Thymidine phosphorylase expression in gastric carcinoma as a marker for metastasis.

abstract：:Multidrug resistance (MDR) is a major clinical obstacle in the treatment of several cancers including hematological malignancies and solid tumors. The ATP-binding cassette transporter B1 (ABCB1) gene and its product, P-glycoprotein (P-gp), is one molecule that is involved in drug resistance. Here we report on the effe...

journal_title：Anticancer research

authors： Onda K,Suzuki R,Tanaka S,Oga H,Oka K,Hirano T

更新日期：2012-10-01 00:00:00

abstract：AIM:We analyzed pentafecta outcomes [complication-free, continence, potency, negative surgical margins (NSM)], biochemical recurrence (BCR)-free] of 230 patients undergoing robotic-assisted radical prostatectomy (RARP) with bilateral neurovascular (NVB) preservation. PATIENTS AND METHODS:Patient outcomes (group I, cas...

journal_title：Anticancer research

authors： Ou YC,Yang CK,Kang HM,Chang KS,Wang J,Hung SW,Tung MC,Tewari AK,Patel VR

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND/AIM:Activation of the c-JUN N-terminal kinase (JNK) signaling pathway has been associated with poor survival of ovarian cancer patients, but the role(s) and significance of JNK signaling in ovarian cancer cells remain poorly understood. In the present study, we aimed to investigate the role of JNK specifical...

journal_title：Anticancer research

authors： Seino M,Okada M,Shibuya K,Seino S,Suzuki S,Ohta T,Kurachi H,Kitanaka C

更新日期：2014-09-01 00:00:00

abstract：:Beta-casein-like protein (BCLP) is a putative protein on cervical cancer and exhibits immunological characteristics similar to those of bovine beta-casein. We evaluated if BCLP mRNA detection in the blood is useful in gynecologic malignancies. We examined 30 patients with uterine cancer, nine cultured cancer cell line...

journal_title：Anticancer research

authors： Baba T,Koizumi M,Suzuki T,Yamanaka I,Yamashita S,Kudo R

更新日期：2001-07-01 00:00:00

abstract：:Norcantharidin[3], the demethylated product of cantharidin[1] has been used for the treatment of hepatoma, carcinomas of esophagus and gastric cardia, leukopenia and hepatitis. Since the enzyme xanthine oxidase is involved in the diseases mentioned above, and the reactive oxygen species produced by the enzyme induces ...

journal_title：Anticancer research

authors： Tsauer W,Lin JG,Lin PY,Hsu FL,Chiang HC

更新日期：1997-05-01 00:00:00

abstract：:Among the limiting side-effects of anticancer drugs, hematological toxicity is the most frequent. Hematological analysis focuses on nucleated blood cells from mouse peripheral blood or hematopoietic organs (bone marrow, spleen, thymus). We have developed an automated method called A.H.E.A.D. (Automated Hematotoxicolog...

journal_title：Anticancer research

authors： Saint-Dizier D,Sancier M,Cudennec CA

更新日期：1990-05-01 00:00:00

abstract：BACKGROUND:Cervical cancer constitutes the second most common cancer in women. Estrogen promotes development of cervical cancer in cells infected with high risk human papillomaviruses (HPVs). We asked whether the phytochemical indole-3-carbinol (I3C) has anti-estrogenic activities in cervical cells with the goal of pre...

journal_title：Anticancer research

authors： Yuan F,Chen DZ,Liu K,Sepkovic DW,Bradlow HL,Auborn K

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:The mouse epidermal JB6 cell system is a model for studying tumor promotion. We used the JB6 Cl 41 cell line to examine the mechanism of the anti-tumor-promoting effect of tetrandrine, an alkaloid isolated from Stephania tetrandra S Moore. MATERIALS AND METHODS:The anti-tumor-promoting effect of tetrandrine...

journal_title：Anticancer research

authors： Nomura M,Yamazaki R,Takaya M,Kikuchi M,Takahashi-Nishioka T,Akiyama K,Akiyama N,Moritani S,Kobayashi S

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:S100(+) dendritic cells and CD57(+) lymphocytes are factors reflecting the immune system's ability to suppress the progress of tumor growth. CD57(+) cells include natural killer cells and late stages of T-effector lymphocytes. We evaluated the relationship between the known clinical and histological factors ...

journal_title：Anticancer research

authors： Liska V,Vycital O,Daum O,Novak P,Treska V,Bruha J,Pitule P,Holubec L

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:To evaluate the existence of an association between cervicovaginal infections and precancerous lesions of the uterine cervix, through determination of prevalent cervicovaginal micro-organisms, alone and in association with human papillomavirus (HPV), in patients with abnormal and normal vaginal cytology. PAT...

journal_title：Anticancer research

authors： Lukic A,Canzio C,Patella A,Giovagnoli M,Cipriani P,Frega A,Moscarini M

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND/AIM:To investigate the outcomes of laparoscopic surgery in colorectal cancer patients with dialysis. PATIENTS AND METHODS:Fourteen dialysis (dialysis group) and 567 non-dialysis (non-dialysis group) patients who underwent laparoscopic and open surgery for colorectal cancer between April 2008 and December 20...

journal_title：Anticancer research

authors： Higashino N,Matsuda T,Hasegawa H,Yamashita K,Sakamoto H,Fujikawa M,Yamamoto M,Kanaji S,Oshikiri T,Nakamura T,Suzuki S,Kakeji Y

更新日期：2020-04-01 00:00:00

abstract：:A universal intracellular factor, the "M phase-promoting factor" (MPF), triggers the G2/M transition of the cell cycle in all organisms. In late G2, it is present as an inactive complex of tyrosine-phosphorylated p34cdc2 and unphosphorylated cyclin Bcdc13. In M phase, its activation as an active MPF displaying histone...

journal_title：Anticancer research

authors： Baratte B,Meijer L,Galaktionov K,Beach D

更新日期：1992-05-01 00:00:00

abstract：:In order to improve the treatment of advanced H&N cancer we must consider to adopt new strategies as: new/better cytostatic agents; new combinations of present cytostatic agents and; potentiation of radiotherapy and cytostatic agents by biochemical modulation, which we define as potentiation of therapy by non-chemothe...

journal_title：Anticancer research

authors： Wennerberg J,Kjellén E,Lybak S,Rydell R,Pero R

更新日期：1993-11-01 00:00:00

abstract：:Prophylactic cranial irradiation (PCI) is still an open question despite the fact that ten randomized trials have been published in the past, addressing its impact on overall survival, disease-free survival and incidence of brain recurrences. The majority of these trials allow us to conclude that PCI is only useful in...

journal_title：Anticancer research

authors： Vitale V,Scolaro T,Orsatti M

更新日期：1994-01-01 00:00:00

abstract：:The poor prognosis of advanced gastric carcinoma requires new therapeutic approaches. Among these, the specific activation of resting lymphocytes by bispecific antibodies may be promising. Here we describe the generation and function of a bispecific monoclonal antibody (bi-mab) with specificity for CD3 and for the tum...

journal_title：Anticancer research

authors： Hombach A,Mathas S,Jensen M,Tillmann T,Menges M,Diehl V,Kruis W,Pohl C

更新日期：1997-05-01 00:00:00

abstract：:Taking into account the possible regulatory influences of the beta-adrenergic system on lymphocyte proliferation as well as the proposed role of cyclic 3'-5'-adenosine monophosphate (cAMP) in the modulation of multidrug resistance (MDR) in tumour cells, we have tried to assess the status of the interactions between th...

journal_title：Anticancer research

authors： D'Amico C,Crescimanno M,Armata MG,Leonardi V,Palazzoadriano M,D'Alessandro N

更新日期：1992-11-01 00:00:00

abstract：:In the clinical setting, administration of high daily or bolus doses of vitamin D is often solely based on 25-hydroxyvitamin D [25(OH)D] testing. This review summarizes the evidence of the effect of vitamin D on cardiovascular disease (CVD). Meta-analyses of randomized controlled trials (RCTs) have demonstrated that C...

journal_title：Anticancer research

authors： Zittermann A,Pilz S

更新日期：2019-09-01 00:00:00

abstract：:Information on chromosomal structural rearrangements in leukemia and solid tumors was retracted from a computerized databank and the literature. A binomial test procedure was used to determine the statistical significance of the observed numbers of breaks. Some 131 human cancer-specific chromosomal structural rearrang...

journal_title：Anticancer research

authors： De Braekeleer M

更新日期：1988-11-01 00:00:00

abstract：:Colorectal cancers are often preceded by noninvasive neoplasias arising in the surface epithelium, namely tubular, tubulovillous and villous adenomas. That neoplasias may also arise in the colorectal crypts is less well known. Between 1998 and 2002, colonoscopies, rectoscopies and colorectal surgical specimens from 86...

journal_title：Anticancer research

authors： Rubio CA

更新日期：2005-11-01 00:00:00

abstract：:D-Penicillamine, a structural analog of cysteine, has the ability to chelate metal ions and reacts with cysteine. We have shown earlier that D-Penicillamin is a potential inhibitor of tat-mediated transactivation of HIV-1-LTR (14) and possesses anti-HIV-1 activity (23). Following this approach, we evaluated the anti-t...

journal_title：Anticancer research

authors： Demirhan I,Chandra A,Sarin PS,Hasselmayer O,Hofmann D,Chandra P

更新日期：2000-07-01 00:00:00

abstract：:The interleukins (IL)-6 and -10 and heat shock proteins (HSP) have an important role in the host-tumor interaction and in tumor bulk. HSP-90 may have a regulatory role in cytokine biosynthesis and prognostic value in some tumors. To define the role of IL-6, IL-10 and HSP-90 in prostate cancer progression the immunohis...

journal_title：Anticancer research

authors： Cardillo MR,Ippoliti F

更新日期：2006-09-01 00:00:00

abstract：:The effects of all-trans retinoic acid (ATRA), either alone or in combination with GM-CSF, on the induction of differentiation of a human myeloblastic leukemia cell line, ML-1, were investigated. ATRA alone caused only slight induction of NBT-reducing activity even at a high concentration (10(-7) M), but when combined...

journal_title：Anticancer research

authors： Oka Y,Takeda K

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND/AIM:AKT, also known as protein kinase B (PKB), is an established therapeutic target in cancer and its inhibitors are increasingly designed. The anti-cancer potential of a compound class naphthoquinones has been constantly realized. The current work aimed to explore AKT1 inhibitors from 1,4-naphthoquionone de...

journal_title：Anticancer research

authors： Rehan M,Mostafa M

更新日期：2019-07-01 00:00:00

abstract：:Game theory can be a powerful tool for generating testable hypotheses concerning biological systems. We present a simple game that has many features analogous to a developing cellular system. The game mimics random turning on of genes in cells. Despite the randomness explicit in the mechanism, the game nonetheless res...

journal_title：Anticancer research

authors： Root-Bernstein RS,Bernstein MI

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Cardiac tamponade, due to bleeding in the pericardial space after esophagectomy for esophageal cancer, is an extremely rare complication and may be associated with sudden hemodynamic instability that can lead to death unless there is prompt diagnosis and appropriate treatment. CASE REPORT:A 76-year-old man ...

journal_title：Anticancer research

authors： Ito S,Morita M,Nanbara S,Nakaji Y,Ando K,Hiyoshi Y,Okamoto T,Saeki H,Oki E,Kawanaka H,Tanoue Y,Maehara Y

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The feasibility and diagnostic reliability of sentinel lymph node biopsy of gastric carcinoma are still unclear and controversial. PATIENTS AND METHODS:To assess the applicability of the sentinel node concept to gastric carcinoma, we retrospectively analyzed the location of metastatic lymph nodes in patient...

journal_title：Anticancer research

authors： Moenig SP,Luebke T,Baldus SE,Schroeder W,Bollschweiler E,Schneider PM,Hoelscher AH

更新日期：2005-03-01 00:00:00

abstract：:Eighteen patients with advanced melanoma of the limbs underwent a single isolation perfusion with melphalan under normothermic conditions, i.e. tissue temperatures between 37.0 and 38.0 degrees C. There were no major complications. In 7 patients complete remission was achieved and in 8 the remission was partial, i.e. ...

journal_title：Anticancer research

authors： Kroon BB,Van Geel AN,Benckhuijsen C,Wieberdink J

更新日期：1987-05-01 00:00:00

abstract：BACKGROUND:Multidrug resistance, the principal mechanism by which cancer cells develop resistance to chemotherapy drugs, is a major factor in the failure of many forms of chemotherapies. AIM:The aim of the study was to investigate the effect of K-2-11 on the reversal of multidrug resistance. MATERIALS AND METHODS:The...

journal_title：Anticancer research

authors： Cindric M,Cipak A,Serly J,Plotniece A,Jaganjac M,Mrakovcic L,Lovakovic T,Dedic A,Soldo I,Duburs G,Zarkovic N,Molnár J

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND/AIM:We performed a phase II study of triple-drug combination chemoradiotherapy (DCF-R therapy), in which docetaxel was added to the standard chemoradiotherapy (cisplatin [CDDP]/5-fluorouracil [5-FU]) for unresectable advanced esophageal cancer. PATIENTS AND METHODS:Sixty-one patients with unresectable advan...

journal_title：Anticancer research

authors： Takahashi K,Osaka Y,Ota Y,Watanabe T,Iwasaki K,Tachibana S,Nagakawa Y,Katsumata K,Tsuchida A

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Carbon ion radiotherapy has precise dose distribution and high biological effectiveness and is likely a promising therapy for patients with sarcomas. We evaluated the outcomes of carbon ion radiotherapy in patients with unresectable chondrosarcomas. PATIENTS AND METHODS:A retrospective analysis of 75 tumors...

journal_title：Anticancer research

authors： Imai R,Kamada T,Araki N,WORKING GROUP FOR BONE and SOFT-TISSUE SARCOMAS.

更新日期：2017-12-01 00:00:00