Abstract:
BACKGROUND:The determination of dihydropyrimidine dehydrogenase (DPD) deficiency is important in avoiding severe 5-fluorouracil (FU) toxicity. The dihydrouracil (UH2)-uracil (Ura) ratio (UH2/Ura) in plasma might be an important indicator of the risk of 5-FU catabolic deficiency. In order to clarify this possibility, the pyrimidine metabolites and the UH2/Ura were measured in urine and the plasma level of 5-FU was evaluated in patients with gastric and colorectal cancer. PATIENTS AND METHODS:Patients with primary gastric (n=14) and colorectal (n=8) cancer who had undergone surgery were recruited in this study. These patients were divided into the S-1 treatment group, which drug is a novel oral formulation of tegafur, oxonic acid and 5-chloro-2, 4-dihydroxypyridine (CDHP) (n=14) and a group receiving other drugs which include UFT (Uracil/Tegafur) or oral doxifluridine (n=8). The urinary levels of UH2 and Ura were measured by high-performance liquid chromatography (HPLC) using column swiching. The plasma level of 5-FU was assessed by gas chromatography-mass spectrometry (GC-MS). RESULTS:The UH2/Ura or UH2/Ura (treated/no treated) in the S-1 group significantly decreased in comparison to that in the other-drug group and the plasma 5-FU concentration in the S-1 group significantly increased compared to that in the group treated with other drugs. The plasma 5-FU concentration levels significantly indicated a positive correlation with urinary Ura. Moreover, UH2/Ura treated with 5-FU analogs or UH2/Ura (treated/no treated) significantly showed a negative correlation with the plasma 5-FU concentration levels. CONCLUSION:Our findings indicate that either urinary Ura, the UH2/Ura or UH2/Ura (treated/no treated) can predict the plasma 5-FU concentration levels or DPD deficiencies.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Nakayama Y,Matsumoto K,Inoue Y,Katsuki T,Kadowaki K,Shibao K,Tsurudome Y,Hirata K,Sako T,Nagata N,Itoh Hsubject
Has Abstractpub_date
2006-09-01 00:00:00pages
3983-8issue
5Beissn
0250-7005issn
1791-7530journal_volume
26pub_type
杂志文章abstract::The influence of psychoactive and nonpsychoactive cannabinoids on macromolecular biosynthesis and cell proliferation was compared in normal and transformed human cells which differ with respect to their abilities to metabolize polycyclic hydrocarbon-containing carcinogens. delta 9-THC, delta 8-THC, 11-OH-delta 9-THC, ...
journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1983-05-01 00:00:00
abstract:BACKGROUND/AIM:The impact of testosterone or obesity on the pathological grade of prostate cancer remains controversial. Therefore, in this study, we investigated the relationship of serum testosterone and body mass index (BMI) to Gleason score at biopsy. PATIENTS AND METHODS:This study included 128 Japanese patients ...
journal_title:Anticancer research
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doi:
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1999-07-01 00:00:00
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journal_title:Anticancer research
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doi:
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journal_title:Anticancer research
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更新日期:2003-05-01 00:00:00
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journal_title:Anticancer research
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doi:
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doi:
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journal_title:Anticancer research
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doi:
更新日期:2005-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Anticancer research
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doi:
更新日期:2004-11-01 00:00:00
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journal_title:Anticancer research
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更新日期:2005-05-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2010-10-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2007-09-01 00:00:00
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pub_type: 临床试验,杂志文章
doi:
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2006-01-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1999-05-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2003-03-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:10.21873/anticanres.12098
更新日期:2017-11-01 00:00:00
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pub_type: 杂志文章,评审
doi:
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
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journal_title:Anticancer research
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doi:
更新日期:2010-07-01 00:00:00
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更新日期:2017-08-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2010-11-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2011-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:1992-09-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2000-11-01 00:00:00
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journal_title:Anticancer research
pub_type: 杂志文章
doi:
更新日期:2008-01-01 00:00:00
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