Serum proteinase activities in head and neck squamous cell carcinoma patients.

Abstract:

:Proteinases are known to be involved in carcinogenesis, and various substrates are now available to measure the activity of these enzymes. No suitable serum tumour marker for head and neck squamous cell carcinoma (HNSCC) exists at this moment. Therefore, we compared proteinase-activity in serum of 20 untreated HNSCC patients with that of 20 non-cancer individuals. When N-benzoyl-DL-arginine-beta-naphtylamide (BANA) was used as the substrate, proteinase-activity seemed higher among patients, but this difference disappeared after adjustment for alcohol and tobacco consumption. Applying N-a-benzoyloxycarbonyl-L-arginyl-L-arginine-7-amido-4-methylcou marine (ZAAM) as the substrate no difference was found. Addition of E-64, an inhibitor of cysteine proteinase showed that cathepsin B contributed minimally to the ZAAM-specific activity.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Bongers V,Konings CH,Grijpma AM,Steen I,Braakhuis BJ,Snow GB

subject

Has Abstract

pub_date

1995-11-01 00:00:00

pages

2763-6

issue

6B

eissn

0250-7005

issn

1791-7530

journal_volume

15

pub_type

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