Relevance of calcitonin cut-off in the follow-up of medullary thyroid carcinoma for conventional imaging and 18-fluorine-fluorodihydroxyphenylalanine PET.

abstract：:A universal intracellular factor, the "M phase-promoting factor" (MPF), triggers the G2/M transition of the cell cycle in all organisms. In late G2, it is present as an inactive complex of tyrosine-phosphorylated p34cdc2 and unphosphorylated cyclin Bcdc13. In M phase, its activation as an active MPF displaying histone...

journal_title：Anticancer research

authors： Baratte B,Meijer L,Galaktionov K,Beach D

更新日期：1992-05-01 00:00:00

abstract：:Malignant gliomas are often treated with cisplatin (cis-diamminedichloroplatinum(II), CDDP) and radiation but results remain unsatisfactory. To investigate whether CDDP induces radioresistance in glioma, T98G human glioblastoma cells were pretreated 5 times with 10(-6)M CDDP for 24 hours and then the sensitivity of wi...

journal_title：Anticancer research

authors： Poppenborg H,Münstermann G,Knüpfer MM,Hotfilder M,Hacker-Klom U,Wolff JE

更新日期：1997-03-01 00:00:00

abstract：:Cathepsin B (CB) is involved in degradation of extracellular matrix proteins during tumor progression in human solid organ tumors (such as colorectal, bladder, and breast cancers), including human prostate cancer. Its activities are regulated by endogenous inhibitors (such as stefins or cystatins). Increased expressio...

journal_title：Anticancer research

authors： Sinha AA,Quast BJ,Korkowski JC,Wilson MJ,Reddy PK,Ewing SL,Sloane BF,Gleason DF

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:The effectiveness and improvement in quality of life (QOL) of a long-acting formulation of octreotide (LAR) administration for cancer patients, with chronic loperamide-refractory diarrhea not attributed to medical therapy, were investigated. PATIENTS AND METHODS:Twenty-nine patients with chronic loperamide-r...

journal_title：Anticancer research

authors： Mystakidou K,Katsouda E,Tsilika E,Smyrniotis V,Vassiliou I,Tsiatas M,Vlahos L

更新日期：2006-05-01 00:00:00

abstract：:In furtherance of our structure-activity relationship studies on the antitumor activity of indolo[2,3-b]quinolines, novel cytotoxic derivatives bearing methyl groups at N-5, C-11, C-2 and/or C-9, as well as methoxy-groups at C-2 and/or C-9, were synthesized by the modified Graebe-Ullmann reaction. To elucidate the met...

journal_title：Anticancer research

authors： Osiadacz J,Kaczmarek L,Opolski A,Wietrzyk J,Marcinkowska E,Biernacka K,Radzikowski C,Jon M,Peczyńska-Czoch W

更新日期：1999-07-01 00:00:00

abstract：:Advanced or metastatic pancreatic cancer is an incurable disease. The main treatment is chemotherapy with cytotoxic agents. On the basis of our experience in clinical trials, the objectives have been to determine response rate, life prolongation and clinical benefit. In our trials and in those of other authors, all of...

journal_title：Anticancer research

authors： Stathopoulos GP,Androulakis N,Souglakos J,Stathopoulos J,Georgoulias V

更新日期：2008-03-01 00:00:00

abstract：:We assessed the prognostic value of the local tumor characteristics inflammatory stromal reaction (ISR) and vascular space invasion (VSI) together with established prognostic criteria, in cervical cancer patients. One hundred and forty-two patients with carcinoma of the cervix stage IB to IIB undergoing radical hyster...

journal_title：Anticancer research

authors： Kainz C,Gitsch G,Tempfer C,Heinzl H,Koelbl H,Breitecker G,Reinthaller A

更新日期：1994-09-01 00:00:00

abstract：:We have previously reported the presence of human beta-defensin-2 (HBD-2), a peptide with antimicrobial and cytotoxic properties, in oral squamous cell carcinomas. The aim of the present study was to measure the concentration of HBD-2 in abnormal tissues such as oral squamous cell carcinomas. HBD-2 was extracted from ...

journal_title：Anticancer research

authors： Sawaki K,Mizukawa N,Yamaai T,Yoshimoto T,Nakano M,Sugahara T

更新日期：2002-07-01 00:00:00

abstract：:NMR spectroscopy was used to analyse perchloric acid extracts of normal human brain, murine brain cell cultures, glioblastoma tissue and the glioblastoma cell line U-87. 1H NMR spectra revealed the presence of elevated levels of UDP-N-acetylglucosamine and UDP-N-acetylgalactosamine in glioblastoma extracts and the gli...

journal_title：Anticancer research

authors： Sonnewald U,Isern E,Gribbestad IS,Unsgård G

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND/AIM:Elderly patients with HPV+ oropharyngeal cancer (OPC) represent an understudied cohort of the HPV epidemic. We aimed to investigate the clinical presentation, treatment tolerability and outcomes in patient's ≥65 years old with HPV+ OPC. PATIENTS AND METHODS:We identified all patients aged 65 and older t...

journal_title：Anticancer research

authors： Dave E,Su W,Gupta V,Miles B,Demicco E,Soriano T,Bakst RL

更新日期：2017-04-01 00:00:00

abstract：:Metastatic renal cell carcinoma (RCC) has a poor response to anticancer chemotherapy and radiotherapy. While immunotherapy and molecular targeted drugs have been used as first-line therapy for RCC metastasis, the response rate to these agents is low. We report the case of a patient with lung and bone metastases of RCC...

journal_title：Anticancer research

authors： Nishida H,Shirai T,Hayashi K,Takeuchi A,Tanzawa Y,Mizokami A,Namiki M,Tsuchiya H

更新日期：2011-09-01 00:00:00

abstract：:A high-throughput 32D(L858R/T790M) cell-based assay to identify inhibitors of the L858R/T790M mutant epidermal growth factor receptor (EGFR) pathway was established. After screening, ten hits from among 60,000 compounds in our in-house compound library were initially identified. In the secondary assays, one hit, 1-[2-...

journal_title：Anticancer research

authors： Lin WH,Song JS,Lien TW,Chang CY,Wu SH,Huang YW,Chang TY,Fang MY,Yen KJ,Chen CH,Chu CY,Hsieh HP,Chen YR,Chao YS,Hsu JT

更新日期：2012-01-01 00:00:00

abstract：UNLABELLED:Magnetic drug targeting (MDT) is a new locoregional chemotherapy method that increases the drug dose in the tumour region, while simultaneously reducing the overall dose through the application of chemotherapeutic-bound superparamagnetic nanoparticles, which are focused by an external magnetic field to the d...

journal_title：Anticancer research

authors： Lyer S,Tietze R,Jurgons R,Struffert T,Engelhorn T,Schreiber E,Dörfler A,Alexiou C

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Concurrent chemoradiotherapy with gemcitabine improves median survival for patients with unresectable pancreatic cancer. Recently, hyperfractionated accelerated radiotherapy (HART) has been used to treat these patients; however, the safety and efficacy are not well defined. PATIENTS AND METHODS:The standard...

journal_title：Anticancer research

authors： Maemura K,Shinchi H,Noma H,Mataki Y,Kurahara H,Maeda S,Hiraki Y,Nakajo M,Natsugoe S,Takao S

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Principal caregivers (PCs) of cancer patients experience high levels of stress that may significantly impact their quality of life (QoL). PCs' QoL during early phases of the disease (when patients were still on chemotherapy) were assessed. PATIENTS AND METHODS:The PCs of all patients meeting the inclusion c...

journal_title：Anticancer research

authors： Pellegrino R,Formica V,Portarena I,Mariotti S,Grenga I,Del Monte G,Roselli M

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND/AIM:We evaluated patients undergoing salvage hysterectomy after brachytherapy (BT) following concomitant chemoradiation (CRT) for locally advanced cervical cancers (LACC), when residual disease was suspected. PATIENTS AND METHODS:From 2004 to 2013, 29 patients had a radical hysterectomy at the Gustave Rouss...

journal_title：Anticancer research

authors： Gosset M,Chargari C,Bentivegna E,Leary A,Genestie C,Maulard A,Morice P,Gouy S

更新日期：2019-06-01 00:00:00

abstract：:Germ line point mutations in the RET proto-oncogene have been implicated in four inherited disorders: multiple endocrine neoplasia 2A (MEN 2A) and 2B (MEN 2B); familial medullary thyroid carcinoma (FMTC); and Hirschprung's disease, a congenital lack of enteric plexus neurons. Oncogenically activated RET has also been ...

journal_title：Anticancer research

authors： Alemi M,Lucas SD,Sällström JF,Akerström G,Wilander E

更新日期：1996-09-01 00:00:00

abstract：BACKGROUND:Screening gastroscopic examinations were performed in a cohort of individuals at high risk for developing gastric carcinoma (GC). PATIENTS AND METHODS:Five gastric biopsies were obtained following the Houston schema. Five histological parameters of gastritis were investigated: acute gastritis, chronic gastr...

journal_title：Anticancer research

authors： Saieva C,Rubio CA,Nesi G,Zini E,Filomena A

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND/AIM:MicroRNAs (miRNAs) regulate the development of colorectal cancer (CRC). We aimed to investigate miRNAs and their relation to cancer-related signaling pathways in site-specific CRC. MATERIALS AND METHODS:We used a total of 24 left- and right-sided Finnish CRC samples (discovery cohort) and The Cancer Gen...

journal_title：Anticancer research

authors： Eneh S,Heikkinen S,Hartikainen JM,Kuopio T,Mecklin JP,Kosma VM,Mannermaa A

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVES:To investigate the roles of insulin-like growth factor II (IGF2), myeloperoxidase (MPO), E-cadherin (CDH1), urokinase and xeroderma pigmentosum group A and D (XPA, XPD) polymorphisms upon leiomyoma susceptibility. STUDY DESIGN:Women were divided into: group 1, leiomyoma (n=158); group 2, non-leiomyoma (n=15...

journal_title：Anticancer research

authors： Hsieh YY,Chang CC,Wang YK,Hsu KH,Chen CP,Hsu CM,Tsai FJ

更新日期：2010-06-01 00:00:00

abstract：:A series of simple alpha, beta-unsaturated carbonyl compounds (1-26) was characterized for their cytotoxic profiles against oral human normal and tumor cells. Several cycloalkenones showed potent cytotoxic activities against human oral squamous cell carcinoma HSC-2 cell line. Among them, 4,4-dimethyl-2-cyclopenten-1-o...

journal_title：Anticancer research

authors： Nakayachi T,Yasumoto E,Nakano K,Morshed SR,Hashimoto K,Kikuchi H,Nishikawa H,Kawase M,Sakagami H

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND:The p53 tumor suppressor gene is altered in up to 70% of colorectal cancers. MATERIALS AND METHODS:We infected the colorectal cancer cell lines SW620 and KM12L4, in which p53 is mutated, with the replication-defective adenovirus Ad5/CMV/p53 to evaluate the effects of adenovirus-mediated wild-type p53 gene t...

journal_title：Anticancer research

authors： Spitz FR,Nguyen D,Skibber JM,Cusack J,Roth JA,Cristiano RJ

更新日期：1996-11-01 00:00:00

abstract：BACKGROUND/AIM:The aim of the present study was to determine the efficacy of trabectedin combined with FOLFIRI (irinotecan, leucovorin and 5-fluorouracil) on a colorectal cancer (CRC) patient-derived orthotopic xenograft (iPDOX) mouse model. MATERIALS AND METHODS:A CRC tumor from a patient previously established in nu...

journal_title：Anticancer research

authors： Zhu G,Zhao M,Han Q,Tan Y,Sun YU,Bouvet M,Clary B,Singh SR,Ye J,Hoffman RM

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Bisphosphonates (BPs) are considered the standard of care in metastatic breast cancer (MBC) patients with bone metastases. Because the survival for these patients may be prolonged compared with those patients with visceral metastases, they may be prescribed BPs for several years. The effects of this long-ter...

journal_title：Anticancer research

authors： Simmons C,Amir E,Dranitsaris G,Clemons M,Wong B,Veith R,Cole DE

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Genetic alterations occurring in lung cancer are the basis for defining molecular subtypes and essential for targeted therapies. Exhaled breath condensate (EBC) is a form of non-invasive sample that, amongst components, contains DNA from pulmonary tissue. Next-generation sequencing (NGS) was herein used to a...

journal_title：Anticancer research

authors： Youssef O,Knuuttila A,Piirilä P,Böhling T,Sarhadi V,Knuutila S

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:The long-term goal of this work is to develop a new therapeutic regimen for the treatment of colon cancer in humans which will include hyperthermic intraperitoneal perfusion of verapamil as an alternative to administration of chemotherapy. METHODS AND RESULTS:Hyperthermia and verapamil caused a significant ...

journal_title：Anticancer research

authors： Shchepotin IB,McRae DA,Shabahang M,Buras RR,Evans SR

更新日期：1997-05-01 00:00:00

abstract：:Cytogenetic and DNA flow cytometric analysis was carried out on four SV40T-transfected human buccal epithelial cells lines. One of these was immortalized and showed a nontumorigenic phenotype when tested in athymic nude mice. DNA flow cytometric ploidy values correlated well with cytogenetic ploidy values as calculate...

journal_title：Anticancer research

authors： Kulkarni Schmidt-Kastner PS,Heiden T,Tribukait B,Grafström RC

更新日期：1996-09-01 00:00:00

abstract：:Two human herpesviruses, HHV-6 and HHV-7, recently identified and closely related, were studied for their influence on cellular apoptosis and proliferation. Infection was monitored by viral DNA--and antigen expression. Apoptosis and cell proliferation were determined by immunocytological techniques and the markers p53...

journal_title：Anticancer research

authors： Kirn E,Krueger E,Boehmer S,Klussmann JP,Krueger GR

更新日期：1997-11-01 00:00:00

abstract：AIM:To investigate the possibility of enhancing an anti-metastatic effect of 5-fluorouracil (5-FU) on colorectal cancer (CRC) cells by combining it with continuous calcium supplementation. MATERIALS AND METHODS:Optimal doses of 5-FU with/without lactate salt (CaLa) were determined via clonogenicity and 3-(4,5-dimethyl...

journal_title：Anticancer research

authors： Park M,Sundaramoorthy P,Sim JJ,Jeong KY,Kim HM

更新日期：2017-01-01 00:00:00

abstract：:Immunohistochemical expression of p53 protein was studied in FNA specimens of 20 breast ductal carcinomas, 20 fibroadenomas and 20 atypical ductal hyperplasia of the breast. Nine cases of breast carcinomas (45%), five fibroadenomas (25%) and four atypical ductal hyperplasia (20%) were found to be p53-immuno-positive. ...

journal_title：Anticancer research

authors： Kalogeraki A,Panayiotides J,Tamiolakis D,Tzardi M,Chaniotis V,Chalkiadakis G,Melissas J,Stiftsis D,Kanavaros P,Delides GS

更新日期：2000-05-01 00:00:00