Radiation induced effect of the vitamins C, E and beta-carotene on sanazole efficiency. A study in vitro.

abstract：BACKGROUND/AIM:Orbital metastasis of systemic cancer is exceedingly rare. This is a case report of a patient treated for locally recurrent vulvar melanoma who later presented with unilateral proptosis and was found to have an isolated biopsy-proven extraocular muscle metastasis. PATIENTS AND METHODS:A 94-year-old fema...

journal_title：Anticancer research

authors： Pirlamarla AK,Tang J,Amin B,Kabarriti R

更新日期：2018-06-01 00:00:00

abstract：BACKGROUND:We hypothesize that dendritic cells (DCs) can process antigens from autologous melanoma apoptotic bodies (MABs) and induce effector T cells in melanoma patients. MATERIALS AND METHODS:Peripheral blood mononuclear cells were obtained from three stage IV melanoma patients and adherent cells were cultured in c...

journal_title：Anticancer research

authors： Chang JW,Peng M,Vaquerano JE,Zhou YM,Clinton RA,Hyun WC,Giedlin MA,Leong SP

更新日期：2000-05-01 00:00:00

abstract：AIM:Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a promising target for cancer therapy. We have already started a phase I study of CRM197, a specific HB-EGF inhibitor, for advanced ovarian cancer. In this study, we evaluated possible clinical adaptations of CRM197 in combination with conventio...

journal_title：Anticancer research

authors： Tsujioka H,Fukami T,Yotsumoto F,Ueda T,Hikita S,Takahashi Y,Kondo H,Kuroki M,Miyamoto S

更新日期：2011-07-01 00:00:00

abstract：:Receptors for peanut agglutinin (PNA) were isolated from Lewis lung carcinoma cells (3LL) by detergent solubilization and affinity chromatography on PNA-agarose. The isolated receptors showed heterogeneous yet distinct molecular species when they were analyzed by SDS gel electrophoresis. In vivo inoculation of the iso...

journal_title：Anticancer research

authors： Adachi M,Mizuta T,Yokota M,Shibusawa H,Yamamura M,Hamada Y,Uetsuji S,Yamamoto M,Miwa H

更新日期：1984-01-01 00:00:00

abstract：:To evaluate the treatment-related late sequelae including gonadal function and second malignancy 94 patients with stage I and II testicular seminoma treated with postorchiectomy radiation therapy were analyzed retrospectively. The 10-year cause specific, disease free and actuarial survival rates were 100, 98.5 and 96....

journal_title：Anticancer research

authors： Akimoto T,Takahashi I,Takahashi M,Yamakawa M,Hayakawa K,Mitsuhashi N,Niibe H

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:Chemotherapy is considered to have a marginal impact on survival. The purpose of this study was to evaluate the rate of long-term survival in patients treated with chemotherapy for advanced non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:The case records of 109 patients with NSCLC treated with chem...

journal_title：Anticancer research

authors： Satoh H,Ishikawa H,Ohara G,Kagohashi K,Kurishima K,Ohtsuka M,Hizawa N

更新日期：2007-11-01 00:00:00

abstract：:We report a case of secondary chondrosarcoma arising in the ilium showing spontaneous regression after frequent local tumor recurrences followed by multiple surgeries of marginal or intralesional excision. The patient was a 16-year-old boy who had been diagnosed as having multiple exostosis from 9 years of age. He exp...

journal_title：Anticancer research

authors： Nakamura S,Kusuzaki K,Murata H,Takeshita H,Hirata M,Hashiguchi S,Hirasawa Y

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:F-Box protein 45 (FBXO45) is reported to be associated with cancer aggressiveness. We investigated the relationship between FBXO45 and clinicopathological factors in gastric cancer (GC). MATERIALS AND METHODS:We used immunohistochemistry to investigate FBXO45 expression in 104 GC samples; the prognostic val...

journal_title：Anticancer research

authors： Kogure N,Yokobori T,Ogata K,Altan B,Mochiki E,Ohno T,Toyomasu Y,Yanai M,Kimura A,Yanoma T,Suzuki M,Bai T,Asao T,Kuwano H

更新日期：2017-01-01 00:00:00

abstract：:Human immortal cells maintain their telomeres either by telomerase or by alternative lengthening of telomeres (ALT) that is based on homologous telomeric recombination. Previous studies showed that the ALT mechanism is activated in non-ALT cells when heterochromatic features are reduced. In this study, we examined the...

journal_title：Anticancer research

authors： Jung AR,Yoo JE,Shim YH,Choi YN,Jeung HC,Chung HC,Rha SY,Oh BK

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Despite many years of clinical research and development, nausea and vomiting remain challenging toxicities related to chemotherapy. The aim of our study was to clarify the significance of non-pharmacological, patient-related risk factors for chemotherapy-induced nausea and vomiting. Furthermore, we aimed to ...

journal_title：Anticancer research

authors： Rittmeister H,Oskay-Özcelik G,Richter R,Sehouli J,Grabowski JP

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Lysozyme is a natural antimicrobial enzyme that is up-regulated in inflammatory diseases of the gastrointestinal tract. Pathogenic microbes have recently been identified in the esophageal mucosa in patients with Barrett's esophagus (BE). Lysozyme expression was evaluated in biopsies from patients with BE. M...

journal_title：Anticancer research

authors： Rubio CA

更新日期：2012-11-01 00:00:00

abstract：:The local growth and metastatic potential of colorectal cancer is the outcome of a dynamic balance between cancer cells and the immune system, at both a local and systemic level, summarized as the "seed and soil" hypothesis. Until recently, the staging and treatment approaches for colorectal cancer appeared to be orie...

journal_title：Anticancer research

authors： Seretis F,Seretis C,Youssef H,Chapman M

更新日期：2014-05-01 00:00:00

abstract：:CD62L is the human homologue of the murine lymphocyte homing receptor, mel-14. We investigated CD62L + cells in the spleen from patients with gastric cancer. Flow cytometric analysis revealed that CD62L + cells were decreased in the peripheral blood, but inversely increased in the spleen in parallel with disease progr...

journal_title：Anticancer research

authors： Noma K,Yamaguchi Y,Okita R,Matsuura K,Toge T

更新日期：2005-01-01 00:00:00

abstract：:The melastatin-like transient receptor potential M2 (TRPM2) channel is a Ca2+ permeable channel that is activated by reactive oxygen species (ROS), and its activation induces necrotic cell death. The effect of insertion of TRPM2 into A172 human glioblastoma cells (A172 cells) was investigated. The insertion of TRPM2 c...

journal_title：Anticancer research

authors： Ishii M,Oyama A,Hagiwara T,Miyazaki A,Mori Y,Kiuchi Y,Shimizu S

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND/AIM:4H-1-Benzopyran-4-ones (chromones) provide a backbone structure for the chemical synthesis of potent anticancer drugs. In contrast to 2-(N-cyclicamino)chromones, the biological activity of 3-(N-cyclicamino)chromones has not been reported. In this study, cytotoxicity of 15 3-(N-cyclicamino)chromone deriva...

journal_title：Anticancer research

authors： Shi H,Nagai J,Sakatsume T,Bandow K,Okudaira N,Uesawa Y,Sakagami H,Tomomura M,Tomomura A,Takao K,Sugita Y

更新日期：2018-08-01 00:00:00

abstract：:A pharmacokinetic study on cis-(glycolato-O,O)/ (4R,5R)-4,5-bis(aminomethyl)-1,3-dioxolane-2-spiro-1'- cyclohexane]platinum(II) (SKI 2032R) was performed in dogs. A single dose of 2.0 mg/kg of SKI 2032R was administered i.v. bolus to three beagle dogs. Plasma samples were analyzed for platinum by flameless atomic abso...

journal_title：Anticancer research

authors： Kim DK,Cho YB,Kim HT,Kim TS,Kim KH,Hong WS

更新日期：1996-05-01 00:00:00

abstract：:Independently of tumour and treatment modulation, the host immune response status plays an important role in the clinical outcome of patients with cancer. The influence of single nucleotide polymorphisms (SNPs) and adjuvant radiotherapy (RT) on the systemic immune response status of patients with breast cancer was inv...

journal_title：Anticancer research

authors： Lewin NL,Luetragoon T,Andersson BÅ,Oliva D,Nilsson M,Strandeus M,Löfgren S,Rutqvist LE,Lewin F

更新日期：2019-03-01 00:00:00

abstract：: Aim: The aim of the study was to assess possible correlation of fluorogeoxyglucose (FDG) uptake and iodine-related attenuation values derived from positron-emission tomography/computed tomography (PET/CT) using single-source dual-energy CT scan (DE-CT) in non-small cell lung cancer (NSCLC). Materi...

journal_title：Anticancer research

authors： Baxa J,Matouskova T,Ludvik J,Sedlmair M,Flohr T,Schmidt B,Bejcek J,Pesek M,Ferda J

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Licofelone, a potent antiinflammatory agent has been reported to interfere with the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) signaling pathways with few side-effects. However, the underlying mechanism of licofelone against human cancer is not understood. MATERIALS AND METHODS:Human and mouse pros...

journal_title：Anticancer research

authors： Narayanan NK,Nargi D,Attur M,Abramson SB,Narayanan BA

更新日期：2007-07-01 00:00:00

abstract：:The immunomodulatory and antimetastatic/antitumor activity of thymic humoral factor-gamma 2 (THF-gamma 2) was evaluated in BALB/c-mice. Daily subcutaneous applications (7 consecutive days, 20, 200 ng of THF-gamma 2 per injection/mouse) upregulated counts of thymocytes and peripheral blood cells in tumor bearing mice. ...

journal_title：Anticancer research

authors： Beuth J,Schierholz JM,Mayer G,Keisari Y

更新日期：2000-11-01 00:00:00

abstract：:Between 1975 and 1982, 202 previously untreated patients with multiple myeloma (MM) and clinical evidence of disease progression received intensive chemotherapy every 3-5 weeks to induce remission. Treatment regimen included intermittent courses of a combination of cycle non-specific drugs (melphalan, cyclophosphamide...

journal_title：Anticancer research

authors： Bataille R,Souteyrand P,Sany J

更新日期：1984-11-01 00:00:00

abstract：:Methodological aspects of testing chemosensitivity by the 6-day subrenal capsule (SRC) assay in immunocompetent mice were investigated. Human tumor xenografts, serially transplanted in athymic nude mice, were used as source of material. All drugs were given by the intravenous route. Administration of the drugs on days...

journal_title：Anticancer research

authors： Aamdal S,Fodstad O,Pihl A

更新日期：1985-07-01 00:00:00

abstract：UNLABELLED:The aim of the present study was to evaluate the effectiveness and safety of hepatic re-resection for breast cancer liver metastases. PATIENTS AND METHODS:Between January 2004 and December 2014 seven patients were submitted to liver re-resection for breast cancer liver metastases at our Center. The main inc...

journal_title：Anticancer research

authors： BacalbaȘa N,Balescu I,Dima S,Popescu I

更新日期：2015-12-01 00:00:00

abstract：:We describe the case of a patient with terminal adenocarcinoma of the lung with no response to lymphokine-activated killer (LAK) cell therapy alone who distinctly responded clinically to a combination of high-dose glucocorticoids (GC) and LAK cell therapy, administered by chance. However, after decreasing the dose of ...

journal_title：Anticancer research

authors： Kato M,Goto S,Soma G

更新日期：2010-08-01 00:00:00

abstract：:Apoptotic cell death, in conjunction with mitosis, plays an important role in maintaining tissue homeostasis. Many cancer treatment modalities have been shown to induce apoptosis in sensitive cells. The purpose of this study was to determine the amount of apoptosis in-situ, the expression of apoptosis related genes p5...

journal_title：Anticancer research

authors： Pulkkinen JO,Klemi P,Martikainen P,Grénman R

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Although in vitro and clinical studies indicate that overexpression of P-glycoprotein (Pgp), p53, or metallothionein (MT) is involved in modulating drug resistance/sensitivity of cancer cells, the clinical relevance of the overexpression remains to be elucidated. MATERIALS AND METHODS:In this paper the expr...

journal_title：Anticancer research

authors： Eid H,Géczi L,Mágori A,Bodrogi I,Institoris E,Bak M

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Genetic polymorphisms of carcinogen-metabolizing enzyme genes have been associated with the risk of oral squamous cell carcinoma and oral leukoplakia. The overexpression of p53 protein is the most common genetic alteration in head and neck cancer. In the present study the combined or isolated presence of glu...

journal_title：Anticancer research

authors： Duarte EC,Ribeiro DC,Gomez MV,Ramos-Jorge ML,Gomez RS

更新日期：2008-03-01 00:00:00

abstract：:The effect of selenite on mitochondrial morphology, selenoprotein synthesis, membrane potential, phosphorylating respiration, P/O ratio and respiratory control index were evaluated relative to selenite inhibition of DNA synthesis in murine mammary epithelial cell lines. No inhibition of mitochondrial function was note...

journal_title：Anticancer research

authors： Morrison DG,Pauly DF,Berdan RC,Dishart MK,Turner DS,Oborn CJ,Medina D

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND/AIM:Pyruvate kinase M2 (PKM2) is an enzyme that is predominantly overexpressed in various types of cancer. The role of PKM2 in liver fluke-associated cholangiocarcinoma (CCA) remains unclear. This study aimed to investigate the antitumor activity of shikonin, a PKM2 inhibitor, in CCA cells. MATERIALS AND ME...

journal_title：Anticancer research

authors： Thonsri U,Seubwai W,Waraasawapati S,Wongkham S,Boonmars T,Cha'on U,Wongkham C

更新日期：2020-09-01 00:00:00

abstract：:We examined the influence of a regularly moderate endurance training program on qualitative and quantitative alterations of monocytes from 24 breast cancer patients. At the beginning, after 5 weeks and 7 months of bicycle training we analyzed the composition of leucocytes and phagocytotic activity of monocytes using t...

journal_title：Anticancer research

authors： Peters C,Lötzerich H,Niemeir B,Schüle K,Uhlenbruck G

更新日期：1995-01-01 00:00:00