The in vitro effect of paclitaxel on a LacZ-transfected malignant transitional cell line.

abstract：:Between 1981 and 1987, 533 patients from 9 institutions were entered in a randomized trial to assess the value of adjuvant perioperative portal infusion with Fluorouracil and Mitomycin as compared to radical surgery alone. Analysis of 469 evaluable patients at a median follow-up of 5.8 years revealed 110 recurrences i...

journal_title：Anticancer research

authors： Weber W,Laffer U,Metzger U

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND/AIM:AZD8055 is an inhibitor of mammalian target of rapamycin (mTOR) that can suppress both mTOR complex 1 (mTORC1) and mTORC2. This study investigated the antitumor effects of AZD8055 on colon cancer. MATERIALS AND METHODS:The effects of AZD8055 on proliferation, apoptosis, and cell cycle of colon cancer ce...

journal_title：Anticancer research

authors： Chen Y,Lee CH,Tseng BY,Tsai YH,Tsai HW,Yao CL,Tseng SH

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Renal oncocytomas (ROs), and clear cell (RCC) and urothelial carcinomas (UC), are common renal neoplasms. Nicotinamide phosphoribosyltransferase (Nampt) catalyzes the rate-limiting step of NAD+ synthesis and its expression is increased in several tumors. Nampt concomitantly regulates hydrogen sulfide (H2S)-s...

journal_title：Anticancer research

authors： Shackelford RE,Abdulsattar J,Wei EX,Cotelingam J,Coppola D,Herrera GA

更新日期：2017-07-01 00:00:00

abstract：:The metastatic involvement of the spleen in epithelial ovarian cancer is rare and usually reflects late disseminated disease. Isolated parenchymal metastasis in the spleen is an extremely unusual event, in fact in most cases in medical literature, the spleen was involved as part of diffuse peritoneal carcinomatosis. W...

journal_title：Anticancer research

authors： Lauro S,Trasatti L,Capalbo C,Conti A,Ricci F,Mingazzini PL,Vecchione A

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:The objective of this study was to evaluate the possible effects of a paclitaxel containing chemotherapy on different neuropsychological parameters in women with ovarian cancer. MATERIALS AND METHODS:Twenty-eight women with histologically documented epithelial ovarian carcinoma and treated with a combinatio...

journal_title：Anticancer research

authors： Mayerhofer K,Bodner-Adler B,Bodner K,Saletu B,Schindl M,Kaider A,Hefler L,Leodolter S,Kainz C

更新日期：2000-09-01 00:00:00

abstract：:Tissue polypeptide specific antigen (TPS) is a new tumor proliferation serotest marker. The respective radioimmunodetective procedure is based on the application of monoclonal antibodies raised against one the principle epitopes of tissue polypeptide antigen (TPA). TPS is useful tool for the identification of prolifer...

journal_title：Anticancer research

authors： Tarle M,Kovacić K,Kastelan M

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND/AIM:We aimed to analyze the clinical impact of solid and micropapillary components in a series of Japanese patients resected for ≤3 cm lung adenocarcinoma. PATIENTS AND METHODS:A total of 115 patients with ≤3 cm lung adenocarcinomas were reviewed and classified according to the American Thoracic Society and...

journal_title：Anticancer research

authors： Matsuoka Y,Yurugi Y,Takagi Y,Wakahara M,Kubouchi Y,Sakabe T,Haruki T,Araki K,Taniguchi Y,Nakamura H,Umekita Y

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Histone deacetylase inhibitors (HDACIs) can inhibit cell proliferation, induce cell cycle arrest and stimulate apoptosis of cancer cells. MATERIALS AND METHODS:The effects of a novel HDACI, MS-275, on 4 endometrial cancer cell lines and normal human endometrial epithelial cells was investigated. Endometrial...

journal_title：Anticancer research

authors： Takai N,Ueda T,Nishida M,Nasu K,Narahara H

更新日期：2006-03-01 00:00:00

abstract：:The development of T-lymphocytes (T cells) constitute one of the basic and most vital processes in immunology. Conventional mathematical models, being based on the systems theory, fail to sufficiently distinguish the constituents of thymocytes and are thus of limited significance. On the basis of some well thought-out...

journal_title：Anticancer research

authors： Wang G,Krueger GR,Buja LM

更新日期：2004-05-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) and v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations are common in non-small cell lung cancer (NSCLC) and colorectal cancer (CRC). The aim of the present study was to develop a simple and versatile tool to determine EGFR and KRAS mutations for pre-clinical r...

journal_title：Anticancer research

authors： Furugaki K,Yasuno H,Iwai T,Moriya Y,Harada N,Fujimoto-Ouchi K

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:Concurrent chemoradiotherapy (CCRT) is used to treat advanced head and neck cancer. The accuracy of evaluating lymph nodes metastases following CCRT is important for subsequent therapy. PATIENTS AND METHODS:Patients were divided into two groups, the complete response (CR) and the non-CR groups, as determine...

journal_title：Anticancer research

authors： Nishimura G,Matsuda H,Taguchi T,Takahashi M,Komatsu M,Sano D,Sakuma N,Arai Y,Takahashi H

更新日期：2012-02-01 00:00:00

abstract：:Osteosarcoma of the jaw is a rare disease; we report two cases, one in which the primary osteosarcoma had occurred in the sacrum and ileum, the second at the mandible. Dissemination of osteosarcoma to other organs, especially early dissemination to the lung, is common, but metastasis to the jaw has only rarely been re...

journal_title：Anticancer research

authors： Angiero F,Moltrasio F,Cattoretti G,Valente MG

更新日期：2011-12-01 00:00:00

abstract：AIM:To identify predictors of poor prognosis of patients with colon cancer (CC) who underwent surgery with curative intent, we investigated the association between the albumin to globulin ratio (AGR) with clinicopathological findings such as overall (OS) and disease-free (DFS) survival. PATIENTS AND METHODS:We conduct...

journal_title：Anticancer research

authors： Fujikawa H,Toiyama Y,Inoue Y,Imaoka H,Shimura T,Okigami M,Yasuda H,Hiro J,Yoshiyama S,Saigusa S,Kobayashi M,Ohi M,Araki T,Mohri Y,Kusunoki M

更新日期：2017-03-01 00:00:00

abstract：:Ovarian tumors of low malignant potential (LMPs) are intermediate between adenomas and ovarian carcinomas (OCs); however, whether an LMP is a precursor of OC or is a unique type of tumor that will not progress to OC is still controversial. To gain better insight into the relationship between LMP and OC, we compared pr...

journal_title：Anticancer research

authors： Nakayama K,Takebayashi Y,Hata K,Fujiwaki R,Iida K,Fukumoto M,Miyazaki K

更新日期：2003-11-01 00:00:00

abstract：:Three sublines have been derived from the parental line Mv1Lu by transfection with normal and mutated Ha-ras, and myc oncogenes, and subsequent cloning. All the oncogenes have increased the growth rate of the cell in vitro, increased their plating efficiency in monolayer and suspension, and reduced their serum depende...

journal_title：Anticancer research

authors： Khan MZ,Spandidos DA,Kerr DJ,McNicol AM,Lang JC,De Ridder L,Freshney RI

更新日期：1991-05-01 00:00:00

abstract：UNLABELLED:Platinum-based chemotherapy has been reported to induce diabetes and hyperosmolar coma in nondiabetic patients. The aim of the present study was to determine whether the administration of chemoradiation for head and neck carcinoma alters glucose metabolism during and after treatment. PATIENTS AND METHODS:We...

journal_title：Anticancer research

authors： Nguyen NP,Vos P,Vinh-Hung V,Borok TL,Dutta S,Karlsson U,Lee H,Martinez T,Jo BH,Nguyen LM,Nguyen N,Sallah S

更新日期：2009-11-01 00:00:00

abstract：AIM:The American thyroid association (ATA) recommends that additional imaging procedures supplement cervical ultrasonography (US) in any patient with a basal calcitonin value above 150 pg/ml in the follow-up of medullary thyroid carcinoma (MTC). The aim of the present study was to reaffirm or challenge this cut-off for...

journal_title：Anticancer research

authors： Sesti A,Mayerhoefer M,Weber M,Anner P,Wadsak W,Dudczak R,Haug A,Karanikas G

更新日期：2014-11-01 00:00:00

abstract：:In the in vivo system, cancer metastasis is a complex multi-step process. We have utilized an in vitro three-dimensional system to study the initial stages of tumour cell invasion. In this communication, the sequence of events in interactions between B16 melanoma cells and normal mouse skin fibroblasts are described. ...

journal_title：Anticancer research

authors： Mok CH,Chew EC,Riches DJ

更新日期：1986-09-01 00:00:00

abstract：BACKGROUND/AIM:The phosphatidylinositol-3-kinase (PI3K) signaling pathway is frequently activated in cancer. Buparlisib (BKM120), an oral pan-PI3K inhibitor, inhibits proliferation of human cancer in preclinical models. Studies of buparlisib in Western and Japanese adults with advanced solid tumors established a recomm...

journal_title：Anticancer research

authors： Wu YL,Zhang LI,Trandafir L,Dong T,Duval V,Hazell K,Xu B

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:In this study, the effect of novel taxane SB-T-1216 and paclitaxel on sensitive MDA-MB-435 and resistant NCI/ADR-RES human breast cancer cells was compared. MATERIALS AND METHODS:Cell growth and survival were evaluated after 96-hour incubation with tested concentrations of taxanes. The effect on the formati...

journal_title：Anticancer research

authors： Kovár J,Ehrlichová M,Smejkalová B,Zanardi I,Ojima I,Gut I

更新日期：2009-08-01 00:00:00

abstract：:Hormone-dependent (HD) mammary tumors can be induced in mice and rats either by endocrine manipulations or by treatment with carcinogens. The tumors metastasize at a low frequency which may be due to immunogenic properties and does not exclude that the tumors are malignant. Hormone deprival may lead to tumor regressio...

journal_title：Anticancer research

authors： Briand P

更新日期：1983-07-01 00:00:00

abstract：BACKGROUND/AIM:The combination of bevacizumab (BEV) plus interferon alpha-2a (IFN) constitutes an option for first-line treatment of metastatic renal cell carcinoma. Real-world data from routine clinical practice are rare and were, therefore, collected during this non-interventional study (NIS). PATIENTS AND METHODS:A...

journal_title：Anticancer research

authors： Schultze-Seemann W,Schulz H,Tschechne B,Häckl M

更新日期：2019-02-01 00:00:00

abstract：:Inflammatory bowel diseases (IBD) are associated with an increased risk of colitis-associated colorectal carcinoma (CAC). CAC is one of the most important causes of morbidity and mortality in patients with Crohn's disease and ulcerative colitis. The aim of the present review was to discuss the most important signaling...

journal_title：Anticancer research

authors： Romano M,DE Francesco F,Zarantonello L,Ruffolo C,Ferraro GA,Zanus G,Giordano A,Bassi N,Cillo U

更新日期：2016-04-01 00:00:00

abstract：:Serially propagated fibroblast clones were treated with 25-mM methionine and a thioguanine resistance assay was performed at each passage to measure mutagenesis at the HGPRT locus. The spontaneous frequency of thioguanine resistant mutants before treatment was less than 5 X 10(-6) in four clones and 22 X 10(-6) in one...

journal_title：Anticancer research

authors： Hill M,Hillova J,Mariage-Samson R,Brada Z

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to analyze the pretreatment cytokeratin serum levels in head and neck squamous cell carcinoma (HNSCC) by three assays in relation to selected clinicopathological characteristics in an effort to find diagnostic/prognostic biomarkers for HNSCC and determine the best assay. PATIEN...

journal_title：Anticancer research

authors： Kalfert D,Ludvik J,Kucera R,Topolcan O,Celakovsky P,Pesta M,Kholova I,Plzak J,Ludvikova M

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:The use of prophylactic cranial irradiation (PCI) to treat brain metastases (BM) in non-small cell lung cancer (NSCLC) is restricted due to the potential associated toxicity and lack of survival benefit. BM can have a negative impact on neurocognitive function (NF) and quality of life (QOL). The aim of this ...

journal_title：Anticancer research

authors： Precival C,Landy M,Poole C,Mullaney L

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The clinical significance of the circulating levels of activin A and matrix metalloproteinase-2 (MMP-2) and -9 (MMP-9) was investigated in patients with breast cancer (BC) or prostate cancer (PC) with (M1) or without (M0) bone metastasis. PATIENTS AND METHODS:MMP-2, MMP-9 and activin A blood concentrations ...

journal_title：Anticancer research

authors： Incorvaia L,Badalamenti G,Rini G,Arcara C,Fricano S,Sferrazza C,Di Trapani D,Gebbia N,Leto G

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:As cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are being increasingly adopted as the standard treatment for peritoneal surface malignancies, familiarity with this procedure's adverse events is also growing. Herein, we describe an unreported adverse event of exocrine panc...

journal_title：Anticancer research

authors： Naffouje SA,Salti GI

更新日期：2018-04-01 00:00:00

abstract：:The high glucose consumption of tumour cells has been well known since Warburg's investigations. Nevertheless, the reason for this phenomenon is still a matter of speculation. Glucose uptake of tumour cells is mainly mediated by GLUT1. In this study, the question of whether glucose uptake as well as expression of GLUT...

journal_title：Anticancer research

authors： Hauptmann S,Grünewald V,Molls D,Schmitt WD,Köbel M,Kriese K,Schürmann A

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Pure or metaplastic squamous cell carcinoma (SCC) of the breast is a rare entity with an unclear pathogeny and aggressive clinical behaviour. An attempt was made to characterize its differential immunohistochemical and biological profile. PATIENTS AND METHODS:Twenty-seven cases of SCC (pure or not) of the b...

journal_title：Anticancer research

authors： Grenier J,Soria JC,Mathieu MC,Andre F,Abdelmoula S,Velasco V,Morat L,Besse B,Dunant A,Spielmann M,Delaloge S

更新日期：2007-01-01 00:00:00