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The Role of Prophylactic Cranial Irradiation for Non-small Cell Lung Cancer.

Abstract：

BACKGROUND:The use of prophylactic cranial irradiation (PCI) to treat brain metastases (BM) in non-small cell lung cancer (NSCLC) is restricted due to the potential associated toxicity and lack of survival benefit. BM can have a negative impact on neurocognitive function (NF) and quality of life (QOL). The aim of this review was to assess the impact of PCI on disease-specific and NF and QOL outcomes. MATERIALS AND METHODS:An electronic database literature search was completed to identify relevant studies. RESULTS:Fourteen published articles were included. PCI significantly reduced the incidence of BM, but no significant survival advantage was found. NF decline was reported in one trial. No significant difference in QOL with PCI was reported. PCI was well tolerated by the majority of patients with NSCLC and associated with a relatively low toxicity. CONCLUSION:PCI reduces the incidence of BM without any significant survival advantage. PCI has the potential to be beneficial in practice for certain patients with locally advanced NSCLC, based on disease factors and patient preference.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Precival C,Landy M,Poole C,Mullaney L

doi

10.21873/anticanres.12185

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

7-14

issue

1

eissn

0250-7005

issn

1791-7530

pii

38/1/7

journal_volume

38

pub_type

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