Norcantharidin-induced Apoptosis of AGS Human Gastric Cancer Cells Through Reactive Oxygen Species Production, and Caspase- and Mitochondria-dependent Signaling Pathways.

abstract：BACKGROUND/AIM:Invasive bladder cancer mortality remains high despite progresses made in early diagnosis and surgical procedures. Thus, there is a need to define new markers for bladder cancer. CLIC1 has not been previously studied in bladder cancer and thus, we aimed to assess its immunohistochemical expression in rel...

journal_title：Anticancer research

authors： Adelmann TG,Camerota TC,Ceausu AR,Cimpean AM,Mazzanti M,Raica M

更新日期：2020-12-01 00:00:00

abstract：:The metabolic transformations of labeled pyridoxine by hepatoma cells were studied. Buffalo rats were fed ad libitum a commercially prepared pyridoxine sufficient diet for 20 days at which time they were inoculated intramuscularly with hepatoma 7777 cells in both hind leg muscles. After tumor development, 50 microCi [...

journal_title：Anticancer research

authors： Tryfiates GP

更新日期：1983-01-01 00:00:00

abstract：:Dynamic liver RES scintigraphy with Nanocoll (99Tcm albumin colloid - 50 nm diameter) assessing RES-macrophage phagocytic function was performed in 40 control, 73 RES-stimulated non-tumour-bearing and 59 tumour-bearing Wistar/FU rats in vivo. Tumour-bearing rats were inoculated with 10(6) x 1.0 cells of a syngeneic ni...

journal_title：Anticancer research

authors： Holmberg SB,Hafström L,Jacobsson L

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:To understand the molecular response of tumor cells to therapeutic ionizing radiation (IR), we previously reported that human breast cancer cells derived following chronic exposure to fractionated ionizing radiation (MCF+FIR) showed a transient radioresistance. MCF+FIR cells also demonstrated increased activ...

journal_title：Anticancer research

authors： Ozeki M,Tamae D,Hou DX,Wang T,Lebon T,Spitz DR,Li JJ

更新日期：2004-09-01 00:00:00

abstract：INTRODUCTION:Malignant tumors of the sweat glands are very rare. Clear cell hidradenoma is a lesion with histopathological features resembling those of eccrine poroma and eccrine spiradenoma. The biological behavior of the tumor is aggressive, with local recurrences reported in more than 50% of the surgically-treated c...

journal_title：Anticancer research

authors： Liapakis IE,Korkolis DP,Koutsoumbi A,Fida A,Kokkalis G,Vassilopoulos PP

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND/AIM:Glioma-associated oncogene 1 (GLI1) is an important transcription factor in the hedgehog signalling pathway and tumour formation. We evaluated the clinical significance of GLI1 expression as a prognostic factor in patients with locally advanced gastric cancer (GC). PATIENTS AND METHODS:GLI1 expression l...

journal_title：Anticancer research

authors： Hashimoto I,Oue N,Kimura Y,Hiroshima Y,Hara K,Maezawa Y,Kano K,Fujikawa H,Aoyama T,Numata M,Yamada T,Tamagawa H,Yamamoto N,Ogata T,Shiozawa M,Morinaga S,Rino Y,Yasui W,Masuda M,Miyagi Y,Oshima T

更新日期：2020-10-01 00:00:00

abstract：:The most widely-known anti-tumor drugs often induce marked immunosuppression which can give rise to one or more sepses. Anti-infection measures immediately applied can sometimes prove largely ineffective or even useless, the patient dying not as a result of the spread of the tumour but as a direct consequence of oppor...

journal_title：Anticancer research

authors： Castelli M,Baggio G,Ruberto AI,Malagoli M,Casolari C,Rossi T,Galatulas I

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:Metastatic involvement of the pancrease is not an uncommon autopsy finding, however, pancreatic metastasis is an infrequent clinical condition and the pattern of the metastases have not been studied. We conducted a retrospective study in order to evaluate the pattern of the metastasis from lung cancer. PATI...

journal_title：Anticancer research

authors： Maeno T,Satoh H,Ishikawa H,Yamashita YT,Naito T,Fujiwara M,Kamma H,Ohtsuka M,Hasegawa S

更新日期：1998-07-01 00:00:00

abstract：:Inflammatory bowel diseases (IBD) are associated with an increased risk of colitis-associated colorectal carcinoma (CAC). CAC is one of the most important causes of morbidity and mortality in patients with Crohn's disease and ulcerative colitis. The aim of the present review was to discuss the most important signaling...

journal_title：Anticancer research

authors： Romano M,DE Francesco F,Zarantonello L,Ruffolo C,Ferraro GA,Zanus G,Giordano A,Bassi N,Cillo U

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Expression of novel stem cell-associated marker human embryonic stem cell 77 (HES77) was studied in rectal neuroendocrine tumors (NETs), which comprise 10 to 15% of gastroenteropancreatic NETs, some with metastatic potential. MATERIALS AND METHODS:WHO 2010 classification was applied, and immunohistochemical...

journal_title：Anticancer research

authors： Jernman J,Hagström J,Mäenpää H,Välimäki MJ,Haapasalo H,Nilsson O,Fermér C,Haglund C,Arola J

更新日期：2015-07-01 00:00:00

abstract：:Methyl-tertiary-butyl ether (MTBE) is a ubiquitous oxygen-bearing additive used to reduce engine knocking and obtain cleaner gasoline combustion. Conflicting data have been reported about a possible carcinogenic role of MTBE in humans. In this study we evaluated the effects of MTBE on cell growth and transformation in...

journal_title：Anticancer research

authors： Iavicoli I,Carelli G,Ardito R,Cittadini A,Sgambato A

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND/AIM:Orbital metastasis of systemic cancer is exceedingly rare. This is a case report of a patient treated for locally recurrent vulvar melanoma who later presented with unilateral proptosis and was found to have an isolated biopsy-proven extraocular muscle metastasis. PATIENTS AND METHODS:A 94-year-old fema...

journal_title：Anticancer research

authors： Pirlamarla AK,Tang J,Amin B,Kabarriti R

更新日期：2018-06-01 00:00:00

abstract：:Tissue-specific expression of 25-hydroxyvitamin D-1alpha-hydroxylase (1alpha-OHase) and vitamin D-hydroxylase (24-OHase) may act as the pivotal link between 25-hydroxyvitamin D3 (25(OH)D3) serum levels and the anticancer effects of 1,25-dihydoxyvitamin D3 (1,25(OH)2D3) and alternative splicing of the enzymes may regul...

journal_title：Anticancer research

authors： Fischer D,Becker S,Cordes T,Bücker B,Diedrich K,Friedrich M,Salehin D,Thill M

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND/AIM:It is well-known that inflammatory bowel disease (IBD) poses an increased, yet not definitely estimated, risk of colitis-associated colon cancer (CAC), which is considered a more aggressive and distinct in both genetic and molecular levels clinical entity compared to sporadic colorectal cancer (CRC). The...

journal_title：Anticancer research

authors： Antoniou E,Margonis GA,Angelou A,Zografos GC,Pikoulis E

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND/AIM:In order to develop an efficient drug-delivery system (DDS), a lipopeptide-loaded liposome that functions as a platform for the transpeptidase reaction mediated by sortase A (SrtA) was constructed and its stability, as well as cell-specific targeting were evaluated in the present study. MATERIALS AND ME...

journal_title：Anticancer research

authors： Tabata A,Ohkubo Y,Anyoji N,Hojo K,Tomoyasu T,Tatematsu Y,Ohkura K,Nagamune H

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Polymorphisms altering DNA repair capacity may lead to synergistic effects with tobacco carcinogen-induced lung cancer risk. Based on this hypothesis, the relationship between APE1 polymorphism, smoking and the risk of lung cancer was explored. MATERIALS AND METHODS:The distribution of the APE1 Asp148Glu po...

journal_title：Anticancer research

authors： Agaçhan B,Küçükhüseyin O,Aksoy P,Turna A,Yaylim I,Görmüs U,Ergen A,Zeybek U,Dalan B,Isbir T

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND/AIM:Osteosarcoma (OS) is a diagnosed primary cancer of the bone. Despite the great advances that have been made during the past decades in OS therapy, drug resistance and tumor recurrence are still major problems. It is urgent to find novel strategies to overcome drug resistance in order to prolong the survi...

journal_title：Anticancer research

authors： He C,Sun Z,Hoffman RM,Yang Z,Jiang Y,Wang L,Hao Y

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Neurofibromatosis type 1 (NF1) is an autosomal dominant hereditary disease with complete penetrance and a very variable phenotype. Recent research has shown that postzygotic NF1 gene mutations occur to a far greater extent than previously thought. The phenotype of affected individuals reflects the time of so...

journal_title：Anticancer research

authors： Friedrich RE,Hagel C,Kohlrusch FK,Schanze I,Wieland I,Zenker M

更新日期：2020-06-01 00:00:00

abstract：:Chloroform (CHCl3) is an established rodent carcinogen and a prevalent contaminant of chlorine-disinfected drinking water. Thus in the United States CHCl3, along with other trihalomethanes, is regulated not to exceed 100 ppb in potable water. Recently, several studies have shown that CHCl3 also has anti-cancer propert...

journal_title：Anticancer research

authors： Daniel FB,Reddy TV,Stober JA,Olson GR

更新日期：1991-03-01 00:00:00

abstract：:L1210 cell lines selected for resistance to deoxyadenosine exhibit altered steady-state levels of the mRNA for the early response genes and p53. In the deoxyadenosine-resistant cell lines (Y8 and ED2), the levels of the mRNAs for p53 and c-jun were markedly decreased while the steady-state levels for mRNAs for c-myc, ...

journal_title：Anticancer research

authors： Cory JG,He AW,Cory AH

更新日期：1996-11-01 00:00:00

abstract：:The use of gene-modified dendritic cells (DC) is a powerful tool to enhance antitumor immune responses stimulated by these cells in cancer immunotherapy. Cationized gelatin is preferably incorporated via phagocytosis and is gradually degraded by proteolysis while buffering lysosomal activity. This may be appropriate f...

journal_title：Anticancer research

authors： Inada S,Fujiwara H,Atsuji K,Takashima K,Araki Y,Kubota T,Tabata Y,Yamagishi H

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:We previously showed the usefulness of a fused protein of human pancreatic ribonuclease1 (hRNase1) with human epidermal growth factor (hEGF) for molecular targeting of EGF receptor (EGFR)-overexpressing cells. In this study, the mechanisms underlying the inhibition of cell growth by RNase-EGF fused proteins ...

journal_title：Anticancer research

authors： Hoshimoto S,Ueda M,Jinno H,Kitajima M,Futami J,Seno M

更新日期：2006-03-01 00:00:00

abstract：:Formalin-fixed paraffin-embedded tumor specimens from 95 patients with supratentorial astrocytic brain tumors were immunostained by a monoclonal antibody against the heat shock protein-27 (Hsp-27) using the streptavidin/peroxidase method. The immunohistochemical analysis was scored in a semiquantitative fashion incorp...

journal_title：Anticancer research

authors： Assimakopoulou M,Sotiropoulou-Bonikou G,Maraziotis T,Varakis I

更新日期：1997-07-01 00:00:00

abstract：:Two different techniques [reduction of a tetrazolium derivative (MTT) and 3HTdR uptake assays] were compared in order to evaluate the cytotoxic effects of different chemotherapeutic agents in vitro. The cytotoxicities of Melphalan, hexamethylmelamine and seven derivatives, and daunorubicin were measured on P388D1 mous...

journal_title：Anticancer research

authors： Arnould R,Dubois J,Abikhalil F,Libert A,Ghanem G,Atassi G,Hanocq M,Lejeune FJ

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Early detection before scintigraphic appearance of osseous metastatic spread might improve the outcome of breast cancer patients. The amino-terminal propeptide (PINP) of type I collagen as an indicator of bone formation is a very promising candidate among all markers of bone metabolism. We investigated the u...

journal_title：Anticancer research

authors： Lüftner D,Jozereau D,Schildhauer S,Geppert R,Müller C,Fiolka G,Wernecke KD,Possinger K

更新日期：2005-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the existence of an association between cervicovaginal infections and precancerous lesions of the uterine cervix, through determination of prevalent cervicovaginal micro-organisms, alone and in association with human papillomavirus (HPV), in patients with abnormal and normal vaginal cytology. PAT...

journal_title：Anticancer research

authors： Lukic A,Canzio C,Patella A,Giovagnoli M,Cipriani P,Frega A,Moscarini M

更新日期：2006-11-01 00:00:00

abstract：:Alterations in histone acetylation status appear to play a central role in the regulation of neoplasia, tumor suppression, cell cycle control, hormone responsiveness and senescence. These alterations of chromatin control gene transcription. The histone acetylation status is regulated by the equilibrium of histone acet...

journal_title：Anticancer research

authors： Dressel U,Renkawitz R,Baniahmad A

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Intermedilysin (ILY) is a human specific cytolysin secreted by Streptococcus intermedius. In the present study, we performed molecular modeling of ILY and cholesterol-dependent cytolysins (CDCs) (pneumolysin, PLY; listeriolysin O, LLO; streptolysin O, SLO; alveolysin, ALV; suilysin, SLY; pyolysin, PLO) to co...

journal_title：Anticancer research

authors： Ohkura K,Nagamune H,Kourai H

更新日期：2004-09-01 00:00:00

abstract：:Smoking is the primary factor responsible for the epidemic of squamous cell lung cancer (SqLC) and small cell lung cancer (SCLC), however, there have been few studies which reported the relationship between smoking and SCLC in female patients. To examine the relationship between smoking and SCLC and SqLC in female pat...

journal_title：Anticancer research

authors： Satoh H,Yamashita YT,Ishikawa H,Kamma H,Ohtsuka M,Sekizawa K

更新日期：1999-11-01 00:00:00

abstract：:We report a case of secondary chondrosarcoma arising in the ilium showing spontaneous regression after frequent local tumor recurrences followed by multiple surgeries of marginal or intralesional excision. The patient was a 16-year-old boy who had been diagnosed as having multiple exostosis from 9 years of age. He exp...

journal_title：Anticancer research

authors： Nakamura S,Kusuzaki K,Murata H,Takeshita H,Hirata M,Hashiguchi S,Hirasawa Y

更新日期：2000-09-01 00:00:00