Abstract:
BACKGROUND/AIM:Elderly patients with HPV+ oropharyngeal cancer (OPC) represent an understudied cohort of the HPV epidemic. We aimed to investigate the clinical presentation, treatment tolerability and outcomes in patient's ≥65 years old with HPV+ OPC. PATIENTS AND METHODS:We identified all patients aged 65 and older treated at our Institution with HPV+ OPC and analyzed patient demographics, disease characteristics, treatment modalities, toxicities, treatment failures, and survival. Charlson comorbidity index was calculated for each patient. RESULTS:43 patients were identified with a mean age of median age was 70.0 (range 65-86). The mean Charlson comorbidity index score for the cohort was 5.2. In total, 72.1% of patients received what was considered standard-of-care based on stage and pathological features. Nine point three percent of patients required RT-related treatment breaks with the majority being women (75%). Three-year actuarial overall survival was 85.5% (95% CI: 71.4%-100%) and 3-year disease-free survival was 67.3% (95% CI: 49.7-91.0%). CONCLUSION:This study presented one of the largest series to date evaluating HPV-related OPC in patients ≥65. Elderly individuals with HPV+ OPC have favorable overall survival with high treatment tolerability independent of Charlson co-morbidity score. Elderly patients should be considered for stage-appropriate care with omission of specific therapies based on absolute contraindications and patient preference, but not assumptions regarding tolerability.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Dave E,Su W,Gupta V,Miles B,Demicco E,Soriano T,Bakst RLdoi
10.21873/anticanres.11520subject
Has Abstractpub_date
2017-04-01 00:00:00pages
1847-1851issue
4eissn
0250-7005issn
1791-7530pii
37/4/1847journal_volume
37pub_type
杂志文章abstract:BACKGROUND/AIM:To evaluate the effectiveness of enzalutamide in Italian patients with hormone-refractory metastatic castration-resistant prostate cancer, progressing after chemotherapy with docetaxel plus prednisone. PATIENTS AND METHODS:A total of 60 patients were enrolled. Reduction in serum prostate-specific antige...
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journal_title:Anticancer research
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journal_title:Anticancer research
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更新日期:2001-01-01 00:00:00
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journal_title:Anticancer research
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journal_title:Anticancer research
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doi:
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pub_type: 杂志文章,评审
doi:
更新日期:1994-07-01 00:00:00
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pub_type: 杂志文章,多中心研究
doi:
更新日期:2007-07-01 00:00:00
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pub_type: 临床试验,杂志文章
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doi:
更新日期:2013-04-01 00:00:00
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