All three polyoma early genes are involved in transformation of rat embryo fibroblast cells.

Abstract:

:The tumor progression concept was first defined by Foulds at the end of the nineteen fifties. His work about the evolution of mammary tumors led to the conclusion that a tumor is initiated as soon as a cell interacts with an oncogenic agent and that the tumor progresses by acquiring in a permanent and irreversible way, new properties which are characteristic of neoplasms. Molecular biology made possible the identification in transformed cells of molecular events such as chromosomal rearrangements, mutations, the loss of certain genes or integration of viral genes. Experimental models have been introduced in order to try to identify in vitro the successive steps leading to transformation and the corresponding cellular phenotypes. One of these models is the cellular transformation phenomenon induced by polyoma virus. In this model, it now seems clear that several steps and several genes are involved in the cellular transformation phenomenon.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Lemieux L

subject

Has Abstract

pub_date

1986-05-01 00:00:00

pages

413-7

issue

3 Pt B

eissn

0250-7005

issn

1791-7530

journal_volume

6

pub_type

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