Abstract:
BACKGROUND/AIM:L-type amino acid transporter 1 (LAT1) is highly expressed in various human cancers. However, the clinicopathological significance of LAT1 and 4F2 cell surface antigen (4F2hc) in patients with colorectal cancer (CRC) is unknown. The aim of this study was to clarify the prognostic significance of LAT1 expression in CRC patients who underwent surgical resection. MATERIALS AND METHODS:Samples from one hundred and forty-seven patients were examined by immunohistochemistry. The expression of LAT1 and 4F2hc, and the Ki-67 labeling index were assessed using resected tumor specimens. RESULTS:The positive expression of LAT1 and 4F2c was 80% (118/147) and 58% (86/147) (p<0.01), respectively. The expression of LAT1 was identified as an independent significant marker linked to worse prognosis in patients with CRC, and was correlated with tumor cell proliferation, tumor aggressiveness, and metastasis. Moreover, LAT1 was closely associated with the expression of 4F2hc and phosphorylation of the mTOR pathway. CONCLUSION:LAT1 is a significant molecular marker used to predict prognosis after surgical resection of CRC patients.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Ogawa H,Kaira K,Motegi Y,Yokobori T,Takada T,Katoh R,Osone K,Takahashi R,Katayama C,Oyama T,Kanai Y,Yao T,Asao T,Kuwano H,Shirabe Kdoi
10.21873/anticanres.13375subject
Has Abstractpub_date
2019-05-01 00:00:00pages
2535-2543issue
5eissn
0250-7005issn
1791-7530pii
39/5/2535journal_volume
39pub_type
杂志文章abstract:BACKGROUND/AIM:Hypoxia offers resistance to therapy in human solid tumors. The aim of the study was to investigate whether SN-38, the active metabolite of irinotecan, acts as a radiosensitizer through inhibition of hypoxia-inducible factor (HIF)-1α in the human colorectal cancer (CRC) cells. MATERIALS AND METHODS:HT29...
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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journal_title:Anticancer research
pub_type: 杂志文章,评审
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更新日期:2014-04-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:
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pub_type: 杂志文章
doi:
更新日期:2002-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2012-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1998-11-01 00:00:00
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pub_type: 临床试验,杂志文章,评审
doi:
更新日期:1981-01-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1991-03-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:2014-10-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2010-12-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1986-03-01 00:00:00
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pub_type: 杂志文章
doi:
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journal_title:Anticancer research
pub_type: 临床试验,杂志文章
doi:
更新日期:1997-11-01 00:00:00
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doi:
更新日期:2001-01-01 00:00:00
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doi:
更新日期:2004-03-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-11-01 00:00:00
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pub_type: 杂志文章
doi:
更新日期:1997-09-01 00:00:00
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更新日期:2019-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
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