当前位置： SCI文献检索 > ANTICANCER RESEARCH期刊下所有文献 > Cloned low metastatic variants from human lung carcinoma metastases.

Cloned low metastatic variants from human lung carcinoma metastases.

Abstract：

:Clonal subpopulations of neoplastic cells were derived, in soft agar, from the spontaneously metastazing variant (MV522) of a human lung carcinoma cell line. The ability of these clones to spontaneously metastasize from subcutaneous sites in athymic mice was then tested. A variation in metastatic ability was expected with the derivation of some low metastatic clones and some high metastatic ones. However, all of the derived clones, although equally tumorigenic, were less metastatic than the parental variant. These clonal cell lines can now be used in a systematic analysis of events associated with the reversion to a less malignant state.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Varki NM,Tseng A,Vu TP,Estes LA

subject

Has Abstract

pub_date

1990-05-01 00:00:00

pages

637-43

issue

3

eissn

0250-7005

issn

1791-7530

journal_volume

10

pub_type

杂志文章

相关文献

ANTICANCER RESEARCH文献大全
  • Radioimmunotherapy of colorectal cancer in small volume disease and in an adjuvant setting: preclinical evaluation in comparison to equitoxic chemotherapy and initial results of an ongoing phase-I/II clinical trial.

    abstract：:The 5-year survival of colorectal cancer patients with distant metastases is below 30%, despite the development and use of a variety of chemotherapeutic regimens. Therefore, new therapeutic strategies are warranted. Whereas radioimmunotherapy (RIT) has shown disappointing results in bulky disease, it may be a promisin...

    journal_title：Anticancer research

    pub_type： 临床试验,杂志文章

    doi：

    authors： Behr TM,Memtsoudis S,Vougioukas V,Liersch T,Gratz S,Schmidt F,Lorf T,Post S,Wörmann B,Hiddemann W,Ringe B,Becker W

    更新日期：1999-07-01 00:00:00

  • Real Clinical Practice in ALK-rearranged NSCLC Patients: A Retrospective Observational Study.

    abstract：BACKGROUND/AIM:To describe real clinical outcomes when using systemic therapy to treat non-small cell lung cancer (NSCLC) patients who have anaplastic lymphoma kinase (ALK) fusion gene mutation. PATIENTS AND METHODS:We performed a retrospective chart review from April 2008 to March 2019 sourced from 16 medical institu...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：10.21873/anticanres.14029

    authors： Okauchi S,Numata T,Nawa T,Ichimura H,Saito T,Hayashihara K,Yamada H,Satoh H,Endo T,Inage Y,Kaburagi T,Kiyoshima M,Yamada Y,Tamura T,Saito K,Inagaki M,Hizawa N,Sato Y,Shiozawa T,Sekine I,Ishikawa H,Kurihima K,S

    更新日期：2020-02-01 00:00:00

  • Synergistic Effects of a Smac Mimetic with Doxorubicin Against Human Osteosarcoma.

    abstract：BACKGROUND/AIM:Second mitochondria-derived activator of caspase (Smac) is a proapoptogenic mitochondrial protein that antagonizes inhibitors of apoptosis proteins (IAPs), resulting in induction of apoptosis. In the present study we investigated the effects of a Smac mimetic in combination with doxorubicin against osteo...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：10.21873/anticanres.12058

    authors： Kamata E,Kawamoto T,Ueha T,Hara H,Fukase N,Minoda M,Morishita M,Takemori T,Fujiwara S,Nishida K,Kuroda R,Kurosaka M,Akisue T

    更新日期：2017-11-01 00:00:00

  • Inhibition of mTOR suppresses experimental liver tumours.

    abstract：:Sirolimus, and its antiproliferative capacity, was studied in vivo in three different syngenic rat tumours in the liver. Sirolimus is an inhibitor of the cytosolic mTOR-kinase, associated with the phosphoinositide-3-kinase/Akt pathway. After one week of daily sirolimus treatment, initiated on the day of tumour-cell in...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Rizell M,Lindner P

    更新日期：2005-03-01 00:00:00

  • Chemoprevention of oral cancer by lyophilized strawberries.

    abstract：BACKGROUND/AIM:Oral cancer represents approximately 2.5% of all cancers in the United States, with five- and 10-year survival rates of 62% and 51%. In the present study, lyophilized strawberries (LS) were evaluated for their potential to inhibit tumorigenesis in the hamster cheek pouch (HCP) model of oral cancer and fo...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Casto BC,Knobloch TJ,Galioto RL,Yu Z,Accurso BT,Warner BM

    更新日期：2013-11-01 00:00:00

  • Cyclooxygenase-2 expression correlates with apoptosis and angiogenesis in endometrial cancer tissue.

    abstract：BACKGROUND:Recent experimental studies have indicated that cyclooxygenase-2 (COX-2) suppresses tumor-cell apoptosis and induces intratumoral angiogenesis. PATIENTS AND METHODS:A series of 70 endometrial cancer cases that had undergone a curative resection was studied to determine the correlation between COX-2 expressi...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Ohno S,Ohno Y,Suzuki N,Soma G,Inoue M

    更新日期：2007-11-01 00:00:00

  • The role of technetium-99m methoxyisobutylisonitrile scintimammography in diagnosis of breast cancer in patients with mammographically dense breasts.

    abstract：:The purpose of this study was to assess the contribution of techentium-99m methoxyisobutylisonitrile (Tc-99m sestamibi) scintimammography in the diagnosis of breast cancer in 32 female patients with indeterminate mammographic probability of malignancy because of mammographically dense breasts. All the breast masses we...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Sun SS,Hsieh JF,Tsai SC,Ho YJ,Kao CH

    更新日期：2000-09-01 00:00:00

  • In vitro reactivity to a protein-bound polysaccharide PSK of peripheral blood lymphocytes from patients with gastrointestinal cancer.

    abstract：:The effect of PSK, a protein-bound polysaccharide and an immunomodulator, on lymphocytes was examined in vitro for 36 patients with gastric cancer and 26 with colorectal cancer. Cultured lymphocytes with PSK at 100 micrograms/ml increased the level of DNA synthesis, as determined by the 3H-thymidine uptake, from 0.9 t...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Sugimachi K,Maehara Y,Kusumoto T,Okamura T,Korenaga D,Kohnoe S,Baba H,Anai H

    更新日期：1995-09-01 00:00:00

  • Dexamethasone enhances expression of membrane and soluble interleukin-6 receptors by prostate carcinoma cell lines.

    abstract：BACKGROUND:Primary prostate carcinoma cells constitutively secrete interleukin-6 (IL-6), and high levels of IL-6 receptor are detected in prostate carcinoma tissues. These findings have implicated IL-6 in the growth and differentiation of prostate carcinomas. Herein, we examined the regulation of IL-6 receptor complex ...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Mori S,Murakami-Mori K,Bonavida B

    更新日期：1998-11-01 00:00:00

  • Docetaxel, estramustine and prednisone for hormone-refractory prostate cancer: a single-center experience.

    abstract：BACKGROUND:The results of chemotherapy in patients with advanced, hormone-refractory prostate cancer (HRPC) have been disappointing. Mitoxantrone has been used in the past for palliation, but it does not prolong survival. It was recently demonstrated that docetaxel is able to improve median survival as compared to mito...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Boehmer A,Anastasiadis AG,Feyerabend S,Nagele U,Kuczyk M,Schilling D,Corvin S,Merseburger AS,Stenzl A

    更新日期：2005-11-01 00:00:00

  • Interleukin-2, interferon-alpha and medroxyprogesterone acetate in metastatic renal cell carcinoma.

    abstract：BACKGROUND:Interleukin-2 (IL-2) and interferon-alpha (IFN-alpha) are the main immuno-biological agents used in the therapy of metastatic renal cell carcinoma (RCC). Unfortunately the promising results obtained in biological studies have not yet been confirmed in clinical studies. One reason is linked to the immunosuppr...

    journal_title：Anticancer research

    pub_type： 临床试验,杂志文章,多中心研究

    doi：

    authors： Naglieri E,Lopez M,Lelli G,Morelli F,Amodio A,Di Tonno P,Gebbia N,Di Seri M,Chetri MC,Rizzo P,Abbate I,Casamassima A,Selvaggi FP,Colucci G

    更新日期：2002-09-01 00:00:00

  • RT-PCR for Detecting ALK Translocations in Cytology Samples from Lung Cancer Patients.

    abstract：BACKGROUND/AIM:We evaluated the usefulness of reverse transcription-polymerase chain reaction (RT-PCR) for detecting anaplastic lymphoma kinase (ALK) translocations using cytology samples from lung cancer patients. MATERIALS AND METHODS:We analyzed ALK translocations by RT-PCR in cytology samples from lung cancer pati...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：10.21873/anticanres.11696

    authors： Nakamichi S,Seike M,Miyanaga A,Chiba M,Matsuda K,Kobayashi K,Takahashi A,Takeuchi S,Minegishi Y,Kubota K,Gemma A

    更新日期：2017-06-01 00:00:00

  • Peroxisome Proliferator-activated Receptors as Potential Targets for Carcinogenic Activity of Polychlorinated Biphenyls: A Computational Perspective.

    abstract：BACKGROUND:Polychlorinated biphenyls (PCBs) are ubiquitous environment-contaminating synthetic chemicals that have been associated with increased risk of hepatic cancer, melanoma, non-Hodgkin lymphoma and cancer of many other body organs. Structural binding analyses of PCB 77 and PCB 118 with peroxisome proliferator-ac...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：10.21873/anticanres.11202

    authors： Sheikh IA,Khweek AA,Beg MA

    更新日期：2016-11-01 00:00:00

  • Docetaxel and S-1 as a first-line treatment in patients with advanced or recurrent gastric cancer.

    abstract：BACKGROUND:The safety and efficacy of docetaxel plus S-1 combination chemotherapy as a first-line treatment in patients with advanced or recurrent gastric cancer was verified retrospectively. PATIENTS AND METHODS:Eighteen patients with advanced or recurrent gastric cancer were enrolled. The regimen used was intravenou...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Tsutani Y,Ohara M,Suzuki T,Minami K,Miyahara E,Kameda A,Noso Y

    更新日期：2009-07-01 00:00:00

  • Activating Gs a mutation rarely occurs in musculoskeletal tumors other than fibrous dysplasia.

    abstract：BACKGROUND:Activating Gs a mutations have been identified in most instances of fibrous dysplasia (FD). This mutation leads to consistently elevated intracellular cyclic adenosine monophosphate (cAMP) levels, with various biological consequences. The development of secondary sarcoma in FD is a rare but well-established ...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Gu W,Ogose A,Matsuba A,Kawashima H,Hotta T,Kudo N,Hoshino M,Kondo N,Mera H,Endo N

    更新日期：2006-03-01 00:00:00

  • Thymidine phosphorylase expression in gastric carcinoma as a marker for metastasis.

    abstract：BACKGROUND:Thymidine phosphorylase (dThdPase) is identical to platelet-derived endothelial cell growth factor (PD-ECCF) and has a function of angiogenesis in vitro and in several types of human carcinoma tissues. We have reported that expression of dThdPase was an independent prognostic factor in 116 gastric carcinomas...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Konno S,Takebayashi Y,Higashimoto M,Katsube T,Kanzaki A,Kawahara M,Takenoshita S,Aiba M,Ogawa K

    更新日期：2003-11-01 00:00:00

  • Clinical pathological and ploidic patterns of juvenile colon cancers.

    abstract：:Details of 197 colorectal carcinomas from 180 patients were retrieved from our files, with the aim of analyzing the clinical histories and pathological parameters of all patients up to 40 years, and to support these data with the results of the DNA content analysis of tumoral cells by static cytometry. The incidence o...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Caruso ML,Rizzi E

    更新日期：1998-05-01 00:00:00

  • Digoxin inhibits neuroblastoma tumor growth in mice.

    abstract：BACKGROUND:Epidemiological data suggest a more favorable outcome of breast carcinoma in women taking cardiac glycosides. This study investigated whether digoxin could inhibit tumor growth in mice. MATERIALS AND METHODS:Tumor growth experiments were done in mice grafted with the neuroblastoma cell lines SH-SY5Y, Neuro-...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Svensson A,Azarbayjani F,Bäckman U,Matsumoto T,Christofferson R

    更新日期：2005-01-01 00:00:00

  • Bevacizumab as front-line treatment of brain metastases from solid tumors: a case series.

    abstract：BACKGROUND:Despite the large use of bevabizumab in the treatment of primary tumors of the brain, there is only limited experience with brain metastases (BM) and no experience in the treatment of previously untreated secondary brain lesions. PATIENTS AND METHODS:We treated patients with BM, not suitable for local treat...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Zustovich F,Ferro A,Lombardi G,Zagonel V,Fiduccia P,Farina P

    更新日期：2013-09-01 00:00:00

  • Monitoring of smokeless tobacco consumers using cytogenetic endpoints.

    abstract：:Smokeless tobacco consumption is causally associated with oral cavity cancers; however, extensive cytogenetic studies have not been done. In the present study, individuals consuming dry snuff or tobacco with lime have been studied for frequency of micronucleated cells (MNC) in exfoliated buccal mucosa and chromosome a...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Trivedi AH,Dave BJ,Adhvaryu SG

    更新日期：1993-11-01 00:00:00

  • Altered glucose metabolism during chemoradiation for head and neck cancer.

    abstract：UNLABELLED:Platinum-based chemotherapy has been reported to induce diabetes and hyperosmolar coma in nondiabetic patients. The aim of the present study was to determine whether the administration of chemoradiation for head and neck carcinoma alters glucose metabolism during and after treatment. PATIENTS AND METHODS:We...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Nguyen NP,Vos P,Vinh-Hung V,Borok TL,Dutta S,Karlsson U,Lee H,Martinez T,Jo BH,Nguyen LM,Nguyen N,Sallah S

    更新日期：2009-11-01 00:00:00

  • Symptomatic Radiation Pneumonitis After Accelerated Partial Breast Irradiation Using Three-dimensional Conformal Radiotherapy.

    abstract：AIM:To examine the relationship between symptomatic radiation pneumonitis and lung dose-volume parameters for patients receiving accelerated partial breast irradiation (APBI) using three dimensional-conformal radiotherapy (3D-CRT). PATIENTS AND METHODS:The prescribed radiation dose was 30 Gy in 5 fractions over 10 day...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Shikama N,Kumazaki YU,Miyazawa K,Miyaura K,Kato S,Nakamura N,Kawamori J,Shimizuguchi T,Saito N,Saeki T

    更新日期：2016-05-01 00:00:00

  • Prognostic factors in ambulatory patients with inoperable locoregionally recurrent rectal cancer following curative surgery.

    abstract：BACKGROUND:The optimal treatment for locoregionally recurrent rectal cancer after curative surgery has not yet been defined. The definition of prognostic factors could lead to the selection of an aggressive therapeutic approach in patients with favourable prognosis alone. PATIENTS AND METHODS:The records of thirty-nin...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Pergolizzi S,Settineri N,Santacaterina A,Maisano R,Frosina P,Loria F,Nardella G,Garufi G,Sansotta G,De Renzis C

    更新日期：1999-03-01 00:00:00

  • Intracellular localization of tenascin in squamous cell carcinoma of oral cavity: an immunohistochemical study.

    abstract：:Tenascin is a multifunctional extracellular matrix glycoprotein generally expressed in epithelial tumors at sites of epithelial tumor-mesenchymal tissue interface. Studies so far have indicated that mesenchymal cells are a major source of tenascin in tumor tissues. The present study evaluated biopsies and surgically r...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Mori M,Muramatsu Y,Yamada K,Shrestha P,Takai Y

    更新日期：1996-09-01 00:00:00

  • Stomach-specific Biomarkers (GastroPanel) Can Predict the Development of Gastric Cancer in a Caucasian Population: A Longitudinal Nested Case-Control Study in Siberia.

    abstract：BACKGROUND/AIM:Atrophic gastritis (AG) is the most important risk condition for gastric cancer (GC). A panel of stomach-specific serum biomarkers: pepsinogen (PG) I, pepsinogen (PG) II, gastrin-17 (G-17), and IgG antibodies to H. pylori (HP-Ab) detects the extent and grade of AG. The aim of the present study was to ass...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Kurilovich S,Belkovets A,Reshetnikov O,Openko T,Malyutina S,Ragino Y,Scherbakova L,Leja M,Paloheimo L,Syrjänen K,Voevoda M

    更新日期：2016-01-01 00:00:00

  • Effect of Xenotransplantation Site on MicroRNA Expression of Human Colon Cancer Stem Cells.

    abstract：BACKGROUND:Cancer stem cells (CSCs) have a high tumorigenic ability to form patient-derived tumor xenografts (PDXs). PDXs are an attractive pre-clinical model, but gene expression and biological behavior of cancer cells in the tumor will change during establishment and passage of PDXs. MATERIALS AND METHODS:Human colo...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Mukohyama J,Shimono Y,Yamashita K,Sumi Y,Mukohara T,Minami H,Kakeji Y

    更新日期：2016-07-01 00:00:00

  • Inhibition of actin polymerization by cytochalasin B induces polyploidization and increases the number of nucleolar organizer regions in human megakaryocyte cell lines.

    abstract：:Megakaryocyte polyploidization is an advantageous and regulated mechanism which leads to an increase in platelet production. In megakaryocyte cell lines, polyploidization can be obtained by using cytochalasin B, an inhibitor of the actin polymerization. The Nucleolar Organizer Regions (AgNORs) are parts of nucleolar D...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Baatout S,Chatelain B,Staquet P,Symann M,Chatelain C

    更新日期：1998-01-01 00:00:00

  • Sarcoidosis in a patient with metastatic melanoma sequentially treated with anti-CTLA-4 monoclonal antibody and selective BRAF inhibitor.

    abstract：:A female patient with stage IV-M1c (distant lymph node and breast metastases), chemotherapy-refractory melanoma was treated with the cytotoxic T-lymphocyte antigen 4 (CTLA-4)-inhibitory monoclonal antibody ipilimumab. At first evaluation following induction treatment, there was marked increase in the volume of the lym...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Wilgenhof S,Morlion V,Seghers AC,Du Four S,Vanderlinden E,Hanon S,Vandenbroucke F,Everaert H,Neyns B

    更新日期：2012-04-01 00:00:00

  • High energy shock waves (HESW) for sonodynamic therapy: effects on HT-29 human colon cancer cells.

    abstract：BACKGROUND:Whether high energy shock waves (HESW), generated by a piezoelectric generator, were able to activate a sonosensitizer, 5-aminolevulinic acid (ALA) and induce inhibition of cell growth in HT-29 human colorectal cancer cells was investigated. MATERIALS AND METHODS:Cell survival and cell death pathways were i...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Canaparo R,Serpe L,Catalano MG,Bosco O,Zara GP,Berta L,Frairia R

    更新日期：2006-09-01 00:00:00

  • Toxic proteins from European mistletoe (Viscum album L.): increase of intracellular IL-4 but decrease of IFN-gamma in apoptotic cells.

    abstract：BACKGROUND:Mistletoe lectins (ML), the major biologically active components of mistletoe extracts, which are used for adjuvant cancer therapy, induce apoptosis in lymphocytes and tumor cells. In addition, ML at toxic concentrations induce the release of cytokines, but it remains unclear as to whether dying or activated...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Stein GM,Pfüller U,Schietzel M,Büssing A

    更新日期：2000-05-01 00:00:00