Abstract：
BACKGROUND:An acidic arabinogalactan from European mistletoe (Viscum album L, VAL; 1.34 x 10(6) Dalton) was studied in detail because its immunological properties are poorly characterised. MATERIALS AND METHODS:Flow cytometric studies focussed on PS-activated proliferation of human lymphocytes measured via incorporation of bromo-deoxyuridine (BrdU), granulocyte phagocytosis via ingestion of FITC-labelled E.coli, and respiratory burst via oxidation of dihydrorhodamine 123 to rhodamine 123. Cytokines were detected in the cell culture supernatants by ELISA. RESULTS:PS, in contrast to mistletoe lectins (ML), significantly stimulated proliferation of CD4+ T-cells but not CD8+ and CD19+ cells. However, ML influenced PS-mediated stimulation, with a synergistic effect in one and an inhibitory effect in another individual. Furthermore, IFN-gamma release was significantly enhanced by PS, favouring a T-helper cell type-1 cytokine pattern, further IL-6 was significantly stimulated, while granulocyte activity was not affected. CONCLUSIONS:VAL-PS exert yet unknown stimulatory activities, especially on specific CD4+ T-cells which may be influenced by other extract components like the ML. These components may contribute to the anti-tumour effect of VAL.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Stein GM,Edlund U,Pfüller U,Büssing A,Schietzel Msubject
Has Abstractpub_date
1999-09-01 00:00:00pages
3907-14issue
5Beissn
0250-7005issn
1791-7530journal_volume
19pub_type
杂志文章abstract：BACKGROUND/AIM:Anthracyclines, such as doxorubicin, though widely used in anticancer therapy, they are associated with cardiotoxic side-effects. The aim of this trial was to investigate long-term follow-up cardiotoxicity findings in patients treated with doxorubicin and concomitant metoprolol or enalapril 10 years earl...
journal_title：Anticancer research
pub_type： 杂志文章,随机对照试验
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2014-08-01 00:00:00
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journal_title：Anticancer research
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journal_title：Anticancer research
pub_type： 临床试验,杂志文章
doi：
更新日期：2008-07-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2003-03-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
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更新日期：1991-03-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2016-08-01 00:00:00
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pub_type： 杂志文章,评审
doi：
更新日期：2007-09-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
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更新日期：2009-08-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章,评审
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2013-08-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2000-05-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2021-01-01 00:00:00
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doi：
更新日期：2007-03-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2012-09-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：1994-01-01 00:00:00
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journal_title：Anticancer research
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doi：
更新日期：2000-11-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
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journal_title：Anticancer research
pub_type： 临床试验,杂志文章
doi：
更新日期：1999-09-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
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