Abstract:
AIM:To evaluate the usefulness of Ki-67 index and survivin as predictive prognostic factors for rectal cancer treated with preoperative chemoradiotherapy. PATIENTS AND METHODS:The Ki-67 index and survivin expression were examined in patients with stage II/III rectal cancer (n=46) by immunohistochemistry. Patients were divided into a high-group and a low-group for the Ki-67 index, and positive and negative groups for survivin expression. Overall and disease-free survival were compared between the groups, and the correlation between Ki-67 index and survivin expression was assessed. RESULTS:The 5-year disease-free survival rate of the group with high Ki-67 index was significantly lower than that of the group with low Ki-67 index (53% and 88%, p=0.03), as was the 5-year overall survival rate (68% and 100%, p=0.03). Findings for survivin were not significant. CONCLUSION:Ki-67 index and survivin may be useful biomarkers for rectal cancer with preoperative CRT.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Yoshikawa K,Shimada M,Higashijima J,Nakao T,Nishi M,Takasu C,Kashihara H,Eto S,Bando Ydoi
10.21873/anticanres.12409subject
Has Abstractpub_date
2018-03-01 00:00:00pages
1735-1739issue
3eissn
0250-7005issn
1791-7530pii
38/3/1735journal_volume
38pub_type
杂志文章abstract:BACKGROUND:A case control association study was carried out to investigate polymorphisms in genes CYP1A1 (3801T > C), GSTM1, and GSTT1 (null genotypes) and oral squamous cell carcinoma (OSCC), including a correlation with some histopathological findings (tumor size, lymph node invasion and degree of tumor differentiati...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
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journal_title:Anticancer research
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journal_title:Anticancer research
pub_type: 杂志文章
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journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
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journal_title:Anticancer research
pub_type: 杂志文章
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更新日期:1992-01-01 00:00:00
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更新日期:2000-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章,评审
doi:
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doi:
更新日期:2006-05-01 00:00:00
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pub_type: 临床试验,杂志文章
doi:
更新日期:2002-11-01 00:00:00
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doi:
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doi:
更新日期:2012-01-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
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更新日期:2017-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2008-05-01 00:00:00
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更新日期:2003-11-01 00:00:00
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章
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doi:
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