Genetic Polymorphisms in IL-10 Promoter Are Associated With Smoking and Prostate Cancer Risk in African Americans.

abstract：BACKGROUND/AIM:Seizures represent a major problem for patients with brain metastases. This study evaluated the role of seizures in patients receiving single-fraction radiosurgery (SRS) or multi-fraction stereotactic radiotherapy (FSRT). PATIENTS AND METHODS:This retrospective study included 195 patients receiving SRS ...

journal_title：Anticancer research

authors： Rades D,Witteler J,Kjaer TW,Tvilsted S,Schild SE

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Fulvestrant ('Faslodex') is a new type of oestrogen receptor (ER) antagonist that down-regulates the ER and has no known agonist effects. PATIENTS AND METHODS:In this open-label, Phase II trial, 30 postmenopausal Japanese women with hormone-sensitive advanced breast cancer, who had progressed on tamoxifen/t...

journal_title：Anticancer research

authors： Watanabe T,Sano M,Ohno S,Inaji H,Nishimura R,Shin E,Nomura Y,Morris C

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND/AIM:Cyclin D1 is a mediator of cell-cycle control that is frequently overexpressed in primary ductal breast carcinomas, but its role is controversial. A polymorphism in the CCND1 gene, G870A, results in an aberrantly spliced protein (cyclin D1b) lacking the Thr-286 phosphorylation site necessary for nuclear ...

journal_title：Anticancer research

authors： Abramson VG,Troxel AB,Feldman M,Mies C,Wang Y,Sherman L,McNally S,Diehl A,Demichele A

更新日期：2010-04-01 00:00:00

abstract：:Giant cell tumor (GCT) is a relatively common and locally aggressive benign bone tumor. The sternum is a rare location. To date, only four cases have been reported with detailed information. Here, we present a case with sternal GCT and discuss the clinical manifestation and treatment, in addition to reviewing the lite...

journal_title：Anticancer research

authors： Futani H,Okumura Y,Fukuda Y,Fukunaga S,Hasegawa S,Yoshiya S

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:A nodular lymphocyte predominant Hodgkin's lymphoma (NLPHL) is a lymphoproliferative neoplasm with a fair prognosis, but the possibility of a malignant transformation into a diffuse large B-cell lymphoma (DLBCL) is high. DLBCL progresses aggressively. Introduction of rituximab into therapy had led to improve...

journal_title：Anticancer research

authors： Gutsch J,Werthmann PG,Rosenwald A,Kienle GS

更新日期：2018-09-01 00:00:00

abstract：:CA 72-4 is a high molecular weight, pancarcinoma human tumor mucin which may play an important role in the identification (i.e., staging) and clinical management of patients with gastric carcinoma. In the present study of 242 patients with primary or recurrent gastric cancer, a higher percentage of these patients had ...

journal_title：Anticancer research

authors： Spila A,Roselli M,Cosimelli M,Ferroni P,Cavaliere F,Arcuri R,Tedesco M,Carlini S,D'Alessandro R,Perri P,Casciani CU,Greiner JW,Schlom J,Guadagni F

更新日期：1996-07-01 00:00:00

abstract：:The cytotoxic effect of 5-FU (5-fluorouracil) was demonstrated to be enhanced by hyperthermia after treatment with 5-FU at even a comparatively low dose over fairly long periods. The cytotoxic effect of the combined treatment with 42 degrees C-hyperthermia and 1 microgram/ml 5-FU for 48 hrs, the cytotoxic effect of 42...

journal_title：Anticancer research

authors： Matsuoka H,Sugimachi K,Abe R,Ueo H,Akiyoshi T

更新日期：1992-09-01 00:00:00

abstract：:One hundred and eighty-seven patients with a transitional cell bladder cancer were followed by retrospectively for a mean of 9.5 years. Clinical stage (p less than 0.0001), histological grade (p less than 0.0001), papillary (p less than 0.0001), SPF (p less than 0.0001), M/V index (p less than 0.0001), MAI (p less tha...

journal_title：Anticancer research

authors： Lipponen PK,Eskelinen MJ,Kiviranta J,Nordling S

更新日期：1991-03-01 00:00:00

abstract：:Immunocytochemical assays were performed on frozen sections of inflammatory breast carcinomas (n = 22) using the following monoclonal antibodies (MoAb): anti-pHER2/neu, cathepsin, pS2, ER, PR and MoAb Ki67. The distribution of these proteins, known as prognostic indicators, was evaluated with an image analysis system ...

journal_title：Anticancer research

authors： Charpin C,Bonnier P,Khouzami A,Vacheret H,Andrac L,Lavaut MN,Allasia C,Piana L

更新日期：1992-05-01 00:00:00

abstract：:We report two cases with small cell lung cancer (SCLC) receiving multicyclic dose-intensified chemotherapy (DI-CT) supported by autologous blood progenitor cell transplantation (ABPCT). Both cases were initially treated with cisplatin (CDDP), etoposide (ETP) and concurrent thoracic irradiation, however they had recurr...

journal_title：Anticancer research

authors： Fujimoto N,Ueoka H,Kiura K,Tabata M,Bessho A,Takata I,Sunami K,Hiramatsu Y,Ikeda K,Tanimoto M,Harada M

更新日期：2003-09-01 00:00:00

abstract：:Methods for improving the estrogen receptor (ER) and progestin receptor (PgR) assay were studied. Using DCC procedure as the basis, the extraction and incubation of ER and PgR is more efficiently achieved by phosphate buffer as compared with water, tris and veronal buffers. The multiple extractions of hormone receptor...

journal_title：Anticancer research

authors： Chen YM,Rice RG,Vaughn CB

更新日期：1986-07-01 00:00:00

abstract：BACKGROUND:Hypoxia represents an important tumor-specific target for cancer therapy. We have reported that hypoxic cytotoxins, such as TX-1102, tirapazamine (TPZ) and TX-402, selectively induced tumor cells to p53-independent apoptosis under hypoxic conditions and inhibited angiogenesis. MATERIALS AND METHODS:We inves...

journal_title：Anticancer research

authors： Nagasawa H,Mikamo N,Nakajima Y,Matsumoto H,Uto Y,Hori H

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:The combined effects of Human papillomavirus (HPV) and Herpes simplex type 1 (HSV-1) infections and their effects on cancer cell radioresistance are unexplored. MATERIALS AND METHODS:An HPV16-positive hypopharyngeal carcinoma cell line (UD-SCC-2) was infected with wt-HSV-1 at low multiplicity of infection (...

journal_title：Anticancer research

authors： Turunen A,Hukkanen V,Kulmala J,Syrjanen S

更新日期：2016-02-01 00:00:00

abstract：:In this study, a protein kinase C inhibitor, H-7, was found to potentiate the antiproliferative effects of difluoromethyl ornithine (DFMO), inhibitor of the polyamine biosynthesis, on NIH 3T3 and 3T3/SV40 cells in culture. Incubation of the cells with DFMO inhibited the cell growth, whereas the addition of polyamine s...

journal_title：Anticancer research

authors： Khan NA,Havouis R,Quemener V,Moulinoux JP

更新日期：1992-07-01 00:00:00

abstract：BACKGROUND/AIM:Long interspersed nuclear element-1 (LINE-1) methylation status is a marker for global DNA methylation. However, the relationship between LINE-1 methylation and the biology of lung adenocarcinoma remains unclear. Here, we aimed to examine the role of LINE-1 in lung cancer. MATERIALS AND METHODS:LINE-1 m...

journal_title：Anticancer research

authors： Kitahara H,Okamoto T,Shimamatsu S,Kohno M,Morodomi Y,Tagawa T,Kitao H,Okano S,Oda Y,Maehara Y,Mori M

更新日期：2020-10-01 00:00:00

abstract：AIM:The current study aimed to determine the prognostic significance of thrombocytosis in patients with colorectal cancer (CRC) by a meta-analysis of the literature. PATIENTS AND METHODS:The meta-analysis followed the 2009 guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses. A systematic l...

journal_title：Anticancer research

authors： Gu D,Szallasi A

更新日期：2017-09-01 00:00:00

abstract：:Sarcomas in the forearm and hand are very rare, accounting for less than 1% of all upper-limb tumors and clinical outcomes after surgery and adjuvant therapies are uncertain. The forearm and hand present specific challenges due to their unique anatomical structures. There is little soft tissue and each compartment is ...

journal_title：Anticancer research

authors： Muramatsu K,Ihara K,Yoshida K,Tominaga Y,Hashimoto T,Taguchi T

更新日期：2013-10-01 00:00:00

abstract：:The cyclin-dependent kinase inhibitor p21WAF1 participates in cell growth, differentiation, and apoptosis. p21WAF1 can be induced by green tea polyphenol EGCG in several cancer cell types, but its role in the oral cancer cell response to EGCG is not known. We found that EGCG upregulates p21WAF1 in an oral carcinoma ce...

journal_title：Anticancer research

authors： Hsu S,Farrey K,Wataha J,Lewis J,Borke J,Singh B,Qin H,Lapp C,Lapp D,Nguyen T,Schuster G

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Regardless of current multimodal treatment strategies, the prognosis of patients harboring glioblastoma multiforme (GBM) is still dismal. The introduction of concomitant radiochemotherapy and adjuvant cyclic temozolomide has significantly improved the overall survival, compared to postoperative radiotherapy-...

journal_title：Anticancer research

authors： Kerschbaumer J,Freyschlag CF,Bauer R,Obwegeser AA,Schubert GA,Thomé C,Seiz M

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:Incidence of brain metastases (BM) from breast cancer (BC) is increasing. However, prognostic evaluation and treatment strategies are still a matter of debate. AIM:To describe the clinical outcome of BM from BC treated by neurosurgical resection and to identify the actual prognostic factors in this specific...

journal_title：Anticancer research

authors： Tabouret E,Metellus P,Tallet-Richard A,Figarella-Branger D,Charaffe-Jauffret E,Viens P,Gonçalves A

更新日期：2013-05-01 00:00:00

abstract：AIM:To retrospectively compare the efficacy of two irinotecan-based chemotherapy regimens combined with bevacizumab in first-line therapy of metastatic colorectal cancer (mCRC). PATIENTS AND METHODS:The data of 558 patients with mCRC treated with first-line bevacizumab plus irinotecan-containing regimen were obtained ...

journal_title：Anticancer research

authors： Kocakova I,Melichar B,Kocak I,Bortlicek Z,Büchler T,Dusek L,Petruzelka L,Kohoutek M,Prausová J,Finek J,Mohelnikova-Duchonova B,Vyzula R

更新日期：2015-06-01 00:00:00

abstract：:Metastatic urothelial carcinoma is one of the most fatal urological malignancies. Cisplatin-based systemic chemotherapy is the standard treatment for metastatic urothelial carcinoma, and there is little evidence to support metastasectomy. The aims of the study were to evaluate the efficacy of metastasectomy and to inv...

journal_title：Anticancer research

authors： Iwamoto H,Izumi K,Shimura Y,Natsagdorj A,Maolake A,Takezawa Y,Nohara T,Shigehara K,Kadono Y,Mizokami A

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Both liposomal doxorubicin (LD) and docetaxel (D) have a broad range of activity against solid tumors, including advanced pancreatic cancer (APC), as single agents, while their combination has produced encouraging response rates in the treatment of several malignancies. We have conducted a Phase-II study in ...

journal_title：Anticancer research

authors： Syrigos KN,Michalaki B,Alevyzaki F,Machairas A,Mandrekas D,Kindilidis K,Karatzas G

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND/AIM:Malignant tumors of the salivary glands are rare and heterogeneous, with more than 20 subtypes, and classified mainly by histopathology. Their diagnosis is often challenging and their etiology unknown. Here, the possible association between human polyomaviruses (PyVs) and one or more salivary gland tumor...

journal_title：Anticancer research

authors： Ramqvist T,Ursu RG,Haeggblom L,Mirzaie L,Gahm C,Hammarstedt-Nordenvall L,Dalianis T,Näsman A

更新日期：2018-05-01 00:00:00

abstract：:Advanced or metastatic pancreatic cancer is an incurable disease. The main treatment is chemotherapy with cytotoxic agents. On the basis of our experience in clinical trials, the objectives have been to determine response rate, life prolongation and clinical benefit. In our trials and in those of other authors, all of...

journal_title：Anticancer research

authors： Stathopoulos GP,Androulakis N,Souglakos J,Stathopoulos J,Georgoulias V

更新日期：2008-03-01 00:00:00

abstract：:The purpose of our study was to evaluate the presence of anatomical and functional damage to the afferent and sensorial fibres using the Neurometer CPT test. A questionnaire regarding pain was sent to 300 women who had undergone surgery six months earlier. Out of 300 patients 67 did not respond; 105 experienced no pai...

journal_title：Anticancer research

authors： Passavanti MB,Pace MC,Barbarisi A,D'Andrea F,Grella E,Nicoletti GF,Aurilio C

更新日期：2006-09-01 00:00:00

abstract：:Metastatic renal cell carcinoma (RCC) has a poor response to anticancer chemotherapy and radiotherapy. While immunotherapy and molecular targeted drugs have been used as first-line therapy for RCC metastasis, the response rate to these agents is low. We report the case of a patient with lung and bone metastases of RCC...

journal_title：Anticancer research

authors： Nishida H,Shirai T,Hayashi K,Takeuchi A,Tanzawa Y,Mizokami A,Namiki M,Tsuchiya H

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND/AIM:Since the first description of five pericytomas with the t(7;12)/ACTB-GLI1 fusion gene, only three new tumors were studied by both cytogenetics and molecular techniques. We report here genetic data on another case of this rare tumor. MATERIALS AND METHODS:Cytogenetic, fluorescence in situ hybridization ...

journal_title：Anticancer research

authors： Panagopoulos I,Gorunova L,Rise TV,Andersen K,Micci F,Heim S

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Estramustine is an anti-mitotic cytostatic drug that also enhances the effect of radiotherapy. The mechanism of radiosensitization is not thoroughly known. Since both radiotherapy and estramustine induce apoptosis in prostate cancer cells, we conducted an experiment to show whether radiosensitization is medi...

journal_title：Anticancer research

authors： Ståhlberg K,Kairemo K,Erkkilä K,Pentikäinen V,Sorvari P,Taari K,Dunkel L,Rannikko S

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND/AIM:Second mitochondria-derived activator of caspase (Smac) is a proapoptogenic mitochondrial protein that antagonizes inhibitors of apoptosis proteins (IAPs), resulting in induction of apoptosis. In the present study we investigated the effects of a Smac mimetic in combination with doxorubicin against osteo...

journal_title：Anticancer research

authors： Kamata E,Kawamoto T,Ueha T,Hara H,Fukase N,Minoda M,Morishita M,Takemori T,Fujiwara S,Nishida K,Kuroda R,Kurosaka M,Akisue T

更新日期：2017-11-01 00:00:00