The role of regulatory T cells in malignant glioma.

abstract：:We studied a combined utilization of serum tumour markers and proton nuclear magnetic resonance 1H NMR spectroscopy of plasma in the detection of pancreatic cancer. Serum concentrations of carcinoembryonic antigen (CEA), carboanhydrate antigens CA 50 and CA 242, and 1H NMR spectra of plasma were determined in a series...

journal_title：Anticancer research

authors： Pasanen PA,Kauppinen R,Eskelinen M,Partanen K,Pikkarainen P,Alhava E

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND/AIM:Exposure of the skin to sunshine is the major natural source of vitamin D. In order to imitate this natural production of vitamin D for patients with chronic kidney disease, hemodialysis patients were exposed three times a week to radiation of the front part of both legs to normalize the vitamin D status...

journal_title：Anticancer research

authors： Krause R,Stange R,Roth HJ,Kaase H,Michalsen A,Holick MF

更新日期：2018-02-01 00:00:00

abstract：:Intracellular accumulation of adriamycin (ADR) has been reported to be influenced by cell membrane potential. We first evaluated intracellular accumulation of ADR and 3,3'-(di-n-hexyl)-2,2'-oxacarbocyanine iodide (NK-2280), an indicator of cell membrane potential, and found a good correlation between ADR and NK-2280 i...

journal_title：Anticancer research

authors： Asaumi JI,Kawasaki S,Gao XS,Kuroda M,Hiraki Y

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:UNC5C, one of the Netrin-1 receptors, belongs to the functional dependence receptor family, members of which share the ability to induce apoptosis in the absence of their ligands. Recently, two reports indicated that UNC5C methylation was closely associated with loss of gene expression in colorectal cancer. ...

journal_title：Anticancer research

authors： Hibi K,Mizukami H,Shirahata A,Goto T,Sakata M,Saito M,Ishibashi K,Kigawa G,Nemoto H,Sanada Y

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Tumorigenesis is a multistep process that begins with the abrogation of normal controls of apoptosis and cell proliferation, and the FAS receptor-ligand system is a key regulator of apoptosis. The aim of this study was to investigate whether functional polymorphisms of death pathway genes (FAS and FASL) are ...

journal_title：Anticancer research

authors： Hsu PI,Lu PJ,Wang EM,Ger LP,Lo GH,Tsay FW,Chen TA,Yang HB,Chen HC,Lin WS,Lai KH

更新日期：2008-01-01 00:00:00

abstract：:Polyamines are ubiquitous cellular compounds which are required for estradiol induced proliferation in breast cancer. Complete polyamine deprivation, using 2 alpha-difluoromethyl-ornithine (DFMO, Eflornithine), a specific inactivator of ornithine decarboxylase (key-enzyme of the polyamine biosynthesis) combined with i...

journal_title：Anticancer research

authors： Leveque J,Foucher F,Havouis R,Desury D,Grall JY,Moulinoux JP

更新日期：2000-01-01 00:00:00

abstract：:The objective of this study was to discover whether the peptides LRMK and LRMK-Ava linked to the N-terminus of peptides HER-2 (774-788) and HER-2 (776-788), respectively, help differentiation of E75-TCR(+)CD8(+) cells. Activation was quantified in terms of proliferation of E75-TCR(+)CD8(+) cells expressing high, mediu...

journal_title：Anticancer research

authors： Matsueda S,Gao H,Efferson CL,Tsuda N,Ishiyama S,Li Y,Ioannides MG,Fisk B,Peoples GE,Ioannides CG

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:The aim of this study was to assess the relationship between p53 status and the clinical outcome of patients with advanced ovarian cancer treated with a paclitaxel-based regimen. PATIENTS AND METHODS:The investigation was conducted on 38 patients with FIGO stage III-IV ovarian cancer from whom tumor tissue ...

journal_title：Anticancer research

authors： Gadducci A,Cianci C,Cosio S,Carnino F,Fanucchi A,Buttitta F,Conte PF,Genazzani AR

更新日期：2000-11-01 00:00:00

abstract：:This study investigates the treatment management and survival of inoperable advanced non-small cell lung cancer (NSCLC) patients. The objective was to treat all patients with induction chemotherapy and then to stratify them for surgery, radiotherapy, second-line chemotherapy or supportive treatment. Of the 359 patient...

journal_title：Anticancer research

authors： Stathopoulos GP,Dafni UG,Malamos NA,Rigatos S,Kouvatseas G,Moschopoulos N

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND/AIM:There is no definite consensus regarding management of hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT). This study aimed to compare clinical outcomes according to initial treatment modality for treatment of naïve HCC combined with subsegmental (Vp1)/ segmental (Vp2) PVTT with live...

journal_title：Anticancer research

authors： Yu JI,Choi GS,Lim DH,Lee E,Joh JW,Kwon CHD,Kim JM,Kim S,Woo SY,Paik SW,Park HC

更新日期：2018-08-01 00:00:00

abstract：:Leukemia inhibitory factor (LIF) is prevalently expressed in human medulloblastomas in vivo and in vitro. Blockage of LIF expression or biological function can inhibit in vitro growth and induce differentiation-like phenotypes of medulloblastoma cells (Med-3), suggesting a redifferentiation potential of Med-3 cells wh...

journal_title：Anticancer research

authors： Liu J,Guo L,Luo Y,Li JW,Li H

更新日期：2000-07-01 00:00:00

abstract：:The relationship between human papillomavirus (HPV) infection and breast cancer is controversial. In this study, paraffin-embedded tissue blocks prepared from 72 patients with benign, premalignant or malignant mammary lesions were randomly collected from the Shanghai region of China and Tokushima in Japan. DNA specime...

journal_title：Anticancer research

authors： Yu Y,Morimoto T,Sasa M,Okazaki K,Harada Y,Fujiwara T,Irie Y,Takahashi E,Tanigami A,Izumi K

更新日期：1999-11-01 00:00:00

abstract：:AIDS-related Epstein-Barr virus (EBV)-associated T cell lymphomas are emerging as a new, distinct histopathological entity. The pathway whereby EBV infects T cells as well as the initial EBV transcriptional program in T cells has not been established. In order to shed light on the early events of the EBV infection of ...

journal_title：Anticancer research

authors： Guan M,Romano G,Henderson EE

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND/AIM:Basaloid squamous cell carcinoma of the oesophagus (BSCCE) is a variant of oesophageal squamous cell carcinoma (ESCC), that has a more aggressive biological behaviour than that of typical ESCC. miR-3687 has been previously identified to be highly expressed in BSCCE. This study aimed to evaluate the progn...

journal_title：Anticancer research

authors： Hagio K,Furuya S,Nakamura J,Maruyama S,Shiraishi K,Shimizu H,Akaike H,Hosomura N,Kawaguchi Y,Amemiya H,Kawaida H,Sudo M,Inoue S,Kono H,Ichikawa D

更新日期：2019-02-01 00:00:00

abstract：:Clinical and hematological parameters, and three derived major staging systems were compared with DNA-cytometric parameters in 73 patients with newly diagnosed multiple myeloma (MM) and correlated in univariate analysis with survival to assess their predictive value. Regarding diagnostic validity, a multi-parameter sy...

journal_title：Anticancer research

authors： Kropff M,Leo E,Steinfurth G,Esselborn H,Adler CP,Böcking A

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Resistance to multiple chemotherapeutic agents results from a variety of factors including a lack of apoptosis in tumor cells. To induce apoptosis in two types of tumor cells, RPMI-8226 and MG-63, a combination of chemotherapeutic agents and retroviral transduction of TRAIL was employed. MATERIALS AND METHO...

journal_title：Anticancer research

authors： Suzuki H,Hotta T,Koyama T,Komagata M,Imakiire A,Yanase N,Yoshimoto T,Mizuguchi J

更新日期：2003-07-01 00:00:00

abstract：BACKGROUND:Histological parameters as well as the status of sentinel lymph node are known to be strong prognostic factors in patients with melanoma. PATIENTS AND METHODS:In this study, we retrospectively analyzed 1,384 patients who were diagnosed with head and neck melanoma between 1976 and 2010 regarding prognostic f...

journal_title：Anticancer research

authors： Uslu U,Schuler G,Breuninger H

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Carbohydrate antigen 15-3 (CA15-3), Kerbs von den Lungen (KL-6) and breast cancer antigen 225 (BCA225) are widely used tumor markers for breast and lung cancer respectively. PATIENTS AND METHODS:We analyzed 460 Japanese volunteers for 99 items on blood examination including 27 serum tumor markers. Correlati...

journal_title：Anticancer research

authors： Ri G,Ohno S,Yamamoto T,Ito E,Furutani M,Furutani Y,Umeda Y,Tsukahara T,Hagita N,Matsuoka R

更新日期：2009-10-01 00:00:00

abstract：:The intratumor and intramuscle distribution of blood flow and plasma volume was studied via isotope techniques in a transplantable rat fibrosarcoma. Administration of two prostaglandin synthesis inhibitors, indomethacin and diclofenac-sodium, had different effects. Indomethacin changed muscle plasma volume significant...

journal_title：Anticancer research

authors： Karlsson L,Alpsten M,Peterson HI

更新日期：1984-05-01 00:00:00

abstract：BACKGROUND/AIM:Fibroblast growth factor (FGF), vascular endothelial growth factor, and hepatocyte growth factor play a critical role in the pathogenesis of hepatocellular carcinoma (HCC). MATERIALS AND METHODS:We assessed nine single nucleotide polymorphisms (SNPs) in the FGF1, FGF2, FGF receptor (FGFR)-2, Flt-1, and ...

journal_title：Anticancer research

authors： Kim SS,Eun JW,Cho HJ,Lee HY,Seo CW,Noh CK,Shin SJ,Lee KM,Cho SW,Cheong JY

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Carbon ion radiotherapy has precise dose distribution and high biological effectiveness and is likely a promising therapy for patients with sarcomas. We evaluated the outcomes of carbon ion radiotherapy in patients with unresectable chondrosarcomas. PATIENTS AND METHODS:A retrospective analysis of 75 tumors...

journal_title：Anticancer research

authors： Imai R,Kamada T,Araki N,WORKING GROUP FOR BONE and SOFT-TISSUE SARCOMAS.

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND/AIM:Since androgens affect urothelial bladder cancer (UBC), we examined whether 5α-reductases (5-AR) have genomic alterations in UBC and whether 5α-reductase inhibitors (5-ARI) affect UBC. MATERIALS AND METHODS:The cBioPortal was used to analyze genomic alternations of 5-ARs in UBC cancer genomic datasets. ...

journal_title：Anticancer research

authors： Chen CC,Huang CP,Tsai YT,Hseih TF,Shyr CR

更新日期：2017-12-01 00:00:00

abstract：:Constitutive activation of estrogen receptor alpha (ER-alpha) expression is an early event in breast cancer tumorigenesis. However, the mechanism whereby ER-alpha is constitutively activated during transformation of normal mammary cells has not been well established. Previously, we reported that haploinsufficiency of ...

journal_title：Anticancer research

authors： Zhang X,Shen P,Coleman M,Zou W,Loggie BW,Smith LM,Wang Z

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:The aim of this retrospective study was to evaluate the clinical relevance of serum p53 antibody (S-p53Ab) as a biomarker and to investigate whether its diagnostic value could be improved when combined with other biomarkers of gastric cancer (GC). PATIENTS AND METHODS:Serum samples were obtained preoperativ...

journal_title：Anticancer research

authors： Kunizaki M,Fukuda A,Wakata K,Tominaga T,Nonaka T,Miyazaki T,Matsumoto K,Sumida Y,Hidaka S,Yasutake T,Sawai T,Hamamoto R,Nanashima A,Nagayasu T

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND/AIM:Previous genetic and morphologic characterisation of mucinous tubular and spindle cell carcinoma (MTSCC) have yielded controversial results. The aim of this study was to explain the phenotypic heterogeneity of MTSCC diagnosed by genetic means. MATERIALS AND METHODS:We analyzed 7 MTSCC by array CGH and m...

journal_title：Anticancer research

authors： Banyai D,Vastag F,Yusenko M,Bugert P,Kovacs G

更新日期：2017-03-01 00:00:00

abstract：:We retrospectively analysed data from 1751 patients with non-metastatic and non-inflammatory breast cancer treated in our institution between 1977 and 1989, in order to evaluate the link between age and prognosis in breast cancer. We chose three age groups (1): < or = 33 (n = 67), 34-40 ( n = 155), > 40 years (n = 152...

journal_title：Anticancer research

authors： Vanlemmens L,Hebbar M,Peyrat JP,Bonneterre J

更新日期：1998-05-01 00:00:00

abstract：:Laryngeal hyperkeratotic lesions can progress to fully developed malignant carcinoma in some cases. These premalignant lesions are proliferative disorders whose potential for further tumour progression is perhaps difficult to assess by mere histology. Immunostaining with PCNA, a protein correlated with cell proliferat...

journal_title：Anticancer research

authors： Pignataro LD,Broich G,Lavezzi AM,Biondo B,Ottaviani F

更新日期：1995-07-01 00:00:00

abstract：AIM:We investigated the relationship between a new index considering the estimated working space and difficulty of robot-assisted radical prostatectomy (RARP) using our database. PATIENTS AND METHODS:Working height was calculated by the obstetric conjugate diameter minus the bladder and rectal wall thicknesses minus t...

journal_title：Anticancer research

authors： Kadono Y,Ueno S,Makino T,Ofude M,Izumi K,Gabata T,Namiki M

更新日期：2014-10-01 00:00:00

abstract：AIM:To identify patients with breast cancer at risk for cardiotoxicity, we evaluated homoarginine (HA) behavior during adjuvant treatment. PATIENTS AND METHODS:Eighty-one patients received radiotherapy (RT) with or without endocrine treatment, and 19 received chemotherapy, RT and endocrine therapy. Serum HA, asymmetri...

journal_title：Anticancer research

authors： Aula H,Skyttä T,Tuohinen S,Luukkaala T,Hämäläinen M,Virtanen V,Raatikainen P,Moilanen E,Kellokumpu-Lehtinen PL

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND/AIM:Intensity-modulated radiation therapy (IMRT) is a form of radiation therapy that allows accurate irradiation with reduced damage to surrounding tissues. Here, we analyzed borderline-resectable pancreatic cancer (BRPC) with arterial abutment (BR-A) patients with IMRT as neoadjuvant therapy and performed c...

journal_title：Anticancer research

authors： Masui T,Takaori K,Anazawa T,Sato A,Nakano K,Uchida Y,Yogo A,Goto Y,Matsumoto S,Kodama Y,Kanai M,Isoda H,Mizumoto M,Kawaguchi Y,Shibuya K,Itasaka S,Uemoto S

更新日期：2017-12-01 00:00:00