Febuxostat as a Prophylaxis for Tumor Lysis Syndrome in Children with Hematological Malignancies.

Abstract:

AIM:The aim of the present study was to determine if febuxostat could prevent tumor lysis syndrome (TLS) in children who received induction chemotherapy for hematologic malignancies. PATIENTS AND METHODS:A retrospective analysis was performed in 45 pediatric patients with hematological malignancies who received febuxostat (10 mg daily, n=20) or allopurinol (300 mg/m2 daily, n=25) as a prophylaxis for TLS. RESULTS:A significant decrease of serum uric acid (UA) level was observed in patients with febuxostat over the first 2 days (6.6±3.8 mg/dl vs. 4.5±2.8 mg/dl, p<0.001). The febuxostat group also showed significant reduction of urinary UA/creatinine ratios during the first two days of treatment (0.98±0.85 vs. 0.51±0.26, p=0.010). No significant differences were observed between febuxostat-treated and allopurinol-treated patients regarding the percent change in serum UA level. CONCLUSION:Febuxostat had a notable effect in reducing serum UA level in children with hematological malignancies.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Kishimoto K,Kobayashi R,Hori D,Sano H,Suzuki D,Kobayashi K

doi

10.21873/anticanres.12028

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

5845-5849

issue

10

eissn

0250-7005

issn

1791-7530

pii

37/10/5845

journal_volume

37

pub_type

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