Bevacizumab with FOLFIRI or XELIRI in the First-line Therapy of Metastatic Colorectal Carcinoma: Results from Czech Observational Registry.

abstract：AIM:The American thyroid association (ATA) recommends that additional imaging procedures supplement cervical ultrasonography (US) in any patient with a basal calcitonin value above 150 pg/ml in the follow-up of medullary thyroid carcinoma (MTC). The aim of the present study was to reaffirm or challenge this cut-off for...

journal_title：Anticancer research

authors： Sesti A,Mayerhoefer M,Weber M,Anner P,Wadsak W,Dudczak R,Haug A,Karanikas G

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Breast cancer is the most frequent cancer and the second leading cause of cancer deaths in women today. A number of 1,4-naphthoquinone derivatives have been found to possess significant pharmacological effects associated with marked antimicrobial and antitumor activities. In the present study, the in vitro e...

journal_title：Anticancer research

authors： Kanaan YM,Das JR,Bakare O,Enwerem NM,Berhe S,Beyene D,Williams V,Zhou Y,Copeland RL Jr

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The E-cadherin/beta-catenin complex plays a crucial role in epithelial cell-cell adhesion and in the maintenance of tissue architecture. We previously reported aberrant expression of beta-catenin in endometrial carcinomas. However, the expression and correlation of E-cadherin and beta-catenin in normal and m...

journal_title：Anticancer research

authors： Shih HC,Shiozawa T,Miyamoto T,Kashima H,Feng YZ,Kurai M,Konishi I

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND/AIM:Hepatitis B virus-encoded X protein (HBx) plays a pivotal role in hepatocellular carcinoma (HCC) progression and treatment resistance. Interestingly, our previous study unexpectedly showed that full-length HBx sensitized HCC cells to lapatinib by up-regulating erb-b2 receptor tyrosine kinase 3 (ERBB3). W...

journal_title：Anticancer research

authors： Chen JY,Huang WC,Wei CT,Chien PH,Chen YJ

更新日期：2019-02-01 00:00:00

abstract：:We investigated the effects of an exogenous cdk inhibitor, butyrolactone-I, on cell growth inhibition, apoptosis induction, and the regulation of apoptosis in pancreatic cancer cells with mutated p53. Cell growth was dose-dependently inhibited by Butyrolactone-I in PANC-1 and AsPC-1 cells. Phosphorylation of pRb and C...

journal_title：Anticancer research

authors： Wada M,Hosotani R,Lee JU,Doi R,Koshiba T,Fujimoto K,Miyamoto Y,Tsuji S,Nakajima S,Okuyama A,Imamura M

更新日期：1998-07-01 00:00:00

abstract：:The feasibility of using low-dose carboplatin (CBDCA) as a radiopotentiator in radiotherapy(RT) for non-small cell lung cancer(NSCLC) patients with unfavorable factors was studied. Fifteen patients with locally advanced and inoperable NSCLC were treated with RT in combination with daily 20 mg/m2 CBDCA. Twelve patients...

journal_title：Anticancer research

authors： Satoh H,Ohara K,Fuji H,Ishikawa H,Yamashita YT,Kamma H,Ohtsuka M,Hasegawa S

更新日期：1998-11-01 00:00:00

abstract：:The chromosomes were studied by an in vitro technique in four parametrial and one gastric leiomyomas. The findings in parametrial myomas (the present four cases and one published earlier) differed from the observations in uterine cases by the absence of normal stemlines and the absence of 1p,6p and 7q changes. As has ...

journal_title：Anticancer research

authors： Havel G,Dahlenfors R,Wedell B,Hogström L,Mark J

更新日期：1994-09-01 00:00:00

abstract：:Formalin-fixed paraffin-embedded tumor specimens from 95 patients with supratentorial astrocytic brain tumors were immunostained by a monoclonal antibody against the heat shock protein-27 (Hsp-27) using the streptavidin/peroxidase method. The immunohistochemical analysis was scored in a semiquantitative fashion incorp...

journal_title：Anticancer research

authors： Assimakopoulou M,Sotiropoulou-Bonikou G,Maraziotis T,Varakis I

更新日期：1997-07-01 00:00:00

abstract：:In the present study, we have investigated the effect of cytotropic heterogeneous molecular lipid (CHML), a new anticancer agent, on growth suppression in a variety of human tumor cell lines. At a non-toxic concentration (a range from 25 micrograms/ml to 100 micrograms/ml), CHML has shown to strongly inhibit tumor cel...

journal_title：Anticancer research

authors： Zhan Q,Xu Z

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND/AIM:Kallikrein-related peptidases (KLKs) comprise a serine protease family with prominent roles in tissue physiology and disease pathogenesis, including cancer. Previously, we have characterized canine Klk4-10 and -14. Herein, we continue our efforts by characterizing three novel members of the canine family...

journal_title：Anticancer research

authors： Angelopoulou K,Karagiannis GS

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Sonic hedgehog (SHH) signaling is related to the pathogenesis of oral squamous cell carcinoma (OSCC), but its role in OSCC is not yet well understood. In this study, we analyzed the role of SHH signaling in OSCC. MATERIALS AND METHODS:We examined the expression pattern of SHH and its signal proteins in clin...

journal_title：Anticancer research

authors： Kuroda H,Kurio N,Shimo T,Matsumoto K,Masui M,Takabatake K,Okui T,Ibaragi S,Kunisada Y,Obata K,Yoshioka N,Kishimoto K,Nagatsuka H,Sasaki A

更新日期：2017-12-01 00:00:00

abstract：:Mutations occurring in sporadic epithelial ovarian carcinomas are reviewed and their functional significance in terms of prognosis and prediction of anticancer drug activity are discussed. Alterations in the BRCA1/2 genes, TP53, PTEN, PI3Kinase, KRAS/BRAF and CTNNB1 are described. TP53 is likely to be a driver in high...

journal_title：Anticancer research

authors： Kalamanathan S,Bates V,Lord R,Green JA

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Patients with advanced pancreatic carcinoma have a risk of relapse after primary therapy, and the prognosis for these patients remains bleak. The effect of immuno-cell therapy in advanced pancreatic carcinoma, with or without other standard therapies, was examined. PATIENTS AND METHODS:Forty-six patients wi...

journal_title：Anticancer research

authors： Kaneko T,Goto S,Kato A,Akeyama A,Tomonaga M,Fujimoto K,Miyamoto Y,Eriguchi M,Egawa K

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Both liposomal doxorubicin (LD) and docetaxel (D) have a broad range of activity against solid tumors, including advanced pancreatic cancer (APC), as single agents, while their combination has produced encouraging response rates in the treatment of several malignancies. We have conducted a Phase-II study in ...

journal_title：Anticancer research

authors： Syrigos KN,Michalaki B,Alevyzaki F,Machairas A,Mandrekas D,Kindilidis K,Karatzas G

更新日期：2002-11-01 00:00:00

abstract：UNLABELLED:Inhibins (INH) are dimeric glycoproteins composed of an alpha-subunit (INH-alpha) and one of two possible beta-subunits (INH-betaA or -betaB), with substantial roles in human reproduction and in endocrine-responsive tumours. The aim of the present study was the determination of the frequency and tissue distr...

journal_title：Anticancer research

authors： Vogl J,Höing A,Schulze S,Kuhn C,Wiest I,Shabani N,Jeschke U,Mylonas I,Friese K

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Activating mutations of the BRAF gene have recently been reported in thyroid carcinomas. In particular, V600E mutation is highly prevalent in papillary thyroid carcinoma (PTC). PATIENTS AND METHODS:In this study, the BRAF (V600E) mutation in 54 PTCs was investigated and the relationship between the BRAF mut...

journal_title：Anticancer research

authors： Nakayama H,Yoshida A,Nakamura Y,Hayashi H,Miyagi Y,Wada N,Rino Y,Masuda M,Imada T

更新日期：2007-09-01 00:00:00

abstract：:Estrogen receptor activation in hormone dependent cells (MCF-7 and T47D) and hormone independent cells (MDA-MB-231) was measured by bioluminescence in stably transfected human breast cancer MCF-7, T47D and MDA-MB-231 cell lines with a reporter gene which allows expression of the firefly luciferase enzyme under the con...

journal_title：Anticancer research

authors： Le Bail JC,Allen K,Nicolas JC,Habrioux G

更新日期：1998-05-01 00:00:00

abstract：:A significant number of human tumors from diverse histological origins contain c-K-ras oncogenes which have been activated by somatic point mutations resulting in single amino acids substitutions in the encoded p21 ras protein. In addition to these qualitative changes, other genetic alterations leading to increased ex...

journal_title：Anticancer research

authors： Kahn S,Yamamoto F,Almoguera C,Winter E,Forrester K,Jordano J,Perucho M

更新日期：1987-07-01 00:00:00

abstract：UNLABELLED:The purpose of this study was to assess the extent of the systemic absorption of cisplatin during intraoperative hyperthermic peritoneal lavage (IHPL) in patients with locally advanced gastric cancer. MATERIALS AND METHODS:The pharmacokinetics and nephrotoxicity of cisplatin were analyzed in patients receiv...

journal_title：Anticancer research

authors： Kern W,Braess J,Kotschofsky M,Samel S,Becker H,Hiddemann W,Schleyer E

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND/AIM:N6-Methyladenosine (m6A), the most abundant internal modification of RNA, plays a critical role in cancer development. However, the clinical implications of m6A in hepatocellular carcinoma (HCC) remain unclear. MATERIALS AND METHODS:We analyzed 177 HCC and paired noncancerous liver tissues from patients...

journal_title：Anticancer research

authors： Nakagawa N,Tanaka K,Sonohara F,Kandimalla R,Sunagawa Y,Inokawa Y,Takami H,Hayashi M,Yamada S,Kanda M,Tanaka C,Nakayama G,Koike M,Kodera Y

更新日期：2020-12-01 00:00:00

abstract：:Urachal cancer is a rare malignancy and the standard treatment is surgical resection. The prognosis of recurrent and metastatic urachal cancer is extremely poor because there is no established chemotherapy regimen. Here, the response of one patient with recurrent urachal cancer to combination chemotherapy of gemcitabi...

journal_title：Anticancer research

authors： Miyata Y,Sagara Y,Matsuo T,Ohba K,Takahashi H,Sakai H,Kanetake H

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:The search for promising modulators of cancer multidrug resistance (MDR) that are able to reduce the activity of P-glycoprotein, thus restoring the cytotoxicity of anticancer drugs, is ongoing. The identification of compounds that overcome the apoptosis deficiency that frequently accompanies MDR is also of g...

journal_title：Anticancer research

authors： Wesolowska O,Wisniewski J,Bielawska-Pohl A,Paprocka M,Duarte N,Ferreira MJ,Dus D,Michalak K

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND/AIM:This study aimed to identify the prognostic factors and outcomes of osteosarcoma (OS) located in proximal versus distal extremity long bones. PATIENTS AND METHODS:A nationwide cohort comprising all Norwegian high-grade OSs in extremity long bones between 1982 and 2009 was investigated. RESULTS:The univ...

journal_title：Anticancer research

authors： Berner K,Bruland ØS

更新日期：2019-05-01 00:00:00

abstract：AIM:We investigated the relationship between a new index considering the estimated working space and difficulty of robot-assisted radical prostatectomy (RARP) using our database. PATIENTS AND METHODS:Working height was calculated by the obstetric conjugate diameter minus the bladder and rectal wall thicknesses minus t...

journal_title：Anticancer research

authors： Kadono Y,Ueno S,Makino T,Ofude M,Izumi K,Gabata T,Namiki M

更新日期：2014-10-01 00:00:00

abstract：AIM:The aim of the present study was to investigate the impact of cyclin E expression on cancer-specific survival, as well as on conventional clinocopathological and prognostic factors in endometrial endometrioid adenocarcinoma. MATERIALS AND METHODS:The study consisted of 211 patients surgically treated for endometri...

journal_title：Anticancer research

authors： Santala S,Talvensaari-Mattila A,Soini Y,Santala M

更新日期：2015-06-01 00:00:00

abstract：:Chloroform (CHCl3) is an established rodent carcinogen and a prevalent contaminant of chlorine-disinfected drinking water. Thus in the United States CHCl3, along with other trihalomethanes, is regulated not to exceed 100 ppb in potable water. Recently, several studies have shown that CHCl3 also has anti-cancer propert...

journal_title：Anticancer research

authors： Daniel FB,Reddy TV,Stober JA,Olson GR

更新日期：1991-03-01 00:00:00

abstract：BACKGROUND:DNA repair capacity may be an important factor in determining both individual susceptibility to cancer and the response to cancer therapy. The aim of this work was to compare DNA damage and the repair process in cells originating from healthy donors and cancer patients. MATERIALS AND METHODS:Using the micro...

journal_title：Anticancer research

authors： Palyvoda O,Mukalov I,Polanska J,Wygoda A,Drobot L,Widel M,Rzeszowska-Wolny J

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:We have identified a novel cancer/testis antigen, TRAG-3, (Taxol Resistance Associated Gene-3) that was initially discovered in search for new genes involved in drug resistance by differential display. Early study of TRAG-3 revealed minimal to absent expression in various normal tissues and over-expression i...

journal_title：Anticancer research

authors： Feller AJ,Duan Z,Penson R,Toh HC,Seiden MV

更新日期：2000-11-01 00:00:00

abstract：:A series of poly (ADP-ribose) synthesis inhibitors was evaluated for their ability to potentiate the cytotoxicity of bleomycin compared with their inhibition of poly(ADP-ribose) synthesis in L1210 cultured cells. Theophylline, nicotinamide, 3-aminobenzamide and thymidine inhibited 70 to 80% of poly(ADP-ribose) synthes...

journal_title：Anticancer research

authors： Kato T,Suzumura Y,Fukushima M

更新日期：1988-03-01 00:00:00

abstract：AIM:To examine patterns of clinical practice in locally advanced esophageal cancer among US radiation oncologists after publication of the CROSS trial. MATERIALS AND METHODS:US radiation oncologists were surveyed on 13 questions pertaining to the management of esophageal cancer. Respondents' demographics and their cli...

journal_title：Anticancer research

authors： Elliott DA,Rana SR,Nabavizadeh N,Chen Y,Kusano A,Holland JM,Mitin T

更新日期：2018-11-01 00:00:00