E-cadherin and alpha-catenin expression in normal, hyperplastic and neoplastic endometrium.

Abstract:

UNLABELLED:The aim of this study was to determine whether modulation of expression of cell adhesion molecules may occur in neoplastic transformation of endometrial epithelium. MATERIALS AND METHODS:E-Cadherin and α-catenin protein expression were evaluated by immunohistochemistry in 124 biopsies representative of normal, hyperplastic and neoplastic endometrium. RESULTS:In normal endometrium (proliferative, secretive and atrophic endometrium) strong homogeneous, E-cadherin and α-catenin reactivity was found; 58.3% and 66.6% of biopsies representative of simple hyperplastic endometrium were homogeneously positive for E-cadherin and α-catenin, respectively, whereas no samples representative of atypical hyperplasia showed evidence of homogeneous E-cadherin or α-catenin expression. No expression of homogeneous E-cadherin was seen in endometrial adenocarcinomas; α-catenin homogeneous immunostaining was observed in 2 G1 and 2 G2 out of 22 adenocarcinoma samples (18.2%). A homogeneous co-expression of both molecules was seen only in normal (70%) and simple hyperplastic (46%) endometrium. CONCLUSION:These results suggest that E-cadherin and α-catenin down-regulation might be associated with neoplastic transformation of endometrial tissues.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Carico E,Atlante M,Giarnieri E,Raffa S,Bucci B,Giovagnoli MR,Vecchione A

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

4993-7

issue

12

eissn

0250-7005

issn

1791-7530

pii

30/12/4993

journal_volume

30

pub_type

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