Predictive relevance of soluble CD44v6 serum levels for the responsiveness to second line hormone- or chemotherapy in patients with metastatic breast cancer.

abstract：BACKGROUND/AIM:The success of proteasome inhibitors in therapy of multiple myeloma has led to their use for other malignancies. For the proteasome inhibitor bortezomib, combination therapies with histone deacetylase inhibitors, which up-regulate ubiquitin-proteasome system (UPS)-related enzymes, produce a beneficial ef...

journal_title：Anticancer research

authors： Takenokuchi M,Miyamoto K,Saigo K,Taniguchi T

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Patients with type 2 diabetes mellitus (T2DM) as well as patients with obesity have increased cancer mortality. In a previous paper we suggested that there was a trend for decreased mortality in obese individuals with T2DM. The aim of the new analyses was to investigate the same relationship after increasing...

journal_title：Anticancer research

authors： Landman GW,Van Hateren KJ,Kleefstra N,Bilo HJ

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND/AIM:Nitric oxide (NO) functions have been studied in many cancer types, but rarely in head and neck squamous cell carcinoma (HNSCC). This study aimed to investigate the behavior of HNSCC cells following exposure to high NO (HNO). MATERIALS AND METHODS:Two pairs of isogenic HNSCC cell lines (HN18/HN17, HN30/...

journal_title：Anticancer research

authors： Utispan K,Koontongkaew S

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Tyrosine kinase inhibitors (TKIs) directed against epidermal growth factor receptor (EGFR) are important in the treatment of non-small cell lung cancer (NSCLC), especially those harboring EGFR mutations. But little is known regarding the clinical value of serum tumor marker levels measured prior to treatment...

journal_title：Anticancer research

authors： Takeuchi A,Oguri T,Sone K,Ito K,Kitamura Y,Inoue Y,Asano T,Fukuda S,Kanemitsu Y,Takakuwa O,Ohkubo H,Takemura M,Maeno K,Ito Y,Niimi A

更新日期：2017-10-01 00:00:00

abstract：:The development of T-lymphocytes (T cells) constitute one of the basic and most vital processes in immunology. Conventional mathematical models, being based on the systems theory, fail to sufficiently distinguish the constituents of thymocytes and are thus of limited significance. On the basis of some well thought-out...

journal_title：Anticancer research

authors： Wang G,Krueger GR,Buja LM

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:The aim of this study was to evaluate whether human papilloma virus (HPV) testing at LLETZ for CIN can be useful to identify patients with high risk of recurrent disease. MATERIALS AND METHODS:In 62 women treated with LLETZ for CIN the status of the resection margins was recorded and related to the HPV stat...

journal_title：Anticancer research

authors： Negri G,Gampenrieder J,Vigl EE,Haitel A,Menia E,Mian C

更新日期：2003-09-01 00:00:00

abstract：AIM:To identify conditions that induce an increase in the sensitivity of highly Halaven (HAL)-resistant cancer cells compared to sensitive cells. MATERIALS AND METHODS:We observed that drug-resistant KBV20C cells are highly resistant to HAL compared to other antimitotic drugs. The concentration required to treat KBV20...

journal_title：Anticancer research

authors： Cheon JH,Lee BM,Kim HS,Yoon S

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:HIC-1 (hypermethylated in cancer-1) is a candidate tumor suppressor gene, identified in a region of frequent loss of heterozygosity on chromosome 17p13.3, which is telomeric from TP53 and often deleted in surgically resected lung cancers. To determine the significance of HIC-1 in lung cancer, we assessed its...

journal_title：Anticancer research

authors： Hayashi M,Tokuchi Y,Hashimoto T,Hayashi S,Nishida K,Ishikawa Y,Nakagawa K,Tsuchiya S,Okumura S,Tsuchiya E

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND/AIM:The matrix metalloproteinase (MMP) family of enzymes are in charge of degradation of various components of the extracellular matrix and their functional genetic polymorphisms may be associated with cancer susceptibility. The functional polymorphisms in the promoter region of MMP7 (A-181G and C-153T) have...

journal_title：Anticancer research

authors： Chou AK,Hsiao CL,Shih TC,Wang HC,Tsai CW,Chang WS,Liu LC,Way TD,Chung JG,Bau DT

更新日期：2017-09-01 00:00:00

abstract：UNLABELLED:Distant metastases to the oral cavity, the face or facial skeleton are rare and/in are usually found in such locations at a late stage of the malignancy. In the majority of cases, the malignancy is already known at the time of admission. However, a distant metastasis as the first sign of a cancer developing ...

journal_title：Anticancer research

authors： Friedrich RE,Abadi M

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:An acidic arabinogalactan from European mistletoe (Viscum album L, VAL; 1.34 x 10(6) Dalton) was studied in detail because its immunological properties are poorly characterised. MATERIALS AND METHODS:Flow cytometric studies focussed on PS-activated proliferation of human lymphocytes measured via incorporati...

journal_title：Anticancer research

authors： Stein GM,Edlund U,Pfüller U,Büssing A,Schietzel M

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Chemotherapy sensitivity of soft-tissue sarcomas (STS) is limited, which may be due to multidrug resistance (MDR). MDR is associated with expression of P-glycoprotein (P-gp), Multidrug Resistance-associated Protein 1 (MRP1) and Lung Resistance-related Protein (LRP). It is unknown whether in STS metastasis is...

journal_title：Anticancer research

authors： Komdeur R,Molenaar WM,Zwart N,Hoekstra HJ,van den Berg E,van der Graaf WT

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND/AIM:To investigate the impact of inguinal lymph node dissection (ILND) following neoadjuvant chemoradiotherapy (NACRT) for rectal cancer patients with ILN metastasis. PATIENTS AND METHODS:Forty-three patients with rectal cancer underwent NACRT followed by curative surgery between January 2005 and December 2...

journal_title：Anticancer research

authors： Ueta K,Matsuda T,Yamashita K,Hasegawa H,Mukohyama J,Yamamoto M,Matsuda Y,Kanaji S,Oshikiri T,Nakamura T,Suzuki S,Kakeji Y

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND/AIM:The toxicity of the proteasome inhibitor MG132 was tested alone and combined either with the topoisomerase I inhibitor topotecan or the topoisomerase II inhibitor etoposide against a panel of 18 cell lines representing six pediatric tumor types. MATERIALS AND METHODS:MG132, topotecan, etoposide and thei...

journal_title：Anticancer research

authors： Destanovic E,Boos J,Lanvers-Kaminsky C

更新日期：2018-07-01 00:00:00

abstract：:To evaluate the association and interaction of genotypic polymorphism the gene for DNA-apurinic/apyrimidinic endonuclease (APEX1) with personal smoking habit and lung cancer risk in Taiwan, the polymorphic variants of APEX1, Asp(148)Glu (rs1130409), were analyzed in association with lung cancer risk, and their joint e...

journal_title：Anticancer research

authors： Chen WC,Tsai CW,Hsia TC,Chang WS,Lin LY,Liang SJ,Tu CY,Cheng WE,Chen HJ,Wang SM,Bau dT

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND/AIM:We evaluated the clinical impact of FOLFOXIRI regimen aiming for conversion surgery in patients with unresectable multiple colorectal liver metastasis (CRLM). PATIENTS AND METHODS:A total of 42 patients with unresectable multiple CRLM who received chemotherapy with molecular agents were included in the ...

journal_title：Anticancer research

authors： Morine Y,Ikemoto T,Iwahashi S,Saito YU,Yamada S,Takasu C,Higashijima J,Imura S,Shimada M

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND/AIM:It is well-known that inflammatory bowel disease (IBD) poses an increased, yet not definitely estimated, risk of colitis-associated colon cancer (CAC), which is considered a more aggressive and distinct in both genetic and molecular levels clinical entity compared to sporadic colorectal cancer (CRC). The...

journal_title：Anticancer research

authors： Antoniou E,Margonis GA,Angelou A,Zografos GC,Pikoulis E

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Cancer of the small intestine is a rare disease, and its clinical features have not been clearly elucidated. Techniques such as double balloon endoscopy and capsule endoscopy allow the preoperative diagnosis of cancer of the small intestine, but this cancer is often detected at an advanced state and in many ...

journal_title：Anticancer research

authors： Higashi D,Ishibashi Y,Tamura T,Nii K,Egawa Y,Koga M,Tomiyasu T,Harimura T,Tanaka R,Futatsuki R,Noda S,Futami K,Maekawa T,Takaki Y,Hirai F,Matsui T

更新日期：2010-08-01 00:00:00

abstract：:Several studies have reported that high F18-fluorodeoxyglucose (FDG) uptake is predictive of poor prognosis and aggressive features in patients with breast cancer. While these studies evaluated the prognostic value for cases with high FDG uptake, they did not elucidate the meaning of FDG negativity in primary breast c...

journal_title：Anticancer research

authors： Fujii T,Yajima R,Tsuboi M,Higuchi T,Obayashi S,Tokiniwa H,Nagaoka R,Takata D,Horiguchi J,Kuwano H

更新日期：2016-06-01 00:00:00

abstract：:The macrolide antibiotic erythromycin has recently been shown to overcome the resistance to anticancer drugs that results from overexpression of P-glycoprotein. The present study, using erythromycin lactobionic acid as a model drug, investigated the inhibitory effects of erythromycin on the efflux of doxorubicin from ...

journal_title：Anticancer research

authors： Kiso S,Cai SH,Kitaichi K,Furui N,Takagi K,Takagi K,Nabeshima T,Hasegawa T

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Recent experimental studies have indicated that cyclooxygenase-2 (COX-2) suppresses tumor-cell apoptosis and induces intratumoral angiogenesis. PATIENTS AND METHODS:A series of 70 endometrial cancer cases that had undergone a curative resection was studied to determine the correlation between COX-2 expressi...

journal_title：Anticancer research

authors： Ohno S,Ohno Y,Suzuki N,Soma G,Inoue M

更新日期：2007-11-01 00:00:00

abstract：:The polysaccharide produced by the red microalga Porphyridium sp. was highly inhibitory for cell transformation of mouse fibroblast cells by an MSV-124 virus stock. This inhibition was most effective if the polysaccharide was added 2 h before or at the time of infection. The finding that the inhibition of cell transfo...

journal_title：Anticancer research

authors： Huleihel M,Arad S

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Notch activation is involved in the growth of leukemia cells. gamma-Secretase inhibitors (GSIs), which block Notch activation, may be candidates for molecular target therapy against leukemia. MATERIALS AND METHODS:The effects of three kinds of GSIs: GSI-IX, GSI-XII and GSI-XXI, on the in vitro growth of var...

journal_title：Anticancer research

authors： Okuhashi Y,Nara N,Tohda S

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to investigate the effects of the macrophage colony-stimulating factor (M-CSF) receptor antagonist on hepatic carcinogenesis in mice. MATERIALS AND METHODS:Mice were injected with diethylnitrosamine (DEN) and treated with M-CSF receptor antagonist GW2580 (GW) or a saline vehicl...

journal_title：Anticancer research

authors： Akazawa Y,Kono H,Hara M,Furuya S,Nakata Y,Wakana H,Fukushima H,Sun C,Fujii H,Ichikawa D

更新日期：2019-09-01 00:00:00

abstract：:Cancer is mostly environmental in origin and therefore is theoretically preventable by control of environmental conditions. From the viewpoint of the natural history of cancer, the multi-step nature of neoplasia and the generally long latent period are stressed. The molecular biology of cancer tells us that neoplasia ...

journal_title：Anticancer research

authors： Sugano H

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:A drawback of cancer gene therapy is the failure of toxic gene introduction into a proportion of the tumor cells, resulting in re-progression of the disease. Cancer cell-specificity of the gene introduction has also been problematic. MATERIALS AND METHODS:Previously defined promoter/enhancer DNA of Q5 tumor...

journal_title：Anticancer research

authors： Kuwada E,Noguchi K,Seo N,Yamashiro H,Egawa K

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND/AIM:MicroRNAs (miRNAs) regulate the development of colorectal cancer (CRC). We aimed to investigate miRNAs and their relation to cancer-related signaling pathways in site-specific CRC. MATERIALS AND METHODS:We used a total of 24 left- and right-sided Finnish CRC samples (discovery cohort) and The Cancer Gen...

journal_title：Anticancer research

authors： Eneh S,Heikkinen S,Hartikainen JM,Kuopio T,Mecklin JP,Kosma VM,Mannermaa A

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND/AIM:We evaluated the efficacy and safety of carbon-ion radiotherapy (CIRT) alone for Stage III non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS:Data of 65 patients (median age=73 years) with Stage III NSCLC who underwent CIRT alone in the QST Hospital, Chiba, Japan, between 1997 and 2015 were retros...

journal_title：Anticancer research

authors： Anzai M,Yamamoto N,Hayashi K,Nakajima M,Nomoto A,Ogawa K,Tsuji H

更新日期：2020-01-01 00:00:00

abstract：:Proteolytic enzymes are believed to be necessary for tumor cell invasion. We have studied the effects of the cysteine proteinase inhibitor E-64 and the serine and cysteine proteinase inhibitor leupeptin, on the ability of human malignant melanoma cells (LOX) to pass through an artificial basement membrane. Transwell c...

journal_title：Anticancer research

authors： Bjørnland K,Buø L,Kjønniksen I,Larsen M,Fodstad O,Johansen HT,Aasen AO

更新日期：1996-07-01 00:00:00

abstract：AIM:To clarify how patients with epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma with acquired resistance to EGFR-tyrosine kinase inhibitors (TKIs) respond to radiotherapy (RT) for brain metastases. PATIENTS AND METHODS:Forty-seven patients were divided into the following three groups: a TKI-naïve g...

journal_title：Anticancer research

authors： Hirata H,Nakamura K,Kunitake N,Shioyama Y,Sasaki T,Ohga S,Nonoshita T,Yoshitake T,Asai K,Inoue K,Nagashima A,Ono M,Honda H

更新日期：2013-04-01 00:00:00