Relationship Between Postoperative CRP and Prognosis in Thoracic Esophageal Squamous Cell Carcinoma.

Abstract:

BACKGROUND/AIM:Few studies have examined postoperative CRP in esophageal cancer. We investigated the relationship between postoperative CRP values according to the postoperative period and prognosis in esophageal cancer. PATIENTS AND METHODS:We performed a retrospective cohort study including 187 patients who underwent esophagectomy for esophageal squamous cell carcinoma (ESCC) between January 2008 and October 2016. RESULTS:CRP within 1 month of surgery was not related to overall survival (OS) or recurrence-free survival (RFS). In a univariate analysis, postoperative 2 months (2M)-CRP ≥0.15 ml/dl was associated with poorer OS (41.4 vs. 71.4%, p=0.0002) and RFS (28.9 vs. 51.3%, p=0.007). In a multivariate analysis, 2M-CRP ≥0.15 ml/dl was an independent factor for poorer OS (HR=2.27, 95%CI=1.03-3.34, p=0.005) and RFS (HR=1.65, 95%CI=1.08-2.52, p=0.020). The incidence of postoperative pneumonia was significantly higher in the 2M-CRP ≥0.15 ml/dl group (p=0.026). CONCLUSION:2M-CRP ≥0.15 ml/dl is an independent prognostic factor for ESCC. Furthermore, postoperative pneumonia may be associated with patient prognosis after esophagectomy.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Katsurahara K,Shiozaki A,Fujiwara H,Konishi H,Kudou M,Shoda K,Arita T,Kosuga T,Morimura R,Murayama Y,Kuriu Y,Ikoma H,Kubota T,Nakanishi M,Okamoto K,Otsuji E

doi

10.21873/anticanres.13016

subject

Has Abstract

pub_date

2018-11-01 00:00:00

pages

6513-6518

issue

11

eissn

0250-7005

issn

1791-7530

pii

38/11/6513

journal_volume

38

pub_type

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