Pharmacokinetics of a new platinum compound, cis-(glycolato-O,O) [(4R,5R)-4,5-bis(aminomethyl)-1,3-dioxolane-2-spiro-1'-cyclohexane]plat inum (II) in dogs.

Abstract:

:A pharmacokinetic study on cis-(glycolato-O,O)/ (4R,5R)-4,5-bis(aminomethyl)-1,3-dioxolane-2-spiro-1'- cyclohexane]platinum(II) (SKI 2032R) was performed in dogs. A single dose of 2.0 mg/kg of SKI 2032R was administered i.v. bolus to three beagle dogs. Plasma samples were analyzed for platinum by flameless atomic absorption spectrophotometry. Plasma concentrations of total and ultrafiltrable platinum for SKI 2032R declined in a biexponential fashion. The mean area under the concentration-time curve (AUC0 --> infinity) determined for ultrafiltrable platinum derived from SKI 2032R, as an active component, was 2.36 +/- 0.23 micrograms. h/ml (mean +/- S.D.), with an initial half-life of 0.23 +/- 0.20 hour, a terminal half-life of 1.32 +/- 0.49 hour, a total clearance of 14.17 +/- 1.50 ml/min/kg, and a steady-state volume of distribution of 1.21 +/- 0.24 l/kg.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Kim DK,Cho YB,Kim HT,Kim TS,Kim KH,Hong WS

subject

Has Abstract

pub_date

1996-05-01 00:00:00

pages

1167-9

issue

3A

eissn

0250-7005

issn

1791-7530

journal_volume

16

pub_type

杂志文章
  • Role of Amino Acid Transporter Expression as a Prognostic Marker in Patients With Surgically Resected Colorectal Cancer.

    abstract:BACKGROUND/AIM:L-type amino acid transporter 1 (LAT1) is highly expressed in various human cancers. However, the clinicopathological significance of LAT1 and 4F2 cell surface antigen (4F2hc) in patients with colorectal cancer (CRC) is unknown. The aim of this study was to clarify the prognostic significance of LAT1 exp...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.13375

    authors: Ogawa H,Kaira K,Motegi Y,Yokobori T,Takada T,Katoh R,Osone K,Takahashi R,Katayama C,Oyama T,Kanai Y,Yao T,Asao T,Kuwano H,Shirabe K

    更新日期:2019-05-01 00:00:00

  • Metallothionein expression prevents apoptosis. II: Evaluation of the role of metallothionein expression on the chemotherapy-induced apoptosis during the treatment of acute leukemia.

    abstract::Metallothioneins (MT) are low molecular weight cysteine-rich proteins, present in a wide variety of eukaryotes. Although their physiological function is not entirely understood, recently it was found that in vitro human MTs (hMTs) expression prevents apoptosis. In the present study, the apoptosis preventing effect of ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Tsangaris GT,Vamvoukakis J,Politis I,Kattamis AC,Tzortzatou-Stathopoulou F

    更新日期:2000-11-01 00:00:00

  • Surgical pathology examination of radical prostatectomy specimens. Updated protocol based on the Italian TAP study.

    abstract::Between January 1996 and June 2000, 192 men with prostate cancer underwent radical retropubic prostatectomy (RP) and bilateral pelvic node dissection in 26 centers participating in the Italian randomized prospective TAP study. The reviewing pathologist evaluated 145 RP specimens. Seventy-five cases had not been treate...

    journal_title:Anticancer research

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Mazzucchelli R,Montironi R,Prezioso D,Bono AV,Ferrari P,Manganelli A,Morelli P,De Vito ML,Santinelli A,Diamanti L,Lotti T,Polito M,Takeda Italian TAP Study Group.

    更新日期:2001-09-01 00:00:00

  • The induction of NB rat prostatic carcinomas.

    abstract::The NB rat prostate adenocarcinoma model is one in which microscopic carcinoma can be induced via the use of testosterone and estrogen silastic implants. There is an incidence of large, grossly-positive tumors; which approaches 10% to 15%. Seventy-three percent of the animals subjected to this induction method for per...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Drago JR

    更新日期:1984-07-01 00:00:00

  • Cytokines, tryptophan and anorexia in cancer patients before and after surgical tumor ablation.

    abstract::Serotoninergic system activity and cytokine production have been both implicated in the pathogenesis of cancer anorexia. To verify the existence of relationships between tryptophan, cytokines and anorexia, twenty cancer and six non-neoplastic patients were studied. Plasma amino acid concentration, including tryptophan...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Cangiano C,Testa U,Muscaritoli M,Meguid MM,Mulieri M,Laviano A,Cascino A,Preziosa I,Conversano L,Rossi Fanelli F

    更新日期:1994-05-01 00:00:00

  • Electrochemotherapy with cisplatin in the treatment of tumor cells resistant to cisplatin.

    abstract::The aim of our study was to investigate the role of electroporation in the treatment of cisplatin resistant tumor cells in vitro. For this purpose we used well characterized human ovarian carcinoma IGROV I cells and their resistant subclone IGROV 1/DDP. The cells were either continuously exposed to cisplatin or treate...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Cemazar M,Sersa G,Miklavcic D

    更新日期:1998-11-01 00:00:00

  • Radiofrequency Heat Ablation and Vertebroplasty in the treatment of neoplastic vertebral body fractures.

    abstract:BACKGROUND:Metastatic cancer is the most common malignant disease of the skeletal system. Traditionally, conventional fractionated external beam radiotherapy has been the treatment of choice. Recently, minimally invasive surgical techniques (MISS) have been added to the therapeutic armamentarium. The purpose of our stu...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Masala S,Roselli M,Massari F,Fiori R,Ursone A,Fossile E,Laudisi A,Simonetti G

    更新日期:2004-09-01 00:00:00

  • The bisphosphonate, zoledronic acid reduces experimental neuroblastoma growth by interfering with tumor angiogenesis.

    abstract:BACKGROUND:Zoledronic acid is a new member of the bisphosphonate (BP) class of compounds, a family of closely related synthetic molecules originally derived from the naturally occurring pyrophosphate. These compounds that are potent inhibitors of bone resorption, have been shown to reduce the growth of several cancer c...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Bäckman U,Svensson A,Christofferson RH,Azarbayjani F

    更新日期:2008-05-01 00:00:00

  • Advances in Experimental Targeted Therapy and Immunotherapy for Patients with Glioblastoma Multiforme.

    abstract::Glioblastoma multiforme (GBM) represents the most malignant primary brain tumor in adults with generally dismal prognosis, early clinical deterioration and high mortality. GBM is extremely invasive, characterized by intense and aberrant vascularization and high resistance to multimodal treatment. Standard therapy (sur...

    journal_title:Anticancer research

    pub_type: 杂志文章,评审

    doi:10.21873/anticanres.11285

    authors: Polivka J Jr,Polivka J,Holubec L,Kubikova T,Priban V,Hes O,Pivovarcikova K,Treskova I

    更新日期:2017-01-01 00:00:00

  • Lysozyme is up-regulated in columnar-lined Barrett's mucosa: a possible natural defence mechanism against Barrett's esophagus-associated pathogenic bacteria.

    abstract:BACKGROUND:Lysozyme is a natural antimicrobial enzyme that is up-regulated in inflammatory diseases of the gastrointestinal tract. Pathogenic microbes have recently been identified in the esophageal mucosa in patients with Barrett's esophagus (BE). Lysozyme expression was evaluated in biopsies from patients with BE. M...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Rubio CA

    更新日期:2012-11-01 00:00:00

  • Angiogenesis: prognostic significance in laryngeal cancer.

    abstract::The aim of this study was to evaluate the role of angiogenesis in the progression of laryngeal squamous cell carcinoma (LSCC). We correlated disease-free survival with microvessel count (MC) in the hot spot areas of 97 randomly selected caucasian males with LSCC followed for 60 to 90 months after surgery with or witho...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Beatrice F,Cammarota R,Giordano C,Corrado S,Ragona R,Sartoris A,Bussolino F,Valente G

    更新日期:1998-11-01 00:00:00

  • Comparison of clofarabine activity in childhood and adult acute leukemia: individual tumor response study.

    abstract:BACKGROUND:Clofarabine is a second-generation nucleoside analogue. The aim of the study was the analysis of ex vivo activity of clofarabine and 14 other anticancer drugs in pediatric and adult acute lymphoblastic (ALL) and myeloid (AML) leukemia. PATIENTS AND METHODS:The ex vivo drug resistance profile was analyzed in...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Styczynski J,Gil L,Derwich K,Wachowiak J,Balwierz W,Badowska W,Krawczuk-Rybak M,Matysiak M,Wieczorek M,Balcerska A,Sonta-Jakimczyk D,Stefaniak J,Kowalczyk J,Urasinski T,Sobol G,Komarnicki M,Wysocki M

    更新日期:2009-05-01 00:00:00

  • Inconsistent Reporting Between Meta-analysis Protocol and Publication - A Cross-Sectional Study.

    abstract:BACKGROUND:Inconsistent reporting in published meta-analyses compared to registered protocol are poorly understood. The aim of the study was to assess inconsistencies between registered protocols and published reports among oncology drug meta-analyses. MATERIALS AND METHODS:A cross-sectional study was performed includ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.11928

    authors: Delgado AF,Delgado AF

    更新日期:2017-09-01 00:00:00

  • The importance of prognostic factors in premenopausal women with breast cancer.

    abstract:BACKGROUND:Basic conventional prognostic factors for breast cancer include the age of the patient, tumor grade, regional lymph nodes status, and estrogen (ER) and progesterone (PR) receptor status. Positivity of the HER2 receptor (c-erbB-2) seems to be a new prognostic and predictive factor. Prognostic factors seem to ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Finek J,Holubec L Jr,Topolcan O,Elgrova L,Skalova A,Pecen L

    更新日期:2007-07-01 00:00:00

  • Apoptosis induced by oxaliplatin in human colon cancer HCT15 cell line.

    abstract:BACKGROUND:Oxaliplatin (L-OHP), active in a wide range of human and animal tumours, also CDDP-resistant, possesses unique molecular characteristics of action. However, the mechanisms by which the damage induced by L-OHP triggers a death signal are not yet fully defined. MATERIALS AND METHODS:After L-OHP treatment of t...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Marchetti P,Galla DA,Russo FP,Ricevuto E,Flati V,Porzio G,Ficorella C,Cifone MG

    更新日期:2004-01-01 00:00:00

  • Validation of Systemic and Local Tumour Immune Response to Eribulin Chemotherapy in the Treatment of Breast Cancer.

    abstract:BACKGROUND/AIM:In addition to its cytocidal effects as a microtubule dynamics inhibitor, eribulin mesylate (eribulin) regulates the tumour microenvironment. We examined the clinical significance of tumour infiltrating lymphocytes (TILs) and transforming growth factor-β (TGF-β), which are local markers of host immunity,...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.14317

    authors: Kashiwagi S,Asano Y,Goto W,Takada K,Morisaki T,Kouhashi R,Yabumoto A,Tanaka S,Takashima T,Ohsawa M,Hirakawa K,Ohira M

    更新日期:2020-06-01 00:00:00

  • Antitumor Activity of Novel Bone-seeking, α-emitting 224Ra-solution in a Breast Cancer Skeletal Metastases Model.

    abstract:BACKGROUND/AIM:Bone metastases are associated with increased morbidity and poor prognosis in a variety of cancers. The present study investigated the effects of targeted radionuclide therapy with α-emitting, bone-seeking radium-224 (224Ra) on osteolytic bone metastasis of MDA-MB-231(SA)-GFP human breast cancer cells in...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.12432

    authors: Juzeniene A,Bernoulli J,Suominen M,Halleen J,Larsen RH

    更新日期:2018-04-01 00:00:00

  • Non-cytotoxic and sublethal paclitaxel treatment potentiates the sensitivity of cultured ovarian tumor SKOV-3 cells to lysis by lymphokine-activated killer cells.

    abstract:BACKGROUND:The standard treatment of epithelial ovarian cancer is tumor debulking by surgery, followed by six cycles of chemotherapy consisting of cisplatinum and paclitaxel. However, this therapy protocol is not satisfactory, since about 50% of the treated patients eventually experience recurrence within a few years o...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Law KS,Chen HC,Liao SK

    更新日期:2007-03-01 00:00:00

  • Transcriptional regulatory regions of the survivin gene activate an exogenous suicide gene in human tumors and enhance the sensitivity to a prodrug.

    abstract::Selective expression of a therapeutic gene in tumors contributes to the efficacy and the safety of cancer therapy. Regulatory regions of genes that are preferentially expressed in tumors have been examined. The regions of the survivin gene exhibited the greatest activity in human hepatocellular carcinoma cells. Deleti...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Kawamura K,Yu L,Tomizawa M,Shimozato O,Ma G,Li Q,Sato A,Yang Y,Suzuki T,Abdel-Aziz NM,Tagawa M

    更新日期:2007-01-01 00:00:00

  • Mapping the methylation pattern by bisulfite genomic sequencing of the E-cadherin promoter CpG island in nasopharyngeal carcinoma.

    abstract:BACKGROUND:It is hypothesised that hypermethylation of the CpG island in the promoter region in several tumour suppressor genes contributes one of the mechanisms for silencing or down-regulating the expression of the tumour suppressor genes. One of the putative tumour suppressor genes, the E-cadherin gene, has shown do...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Kao RH,Huang LC,Hsu YH

    更新日期:2002-11-01 00:00:00

  • Depth of Hepatic Infiltration and Lymph Node Swelling as Factors for Considering Surgery for T2-4 Gallbladder Carcinoma Patients.

    abstract:BACKGROUND/AIM:The aim of the present study was to clarify if the degree of hepatic infiltration and lymph node swelling of gallbladder carcinoma (GBC) should be held as deciding factors for T2-4 GBC patients to undergo surgery. PATIENTS AND METHODS:Fifty consecutive patients with T2-4 GBC who underwent surgery were r...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Okada K,Kawai M,Ueno M,Hirono S,Miyazawa M,Hayami S,Shimizu A,Shigekawa Y,Kitahata Y,Miyamoto A,Yamaue H

    更新日期:2016-06-01 00:00:00

  • Expression of inhibins in the endometrial carcinoma cell line RL-95-2 after stimulation with cortisol and estradiol.

    abstract:UNLABELLED:Inhibins (INH) are dimeric glycoproteins composed of an alpha-subunit (INH-alpha) and one of two possible beta-subunits (INH-betaA or -betaB), with substantial roles in human reproduction and in endocrine-responsive tumours. The aim of the present study was the determination of the frequency and tissue distr...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Vogl J,Höing A,Schulze S,Kuhn C,Wiest I,Shabani N,Jeschke U,Mylonas I,Friese K

    更新日期:2007-07-01 00:00:00

  • New sarcomatoid cancer cell line SAR-HCV established from a hepatitis C virus-related liver tumour lesion.

    abstract::A sarcomatoid carcinoma cell line (SAR-HCV) was established from a malignant liver lesion of a patient infected with hepatitis C virus. SAR-HCV cells were successfully xenografted in SCID mice. Vimentin was strongly positive in cultured SAR-HCV cells, the primary tumour lesion and the xenografts. Hepatocyte paraffin 1...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Tai DI,Shen YJ,Weng WH,Chen HW,Kang CC,Chen TC,Liao SK

    更新日期:2011-01-01 00:00:00

  • Present treatment and future expectations in advanced pancreatic cancer.

    abstract::Advanced or metastatic pancreatic cancer is an incurable disease. The main treatment is chemotherapy with cytotoxic agents. On the basis of our experience in clinical trials, the objectives have been to determine response rate, life prolongation and clinical benefit. In our trials and in those of other authors, all of...

    journal_title:Anticancer research

    pub_type: 杂志文章,评审

    doi:

    authors: Stathopoulos GP,Androulakis N,Souglakos J,Stathopoulos J,Georgoulias V

    更新日期:2008-03-01 00:00:00

  • Transitory Stoma at the Time of Complete Cytoreductive Surgery Affects Survival for Patients with Advanced-stage Ovarian Cancer.

    abstract:AIM:To evaluate the influence on relapse-free survival (RFS) and overall survival (OS) of a transitory protective stoma (TPS) at the time of complete cytoreductive surgery for advanced-stage ovarian cancer. PATIENTS AND METHODS:From our Institution, we retrospectively selected patients from 2006 to 2011 with ovarian c...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.12379

    authors: Canlorbe G,Touboul C,Chargari C,Bentivegna E,Maulard A,Pautier P,Genestie C,Morice P,Gouy S

    更新日期:2018-03-01 00:00:00

  • Serum levels of soluble syndecan-1 in Hodgkin's lymphoma.

    abstract:BACKGROUND:Syndecan-1 (CD138) is expressed by the Hodgkin-Reed-Sternberg (HRS) cells of classic Hodgkin's lymphoma (cHL), but not in nodular lymphocyte-predominant HL. Syndecan-1 may be involved in the interaction between HRS cells and the cellular and stromal microenvironment typical of nodular sclerosing HL. PATIENT...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Vassilakopoulos TP,Kyrtsonis MC,Papadogiannis A,Nadali G,Angelopoulou MK,Tzenou T,Dimopoulou MN,Siakantaris MP,Kontopidou FN,Kalpadakis C,Kokoris SI,Dimitriadou EM,Tsaftaridis P,Pizzolo G,Pangalis GA

    更新日期:2005-11-01 00:00:00

  • M-CSF Receptor Antagonists Inhibit the Initiation and Progression of Hepatocellular Carcinoma in Mice.

    abstract:BACKGROUND/AIM:The aim of this study was to investigate the effects of the macrophage colony-stimulating factor (M-CSF) receptor antagonist on hepatic carcinogenesis in mice. MATERIALS AND METHODS:Mice were injected with diethylnitrosamine (DEN) and treated with M-CSF receptor antagonist GW2580 (GW) or a saline vehicl...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.13663

    authors: Akazawa Y,Kono H,Hara M,Furuya S,Nakata Y,Wakana H,Fukushima H,Sun C,Fujii H,Ichikawa D

    更新日期:2019-09-01 00:00:00

  • Quantitative chemiluminescent immunoassay of p53: prognostic significance in 220 node-negative breast cancer tissue.

    abstract::The prognostic and predictive role of p53 overexpression in breast cancer samples is usually investigated by using molecular biology or immunohistochemical methods. However, the results are to date controversial, and this is in part due to the methodological pitfalls of both the methods. To study the possibility of ov...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Dittadi R,Brazzale A,Mione R,Di Fresco S,Gatti C,Vinante O,Bassan F,Nascimben O,Gion M

    更新日期:1997-11-01 00:00:00

  • Bortezomib Causes ER Stress-related Death of Acute Promyelocytic Leukemia Cells Through Excessive Accumulation of PML-RARA.

    abstract:BACKGROUND/AIM:The success of proteasome inhibitors in therapy of multiple myeloma has led to their use for other malignancies. For the proteasome inhibitor bortezomib, combination therapies with histone deacetylase inhibitors, which up-regulate ubiquitin-proteasome system (UPS)-related enzymes, produce a beneficial ef...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Takenokuchi M,Miyamoto K,Saigo K,Taniguchi T

    更新日期:2015-06-01 00:00:00

  • A KIT-negative, DOG1-positive epithelioid GIST of the stomach harboring a novel PDGFRA exon 14 single nucleotide deletion.

    abstract::Gastrointestinal stromal tumors (GISTs) are the most common primary mesenchymal tumors of the gastrointestinal tract, and most of them harbor KIT or platelet-derived growth factor receptor alpha (PDGFRA) gain-of-function mutations. Proper diagnostic assessment of GISTs has become very important since the availability ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Rizzardi C,Marzinotto S,Avellini C,Melato M,Mariuzzi L

    更新日期:2012-05-01 00:00:00