Estrogen-dependent release of serum proteins from MCF-7 breast carcinoma cells in vitro.

Abstract:

:The human breast carcinoma cell line MCF-7, propagated in a chemically defined medium, released alfa-1-antitrypsin and alfa-1-antichymotrypsin to the medium under the influence of estradiol. Furthermore, an estrogen-independent release of antigenic material crossreacting with alfa-1-lipoprotein was demonstrated. In the presence of estrogen, the mean concentration of these proteins in the medium was 38 micrograms/l, for alfa-1-antitrypsin and 5 micrograms/l for alfa-1-antichymotrypsin and 34 micrograms/l for alfa-1-lipoprotein. It is suggested that alfa-1-antitrypsin and alfa-1-antichymotrypsin might be oncogene products of possible significance for MCF-7 tumor growth in vivo, while alfa-1-lipoprotein could be essential for the ability of the MCF-7 cells to proliferate in a chemically defined medium in vitro.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Krøll J,Briand P

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

89-91

issue

1

eissn

0250-7005

issn

1791-7530

journal_volume

8

pub_type

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