Renal cell carcinoma: relevance of angiogenetic factors.

Abstract:

:Angiogenesis is essential for tumour growth. Mostly hypervasculariced renal cell carcinoma (RCC) usually express angiogenic factors, e.g. basic fibroblast factor (bFGF), vascular endothelial growth factor, and angiogenin (ag). This study was designed to evaluate the improvement of serological angiogenesis-factors, their prognostic relevance and correlation to tumour-grade, -stage and -volume. Measurement of bFGF, vEGF and ag was done with ELISA (Quantikine), R and D-Systems Europe Abbington, United Kingdom. The control group comprised 39 healthy blood donors, RCC-group were 35 patients with different RCC. Survival dates were presented with Kaplan-Meyer-curves, significance was tested with students-t-test. For all angiogenic factors a highly significant difference between the healthy and RCC-group was found. A strong correlation between angiogenic factors and tumor grade, -stage and -volume, was not found, but a trend for each of the angiogenic factors to correlate with grade was seen. No survival benefit was seen between patients with normal angiogenic factor over those with elevated angiogenic levels.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Wechsel HW,Bichler KH,Feil G,Loeser W,Lahme S,Petri E

subject

Has Abstract

pub_date

1999-03-01 00:00:00

pages

1537-40

issue

2C

eissn

0250-7005

issn

1791-7530

journal_volume

19

pub_type

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