Molecular mechanisms governing melanogenesis in hamster melanomas: relative abundance of tyrosinase and catalase-B (gp 75).

abstract：:Recently we demonstrated that several flavonoids can inhibit the proliferation of certain human thyroid cancer cell lines. Among the flavonoids tested, apigenin and luteolin are the most effective inhibitors of these tumor cell lines. In the present study, we investigated the signal transduction mechanism associated w...

journal_title：Anticancer research

authors： Yin F,Giuliano AE,Van Herle AJ

更新日期：1999-09-01 00:00:00

abstract：:The in vitro antioxidative activity of benzylideneascorbate (SBA) and the in vivo effect on adriamycin (ADR)-induced cardiotoxicity in a mouse model were investigated. The radical-scavenging activity of SBA was assayed in terms of reduction of chemiluminescence induced by O2-, generated in xanthine/xanthine oxidase an...

journal_title：Anticancer research

authors： Kojima S,Iizuka H,Yamaguchi H,Tanuma S,Kochi M,Ueno Y

更新日期：1994-09-01 00:00:00

abstract：:The effects of two gallium (Ga) compounds, Ga chloride (GaCl3) and tris(8-quinolinolato)Ga (III) on the viability of A549 human malignant lung adenocarcinoma cells were investigated. The results demonstrated that both drugs reduced the viability of A549 cells but to different extents. The inhibitory effects of tris(8-...

journal_title：Anticancer research

authors： Collery P,Lechenault F,Cazabat A,Juvin E,Khassanova L,Evangelou A,Keppler B

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Bone lesions in multiple myeloma (MM) are screened with radiological skeletal survey (RSS) due to its widespread availability. Although bone lesions can be missed by RSS, more sensitive radiological surveys are not as yet recommended for routine use due to the low availability of the methodology and economic...

journal_title：Anticancer research

authors： Engelhardt M,Kleber M,Frydrychowicz A,Pache G,Schmitt-Gräff A,Wäsch R,Durie BG

更新日期：2009-11-01 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy in humans including type I diabetic and normal rats. Tobacco and alcohol, as well as dysregulation of oncogenes and tumor suppressor genes, epigenetic changes and mitochondrial mutations have been implicated in OSCC development. Recent epidemiolog...

journal_title：Anticancer research

authors： Vairaktaris E,Spyridonidou S,Goutzanis L,Vylliotis A,Lazaris A,Donta I,Perrea D,Yapijakis C,Patsouris E

更新日期：2007-11-01 00:00:00

abstract：:Pyrimidine nucleoside phosphorylase (PyNPase) is an enzyme which converts 5'-deoxy-5-fluorouridine (5'-DFUR) to 5-fluorouracil (5-FU), and is induced by various cytokines in tumor cells. We evaluated a combination of 5'-DFUR and lentinan which is widely used as a biological response modifier (BRM), to verify antitumor...

journal_title：Anticancer research

authors： Ogawa T,Ohwada S,Sato Y,Izumi M,Nakamura S,Takeyoshi I,Kawashima Y,Ohya T,Koyama T,Morishita Y

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:The effectiveness and improvement in quality of life (QOL) of a long-acting formulation of octreotide (LAR) administration for cancer patients, with chronic loperamide-refractory diarrhea not attributed to medical therapy, were investigated. PATIENTS AND METHODS:Twenty-nine patients with chronic loperamide-r...

journal_title：Anticancer research

authors： Mystakidou K,Katsouda E,Tsilika E,Smyrniotis V,Vassiliou I,Tsiatas M,Vlahos L

更新日期：2006-05-01 00:00:00

abstract：BACKGROUND:We have recently demonstrated that Thymax, a gross thymic extract, induces an apoptotic effect against human breast cancer cells. In this study, the ability of Thymax to activate human dendritic cells (DCs) and the DC-directed T-cell response was examined in an in vitro culture model of peripheral blood mono...

journal_title：Anticancer research

authors： Ghoneum M,Seto Y,Agrawal S

更新日期：2009-11-01 00:00:00

abstract：:Hormone refractory prostate cancer remains an incurable disease. Newer agents with more activity are required. Genistein is a flavone compound with anti-tumor activity against various tumor systems in vitro. This study is undertaken to assess the efficacy of genistein against hormone refractory prostate cancer. In vit...

journal_title：Anticancer research

authors： Naik HR,Lehr JE,Pienta KJ

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:The E-cadherin/beta-catenin complex plays a crucial role in epithelial cell-cell adhesion and in the maintenance of tissue architecture. We previously reported aberrant expression of beta-catenin in endometrial carcinomas. However, the expression and correlation of E-cadherin and beta-catenin in normal and m...

journal_title：Anticancer research

authors： Shih HC,Shiozawa T,Miyamoto T,Kashima H,Feng YZ,Kurai M,Konishi I

更新日期：2004-11-01 00:00:00

abstract：:Reduction of nitroblue tetrazolium by blood monocytes was significantly increased following post-operative radiation therapy for breast cancer. Attachment and ingestion of yeast particles by monocytes was not affected. Exposure of purified monocytes in vitro to 13 Gy did not significantly affect NBT reduction of yeas...

journal_title：Anticancer research

authors： Jarstrand C,Petrini B,Wasserman J,Blomgren H,Strender LE

更新日期：1982-07-01 00:00:00

abstract：BACKGROUND:Few studies have successfully established an amylase-producing lung cancer cell line or have examined its cytological, biochemical and biological features. PATIENTS AND METHODS:Cancer cells, isolated from pleural effusion using a gradient method, were cultivated. RESULTS:Amylase production from the newly e...

journal_title：Anticancer research

authors： Yokouchi H,Yamazaki K,Asahina H,Shigemura M,Moriyama T,Takaoka K,Moriya J,Itoh T,Kinoshita I,Dosaka-Akita H,Tsutsumi Y,Nishimura M

更新日期：2006-07-01 00:00:00

abstract：:Receptors for peanut agglutinin (PNA) were isolated from Lewis lung carcinoma cells (3LL) by detergent solubilization and affinity chromatography on PNA-agarose. The isolated receptors showed heterogeneous yet distinct molecular species when they were analyzed by SDS gel electrophoresis. In vivo inoculation of the iso...

journal_title：Anticancer research

authors： Adachi M,Mizuta T,Yokota M,Shibusawa H,Yamamura M,Hamada Y,Uetsuji S,Yamamoto M,Miwa H

更新日期：1984-01-01 00:00:00

abstract：:Multiple components in cigarette smoke were analyzed for their ability to form active oxygen species using a spin trapping agent, 5, 5-dimethyl-1-pyrroline-N-oxide. The main source of O2 and H2O2 was ascribed to polyphenols in a particulate phase, whereas a synergistic effect was also observed between these polyphenol...

journal_title：Anticancer research

authors： Kodama M,Kaneko M,Aida M,Inoue F,Nakayama T,Akimoto H

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Since the anti-HER2 monoclonal antibody trastuzumab made its triumphant advance into breast cancer therapy, new selective agents, including pan-HER inhibitors are entering clinical practice. MATERIALS AND METHODS:This study investigates the expression of the four HER-family members, HER1-4, in 48 primary br...

journal_title：Anticancer research

authors： Fuchs IB,Siemer I,Bühler H,Schmider A,Henrich W,Lichtenegger W,Schaller G,Kuemmel S

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Various prognostic factors have been investigated in order to predict the minority of male germ cell tumor (GCT) patients who will develop resistant disease. However, no prognostic system has been proven accurate. MATERIALS AND METHODS:Paraffin-embedded tissue specimens, obtained from primary lesions during...

journal_title：Anticancer research

authors： Pectasides D,Papaxoinis G,Nikolaou M,Valavanis C,Aravantinos G,Fountzilas G,Tamvakis N,Pectasides E,Lekka I,Arapantoni-Dadioti P,Zizi A,Ghiconti I,Economopoulos T

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:The expression of oestrogen and progesterone receptors in patients with adenocarcinoma of the uterine cervix was examined in order to determine their influence on prognosis and to evaluate the association between the steroid receptor expression and various clinicopathologic parameters. PATIENTS AND METHODS:O...

journal_title：Anticancer research

authors： Bodner K,Laubichler P,Kimberger O,Czerwenka K,Zeillinger R,Bodner-Adler B

更新日期：2010-04-01 00:00:00

abstract：:The limited restriction of eucaryotic chromosomes would facilitate our understanding of the aberrant genomes of genetic diseases and cancer. We have described methods for methylating eucaryotic chromosomes embedded in agarose plugs. We now describe how Cla I methylase can be utilized in a methylation-dependent restric...

journal_title：Anticancer research

authors： Wilson WW,Mebane EW,Hoffman RM

更新日期：1993-01-01 00:00:00

abstract：:Cells cultured as spheroids present an heterogeneity similar to that of tumours in vivo. In the spheroid peripheral layers, cells are proliferating, deeper cells are non-cycling, when in the aggregate centre, cells form often a necrotic core. A multicellular resistance is related on the cell contact to other cells or ...

journal_title：Anticancer research

authors： Desoize B,Gimonet D,Jardiller JC

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Notch activation is involved in the growth of leukemia cells. gamma-Secretase inhibitors (GSIs), which block Notch activation, may be candidates for molecular target therapy against leukemia. MATERIALS AND METHODS:The effects of three kinds of GSIs: GSI-IX, GSI-XII and GSI-XXI, on the in vitro growth of var...

journal_title：Anticancer research

authors： Okuhashi Y,Nara N,Tohda S

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:The BCL2 proto-oncogene in non-Hodgkin's lymphoma is a dominant inhibitor of apoptosis. The goal of this work was to develop a (177)Lu-labeled anti-BCL2-peptide nucleic acid (PNA) conjugate designed for dual modality NHL therapy, i.e., simultaneous down-regulation of BCL2-mediated resistance to apoptosis and...

journal_title：Anticancer research

authors： Balkin ER,Jia F,Miller WH,Lewis MR

更新日期：2011-10-01 00:00:00

abstract：:Four human melanoma cell lines with different copy numbers of chromosomes 9 and 21q, as studied by the G-band technique, fluorescent in situ hybridisation (FISH) and Polymerase chain reaction (PCR), were tested for their sensitivity to Interferon-alpha (IFN-alpha) and Interferon-beta (IFN-beta) in relation to dosage o...

journal_title：Anticancer research

authors： Köpf J,Hanson C,Delle U,Weimarck A,Stierner U

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND/AIM:Metabolomics is widely used for biomarker discovery, but conventional mass-spectrometry extraction procedures lose the spatial localization of metabolites. In this study, we directly analyzed breast carcinoma tissues embedded in frozen tissue microarrays (fTMAs) using MALDI mass-spectrometry imaging (MAL...

journal_title：Anticancer research

authors： Torata N,Kubo M,Miura D,Ohuchida K,Mizuuchi Y,Fujimura Y,Hayakawa E,Kai M,Oda Y,Mizumoto K,Hashizume M,Nakamura M

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND/AIM:To compare the GeneXpert® O6-methylguanine DNA methyltransferase (MGMT) methylation prototype (GX MGMT) assay with pyrosequencing in glioblastomas. MATERIALS AND METHODS:The MGMT methylation status was retrospectively assessed in formalin-fixed paraffin embedded (FFPE) tumor blocks from 262 glioblastoma...

journal_title：Anticancer research

authors： Filipits M,Preusser M,Hainfellner JA,Spiegl-Kreinecker S,Berghoff AS,Lai EW,Kocmond K,Kohlway A,Weidler J,Bates M,Corless C

更新日期：2020-11-01 00:00:00

abstract：AIM:We examined whether the perioperative systemic inflammation score (SIS), which describes systemic inflammation and/or malnutrition, affected the tumor recurrence and survival in advanced gastric cancer patients. PATIENTS AND METHODS:The study retrospectively analyzed 160 patients with stage II/III gastric cancer w...

journal_title：Anticancer research

authors： Hara K,Aoyama T,Yamada T,Nakazono M,Nagasawa S,Shimoda Y,Kumazu Y,Numata M,Hayashi T,Tamagawa H,Shiozawa M,Morinaga S,Yukawa N,Rino Y,Masuda M,Ogata T,Oshima T

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Primary prostate carcinoma cells constitutively secrete interleukin-6 (IL-6), and high levels of IL-6 receptor are detected in prostate carcinoma tissues. These findings have implicated IL-6 in the growth and differentiation of prostate carcinomas. Herein, we examined the regulation of IL-6 receptor complex ...

journal_title：Anticancer research

authors： Mori S,Murakami-Mori K,Bonavida B

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Tyrosine kinase inhibitors (TKIs) directed against epidermal growth factor receptor (EGFR) are important in the treatment of non-small cell lung cancer (NSCLC), especially those harboring EGFR mutations. But little is known regarding the clinical value of serum tumor marker levels measured prior to treatment...

journal_title：Anticancer research

authors： Takeuchi A,Oguri T,Sone K,Ito K,Kitamura Y,Inoue Y,Asano T,Fukuda S,Kanemitsu Y,Takakuwa O,Ohkubo H,Takemura M,Maeno K,Ito Y,Niimi A

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND/AIM:Few data are available on the utility of definitive radiation therapy (RT) for pediatric craniopharyngioma. This study sought to evaluate practice patterns and patient outcomes using the Surveillance Epidemiology and End Results database from 2004-2014. MATERIALS AND METHODS:Overall survival (OS) was co...

journal_title：Anticancer research

authors： Hill TK,Baine MJ,Verma V,Alam M,Lyden ER,Lin C,Connolly EP,Zhang C

更新日期：2019-02-01 00:00:00

abstract：:We have previously shown biopsies from human malignant melanoma, as well as a cell line (MELUR) derived from human malignant melanoma cells, to contain dexamethasone (DEX) - and medroxyprogesterone acetate (MPA) - binding macromolecules exhibiting properties of glucocorticoid receptors from well-known target organs. I...

journal_title：Anticancer research

authors： Bojar H,Fabry W

更新日期：1985-03-01 00:00:00

abstract：:A relationship was established between estradiol 16 alpha-hydroxylation, papillomavirus and its malignant sequelae. In this study, we determined that 16 alpha-hydroxylation was substantial in normal larynx and further increased in laryngeal papillomas. Estradiol or 16 alpha-hydroxyestrone stimulated proliferation in b...

journal_title：Anticancer research

authors： Newfield L,Goldsmith A,Bradlow HL,Auborn K

更新日期：1993-03-01 00:00:00