Abstract：
:Thalidomide was recently suggested to be angiogenesis-inhibitor following the demonstration of its activity in a rabbit cornea micropocket model. The purpose of the present study was to test its efficacy in solid tumors in mice. B16-F10 melanoma and CT-26 colon carcinoma cells were injected subcutaneously, intravenously and intraperitoneally, and mice received daily gavage of 0.3-1.0 mg thalidomide starting either two or 10 days following tumor cell injection. The tumors were measured and compared with controls. There was no growth retardation in CT-26 bearing mice nor in mice with pulmonary or peritoneal metastases of B16-F10 melanoma. In 3/7 groups of mice with SC B16-F10 tumors, growth retardation was demonstrated, however the difference was not statistically significant. All tumors eventually reached maximal size, similar to controls. Morphological evaluation of the blood vessels oriented towards the tumor revealed that in both thalidomide and control groups, all mice had developed an intact network of new blood vessels. In our model for the oral administration of thalidomide inhibition of tumor growth and angiogenesis did not occur. We hypothesize that the lack of sustained antiangiogenic response was either due to immune modulation or to tumor heterogeneity and adaptation.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Gutman M,Szold A,Ravid A,Lazauskas T,Merimsky O,Klausner JMsubject
Has Abstractpub_date
1996-11-01 00:00:00pages
3673-7issue
6Beissn
0250-7005issn
1791-7530journal_volume
16pub_type
杂志文章abstract：:The response of the blood-forming and supportive stromal compartments of the marrow to a localized, fractionated course of radiotherapy [FxRT; 2.0 Gy (q24 h x 5)-->74 Gy] was examined in the C57Bl/6 mouse using the hematopoietic progenitor and the cobblestone-forming cell (CAFC) assays as end-points for the blood-form...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2003-05-01 00:00:00
abstract：BACKGROUND/AIM:The aim of this study was to determine the natural history of benign thyroid nodules using ultrasonography. PATIENTS AND METHODS:The records of 223 patients with benign thyroid nodules treated at the Kochi Medical School from 2010 to 2012 were reviewed retrospectively. Repeated ultrasonography was perfo...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.13317
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:Human herpesviruses types 4 and 6 (EBV, HHV-6) are frequently found in Hodgkin 's disease (HD) and--to a certain extent--in Kikuchi-Fujimoto's disease (KFD). Both viruses are apparently related to proliferative and/or apoptotic processes as represented by HD or KFD respectively. OBJECTIVE:To correlate frequ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2001-05-01 00:00:00
abstract：:Cathepsin B (CB) is involved in degradation of extracellular matrix proteins during tumor progression in human solid organ tumors (such as colorectal, bladder, and breast cancers), including human prostate cancer. Its activities are regulated by endogenous inhibitors (such as stefins or cystatins). Increased expressio...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1999-07-01 00:00:00
abstract：AIM:To assess the correlation between advanced non-small cell lung cancer (NSCLC) with or without pulmonary lymphangitic carcinomatosis (PLC) and fluorodeoxyglucose (FDG) uptake and its effect on survival outcomes. PATIENTS AND METHODS:We retrospectively reviewed 157 patients with NSCLC. The mean and maximum standardi...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2016-08-01 00:00:00
abstract：BACKGROUND:Neuroendocrine (NE) carcinomas of the lung exhibit expression of various stem cell antigens, and except for carcinoid tumours, carry a poor prognosis. Despite the fact that 10%-30% of all non-small cell lung carcinomas (NSCLC) which are not classified as NE carcinomas also show expression of NE markers, data...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2013-03-01 00:00:00
abstract：:Iceland has a total population of 300,000 inhabitants. All patients consulting for symptoms of the lower digestive tract during a four-year period (2003-2006) were subjected to a colonoscopic examination; all polyps were endoscopically removed. Out of the total 3,037 colorectal adenomas (CRAs), 308 (10.2%) were tradit...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:Recent developments in detection of micrometastasis have revealed a considerable incidence of systemic disease in patients who would previously have been diagnosed as having solid tumours only. The purpose of this study was to investigate the prevalence and clinical significance of circulating carcinoma cell...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2000-11-01 00:00:00
abstract：:In a retrospective study, immunohistochemical determinations of p53 were performed on paraffinised tissue sections of 243 patients with node negative breast cancer. These patients were primary treated in the years 1980-1986 at the UFK-Würzburg. A complete follow up could be performed in 92% of all cases. The median fo...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1997-07-01 00:00:00
abstract：BACKGROUND:Apart from inactivation of the MEN1 gene, the molecular mechanisms involved in tumorigenesis of the endocrine organs and MEN1-associated non-endocrine lesions remain unknown. MATERIALS AND METHODS:In order to learn more about down-stream effects upon MEN1 gene inactivation BON1 cells were transfected with a...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2009-06-01 00:00:00
abstract：BACKGROUND:E-selectin expression is very low in normal adult blood vessels, but is significantly elevated in newly formed tumor capillaries. We hypothesized that a viral vector which has transcriptional specificity for the tumor vasculature may be a tool for angiogenesis-targeted gene therapy. We therefore designed an ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1998-05-01 00:00:00
abstract：AIM:To evaluate whether the congested area that develops in associating liver partition with portal vein ligation for staged hepatectomy (ALPPS) contributes to rapid future liver remnant (FLR) hypertrophy. PATIENTS AND METHODS:Eight patients undergoing liver partition and right portal vein (RPV) ligation within the FL...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.11028
更新日期：2016-09-01 00:00:00
abstract：:Long-term results of different studies employing cisplatin-based chemotherapy in advanced ovara in cancer are just beginning to be published. Available data suggest that the rate of relapse decreases but does not cease, and the question of whether cisplatin-based chemotherapy results in an improved cure in advanced ov...
journal_title：Anticancer research
pub_type： 临床试验,杂志文章,评审
doi：
更新日期：1989-11-01 00:00:00
abstract：BACKGROUND:Different phenomena can result in enlargement of mental foramen and mandibular canal. At the foreground of diagnosis is the assessment of the biological properties of the tissue which causes such detailed lesions of the skeleton. CASE REPORT:This report describes a palpable mass at the site of the mental fo...
journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：10.21873/anticanres.13554
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:NSC697923, a ubiquitin-conjugating enzyme E2 (UBE2) inhibitor, was suggested as an agent to degrade hypoxia-inducible factor 1 alpha subunit (HIF1α), a key factor in radiation resistance. We attempted to clarify whether NSC697923 could overcome radiation resistance. MATERIALS AND METHODS:Radiation resistanc...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.11582
更新日期：2017-05-01 00:00:00
abstract：:A female patient with stage IV-M1c (distant lymph node and breast metastases), chemotherapy-refractory melanoma was treated with the cytotoxic T-lymphocyte antigen 4 (CTLA-4)-inhibitory monoclonal antibody ipilimumab. At first evaluation following induction treatment, there was marked increase in the volume of the lym...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2012-04-01 00:00:00
abstract：AIM:To evaluate the usefulness of Ki-67 index and survivin as predictive prognostic factors for rectal cancer treated with preoperative chemoradiotherapy. PATIENTS AND METHODS:The Ki-67 index and survivin expression were examined in patients with stage II/III rectal cancer (n=46) by immunohistochemistry. Patients were...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.12409
更新日期：2018-03-01 00:00:00
abstract：:Mammalian cells transfected with the S. cerevisiae APN1 protein acquire resistance to oxidizing agents, the damage of which is mainly repaired via DNA base excision repair (BER). We have recently hypothesized that this effect might be linked to the possible capacity of APN1 to accelerate mammalian BER by its 3' dieste...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2003-09-01 00:00:00
abstract：BACKGROUND:Parathyroid hormone-related protein (PTHrP) is a key regulator of osteolytic metastasis of breast cancer (BC) cells, but its targets and mechanisms of action are not fully understood. This study investigated whether/how PTHrP (1-34) signaling regulates expression of vascular endothelial growth factor (VEGF) ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2010-07-01 00:00:00
abstract：BACKGROUND:Histone acetyltransferase E1A-binding protein p300 (EP300), tumor protein p53 (TP53) and B-cell lymphoma-2-associated X protein (BAX) contribute to the regulation of the cell cycle and apoptosis, cellular processes that are often impaired in cancer cells. The aim of this study was to determine the expression...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.11646
更新日期：2017-06-01 00:00:00
abstract：BACKGROUND:Embryonic stem cell expressed Ras (ERas) oncogene is associated with the tumorigenicity of embryonic stem cells. The aim of this study was to clarify the significance of ERas expression in clinical samples of gastric carcinomas. MATERIALS AND METHODS:Three hundred and few tissues from gastric cancer patient...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2009-06-01 00:00:00
abstract：:The aim of this study was to determine a possible risk of malignancies in the haematopoietic tissues of rats treated with styrene, either by injection or by inhalation. Two experiments were carried out: in the first (acute treatment), 12 male rats were treated intraperitoneally with different doses of styrene (40 mg/K...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2000-05-01 00:00:00
abstract：BACKGROUND:Adverse outcomes in breast cancer patients treated with recombinant human erythropoietin (rhEpo) have been linked to the expression of Epo-receptors (EpoR) in cancer cells, although limited data on the clinical significance of these observations are available. PATIENTS AND METHODS:Tissue samples from 107 pa...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2010-09-01 00:00:00
abstract：:An adenovirus type 2-transformed rat embryo brain cell line (F 17 A2AS) and two of its subclones (F 17 CI, F 17 C2) have been studied using chromosome banding and flow cytometric techniques. In determining the modal chromosome number, a bimodal distribution was observed in each of the cell lines. In each case the firs...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1984-11-01 00:00:00
abstract：BACKGROUND:As the incidence of lung cancer in the elderly is increasing worldwide, there exists a need to develop a clinically effective, less toxic therapy for this patient population. Although erlotinib has shown proven effectiveness against non-small cell lung cancer (NSCLC), few studies have prospectively investiga...
journal_title：Anticancer research
pub_type： 杂志文章,多中心研究
doi：
更新日期：2016-06-01 00:00:00
abstract：BACKGROUND/AIM:Due to their unique composition of health-promoting compounds, the consumption of hazelnuts may contribute to the prevention of colon cancer. MATERIALS AND METHODS:Since hazelnuts are often consumed roasted, the impact of different roasting conditions (RC1=140.6°C/25 min, RC2=155.1°C/20 min and RC3=180....
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.12195
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:5-Fluoro-2'-deoxyuridine (5-FdU), a drug against gastric cancer, was covalently linked via its nucleobase with the amino-bisphosphonate alendronate (Ale), resulting in a new antimetabolite-bisphosphonate conjugate (5-FdU-Ale), designed for bone-targeting. MATERIALS AND METHODS:The cytostatic effect of 5-FdU...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2012-10-01 00:00:00
abstract：:The value of metabolic proton NMR spectroscopic imaging to detect and classify tumours increases with the spatial resolution and the information content of the spectra. Several factors influencing these quantities are discussed. ...
journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：1996-05-01 00:00:00
abstract：:Most patients with musculoskeletal sarcoma do not recover satisfactory limb function after limb salvage surgery. To achieve satisfactory improvement of limb function, we developed a unique surgical modality of photodynamic therapy using acridine orange (AO-PDT) and clinically applied it to patients with musculoskeleta...
journal_title：Anticancer research
pub_type： 临床试验,杂志文章
doi：
更新日期：2005-03-01 00:00:00
abstract：BACKGROUND:The optimal treatment for locoregionally recurrent rectal cancer after curative surgery has not yet been defined. The definition of prognostic factors could lead to the selection of an aggressive therapeutic approach in patients with favourable prognosis alone. PATIENTS AND METHODS:The records of thirty-nin...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1999-03-01 00:00:00
