The role of technetium-99m methoxyisobutylisonitrile scintimammography in diagnosis of breast cancer in patients with mammographically dense breasts.

abstract：BACKGROUND:5-Fluorouracil (5-FU) and cisplatin combined chemotherapy (FP) is commonly used for esophageal cancer. Acquired resistance needs to be overcome to improve the chemotherapeutic effect. MATERIALS AND METHODS:The FP-resistant xenograft model using severe combined immunodeficient (SCID) mice was established as ...

journal_title：Anticancer research

authors： Yoshida T,Miyoshi T,Seike J,Yamai H,Takechi H,Yuasa Y,Tangoku A

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:F-Box protein 45 (FBXO45) is reported to be associated with cancer aggressiveness. We investigated the relationship between FBXO45 and clinicopathological factors in gastric cancer (GC). MATERIALS AND METHODS:We used immunohistochemistry to investigate FBXO45 expression in 104 GC samples; the prognostic val...

journal_title：Anticancer research

authors： Kogure N,Yokobori T,Ogata K,Altan B,Mochiki E,Ohno T,Toyomasu Y,Yanai M,Kimura A,Yanoma T,Suzuki M,Bai T,Asao T,Kuwano H

更新日期：2017-01-01 00:00:00

abstract：UNLABELLED:The purpose of this study was to clarify the role and the predictive strength of the adhesion molecule CD44s (standard isoform) in colorectal carcinogenesis. MATERIALS AND METHODS:CD44s immunohistochemical expression was evaluated in 100 patients with colon adenoma and 100 patients with colon adenocarcinoma...

journal_title：Anticancer research

authors： Visca P,Del Nonno F,Botti C,Marandino F,Sebastiani V,Di Tondo U,Donnorso RP,Trombetta G,Filippi S,Alo PL

更新日期：2002-09-01 00:00:00

abstract：:We generated a recombinant immunotoxin, named scFv(MGR6)-Cla, composed of the Fv region of an anti ErbB2 monoclonal antibody (MGR6) fused to clavin, a type 1 ribosome-inactivating protein (RIP) from Aspergillus clavatus. ErbB2 is a tyrosine kinase receptor which is overexpressed in most adenocarcinomas; clavin is a 17...

journal_title：Anticancer research

authors： D'Alatri L,Di Massimo AM,Anastasi AM,Pacilli A,Novelli S,Saccinto MP,De Santis R,Mele A,Parente D

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) is thought to be the most powerful angiogenic factor in many malignancies while and several reports have determined serum VEGF to be a prognostic indicator for various malignancies. However, serum VEGF may not be suitable for the measurement of circulating VEGF level...

journal_title：Anticancer research

authors： Nakayama Y,Sako T,Shibao K,Okazaki K,Rempo N,Onitsuka K,Minagawa N,Akahane K,Nagashima N,Nagata N,Itoh H

更新日期：2002-07-01 00:00:00

abstract：:We describe herein a brother and sister diagnosed with xeroderma pigmentosum variant (XP-V) in early adult life, who presented with increased sensitivity to sunlight and with cutaneous carcinomas on sun-damaged skin. The 27-year-old male farmer (Case 1.) was diagnosed with advanced squamous cell carcinoma (SCC) and mu...

journal_title：Anticancer research

authors： Somos S,Farkas B,Schneider I

更新日期：1999-05-01 00:00:00

abstract：:Four heart hormones, namely atrial natriuretic peptide (ANP), long-acting natriuretic peptide (LANP), vessel dilator and kaliuretic peptide reduce up to 97% of cancer cells in vitro. These four cardiac hormones eliminate up to 80% of human pancreatic adenocarcinomas, two-thirds of human breast carcinomas and up to 86%...

journal_title：Anticancer research

authors： Vesely DL

更新日期：2016-11-01 00:00:00

abstract：BACKGROUND:Combination chemotherapy of irinotecan and amrubicin for advanced non-small cell lung cancer (NSCLC) has not been fully evaluated. To determine the maximum-tolerated dose (MTD), a phase I study in patients with advanced NSCLC was conducted. MATERIALS AND METHODS:Patients with stage IIIB/IV NSCLC were enroll...

journal_title：Anticancer research

authors： Hotta K,Takigawa N,Kiura K,Tabata M,Umemura S,Ogino A,Uchida A,Bessho A,Segawa Y,Shinkai T,Nogami N,Harita S,Okimoto N,Ueoka H,Tanimoto M

更新日期：2005-05-01 00:00:00

abstract：:Ovarian cancer is the most lethal malignancy among gynaecological cancers. Although many anticancer agents have been developed for the treatment of ovarian cancer, it continues to have an extremely poor prognosis. Heparin-binding epidermal growth factor-like grown factor (HB-EGF) has been reported to be a rational the...

journal_title：Anticancer research

authors： Miyata K,Yotsumoto F,Fukagawa S,Kiyoshima C,Ouk NS,Urushiyama D,Ito T,Katsuda T,Kurakazu M,Araki R,Sanui A,Miyahara D,Murata M,Shirota K,Yagi H,Takono T,Kato K,Yaegashi N,Akazawa K,Kuroki M,Yasunaga S,Miyamoto S

更新日期：2017-07-01 00:00:00

abstract：:In tumor cells, doxorubicin (DOX) is excreted by P-glycoprotein (P-gp) and the multidrug resistance-associated protein (mrp). Both transporters might also be involved in cellular regulatory volume decrease (RVD). To study the hepatobiliary excretion of DOX during RVD, isolated livers of Wistar and multidrug resistance...

journal_title：Anticancer research

authors： Gaugg M,Haslmayer P,Jäger W,Thalhammer T

更新日期：2001-07-01 00:00:00

abstract：:Tumour growth curve experiments play an important role in experimental oncology and established methods exist for their unbiased interpretation. However, many authors till introduce systemic biases to their data by using the so-called "relative tumour size" transformation, inspite of wide awarance about the limitation...

journal_title：Anticancer research

authors： Bassukas ID,Hofmockel G

更新日期：2001-03-01 00:00:00

abstract：AIM:The purpose of this prospective study was to evaluate single-frequency whole-body bioelectrical impedance analysis (BIA) as a predictor for the onset of edema of the upper limb in patients undergoing treatment for breast cancer. MATERIALS AND METHODS:Whole-body BIA was performed before surgery, as well as at two d...

journal_title：Anticancer research

authors： Berlit S,Brade J,Tuschy B,Hornemann A,Leweling H,Eghardt V,Sütterlin M

更新日期：2013-10-01 00:00:00

abstract：BACKGROUND:Extracts from Viscum album L. are widely used as an adjuvant in complementary cancer therapy. While the mechanisms of mistletoe lectin (ML) cytotoxicity are well described, the viscotoxin (VT) effects are unclear at present. Thus, we treated human lymphocytes with VT and measured cell death-associated change...

journal_title：Anticancer research

authors： Büssing A,Schaller G,Pfüller U

更新日期：1998-11-01 00:00:00

abstract：:Radiomics, an emerging field in radiation therapy, is hypothesized to improve classification of tumour risk and prognosis. Despite encouraging results, there are issues of practicality and interpretation of radiomic data. This study investigates the emerging role of radiomics in tumour risk classification and prognosi...

journal_title：Anticancer research

authors： Li Wen Y,Leech M

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND/AIM:The European MRI and Rectal Cancer Surgery (EuMaRCS) score was proposed to identify preoperatively difficult laparoscopic total mesorectal excision (L-TME) for locally advanced rectal cancer (LARC). This study aimed to test EuMaRCS's validity. PATIENTS AND METHODS:Data were retrieved from a European mul...

journal_title：Anticancer research

authors： de'ANGELIS N,Martínez-Pérez A,Vitali GC,Pigneur F,Luciani A,Brunetti F,Kraft M,Martí-Martínez E,Moroni P,Espin E,Ris F,Pucciarelli S,EuMaRCS Study Group.

更新日期：2020-04-01 00:00:00

abstract：:The melastatin-like transient receptor potential M2 (TRPM2) channel is a Ca2+ permeable channel that is activated by reactive oxygen species (ROS), and its activation induces necrotic cell death. The effect of insertion of TRPM2 into A172 human glioblastoma cells (A172 cells) was investigated. The insertion of TRPM2 c...

journal_title：Anticancer research

authors： Ishii M,Oyama A,Hagiwara T,Miyazaki A,Mori Y,Kiuchi Y,Shimizu S

更新日期：2007-11-01 00:00:00

abstract：BACKGROUND/AIM:We evaluated the clinical impact of FOLFOXIRI regimen aiming for conversion surgery in patients with unresectable multiple colorectal liver metastasis (CRLM). PATIENTS AND METHODS:A total of 42 patients with unresectable multiple CRLM who received chemotherapy with molecular agents were included in the ...

journal_title：Anticancer research

authors： Morine Y,Ikemoto T,Iwahashi S,Saito YU,Yamada S,Takasu C,Higashijima J,Imura S,Shimada M

更新日期：2019-09-01 00:00:00

abstract：:This review focuses on the functional role and structural features of the genes involved in common hereditary cancers. Most of these tumors are sporadic and the genetic alterations responsible for their genesis take place over several cell generations; nevertheless, 5 to 10% of the human tumors are hereditary, with a ...

journal_title：Anticancer research

authors： Russo A,Zanna I,Tubiolo C,Migliavacca M,Bazan V,Latteri MA,Tomasino RM,Gebbia N

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:The possibilities and limitations of computer tomography (CT) examination for detecting primary gastric cancer tumors have been poorly understood. The aim of the present study was to evaluate the pre-operative assessment of gastric cancer tumors using 32-multidetector row-CT. PATIENTS AND METHODS:A prospect...

journal_title：Anticancer research

authors： Kikuchi S,Futawatari N,Sakuramoto S,Watanabe M,Kubota K,Sasaki M,Murata K,Kida M

更新日期：2006-11-01 00:00:00

abstract：:Ovarian clear cell carcinoma represents a distinct histopathological subtype of epithelial ovarian cancer, with poor outcomes, especially in cases diagnosed in advanced stages of disease. However, even in these cases, it seems that the most effective treatment remains debulking surgery to no residual disease. We prese...

journal_title：Anticancer research

authors： Bacalbasa N,Balescu I,Filipescu A

更新日期：2017-10-01 00:00:00

abstract：:Partial deletion of chromosome 5q (5q-) is a frequent aberration in myelodysplasias and acute nonlymphocytic leukemias. It causes clinical and hematological symptoms termed the 5q-syndrome. Although more than 30 different 5q deletions are described, recent studies have demonstrated 5q31 as the common deleted region an...

journal_title：Anticancer research

authors： Pedersen B

更新日期：1993-09-01 00:00:00

abstract：:Proteolytic enzymes are believed to be necessary for tumor cell invasion. We have studied the effects of the cysteine proteinase inhibitor E-64 and the serine and cysteine proteinase inhibitor leupeptin, on the ability of human malignant melanoma cells (LOX) to pass through an artificial basement membrane. Transwell c...

journal_title：Anticancer research

authors： Bjørnland K,Buø L,Kjønniksen I,Larsen M,Fodstad O,Johansen HT,Aasen AO

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:Circulating nucleosomes are valuable biomarkers for therapy monitoring and estimation of prognosis in cancer disease. While epigenetic and genetic modifications of DNA have been reported in blood of cancer patients, little is known about modifications of histones on circulating nucleosomes. PATIENTS AND MET...

journal_title：Anticancer research

authors： Leszinski G,Gezer U,Siegele B,Stoetzer O,Holdenrieder S

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Prognosis of renal cell carcinoma (RCC) differs within the same stage and grade. Our aim was to investigate the incidence of COX-2 in primary RCC tumors at different stages according to the occurrence of metastasis, and the impact of this biomarker on the survival of RCC patients. PATIENTS AND METHODS:The c...

journal_title：Anticancer research

authors： Kankuri-Tammilehto MK,Söderström KO,Pelliniemi TT,Vahlberg T,Pyrhönen SO,Salminen EK

更新日期：2010-07-01 00:00:00

abstract：:Amifostine (Ethyol, WR-2721) has been clinically used in combination with high dose therapy of neuroblastoma stage 4 with melphalan, carboplatin and VP-16 in 14 patients. The amifostine group was compared to a historical control group of 24 comparably-treated patients. There were no significant differences regarding t...

journal_title：Anticancer research

authors： Renner S,Krümpelmann S,Bruchelt G,Wiesinger H,Niethammer D,Klingebiel T

更新日期：2000-11-01 00:00:00

abstract：:Uncertainty exists about the adequate treatment of adult patients with unresectable, primary, biopsy-proven glioblastoma multiforme (GBM), because the different options for this group of patients have not been evaluated in randomized clinical trials to date. Usually, these patients are lumped together in studies of ra...

journal_title：Anticancer research

authors： Nieder C,Grosu AL,Astner S,Molls M

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND/AIM:We retrospectively investigated the relationship between pathological complete response (pCR) and tumor volume (TV) reduction during neoadjuvant chemoradiation therapy (NACRT) in non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:We evaluated patients who received NACRT (50 Gy/25 fractions with pl...

journal_title：Anticancer research

authors： Takahashi S,Go T,Anada M,Kinoshita T,Nishide T,Yokomise H,Shibata T

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:The safety and efficacy of second-line chemotherapy for treating patients with small cell lung cancer (SCLC) and interstitial lung disease (ILD) have not been elucidated to date. PATIENTS AND METHODS:Between January 2005 and September 2013, we analyzed 23 patients with SCLC and ILD who received second-line ...

journal_title：Anticancer research

authors： Fujimoto D,Shimizu R,Kato R,Sato Y,Kogo M,Ito J,Teraoka S,Otoshi T,Nagata K,Nakagawa A,Otsuka K,Katakami N,Tomii K

更新日期：2015-11-01 00:00:00

abstract：BACKGROUND:Granulosa cell tumors (GCT) are rare malignant neoplasms of the ovaries with, usually, indolent biological behavior. PATIENTS AND METHODS:The epidemiological, clinical and pathological features of 34 patients with adult GCT, from the registry of the HeCOG, were analyzed retrospectively for their prognostic ...

journal_title：Anticancer research

authors： Pectasides D,Papaxoinis G,Fountzilas G,Aravantinos G,Pectasides E,Mouratidou D,Economopoulos T,Andreadis Ch

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:Molecular mechanisms responsible for carcinogenesis in upper urinary tract urothelial carcinoma (UUTUC) are not yet clear. This study aimed to examine and correlate the subcellular localization of activin A, maspin, and the androgen receptor (AR) with demographic characteristics, pathological grade, and stag...

journal_title：Anticancer research

authors： Rau KM,Chen YJ,Sun MT,Kang HY

更新日期：2011-05-01 00:00:00