Abstract:
:The tumor progression concept was first defined by Foulds at the end of the nineteen fifties. His work about the evolution of mammary tumors led to the conclusion that a tumor is initiated as soon as a cell interacts with an oncogenic agent and that the tumor progresses by acquiring in a permanent and irreversible way, new properties which are characteristic of neoplasms. Molecular biology made possible the identification in transformed cells of molecular events such as chromosomal rearrangements, mutations, the loss of certain genes or integration of viral genes. Experimental models have been introduced in order to try to identify in vitro the successive steps leading to transformation and the corresponding cellular phenotypes. One of these models is the cellular transformation phenomenon induced by polyoma virus. In this model, it now seems clear that several steps and several genes are involved in the cellular transformation phenomenon.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Lemieux Lsubject
Has Abstractpub_date
1986-05-01 00:00:00pages
413-7issue
3 Pt Beissn
0250-7005issn
1791-7530journal_volume
6pub_type
杂志文章abstract:BACKGROUND/AIM:Oxysterol plays important physiological roles in diverse biological processes including apoptosis. However, the mechanisms underlying oxysterol-induced apoptosis remain unknown. 25-hydroxycholesterol (25-HC) is an oxysterol synthesized by cholesterol 25-hydroxylase from cholesterol during sterol metaboli...
journal_title:Anticancer research
pub_type: 杂志文章
doi:10.21873/anticanres.14009
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:We have previously shown that human metallopanstimulin (MPS-1) is a 9.4-kDa multifunctional ribosomal S27/nuclear "zinc finger" protein which is expressed in a wide variety of actively proliferating cells and tumor tissues. Furthermore, we have shown that detection of MPS-N immunoreactive material in sera co...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1997-05-01 00:00:00
abstract::Understanding the molecular basis of human disease has been the corner-stone of rationally designed molecular therapies. Medicine has a long history of treating patients with cell therapies (i.e., blood transfusions) and protein therapies (i.e., growth factors and cytokines). Gene therapies are the newest therapeutic ...
journal_title:Anticancer research
pub_type: 杂志文章,评审
doi:
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Paragangliomas are benign, slow-growing tumours of the head and neck region. The candidate gene for familial and some sporadic paragangliomas, SDHD (succinate dehydrogenase, subunit D), has been mapped to the PGL1 locus in 11q23.3. MATERIALS AND METHODS:Normal and tumour DNA of 17 patients with sporadic par...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:This was a validation study of a regional register of oral cancer in Örebro, Sweden. The purpose was to assess the rate of errors in baseline, and treatment, and the completeness and accuracy of data on recurrences. MATERIALS AND METHODS:A total of 653 cases with squamous cell cancer in the oral cavity were...
journal_title:Anticancer research
pub_type: 杂志文章
doi:10.21873/anticanres.13109
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Metastatic involvement of the pancrease is not an uncommon autopsy finding, however, pancreatic metastasis is an infrequent clinical condition and the pattern of the metastases have not been studied. We conducted a retrospective study in order to evaluate the pattern of the metastasis from lung cancer. PATI...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1998-07-01 00:00:00
abstract::Serum levels of thymidine kinase 1 (TK1), an enzyme involved in the G1-S phase of the cell cycle, have been previously shown to correlate with the prognosis of lymphoid malignancies. We hypothesized that TK1 levels will be higher in aggressive, compared to indolent lymphoproliferative, malignancies and this may serve ...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2015-05-01 00:00:00
abstract:AIM:To assess the outcome of patients with vulvar carcinoma unfit for surgery treated with radiotherapy for primary disease and for those with recurrent disease after primary surgery. PATIENTS AND METHODS:The study was conducted on 16 patients with primary disease and 31 with recurrent disease. RESULTS:An objective r...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:The optimal treatment for locoregionally recurrent rectal cancer after curative surgery has not yet been defined. The definition of prognostic factors could lead to the selection of an aggressive therapeutic approach in patients with favourable prognosis alone. PATIENTS AND METHODS:The records of thirty-nin...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1999-03-01 00:00:00
abstract:OBJECTIVES:To investigate the roles of insulin-like growth factor II (IGF2), myeloperoxidase (MPO), E-cadherin (CDH1), urokinase and xeroderma pigmentosum group A and D (XPA, XPD) polymorphisms upon leiomyoma susceptibility. STUDY DESIGN:Women were divided into: group 1, leiomyoma (n=158); group 2, non-leiomyoma (n=15...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2010-06-01 00:00:00
abstract::The aim of this study was to define the clinical prevalence and rate of malignancy of focal thyroid incidentaloma in a relatively large number of individuals with application of 18F-fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) in asymptomatic individuals. The subjects consisted of 4803 physical check-up...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Basic fibroblast growth factor (bFGF) is a potent angiogenetic factor which may influence breast cancer evolution. MATERIALS AND METHODS:Serum bFGF, (cut-off 10 pg/ml), was assayed in 166 breast cancer patients at all stages and compared with CA 15.3. RESULTS:In 99 pre-treatment (PT) sera, 39/99 (39.4%) we...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND:Resistance to multiple chemotherapeutic agents results from a variety of factors including a lack of apoptosis in tumor cells. To induce apoptosis in two types of tumor cells, RPMI-8226 and MG-63, a combination of chemotherapeutic agents and retroviral transduction of TRAIL was employed. MATERIALS AND METHO...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND:Breast cancer cells frequently metastasize to the skeleton and produce and secrete proteinases, such as matrix metalloproteinase-13 (MMP-13), which promote destruction of the bone matrix. However, the mechanism of MMP-13 expression induced in areas of bone metastasis is unknown. Here, the interaction between...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2011-04-01 00:00:00
abstract::Glutathione (GSH) concentration is high in most tumour cells and this may be an important factor in resistance to chemotherapy. Previous in-vitro and animal experiments have shown a differential response of tumour versus normal cells to various cysteine delivery systems. More specifically, an in-vitro assay showed tha...
journal_title:Anticancer research
pub_type: 临床试验,杂志文章
doi:
更新日期:1995-11-01 00:00:00
abstract::In the presence study we demonstrated that hycanthone and chlorophenoxamine can modulate the resistance of multidrug resistant (MDR) murine L1210 leukemia tumor lines in vitro and in vivo. The circumvention of MDR by hycanthone and chlorophenoxamine in vitro was demonstrated by a short-term test using tritiated nuclei...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1991-05-01 00:00:00
abstract::Prospective studies of dose adaptation of continuous 5FU infusion combined with cisplatin have shown that pharmacologically guided dosing was feasible in the treatment of head and neck carcinomas. Adaptative dosing results in reduced haematological toxicity, but few data are available for clinical response rate. Preli...
journal_title:Anticancer research
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND/AIM:Breast cancer treatment represents a substantial amount of health-care costs and has a negative impact on womens' psychological health. Day-Surgery managment (DS) is a favorable alternative to a classic inpatient setting. In our prospective study we evaluated DS-treatment feasibility in terms of patient ...
journal_title:Anticancer research
pub_type: 杂志文章
doi:10.21873/anticanres.13451
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:To evaluate the outcome and discover predictive factors for patients with stage IVA cervical cancer treated with definitive radiation therapy. PATIENTS AND METHODS:We retrospectively reviewed 34 patients with stage IVA cervical cancer who received definitive radiation therapy between 1992 and 2009. RESULTS...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:We investigated the influence of age on short-term complications in women undergoing intraoperative radiotherapy (IORT) for early breast cancer. PATIENTS AND METHODS:We retrospectively analyzed data of 188 women who underwent IORT during breast-conserving surgery (BCS). The study group consisted of 54 patie...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2013-09-01 00:00:00
abstract::1-(phenylmethyl)-4,7,10-tris-[(4'methylphenyl)-sulfonyl]-1,4,7, 10-tetraazacyclododecane proved to possess potent in vivo antineoplastic and in vitro cytotoxicity in murine and human tissue cultured cells. In Tmolt3 leukemic cells 1-(phenylmethyl)-4,7,10-tris-[(4'methylphenyl)sulfonyl]-1,4,7, 10-tetraazacyclododecane ...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1997-03-01 00:00:00
abstract:BACKGROUND/AIM:To study the changes of glioblastoma multiforme during chemoradiotherapy (CRT) and to evaluate the impact of changes on dosimetry and clinical outcomes. PATIENTS AND METHODS:Forty-three patients underwent volumetric imaging-based replanning. Prognostic factors and gross tumor volume changes in relation ...
journal_title:Anticancer research
pub_type: 杂志文章
doi:10.21873/anticanres.14425
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND/AIM:Polyamines are important for the growth of eukaryotic cells. At high levels, they promote proliferation, invasion and migration of tumour cells. Polyamine metabolism is an important new target for anticancer therapy. Some polyamine analogues can have an inhibitory effect on tumour cells. The aim of this ...
journal_title:Anticancer research
pub_type: 杂志文章
doi:10.21873/anticanres.14085
更新日期:2020-03-01 00:00:00
abstract::Seventy five patients suffering from metastatic breast cancer previously unexposed to chemotherapy were treated with Cyclophosphamide, Methotrexate and 5-fluorouracil (CMF) upon diagnosis of their first relapse. Dose Level I (85% or more of the planned dose) was given to 14 patients (19%); Dose Level II (66% to 84% of...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1986-07-01 00:00:00
abstract:UNLABELLED:The pharmacology of progestins includes actions initiated by various cellular targets, including classic receptors characterized as nuclear transcription factors (nPR), G-protein-coupled membrane receptors (mPR), enzymes, membrane channels and transporters. The effects initiated by targets other than nPR are...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2010-12-01 00:00:00
abstract::Dendritic cells (DCs) are professional antigen presenting cells. Two x 10(7) peripheral blood mononuclear cells (PBMCs) from each of 6 melanoma patients and 4 normal donors were incubated in 6-well plates. The adherent cells were cultured in GM-CSF (800 U/ml) and IL-4 (1000 U/ml) for 10 days. Anti-CD80, anti-CD86, ant...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1999-05-01 00:00:00
abstract:BACKGROUND/AIM:Vimentin expression in epithelial cells is reported to be associated with the malignant phenotype of cancer cells in vitro. However, the clinical significance of vimentin expression in carcinomas is not well understood. The aim of this study was to clarify the significance of vimentin-positive gastric ca...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Neurofibromatosis type 1 (NF1) is an autosomal dominant hereditary disease with complete penetrance and a very variable phenotype. Recent research has shown that postzygotic NF1 gene mutations occur to a far greater extent than previously thought. The phenotype of affected individuals reflects the time of so...
journal_title:Anticancer research
pub_type: 杂志文章
doi:10.21873/anticanres.14327
更新日期:2020-06-01 00:00:00
abstract:BACKGROUND:Because of clinicopathologic and genetic differences between left-sided colorectal cancer (LSCRC) and right-sided colon cancer (RSCC), cyclooxygenase-2(COX-2) and adenomatous polyposis coli (APC) expression may be of clinical relevance. MATERIALS AND METHODS:Clinicopathologic information for 72 primary colo...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2011-06-01 00:00:00
abstract::Carcinogenesis is a process that converts normal cells from controllable to uncontrollable growth. Coordinate regulation of the rates of cell proliferation and cell death is an important determinant in maintenance of homeostasis. Loss of control of this balance is central to the development of cancer. This loss may be...
journal_title:Anticancer research
pub_type: 杂志文章,评审
doi:
更新日期:1999-11-01 00:00:00