Application of cisplatin as intraoperative hyperthermic peritoneal lavage (IHPL) in patients with locally advanced gastric cancer: analysis of pharmacokinetics and of nephrotoxicity.

abstract：:The aggressive nature of gliomas is closely related to their capacity to evade the anti-tumoral immune response. The mechanisms implicated in this phenomenon are only partially understood. A subset of T cells, termed CD4+ CD25+ regulatory T cells (Treg), have been shown to inhibit the actions of effector lymphocytes. ...

journal_title：Anticancer research

authors： Sonabend AM,Rolle CE,Lesniak MS

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:The efficacy of positron emission tomography with 18F fluoro-2-deoxy-D-glucose (FDG-PET) is obscure in evaluating viability or the extent of colorectal hepatic metastasis (CHM), down-staged by chemotherapy. PATIENTS AND METHODS:A retrospective lesion-by-lesion analysis was performed for seven consecutive pa...

journal_title：Anticancer research

authors： Takahashi S,Kuroki Y,Nasu K,Nawano S,Konishi M,Nakagohri T,Gotohda N,Saito N,Kinoshita T

更新日期：2006-11-01 00:00:00

abstract：:In a previous study we determined that the fine needle aspiration (FNA) biopsy of thyroid produces 16% of false-negative cases (FNC). In order to determine the value of quantitative cytology (QC) as a tool for predicting the FNC result, thirty-seven cases, 18 of which were operated (histologically benign: 13; malignan...

journal_title：Anticancer research

authors： Liautaud-Roger F,Dufer J,Pluot M,Delisle MJ,Coninx P

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:The determination of dihydropyrimidine dehydrogenase (DPD) deficiency is important in avoiding severe 5-fluorouracil (FU) toxicity. The dihydrouracil (UH2)-uracil (Ura) ratio (UH2/Ura) in plasma might be an important indicator of the risk of 5-FU catabolic deficiency. In order to clarify this possibility, th...

journal_title：Anticancer research

authors： Nakayama Y,Matsumoto K,Inoue Y,Katsuki T,Kadowaki K,Shibao K,Tsurudome Y,Hirata K,Sako T,Nagata N,Itoh H

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:Estramustine is an anti-mitotic cytostatic drug that also enhances the effect of radiotherapy. The mechanism of radiosensitization is not thoroughly known. Since both radiotherapy and estramustine induce apoptosis in prostate cancer cells, we conducted an experiment to show whether radiosensitization is medi...

journal_title：Anticancer research

authors： Ståhlberg K,Kairemo K,Erkkilä K,Pentikäinen V,Sorvari P,Taari K,Dunkel L,Rannikko S

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Human DNA topoisomerase I (topo 1) is an essential nuclear enzyme involved in vital cellular processes and the sole target of antitumor drugs of the camptothecin (CPT) family. The CPT derivative topotecan (Tpt, Hycamtin) is currently used in clinic, its effectiveness varying considerably for different types ...

journal_title：Anticancer research

authors： Devy J,Wargnier R,Pluot M,Nabiev I,Sukhanova A

更新日期：2004-05-01 00:00:00

abstract：:The iron chelator deferoxamine mesylate has been shown to inhibit the growth of a variety of human malignant cell lines and the rat 13762NF mammary adenocarcinoma cell line. In vivo studies in mice have also demonstrated that an iron deficiency induced by either feeding a low iron diet or injecting the iron chelator d...

journal_title：Anticancer research

authors： Wang F,Elliott RL,Head JF

更新日期：1999-01-01 00:00:00

abstract：:Smoking is the primary factor responsible for the epidemic of squamous cell lung cancer (SqLC) and small cell lung cancer (SCLC), however, there have been few studies which reported the relationship between smoking and SCLC in female patients. To examine the relationship between smoking and SCLC and SqLC in female pat...

journal_title：Anticancer research

authors： Satoh H,Yamashita YT,Ishikawa H,Kamma H,Ohtsuka M,Sekizawa K

更新日期：1999-11-01 00:00:00

abstract：:The human breast carcinoma cell line MCF-7, propagated in a chemically defined medium, released alfa-1-antitrypsin and alfa-1-antichymotrypsin to the medium under the influence of estradiol. Furthermore, an estrogen-independent release of antigenic material crossreacting with alfa-1-lipoprotein was demonstrated. In th...

journal_title：Anticancer research

authors： Krøll J,Briand P

更新日期：1988-01-01 00:00:00

abstract：:Lymphocytes isolated from the peripheral blood of patients with chronic lymphocytic leukemia (CLL) and from healthy donors were studied for membrane fluidity and lipid phase separation. The degree of fluidity of the surface membrane lipids was estimated by fluorescence polarization analysis using the probe 1,6-dipheny...

journal_title：Anticancer research

authors： Deliconstantinos G,Daefler S,Krueger GR

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND:In previous reports, changes in oxytocinase activity in human breast cancer tissue and in the serum of N-methyl-nitrosourea (NMU)-induced rat mammary tumors were described. Insulin-regulated aminopeptidase (IRAP) has been identified with oxytocinase and has also been referred to as placental leucine aminopep...

journal_title：Anticancer research

authors： Pilar Carrera M,Ramírez-Expósito MJ,Dueñas B,Dolores Mayas M,Jesús García M,De la Chica S,Cortés P,Ruíz-Sanjuan M,Martínez-Martos JM

更新日期：2006-03-01 00:00:00

abstract：:Anaplastic lymphoma kinase (ALK) gene re-arrangements are present in approximately 4% of patients with non-small cell lung cancer (NSCLC), mostly in non-smokers with adenocarcinoma. V-KI-RAS2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations are more common in smokers. These molecular lesions were usually de...

journal_title：Anticancer research

authors： Homa I,Sawicki M,Wojas-Krawczyk K,Nicoś M,Mlak R,Powrózek T,Krawczyk P,Przybylski P,Czekajska-Chehab E,Milanowski J

更新日期：2014-07-01 00:00:00

abstract：:Between 70 and 75% of ovarian carcinomas are not discovered until they have reached an advanced stage III or later. Efforts should therefore be concentrated on earlier diagnosis. Ovarian cancer is not an entirely silent disease. Today, it is known that there are key symptoms which, depending on their frequency and int...

journal_title：Anticancer research

authors： Argento M,Hoffman P,Gauchez AS

更新日期：2008-09-01 00:00:00

abstract：:The multifactorial process of carcinogenesis in the digestive system involves mutations in oncogenes or tumor suppressor genes, as well as influence of environmental etiological factors. In recent years, common DNA polymorphisms in low penetrance genes emerged as genetic factors that seem to modulate an individual's s...

journal_title：Anticancer research

authors： Tsigris C,Chatzitheofylaktou A,Xiromeritis C,Nikiteas N,Yannopoulos A

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Nucleotide-binding domain and leucine-rich repeat-containing family, pyrin domain-containing 7 (NLRP7) (pyrin-containing apoptotic protease activating factor-1-like protein 3; PYPAF3, NACHT domain-, leucine-rich repeat, and pyrin domain-containing 7; NALP7) has been thought to contribute to innate immunity a...

journal_title：Anticancer research

authors： Ohno S,Kinoshita T,Ohno Y,Minamoto T,Suzuki N,Inoue M,Suda T

更新日期：2008-07-01 00:00:00

abstract：:Sarcomas in the forearm and hand are very rare, accounting for less than 1% of all upper-limb tumors and clinical outcomes after surgery and adjuvant therapies are uncertain. The forearm and hand present specific challenges due to their unique anatomical structures. There is little soft tissue and each compartment is ...

journal_title：Anticancer research

authors： Muramatsu K,Ihara K,Yoshida K,Tominaga Y,Hashimoto T,Taguchi T

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Reduction of E-cadherin in most common epithelial tumors relates to metastasis, which results from the silence of E-cadherin by CpG methylation. MATERIALS AND METHODS:We examined the E-cadherin expression by immunohistochemical staining and detected methylation by methylation-specific polymerase chain react...

journal_title：Anticancer research

authors： Yeh KT,Shih MC,Lin TH,Chen JC,Chang JY,Kao CF,Lin KL,Chang JG

更新日期：2002-11-01 00:00:00

abstract：:To elucidate the rates of appearance of hepatocellular carcinoma (HCC) and the prognosis of alcoholic liver cirrhosis upon infection with hepatitis virus, we retrospectively studied 190 consecutive patients. The patients were divided into three groups based on whether they were exposed either to hepatitis B virus (HBV...

journal_title：Anticancer research

authors： Yamanaka T,Shiraki K,Nakazaawa S,Okano H,Ito T,Deguchi M,Takase K,Nakano T

更新日期：2001-07-01 00:00:00

abstract：:To determine the group of patients for whom a biological response modifier is useful, the efficacy of postoperative adjuvant immunotherapy was investigated with regard to infiltration of dendritic cells (DC) in patients with advanced gastric cancer who underwent absolute curative resection. The infiltration of DC was ...

journal_title：Anticancer research

authors： Tsujitani S,Kakeji Y,Orita H,Watanabe A,Kohnoe S,Baba H,Anai H,Maehara Y,Sugimachi K

更新日期：1992-05-01 00:00:00

abstract：BACKGROUND:Trastuzumab is used for the adjuvant (postoperative) treatment of (HER2)-positive early breast cancer. The duration of treatment is set at one year. The goal of our study was to examine the effective duration of trastuzumab treatment in routine clinical practice. PATIENTS AND METHODS:We performed a retrospe...

journal_title：Anticancer research

authors： Montserrat M,Leveque D,Barthelemy P,Bergerat JP

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:DNA repair capacity may be an important factor in determining both individual susceptibility to cancer and the response to cancer therapy. The aim of this work was to compare DNA damage and the repair process in cells originating from healthy donors and cancer patients. MATERIALS AND METHODS:Using the micro...

journal_title：Anticancer research

authors： Palyvoda O,Mukalov I,Polanska J,Wygoda A,Drobot L,Widel M,Rzeszowska-Wolny J

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Alterations of mitochondrial DNA (mtDNA) have been found in cancer patients, therefore informative mtDNA mutations could serve as biomarkers for the disease. MATERIALS AND METHODS:The two hypervariable regions HVR1 and HVR2 in the D-Loop region were sequenced in ten paired tissue and plasma samples from bre...

journal_title：Anticancer research

authors： Cai FF,Kohler C,Zhang B,Chen WJ,Barekati Z,Garritsen HS,Lenner P,Toniolo P,Zhang JJ,Zhong XY

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND/AIM:γδ T cells mediate cytotoxicity against prostate cancer (PCa) cells in vitro; however, the clinical efficacy of γδ T cell-targeted immunotherapy for recurrent and metastatic PCa is unsatisfactory. We hypothesized that the resistance of recurrent and metastatic PCa to γδ T cells is related to the presence...

journal_title：Anticancer research

authors： Miyashita M,Tomogane M,Nakamura Y,Shimizu T,Fujihara A,Ukimura O,Ashihara E

更新日期：2020-10-01 00:00:00

abstract：:The interaction between sodium 5,6-benzylidene-L-ascorbate (SBA) and dopamine was investigated by three different parameters: radical intensity, prooxidant action and cytotoxic activity. Under alkaline conditions, SBA and dopamine produced doublet and quartet ESR signals, respectively. The addition of increasing conce...

journal_title：Anticancer research

authors： Satoh K,Ida Y,Kochi M,Sakagami H

更新日期：1998-09-01 00:00:00

abstract：:Methyl-tertiary-butyl ether (MTBE) is a ubiquitous oxygen-bearing additive used to reduce engine knocking and obtain cleaner gasoline combustion. Conflicting data have been reported about a possible carcinogenic role of MTBE in humans. In this study we evaluated the effects of MTBE on cell growth and transformation in...

journal_title：Anticancer research

authors： Iavicoli I,Carelli G,Ardito R,Cittadini A,Sgambato A

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Early detection before scintigraphic appearance of osseous metastatic spread might improve the outcome of breast cancer patients. The amino-terminal propeptide (PINP) of type I collagen as an indicator of bone formation is a very promising candidate among all markers of bone metabolism. We investigated the u...

journal_title：Anticancer research

authors： Lüftner D,Jozereau D,Schildhauer S,Geppert R,Müller C,Fiolka G,Wernecke KD,Possinger K

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Oxi4503 has been shown to inhibit tumor growth and improve survival in an animal model of colorectal (CRC) liver metastases. This agent appears to selectively target the endothelial cytoskeleton with resultant vessel occlusion and tumor necrosis. MATERIALS AND METHODS:This study evaluated the pattern of tum...

journal_title：Anticancer research

authors： Chan LS,Malcontenti-Wilson C,Muralidharan V,Christophi C

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:Over expression of Stathmin1 (STMN1), activation-induced cytidine deaminase (AID) and protein kinase C iota (PKCi) proteins participate in the regulation of carcinogenesis. In the present study, we investigated the expression of STMN1 in patients with gastric adenocarcinoma and also determined the correlatio...

journal_title：Anticancer research

authors： Batsaikhan BE,Yoshikawa K,Kurita N,Iwata T,Takasu C,Kashihara H,Shimada M

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Oxidised ferrocenium compounds often possess antineoplastic activity. In contrast, reduced ferrocene derivatives frequently only show activity if cell components can oxidise them inside cells to the ferrocenium species. Ferrocene compounds having the lowest formal reduction potential are normally expected to...

journal_title：Anticancer research

authors： Swarts JC,Vosloo TG,Cronje SJ,Du Plessis WC,Van Rensburg CE,Kreft E,Van Lier JE

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND/AIM:Reportedly, hypertension tends to be associated with response to bevacizumab therapy, because bevacizumab suppresses vascular nitric oxide production. In this study we examined the predictive value of nitric oxide in bevacizumab-treated non-small cell lung cancer (NSCLC) patients. PATIENTS AND METHODS:F...

journal_title：Anticancer research

authors： Muto S,Takagi H,Owada Y,Inoue T,Watanabe Y,Yamaura T,Fukuhara M,Okabe N,Matsumura Y,Hasegawa T,Osugi J,Hoshino M,Higuchi M,Shio Y,Suzuki H

更新日期：2017-06-01 00:00:00