Abstract：
:Tenascin is a multifunctional extracellular matrix glycoprotein generally expressed in epithelial tumors at sites of epithelial tumor-mesenchymal tissue interface. Studies so far have indicated that mesenchymal cells are a major source of tenascin in tumor tissues. The present study evaluated biopsies and surgically resected specimens of oral squamous cell carcinoma from 20 patients for the expression of tenascin using immunohistochemical methods. The normal mucosa included in all surgically resected specimens showed a delicate band in the submucosal connective tissue, with infrequent breaks in continuity in the immediate vicinity of the basement membrane. The hyperplastic/hyperkeratinized or dysplastic mucosa either showed a continuous band or enhanced expression of TN in the submucosal connective tissue. Evaluation of serial sections for immunoreactivity of tenascin in 7 cases of carcinoma showed intracellular localization of tenascin; particularly at the invading fronts of carcinomas of the buccal mucosa and tongue. The results of the present study may imply that despite the possible induction of tenascinllfrom mesenchymal cells by carcinoma cells, carcinoma cells, if they produce tenascin, do so at the invasive fronts.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Mori M,Muramatsu Y,Yamada K,Shrestha P,Takai Ysubject
Has Abstractpub_date
1996-09-01 00:00:00pages
3075-9issue
5Beissn
0250-7005issn
1791-7530journal_volume
16pub_type
杂志文章abstract：PURPOSE:To further evaluate lung cancer risk associated with rare Hras1 VNTR alleles and possible biological mechanisms. MATERIALS AND METHODS:The Hras1 VNTR was genotyped in 295 lung cancer patients and 500 healthy controls by PCR and high resolution electrophoresis. Microsatellite alterations were examined in 168 tu...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1999-11-01 00:00:00
abstract：:Although some types of intestinal metaplasia are considered to be potentially pre-malignant lesions leading to gastric carcinoma, their high frequency and variability limit their usefulness as early markers of malignant progression. The present study was carried out to search for parameters which could be used in conj...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1996-03-01 00:00:00
abstract：:Screening for hereditary tumours provides a basis for secondary prevention. In 1985, the Foundation for the Detection of Hereditary Tumours was established in The Netherlands to coordinate screening in families with hereditary tumours. In the initial period of four years a large number of families were collected. Regi...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to assess the clinical relevance of HER2 amplification by a novel chromogenic in situ hybridisation (CISH) technique in patients with primary breast cancer and to determine its relationship with other prognostic markers. MATERIALS AND METHODS:One hundred and seventy-three breas...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2004-07-01 00:00:00
abstract：:Two rat yolk sac tumour cell lines with different radiosensitivities were used to quantify the extent of apoptosis following irradiation by using a DNA fragmentation assay in vitro. Apoptosis was also confirmed by fluorescence analysis of nuclear morphological changes by using Hoechst 33258. A radiosensitive cell line...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1997-09-01 00:00:00
abstract：BACKGROUND/AIM:We aimed to investigate the efficacy of immune-cell therapy in terms of the survival of patients with neuroendocrine carcinoma of the uterine cervix (NECC), which lacks standardized therapeutic approaches. PATIENTS AND METHODS:We identified 17 patients who were diagnosed as having NECC and treated with ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.14475
更新日期：2020-08-01 00:00:00
abstract：:To evaluate further the chemopreventive role of motherwort (Leonurus sibiricus L; MW) in lesions of the mammary gland and uterus of GR/A mice, the effects on these lesions of the adsorbed (MW1) and unadsorbed (MW2) fractions of MW separated by ion-exchange resins were studied. The incidence of palpable mammary tumours...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：BACKGROUND/AIM:Combretastatin A-4 phosphate (CA4P) is a vascular-disrupting agent which affects the level of circulating neutrophils. Since tumor-associated macrophages and neutrophils may collaborate, we compared the effect of CA4P treatment on monocytes/macrophages and neutrophils. MATERIAL AND METHODS:CDF1 mice wit...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2015-05-01 00:00:00
abstract：:Cell proliferation measurements using bromodeoxyuridine administration to patients and flow cytometry to measure Tpot in head and neck cancer are discussed. Several hundred patients have now been assessed and the majority of studies suggest that this group of tumours represent a relatively fast proliferating site with...
journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：1998-11-01 00:00:00
abstract：BACKGROUND:Protein kinase C (PKC) activity is increased and gap junctional intercellular communication (GJIC) is decreased frequently in Ras-transformed cells. We investigated the roles of Ras and PKC in the deficient gap junctional intercellular communication (GJIC) of K-ras-transformed E9 mouse lung carcinoma cells. ...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1998-11-01 00:00:00
abstract：BACKGROUND/AIM:We evaluated the clinical implications of pre- and post-treatment hematological parameters as prognostic factors in patients with locally advanced cervical cancer (LACC) who received definitive concurrent chemoradiotherapy (CCRT). PATIENTS AND METHODS:We retrospectively analyzed 125 patients with LACC (...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.13973
更新日期：2020-01-01 00:00:00
abstract：:Two monoclonal antibodies, KM227 (IgM) and KM432 (IgG1), were established by immunizing mice with the crude membrane fraction of lung squamous cell carcinoma and the high-molecular-weight antigen in pleural perfusion from patients with lung adenocarcinoma, respectively. They were found to recognize the carbohydrate ep...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1993-05-01 00:00:00
abstract：AIM:We screened nine 1,2-dihydro-quinolines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cytotoxicity assay in HepG2 and SMMC cells and identified ethyl-2-cyano-2-(2- (methoxycarbonyl)allyl)quinoline-1(2H)-carboxylate (compound 5) as a potential anticancer agent. In order to further deve...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2016-05-01 00:00:00
abstract：BACKGROUND:The different clinical evolution of breast cancer with similar pathological characteristics prompted the authors to investigate the prognostic significance of different biological markers. METHODS:Seventy-one primary breast carcinoma specimens obtained by mastectomy or quadrantectomy were examined for the d...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1999-09-01 00:00:00
abstract：:The cyclin-dependent kinase inhibitor (CDK1) p27(kip1) is a negative regulator of cell cycling and has antitumor effects. In our previous study, the recombinant adenovirus expressing wild-type p27(kip1) (Adp27-wt) induced cell cycle arrest and apoptosis, and proved that p27 is a tumor suppressor gene like p53. Another...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2009-06-01 00:00:00
abstract：BACKGROUND:Epstein-Barr virus-associated gastric carcinoma (EBV-GC) has been characterized as a special gastric cancer subset. Lifestyle and other major factors that may contribute to EBV-GC and non-EBV-GC were investigated here. MATERIALS AND METHODS:A total of 247 patients with gastric cancer were interviewed, clini...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND/AIM:Oxaliplatin-induced neurotoxicity (OIN) can be severe and dose-limiting with clinically significant symptoms that persist for years. Few published reports have described postoperative exacerbation of OIN and more longitudinal data are needed to better characterize the phenomenon. PATIENTS AND METHODS:We...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.14019
更新日期：2020-02-01 00:00:00
abstract：:Cancer patients suffer from cancer-induced bone pain, hypercalcemia, and reduced quality of life caused by pathological fractures. Many of these complications related to cancer can be treated, or at least controlled, using new anticancer agents. Recently, two agents used initially to treat osteoporosis demonstrated di...
journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：
更新日期：2013-08-01 00:00:00
abstract：:The members of the matrix metalloproteinase family (MMP) have the ability to degrade macromolecules of the extracellular matrix and are responsible for tumor invasion and infiltration, limiting the effectiveness of the neurosurgical resection of brain tumors. Among the glial brain tumors, astrocytomas and oligodendrog...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2003-09-01 00:00:00
abstract：:Sirolimus, and its antiproliferative capacity, was studied in vivo in three different syngenic rat tumours in the liver. Sirolimus is an inhibitor of the cytosolic mTOR-kinase, associated with the phosphoinositide-3-kinase/Akt pathway. After one week of daily sirolimus treatment, initiated on the day of tumour-cell in...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2005-03-01 00:00:00
abstract：BACKGROUND/AIM:The differentiation of the mouse breast epithelial cell line HC11 is known to require confluence as well as the addition of hydrocortisone, insulin and prolactin. MATERIALS AND METHODS:Since confluence, which triggers the engagement of the cell-to-cell adhesion molecule E-cadherin, induces a dramatic in...
journal_title：Anticancer research
pub_type： 杂志文章
doi：10.21873/anticanres.13401
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND:The aim of this study was to evaluate the role of radiation therapy alone, employing standard fractionation, in stage III-IV hypopharyngeal carcinoma. MATERIALS AND METHODS:Fourteen (38.9%) stage III and 22 (61.1%) stage IV patients with hypopharyngeal carcinoma were submitted, with curative intent, to excl...
journal_title：Anticancer research
pub_type： 临床试验,杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:Consumption of dietary fat has been linked to the high incidence of certain cancers. However, recent research has stimulated interest in conjugated linoleic acid (CLA), a newly recognized anticarcinogenic fatty acid. Human MCF-7 breast cancer cells were incubated for 12 d in culture medium supplemented with various co...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1992-11-01 00:00:00
abstract：:Radiomics, an emerging field in radiation therapy, is hypothesized to improve classification of tumour risk and prognosis. Despite encouraging results, there are issues of practicality and interpretation of radiomic data. This study investigates the emerging role of radiomics in tumour risk classification and prognosi...
journal_title：Anticancer research
pub_type： 杂志文章,评审
doi：10.21873/anticanres.14350
更新日期：2020-07-01 00:00:00
abstract：:To elucidate the rates of appearance of hepatocellular carcinoma (HCC) and the prognosis of alcoholic liver cirrhosis upon infection with hepatitis virus, we retrospectively studied 190 consecutive patients. The patients were divided into three groups based on whether they were exposed either to hepatitis B virus (HBV...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2001-07-01 00:00:00
abstract：BACKGROUND:Antioxidants have the potential to protect normal tissues against radiation-induced damage, but must not protect tumor cells during radiotherapy. The major objectives were to determine whether a metalloporphyrin antioxidant affects prostate tumor response to radiation and identify possible mechanisms of inte...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2007-09-01 00:00:00
abstract：:A human metastatic meningiosarcoma has been established as a cell line as follows: At autopsy performed 12 hours after death, tumour nodules from the left parietal pleura were obtained under sterile conditions, minced and inoculated into culture vessels. The cells obtained were cloned, and clones with abnormal chromos...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：BACKGROUND:The secretory epithelial cells of the prostate gland use sophisticated vehicles in the form of prostasomes to relay important information to sperm cells in semen. This prostasome-forming and secretory ability of the epithelial cells is also preserved in poorly differentiated prostate cancer cells. The aim of...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2010-02-01 00:00:00
abstract：PURPOSE:To evaluate the efficacy and safety of oxaliplatin (L-OHP) fractionated over two days with bimonthly 5-fluorouracil (5-FU) and leucovorin (LV), as first-line treatment of metastatic colorectal cancer (MCC) patients. PATIENTS AND METHODS:Fifty-four patients with inoperable MCC (median age, 60 years) were entere...
journal_title：Anticancer research
pub_type： 临床试验,杂志文章
doi：
更新日期：2004-05-01 00:00:00
abstract：BACKGROUND:Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer that disproportionately affects women with darker skin. Epidemiological studies indicate that higher vitamin D levels prevent incidence of TNBC and translate to higher survival rates in those that have TNBC. MATERIALS AND METHODS:Th...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：2015-02-01 00:00:00
