Vitamin D-24-hydroxylase in benign and malignant breast tissue and cell lines.

abstract：BACKGROUND/AIM:As a result of activation of transcription factors engaged in epithelial-mesenchymal transition (EMT), such as Twist, inhibition of epithelial markers and an increased expression of mesenchymal markers are observed. One of the specific markers of cancer-associated fibroblasts is podoplanin (PDPN) - a muc...

journal_title：Anticancer research

authors： Grzegrzolka J,Wojtyra P,Biala M,Piotrowska A,Gomulkiewicz A,Rys J,Podhorska-Okolow M,Dziegiel P

更新日期：2017-10-01 00:00:00

abstract：:MDL 103,323, an enclomiphene analog, was tested for binding to the estrogen receptor, inhibition of human tumor xenografts and prevention of carcinogen-induced mammary tumors. MDL 103,323 had 5-6 fold greater affinity for the human estrogen receptor than did either tamoxifen or enclomiphene. Consistent with enhanced b...

journal_title：Anticancer research

authors： Bitonti AJ,Baumann RJ,Bush TL,Cashman EA,Wright CL,Prakash NJ

更新日期：1996-09-01 00:00:00

abstract：:The purpose of this analysis was to study the association between the quantity of free circulating DNA and clinical variables in 99 advanced non-small cell lung cancer patients (NSCLC). The quantification in the serum of the gene of the catalytic fraction of telomerase (hTERT) by RT-PCR was used as a reference of the ...

journal_title：Anticancer research

authors： Camps C,Sirera R,Bremnes RM,Ródenas V,Blasco A,Safont MJ,Garde J,Juarez A,Caballero C,Sanchez JJ,Taron M,Rosell R

更新日期：2006-11-01 00:00:00

abstract：:The feasibility of using low-dose carboplatin (CBDCA) as a radiopotentiator in radiotherapy(RT) for non-small cell lung cancer(NSCLC) patients with unfavorable factors was studied. Fifteen patients with locally advanced and inoperable NSCLC were treated with RT in combination with daily 20 mg/m2 CBDCA. Twelve patients...

journal_title：Anticancer research

authors： Satoh H,Ohara K,Fuji H,Ishikawa H,Yamashita YT,Kamma H,Ohtsuka M,Hasegawa S

更新日期：1998-11-01 00:00:00

abstract：:Mast cells are frequently found in close proximity to blood vessels and have been implicated in tumour angiogenesis. The aim of the present ultrastructural study was to characterize, in detail, the mutual association between mast cells and microvasculature in 9 cases of advanced gastric carcinoma. Perivascular mast ce...

journal_title：Anticancer research

authors： Caruso RA,Ieni A,Fabiano V,Basile G,Inferrera C

更新日期：2004-07-01 00:00:00

abstract：: Aim: The aim of the study was to assess possible correlation of fluorogeoxyglucose (FDG) uptake and iodine-related attenuation values derived from positron-emission tomography/computed tomography (PET/CT) using single-source dual-energy CT scan (DE-CT) in non-small cell lung cancer (NSCLC). Materi...

journal_title：Anticancer research

authors： Baxa J,Matouskova T,Ludvik J,Sedlmair M,Flohr T,Schmidt B,Bejcek J,Pesek M,Ferda J

更新日期：2018-07-01 00:00:00

abstract：:Urine and serum samples from a group of 359 individuals were studied in order to evaluate the usefulness of TPA in patients with urological cancers. Serum was taken from 110 people at 12 noon (S1), 5 pm (S2), and 8 am the following day (S3), while urine samples were collected from 73 individuals over three time interv...

journal_title：Anticancer research

authors： Costello CB,Kumar S

更新日期：1986-07-01 00:00:00

abstract：AIM:To analyze how patients experience Stereotactic guided vacuum-assisted breast biopsy (VABB) both physically and mentally. PATIENTS AND METHODS:Two hundred and eleven consecutive women underwent VABB using one of two different biopsy devices (ATEC® and Mammotome®). Patients were queried using a questionnaire. RESU...

journal_title：Anticancer research

authors： Eller A,Janka R,Lux M,Saake M,Schulz-Wendtland R,Uder M,Wenkel E

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Histone deacetylase inhibitors (HDACIs) can inhibit cell proliferation, induce cell cycle arrest and stimulate apoptosis of cancer cells. MATERIALS AND METHODS:The effects of a novel HDACI, MS-275, on 4 endometrial cancer cell lines and normal human endometrial epithelial cells was investigated. Endometrial...

journal_title：Anticancer research

authors： Takai N,Ueda T,Nishida M,Nasu K,Narahara H

更新日期：2006-03-01 00:00:00

abstract：:Neurotrophins are a family of growth factors that are vital to the proper development of the central nervous system. Their effects on cells are governed by the expression and activation of the tyrosine kinase receptors TrkA, TrkB and TrkC. TrkB has been immensely implicated in mediating neuronal migration, development...

journal_title：Anticancer research

authors： Radin DP,Patel P

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Women with recurrent ovarian cancer have a poor prognosis and short survival. However, some women are long-term survivors and it is unclear whether they share specific common characteristics. CASE REPORT:We present the case of a 63-year-old woman with histologically-proven recurrent ovarian cancer and a sur...

journal_title：Anticancer research

authors： Hilal Z,Schultheis B,Hartmann F,Dogan A,Cetin C,Krentel H,Schiermeier S,Tempfer CB

更新日期：2016-10-01 00:00:00

abstract：AIM:To assess outcomes in patients treated with first-line bevacizumab-containing therapy for human epidermal growth factor receptor (HER)2-negative metastatic breast cancer (mBC) at a single centre with a homogenous standard-of-care. PATIENTS AND METHODS:Information on patient and disease characteristics, efficacy, a...

journal_title：Anticancer research

authors： Dieras V,Pop S,Berger F,Dujaric ME,Beuzeboc P,Escalup L,Bidard FC,Cottu PH,LE Tourneau C,Piperno-Neumann S,Laurence V,Robain M,Asselain B,Pierga JY

更新日期：2017-03-01 00:00:00

abstract：AIM:To investigate the clinical significance of ATP-binding cassette transporter 11 (ABCC11) protein expression in colon cancer. MATERIALS AND METHODS:One hundred thirty nine patients with colon cancer resection between 2009 and 2011 were enrolled. The relationship with immunohistochemical ABCC11 staining and clinicop...

journal_title：Anticancer research

authors： Yamada Y,Yoshimatsu K,Yokomizo H,Okayama S,Shiozawa S

更新日期：2020-10-01 00:00:00

abstract：:Hyperthermia is effective for the treatment of cancer when applied concomitantly with chemotherapy and irradiation. However, it is difficult to heat deep portions of the body including the esophagus. Cancer of the esophagus still poses considerable treatment problems, with a poor 5-year survival rate after surgery, an...

journal_title：Anticancer research

authors： Maehara Y,Kuwano H,Kitamura K,Matsuda H,Sugimachi K

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:miR-96 is reported to inhibit reversion cysteine-rich Kazal motif (RECK), which is associated with tumor invasion, in solid cancer types (e.g. breast cancer, non-small cell lung cancer, esophageal cancer). The purpose of this study is to clarify whether miR-96 is similarly associated with tumor invasion in c...

journal_title：Anticancer research

authors： Iseki Y,Shibutani M,Maeda K,Nagahara H,Fukuoka T,Matsutani S,Hirakawa K,Ohira M

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND/AIM:The identification of a series of oxadiazole-based compounds, as promising antiproliferative agents, has been previously reported. The aim of this study was to explore the SAR of newly-synthesized oxadiazole derivatives and identify their molecular targets. MATERIALS AND METHODS:A small library of 1,2,5...

journal_title：Anticancer research

authors： Gelain A,Mori M,Meneghetti F,Porta F,Basile L,Marverti G,Asai A,Hyeraci M,García-Argáez AN,Via LD,Guccione S,Villa S

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Despite the large use of bevabizumab in the treatment of primary tumors of the brain, there is only limited experience with brain metastases (BM) and no experience in the treatment of previously untreated secondary brain lesions. PATIENTS AND METHODS:We treated patients with BM, not suitable for local treat...

journal_title：Anticancer research

authors： Zustovich F,Ferro A,Lombardi G,Zagonel V,Fiduccia P,Farina P

更新日期：2013-09-01 00:00:00

abstract：:The prognosis of patients with pancreatic cancer is very poor because of late diagnosis and the lack of response to various therapies. Pancreatic cancer is generally resistant to chemotherapy and is highly fatal. Gemcitabine (GEM) appears to be the only effective agent for treatment of pancreatic cancer. However, a hi...

journal_title：Anticancer research

authors： Kuramitsu Y,Taba K,Ryozawa S,Yoshida K,Zhang X,Tanaka T,Maehara S,Maehara Y,Sakaida I,Nakamura K

更新日期：2010-09-01 00:00:00

abstract：:The relationship between antioxidant-enzyme defence responses and cellular growth suppression in human MCF-7 (breast) and SW480 (colon) cancer cells, exposed to CLA in culture was studied. MCF-7 and SW480 cells (1 x 10(6)/flask) were cultured in appropriate medium for 4, 8 and 12 days with varying levels of CLA (0-30 ...

journal_title：Anticancer research

authors： O'Shea M,Stanton C,Devery R

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Cyclooxygenase-2 (Cox-2) is expressed by several types of epithelial malignancies, i.e., carcinomas, and inhibition of Cox-2 may have a therapeutic role in chemoprevention and treatment of cancer. The role of Cox-2 in non-epithelial malignancies, however, is unclear. MATERIALS AND METHODS:We investigated, b...

journal_title：Anticancer research

authors： Lassus P,Ristimäki A,Huuhtanen R,Tukiainen E,Asko-Seljavaara S,Andersson LC,Miettinen M,Blomqvist C,Haglund C,Böhling T

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND/AIM:Even though prostate cancer (PCa) has good prognosis, there is a discrepancy in the risk among ethnic groups, with high morbidity in African American men. Single nucleotide polymorphisms (SNPs) in interleukin 10 (IL-10) have been associated with inflammation and cancer risk. We investigated the associati...

journal_title：Anticancer research

authors： Abbas M,Mason T,Ibad A,Khraiwesh M,Apprey V,Kanaan Y,Wilson B,Dunston G,Ricks-Santi L,Brim H

更新日期：2020-01-01 00:00:00

abstract：:In tumor cells, doxorubicin (DOX) is excreted by P-glycoprotein (P-gp) and the multidrug resistance-associated protein (mrp). Both transporters might also be involved in cellular regulatory volume decrease (RVD). To study the hepatobiliary excretion of DOX during RVD, isolated livers of Wistar and multidrug resistance...

journal_title：Anticancer research

authors： Gaugg M,Haslmayer P,Jäger W,Thalhammer T

更新日期：2001-07-01 00:00:00

abstract：:The NB rat prostate adenocarcinoma model is one in which microscopic carcinoma can be induced via the use of testosterone and estrogen silastic implants. There is an incidence of large, grossly-positive tumors; which approaches 10% to 15%. Seventy-three percent of the animals subjected to this induction method for per...

journal_title：Anticancer research

authors： Drago JR

更新日期：1984-07-01 00:00:00

abstract：BACKGROUND:Pleomorphic rhabdomyosarcomas of the uterus, mainly occurring in postmenopausal women with leading symptoms of vaginal bleeding and abdominal pain, are very rare malignant tumors of the female genital tract. Due to the inefficiency of the adjuvant therapy, the outcome remains poor in the majority of the repo...

journal_title：Anticancer research

authors： Alavi S,Eckes L,Kratschell R,Taube ET,Rosseck F,Wieners G,Sehouli J

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND/AIM:We evaluated the usefulness of reverse transcription-polymerase chain reaction (RT-PCR) for detecting anaplastic lymphoma kinase (ALK) translocations using cytology samples from lung cancer patients. MATERIALS AND METHODS:We analyzed ALK translocations by RT-PCR in cytology samples from lung cancer pati...

journal_title：Anticancer research

authors： Nakamichi S,Seike M,Miyanaga A,Chiba M,Matsuda K,Kobayashi K,Takahashi A,Takeuchi S,Minegishi Y,Kubota K,Gemma A

更新日期：2017-06-01 00:00:00

abstract：:The pharmacokinetics of platinum in cancer patients were examined following an intravenous infusion of cis-diammine(glycolato) platinum, 254-S. The plasma concentrations of total platinum, which decreased biexponentially after the infusion, were proportional to the dose over the range of 10 to 120 mg/m2, suggesting li...

journal_title：Anticancer research

authors： Ota K,Oguma T,Shimamura K

更新日期：1994-05-01 00:00:00

abstract：:The expression of the HMG-CoA-reductase and LDL-receptor genes was examined in primary human embryonic tumours and in normal human first trimester foetal tissues. All embryonic and extra-embryonic tissues examined contained RNA that hybridized with the HMG-CoA-reductase and LDL-receptor cDNA-probes. However, the trans...

journal_title：Anticancer research

authors： Engström W,Schofield PN

更新日期：1987-05-01 00:00:00

abstract：:A report that effects of butyrate on some cells may be mediated by activation of AMP-activated protein kinase (AMPK) prompted this study which examines if other AMPK activators can induce differentiation and inhibit proliferation of colon cancer cells in a manner similar to butyrate. Using induction of alkaline phosph...

journal_title：Anticancer research

authors： Lea MA,Chacko J,Bolikal S,Hong JY,Chung R,Ortega A,desbordes C

更新日期：2011-02-01 00:00:00

abstract：:We examined the influence of a regularly moderate endurance training program on qualitative and quantitative alterations of monocytes from 24 breast cancer patients. At the beginning, after 5 weeks and 7 months of bicycle training we analyzed the composition of leucocytes and phagocytotic activity of monocytes using t...

journal_title：Anticancer research

authors： Peters C,Lötzerich H,Niemeir B,Schüle K,Uhlenbruck G

更新日期：1995-01-01 00:00:00

abstract：:Lipomas are the most common benign tumors of the mesenchyme; they are composed of mature lipocytes. Benign fatty tumours can arise in any location in which fat is present. Most patients affected by such tumours are in their fifth or sixth decade of life. Only rarely are children affected. Lipomas may be single or mult...

journal_title：Anticancer research

authors： Mazzocchi M,Onesti MG,Pasquini P,La Porta R,Innocenzi D,Scuderi N

更新日期：2006-09-01 00:00:00