treated from 2008 to 2013 in two Institutions. Five patients wer...

journal_title：Anticancer research

authors： Bajetta E,Catena L,Biondani P,Pusceddu S,Valente M,Bianco N,Novelli E

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND/AIM:The prognosis of pancreatic cancer has not improved due to its migratory feature and refractory potential to chemo-resistance with absence of effective diagnosis. Despite continuous efforts, its underlying mechanisms of malignant nature remain ambiguous. The objective of this study was to investigate del...

journal_title：Anticancer research

authors： Lee J,Lee J,Kim DH,Kim JH

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND/AIM:We aimed to investigate the efficacy of immune-cell therapy in terms of the survival of patients with neuroendocrine carcinoma of the uterine cervix (NECC), which lacks standardized therapeutic approaches. PATIENTS AND METHODS:We identified 17 patients who were diagnosed as having NECC and treated with ...

journal_title：Anticancer research

authors： Goto S,Terao Y,Kamigaki T,Takimoto R,Naitoh K,Makita K,Yasumoto K,Okada S,Takizawa K,Yokomichi N,Suzuki N,Takeda S

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:In this study, the effect of novel taxane SB-T-1216 and paclitaxel on sensitive MDA-MB-435 and resistant NCI/ADR-RES human breast cancer cells was compared. MATERIALS AND METHODS:Cell growth and survival were evaluated after 96-hour incubation with tested concentrations of taxanes. The effect on the formati...

journal_title：Anticancer research

authors： Kovár J,Ehrlichová M,Smejkalová B,Zanardi I,Ojima I,Gut I

更新日期：2009-08-01 00:00:00

abstract：:Transcatheter embolization is considered to be less effective for early-stage hepatocellular carcinomas (HCCs) without a hypervascular arterial supply. In the present case report, a 65-year-old male with hepatitis type C and non-hypervascular HCC located in the hepatic hilum was successfully treated by bland transarte...

journal_title：Anticancer research

authors： Tanaka T,Maeda S,Nishiofuku H,Masada T,Sato T,Anai H,Sakaguchi H,Kichikawa K

更新日期：2014-04-01 00:00:00

abstract：:Bone-seeking radionuclides have been used to treat bone pain due to metastatic bone disease for over 40 years. More than 10 clinical studies using radiostrontium (Sr-89) have shown benefit in about 70-80% of patients having refractory bone pain from prostate, breast and other metastatic bone cancers, with minimal hema...

journal_title：Anticancer research

authors： Kim SI,Chen DC,Muggia FM

更新日期：1988-07-01 00:00:00

abstract：:The characteristics of Nepalese breast cancer in relation to reproductive factors have not been studied. One hundred and nine Nepalese breast cancer patients were compared with 108 Japanese breast cancer patients and the expression of estrogen (ER) and progesterone receptor (PgR) was evaluated immunohistochemically in...

journal_title：Anticancer research

authors： Singh Y,Sayami P,Sayami G,Nakagawa H,Koreeda T,Hatano T,Tsubura A

更新日期：2002-01-01 00:00:00

abstract：:BRCA1 acts as a tumour suppressor and germ-line mutations within this gene are found in a large proportion of families with breast cancer. The aim of our study was to unravel the mechanism of action of genistein, the major soy phytoestrogen, in BRCA1-mutant human breast cancer cell lines. Four breast cancer cell lines...

journal_title：Anticancer research

authors： Privat M,Aubel C,Arnould S,Communal Y,Ferrara M,Bignon YJ

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:In breast carcinomas, prolonged signalling through the TGF-beta receptor promotes latent tumour progression, metastasis and the epithelial-to-mesenchymal transition of tumour cells. Previously, it has been found that the 154 amino acid RING finger protein, RNF11, was overexpressed in high-grade breast tumour...

journal_title：Anticancer research

authors： Azmi PB,Seth AK

更新日期：2009-06-01 00:00:00

abstract：AIM:To evaluate the clinical results of two-step intensity-modulated radiation therapy (IMRT) for oropharyngeal cancer. PATIENTS AND METHODS:Eighty patients were treated with two-step IMRT between 2002 and 2014. Whole-neck radiotherapy (44.0-50.0 Gy/22-25 fractions) was delivered by IMRT, followed by boost IMRT to the...

journal_title：Anticancer research

authors： Tatebe H,Doi H,Ishikawa K,Kawakami H,Yokokawa M,Nakamatsu K,Kanamori S,Shibata T,Kitano M,Nishimura Y

更新日期：2018-02-01 00:00:00

abstract：:The requirements on sunscreens have essentially changed, since some years ago it was demonstrated that approximately 50% of free radicals, that are formed in the skin by solar radiation, originate from the visible and infrared regions of the solar spectrum. In addition, a critical radical concentration threshold could...

journal_title：Anticancer research

authors： Zastrow L,Lademann J

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND/AIM:L-type amino acid transporter 1 (LAT1) is highly expressed in various human cancers. However, the clinicopathological significance of LAT1 and 4F2 cell surface antigen (4F2hc) in patients with colorectal cancer (CRC) is unknown. The aim of this study was to clarify the prognostic significance of LAT1 exp...

journal_title：Anticancer research

authors： Ogawa H,Kaira K,Motegi Y,Yokobori T,Takada T,Katoh R,Osone K,Takahashi R,Katayama C,Oyama T,Kanai Y,Yao T,Asao T,Kuwano H,Shirabe K

更新日期：2019-05-01 00:00:00

abstract：AIM:Eudragit® E 100 (EE100) was used to improve the transfection efficiency of polyethylenimine (PEI). MATERIALS AND METHODS:Mobility of PEI-DNA complexes with and without EE100 were visualized by agarose gel electrophoresis and their transfection efficiencies were investigated in KB human oral carcinoma cells by flow...

journal_title：Anticancer research

authors： Kanthamneni N,Yung B,Lee RJ

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Dehydroepiandrosterone (DHEA) and its analogs have potent chemoprotective actions in mouse skin tumorigenesis models. To assess this association in humans, we investigated the relationship of prediagnostic serum concentrations of DHEA and dehydroepiandrosterone sulfate (DHEAS) to the subsequent risk of devel...

journal_title：Anticancer research

authors： Alberg AJ,Gordon GB,Genkinger JM,Hoffman SC,Selvin E,Comstock GW,Helzlsouer KJ

更新日期：2001-11-01 00:00:00

abstract：:Metallopanstimulin (MPS) is a 9.5-kDal subunit "zinc finger" protein which is expressed in a wide variety of actively proliferating cells and tumor tissues (J. Biol. Chem. 268:21198-21204, 1993; Cell Growth & Diff. 5:811-825, 1994). A sensitive and specific radioimmunoassay (RIA) has been developed to measure circulat...

journal_title：Anticancer research

authors： Fernandez-Pol JA

更新日期：1996-07-01 00:00:00

abstract：:Recent studies have addressed the prevalence and prognostic impact of thrombocytosis in various gynecologic and non-gynecologic malignancies. Thrombocytosis appears to be of prognostic value in certain patients with gynecologic malignancies. In this survey we review the published data and attempt to analyze the progno...

journal_title：Anticancer research

authors： Gücer F,Tamussino K,Keil F,Balkanli-Kaplan P,Yüce MA

更新日期：2004-05-01 00:00:00

abstract：:Thirty-four patients of an Italian population affected by neuroblastoma (NB) were evaluated at diagnosis for multidrug resistance gene (MDR1) and N-myc oncogene amplification. No patients showed MDR1 amplification, while extra copies of the N-myc gene were found in 9 out of 34 patients (26%). N-myc amplification was c...

journal_title：Anticancer research

authors： Corrias MV,Cornaglia-Ferraris P,Di Martino D,Stenger AM,Lanino E,Boni L,Tonini GP

更新日期：1990-07-01 00:00:00

abstract：:Inv(3)(q21q26)/t(3;3)(q21;q26) is a feature of a distinctive entity of acute myeloid leukemia (AML) associated with normal or elevated platelet count, atypical megakaryocytes and multilineage dysplasia in the bone marrow, as well as minimal to no response to chemotherapy and poor clinical outcome. The presence of an i...

journal_title：Anticancer research

authors： De Braekeleer E,Douet-Guilbert N,Le Bris MJ,Ianotto JC,Berthou C,Gueganic N,Bovo C,Basinko A,Morel F,De Braekeleer M

更新日期：2013-02-01 00:00:00

abstract：:The members of the matrix metalloproteinase family (MMP) have the ability to degrade macromolecules of the extracellular matrix and are responsible for tumor invasion and infiltration, limiting the effectiveness of the neurosurgical resection of brain tumors. Among the glial brain tumors, astrocytomas and oligodendrog...

journal_title：Anticancer research

authors： Thorns V,Walter GF,Thorns C

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND/AIM:The expression of metallothionein I/II (MT-I/II) was examined in thyroids of Graves' disease (GD) and nodular goiter (NG) patients to determine its role as a potential marker of proliferation and autoimmune inflammation in the thyroid. PATIENTS AND METHODS:MT-I/II and Ki-67 antigen expression was studie...

journal_title：Anticancer research

authors： Domoslawski P,Pula B,Olbromski M,Wojtczak B,Lukienczuk T,Podhorska-Okolow M,Dziegiel P

更新日期：2018-12-01 00:00:00

abstract：BACKGROUND:Sonic hedgehog (SHH) signaling is related to the pathogenesis of oral squamous cell carcinoma (OSCC), but its role in OSCC is not yet well understood. In this study, we analyzed the role of SHH signaling in OSCC. MATERIALS AND METHODS:We examined the expression pattern of SHH and its signal proteins in clin...

journal_title：Anticancer research

authors： Kuroda H,Kurio N,Shimo T,Matsumoto K,Masui M,Takabatake K,Okui T,Ibaragi S,Kunisada Y,Obata K,Yoshioka N,Kishimoto K,Nagatsuka H,Sasaki A

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this retrospective study was to detect the frequency, reasons, and significant factors for not receiving immunotherapy after chemoradiotherapy in non-small cell lung cancer (NSCLC) patients. PATIENTS AND METHODS:Thirty-four patients with NSCLC received definitive chemoradiotherapy. The endpoi...

journal_title：Anticancer research

authors： Morimoto M,Nishino K,Wada K,Imamura F,Konishi K,Kuhara H,Tamiya M,Inoue T,Kunimasa K,Kimura M,Hirata T,Kanayama N,Toratani M,Kawachi H,Ohira K,Nakanishi E,Ohira S,Sagawa T,Miyazaki M,Matsunaga T,Kumagai T,Teshim

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Low 5-fluorouracil (5-FU) concentrations cause a significant increase in DNA synthesis in mitogen-activated human lymphocytes. MATERIALS AND METHODS:We explored 2.5 microM 5-FU-induced DNA synthesis by testing 5-FU activity in hypoxanthine-aminopterin-thymidine (HAT)-containing medium, and its effect on thy...

journal_title：Anticancer research

authors： Eisenthal A,Eytan K,Brazowski E,Gitstein G,Greenberg R,Skornick Y

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND/AIM:Docking protein 2 (Dok2) is an adapter protein which is involved in hematopoiesis. However, it still remains unclear how Dok2 functions in regulation of transcription of hematopoietic genes. To address this issue, we knocked-down Dok2 mRNA in mouse erythroleukemia cells which highly express Dok2 intrinsi...

journal_title：Anticancer research

authors： Tanaka Y,Kulkeaw K,Inoue T,Tan KS,Nakanishi Y,Shirasawa S,Sugiyama D

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study is to find synergistic effect using FH535 and sorafenib by targeting the RAS/RAF/MAPK and WNT/β-catenin pathways. MATERIALS AND METHODS:3H-Thymidine incorporation assays were performed to address Huh7 and liver cancer stem cell (LCSC) inhibition using FH535 and sorafenib, alone and...

journal_title：Anticancer research

authors： Galuppo R,Maynard E,Shah M,Daily MF,Chen C,Spear BT,Gedaly R

更新日期：2014-04-01 00:00:00

abstract：:Selective delivery of a high level of Mitomycin C (MMC) in intraperitoneal disseminated lesions was studied using a new dosage form of MMC, called MMC-CH. Intracavitary MMC-CH delivered a much higher level of MMC selectively to intraperitoneal tissues, with a much lower level of MMC in the whole body, in comparison wi...

journal_title：Anticancer research

authors： Hagiwara A,Takahashi T,Lee R,Ueda T,Takeda M,Itoh T

更新日期：1986-09-01 00:00:00

abstract：:The effect of 5,6,7,8-tetrahydrobiopterin (BPH4) on HL-60 cell damage induced by a nitric oxide (NO) donor, S-nitroso-N-acetyl-penicillamine (SNAP), was investigated. The activity of lactate dehydrogenase (LDH), a marker of cell damage, was elevated dose- and time-dependently after treatment with SNAP. The cells under...

journal_title：Anticancer research

authors： Kojima S,Nimura K,Komatsu H,Taguchi T,Iizuka H

更新日期：1997-03-01 00:00:00

abstract：AIM:To investigate the expression and significance of glypican-3 (GPC3) in human hepatocellular carcinoma (HCC). MATERIALS AND METHODS:DNA chips were used to measure the expression of mRNAs for members of the glypican and syndecan families of heparan sulfate proteoglycans (HSPGs) in normal liver tissue, non-tumor tiss...

journal_title：Anticancer research

authors： Suzuki M,Sugimoto K,Tanaka J,Tameda M,Inagaki Y,Kusagawa S,Nojiri K,Beppu T,Yoneda K,Yamamoto N,Ito M,Yoneda M,Uchida K,Takase K,Shiraki K

更新日期：2010-12-01 00:00:00

abstract：:In addition to fibronectin-derived peptides, several immunologically distinct peptides have been found to co-purify with fibronectin on gelatin-sepharose affinity chromatography of bovine plasma. We have isolated a 25kdal peptide ("25K") which co-purifies with fibronectin and which is mitogenic for cultured fibroblast...

journal_title：Anticancer research

authors： Channon KM,Ayad SR

更新日期：1986-11-01 00:00:00