Preclinical Evaluation of Combined Targeted Approaches in Malignant Rhabdoid Tumors.

abstract：:Selective delivery of a high level of Mitomycin C (MMC) in intraperitoneal disseminated lesions was studied using a new dosage form of MMC, called MMC-CH. Intracavitary MMC-CH delivered a much higher level of MMC selectively to intraperitoneal tissues, with a much lower level of MMC in the whole body, in comparison wi...

journal_title：Anticancer research

authors： Hagiwara A,Takahashi T,Lee R,Ueda T,Takeda M,Itoh T

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND/AIM:Ouabain, a plant-derived product/substance with Na+/K+-ATPase inhibiting properties, has been shown to exert anti-cancer activity on human cancer cells. This is the first study to investigate the effect of ouabain on apoptotic cell death of human osteosarcoma-derived U-2 OS cells. MATERIALS AND METHODS:...

journal_title：Anticancer research

authors： Chou WH,Liu KL,Shih YL,Chuang YY,Chou J,Lu HF,Jair HW,Lee MZ,Au MK,Chung JG

更新日期：2018-01-01 00:00:00

abstract：AIM:Apocrine breast carcinoma often lacks estrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor type-2 (HER2) expression. Accordingly, development of a new treatment strategy is important for this type of cancer. The growth stimulus through the androgen receptor (AR) can be a c...

journal_title：Anticancer research

authors： Sasahara M,Matsui A,Ichimura Y,Hirakata Y,Murata Y,Marui E

更新日期：2014-03-01 00:00:00

abstract：:A quantitative in vivo assay for BCG anticancer efficacy was developed to maximize detection of tumor-antagonistic mechanisms. Cultured S180 sarcoma cells admixed with various quantities of Mycobacterium bovis-BCG organisms were injected subcutaneously into CFW Swiss-Webster mice and response was measured as tumor inc...

journal_title：Anticancer research

authors： Klegerman ME,Zeunert PL,Lajeune J,Lou Y,Groves MJ

更新日期：1991-09-01 00:00:00

abstract：:Thalidomide was recently suggested to be angiogenesis-inhibitor following the demonstration of its activity in a rabbit cornea micropocket model. The purpose of the present study was to test its efficacy in solid tumors in mice. B16-F10 melanoma and CT-26 colon carcinoma cells were injected subcutaneously, intravenous...

journal_title：Anticancer research

authors： Gutman M,Szold A,Ravid A,Lazauskas T,Merimsky O,Klausner JM

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND:Melanoma cells express the nuclear vitamin D receptor (VDR), indicating that malignant melanoma represents a promising target for treatment with 1,25-dihydroxyvitamin D3 (1,25(OH)(2)D(3)) or its analogs. We previously showed that some melanoma cell lines are resistant to the antiproliferative effects of 1,25...

journal_title：Anticancer research

authors： Essa S,Reichrath S,Mahlknecht U,Montenarh M,Vogt T,Reichrath J

更新日期：2012-01-01 00:00:00

abstract：:We have previously shown biopsies from human malignant melanoma, as well as a cell line (MELUR) derived from human malignant melanoma cells, to contain dexamethasone (DEX) - and medroxyprogesterone acetate (MPA) - binding macromolecules exhibiting properties of glucocorticoid receptors from well-known target organs. I...

journal_title：Anticancer research

authors： Bojar H,Fabry W

更新日期：1985-03-01 00:00:00

abstract：:Proteinases are known to be involved in carcinogenesis, and various substrates are now available to measure the activity of these enzymes. No suitable serum tumour marker for head and neck squamous cell carcinoma (HNSCC) exists at this moment. Therefore, we compared proteinase-activity in serum of 20 untreated HNSCC p...

journal_title：Anticancer research

authors： Bongers V,Konings CH,Grijpma AM,Steen I,Braakhuis BJ,Snow GB

更新日期：1995-11-01 00:00:00

abstract：:Eighteen patients with Zollinger-Ellison syndrome were studied with 111In-pentetreotide SPECT in order to localize gastrinoma, the tumour responsible for this pathology. NMR imaging was also carried out. Eight patients were operated. 111In-pentetreotide was reinjected 4 hours before operation and the radioactivity of ...

journal_title：Anticancer research

authors： Scopinaro F,Schillaci O,Delle Fave G,Danieli R,Materia A,Tavolaro R,Angeletti S,Marignani M,Massa R,Gualdi G,Polettini E,Picardi V,Basso N

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND/AIM:For cases of musculoskeletal sarcoma of the knee presenting to our institute, we prioritize joint preservation whenever possible. To investigate patient satisfaction and desire for joint preservation, a questionnaire survey was performed. PATIENTS AND METHODS:Surveys were mailed to 62 patients with musc...

journal_title：Anticancer research

authors： Abe K,Yamamoto N,Hayashi K,Takeuchi A,Kato S,Miwa S,Igarashi K,Inatani H,Aoki YU,Higuchi T,Taniguchi Y,Tsuchiya H

更新日期：2019-04-01 00:00:00

abstract：AIM:Metastasis of unknown primary (MUP) is commonly treated with radiation therapy (RT) to the entire mucosal surfaces and bilateral neck nodes (LN). We report outcomes of oropharynx-targeted RT, retropharyngeal nodes (RPN) and bilateral LN in this context. PATIENTS AND METHODS:Single-Institution retrospective study o...

journal_title：Anticancer research

authors： Mourad WF,Hu KS,Shasha D,Concert C,Ishihara D,Lin W,Shourbaji RA,Ryniak M,Gamez ME,Lukens JN,Li Z,Culliney BE,Khorsandi AS,Tran T,Jacobson A,Manolidis S,Schantz S,Urken M,Persky MS,Harrison LB

更新日期：2014-01-01 00:00:00

abstract：:Intraosseous lipomas are rare benign primary bone tumors, with an incidence of one per thousand bone tumors. We studied eleven cases of intraosseous lipoma of the calcaneus. All the patients received radiographic examinations and MRI with T1-and T2-weighted images with Gd-DTPA enhancement. Seven patients received tumo...

journal_title：Anticancer research

authors： Hirata M,Kusuzaki K,Hirasawa Y

更新日期：2001-11-01 00:00:00

abstract：:260 CB57BL/J6 mice were used in an experimental protocol designed to investigate the effects of 4 different varieties of splenectomy on the growth rate of subcutaneously implanted GB-16 melanoma. In addition, the mean and absolute survival of the mice, the histopathology of the tumour and the effects of the same proce...

journal_title：Anticancer research

authors： Fotiadis C,Zografos G,Aronis K,Troupis TG,Gorgoulis VG,Sechas MN,Skalkeas G

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND/AIM:Hepatic venous isolation and extracorporeal charcoal hemoperfusion (HVI-CHP) can reduce systemic exposure to hepatic arterial infusion (HAI) chemotherapy. The pre-existing HVI-CHP system has limited effectiveness against high-dose cisplatin; therefore, we designed a new system and evaluated its efficacy ...

journal_title：Anticancer research

authors： So S,Komatsu S,Takebe A,Kido M,Tanaka M,Toyama H,Ueno K,Fukumoto T

更新日期：2018-11-01 00:00:00

abstract：:The present study was undertaken to investigate cell death (particularly apoptosis) induced by etoposide, radiation, and both, and to examine p53 protein expression in relation to cell death. Nude mice transplanted with a human tumor (ependymoblastoma) were treated with etoposide (5-40 mg/kg) or 1-2 Gy X-ray irradiati...

journal_title：Anticancer research

authors： Toda H,Hasegawa M,Hayakawa K,Kawashima M,Nakamura Y,Yamakawa M,Mitsuhashi N,Niibe H

更新日期：2000-01-01 00:00:00

abstract：:Human leukocyte antigen (HLA)-E and HLA-F are classified as non-classical HLA class Ib antigens. Ectopic HLA-E and HLA-F expression was recently detected in cancer cells; however, the clinical implication of their expression remains unknown. A total of 209 patients with gastric cancer were enrolled in this study. Immu...

journal_title：Anticancer research

authors： Ishigami S,Arigami T,Okumura H,Uchikado Y,Kita Y,Kurahara H,Maemura K,Kijima Y,Ishihara Y,Sasaki K,Uenosono Y,Natsugoe S

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:The safety and efficacy of docetaxel plus S-1 combination chemotherapy as a first-line treatment in patients with advanced or recurrent gastric cancer was verified retrospectively. PATIENTS AND METHODS:Eighteen patients with advanced or recurrent gastric cancer were enrolled. The regimen used was intravenou...

journal_title：Anticancer research

authors： Tsutani Y,Ohara M,Suzuki T,Minami K,Miyahara E,Kameda A,Noso Y

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:The benefit of tissue microarray (TMA) is its capability to analyse large numbers of tissue samples in a uniform fashion. This study was designed to evaluate the capability of TMA for analyzing the status of death-associated protein kinase 1 (DAPK1) in breast cancer patient and to explore its potential in th...

journal_title：Anticancer research

authors： Chou SE,Huang CY,Sheen-Chen SM,Liu YW,Tsai CH,Lin YH,Huang CC,Tang RP

更新日期：2011-10-01 00:00:00

abstract：AIM:To investigate the protein kinase B (Akt) signalling proteins phosphatase and tensin homolog (PTEN), phosphorylated-Akt (p-Akt) and cyclin-dependent kinase inhibitor 1B (p27(Kip1)) in non-seminomatous germ cell tumors (NST) with a view to future investigative approaches. MATERIALS AND METHODS:The expressions of PT...

journal_title：Anticancer research

authors： Hennenlotter J,Amend B,Vogel U,Renninger M,Springer C,Kuehs U,Stenzl A,Bedke J

更新日期：2011-11-01 00:00:00

abstract：:Arsenic trioxide (ATO) is an inorganic arsenic derivative that is very effective against acute promyelocytic leukemia. However, organic arsenic derivatives (OAD) have a more favorable toxicity profile than ATO. We herein characterized dipropil-S-glycerol arsenic (GMZ27), a novel OAD. GMZ27 had potent antiproliferative...

journal_title：Anticancer research

authors： Cheng X,Quintás-Cardama A,Golemovic M,Zingaro R,Gao MZ,Freireich EJ,Andreeff M,Kantarjian HM,Verstovsek S

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:The description of a new method for the measurement of complexed prostate-specific antigen (cPSA) offers a new approach to the diagnosis of prostate cancer. PATIENTS AND METHODS:We measured PSA (Hybritech and Bayer), free PSA (Hybritech) and complexed PSA (Bayer) in 72 patients with prostate cancer and 128 ...

journal_title：Anticancer research

authors： Filella X,Truan D,Alcover J,Gutierrez R,Molina R,Coca F,Ballesta AM

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Glioblastoma multiforme (GBM) remains the most aggressive and frequently occurring brain neoplasm. Members of the Rho family of small GTP-binding proteins, including Rho, Rac, and Cdc42, have been shown to participate in cell growth differentiation and motility. The mitogen-activated protein kinase (MAPK) pa...

journal_title：Anticancer research

authors： Zohrabian VM,Forzani B,Chau Z,Murali R,Jhanwar-Uniyal M

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND/AIM:γ-Glutamylcyclotransferase (GGCT), a key enzyme involved in glutathione metabolism, catalyzes a specific reaction that generates 5-oxoproline and free amino acids from the γ-glutamyl peptide. Inhibition of GGCT is a promising therapeutic strategy for the treatment of various cancers. MATERIALS AND METHO...

journal_title：Anticancer research

authors： Hanada E,Kageyama S,Murai R,Kubota S,Ii H,Nakata S,Kita H,Kawauchi A,Chano T

更新日期：2019-04-01 00:00:00

abstract：AIM:The aim of the present study was to determine if febuxostat could prevent tumor lysis syndrome (TLS) in children who received induction chemotherapy for hematologic malignancies. PATIENTS AND METHODS:A retrospective analysis was performed in 45 pediatric patients with hematological malignancies who received febuxo...

journal_title：Anticancer research

authors： Kishimoto K,Kobayashi R,Hori D,Sano H,Suzuki D,Kobayashi K

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Previously, the antitumour activity of some flavone-8-acetic acid (FAA) derivatives substituted with an acid function in position 2 of the benzene ring was evaluated. The most active compound resulted the one bearing a fluorine atom in position 7 of the flavone nucleus. In this paper, we evaluated new mono- ...

journal_title：Anticancer research

authors： Carrara M,Zampiron A,Barbera M,Caputo A,Bisi A,Gobbi S,Belluti F,Piazzi L,Rampa A,Valenti P

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Tenascin-C (TNC) is an extracellular matrix glycoprotein, usually derived from myofibroblasts in the cancer microenvironment. Recently, however, the significance of tumor-derived TNC in initiation of cancer metastasis was disclosed. We investigated the clinical significance of cancer-derived TNC in colorecta...

journal_title：Anticancer research

authors： Takahashi Y,Sawada G,Kurashige J,Matsumura T,Uchi R,Ueo H,Ishibashi M,Takano Y,Akiyoshi S,Iwaya T,Eguchi H,Sudo T,Sugimachi K,Yamamoto H,Doki Y,Mori M,Mimori K

更新日期：2013-05-01 00:00:00

abstract：:1-(phenylmethyl)-4,7,10-tris-[(4'methylphenyl)-sulfonyl]-1,4,7, 10-tetraazacyclododecane proved to possess potent in vivo antineoplastic and in vitro cytotoxicity in murine and human tissue cultured cells. In Tmolt3 leukemic cells 1-(phenylmethyl)-4,7,10-tris-[(4'methylphenyl)sulfonyl]-1,4,7, 10-tetraazacyclododecane ...

journal_title：Anticancer research

authors： Hall IH,Elkins AL,Karthikeyan S,Spielvogel BF

更新日期：1997-03-01 00:00:00

abstract：:The objective of the present study was to investigate the effect of dietary phytosterols on the growth and metastasis of the human breast cancer MDA-MB-231 cell line xenografted in SCID mice. Two groups of animals were fed AIN-93G diet supplemented with 0.2% cholic acid and 2% sterol (cholesterol or phytosterol mixtur...

journal_title：Anticancer research

authors： Awad AB,Downie A,Fink CS,Kim U

更新日期：2000-03-01 00:00:00

abstract：:An in vitro pilot study was conducted of the possible utility of combining low doses of cytosine arabinoside (araC) and GM-CSF to stimulate leukemic cell differentiation. Cytosine arabinoside induced macrophage differentiation in some cultures but only when the drug produced substantial cytostatic effects. GM-CSF, whe...

journal_title：Anticancer research

authors： Gao XZ,Yin MY,Preisler HD

更新日期：1989-07-01 00:00:00

abstract：:The incidence of breast cancer is increasing rapidly in Taiwan but is still low compared with western countries. The impact of body size factors in western countries inspired us to have a case-control study. A matched case-control study was done on 122 pairs of incident cases of female breast cancer and community cont...

journal_title：Anticancer research

authors： Chie WC,Chen CF,Lee WC,Chen CJ

更新日期：1996-09-01 00:00:00