当前位置： SCI文献检索 > ANTICANCER RESEARCH期刊下所有文献 > Phase II Study of Docetaxel, Cisplatin, and 5-Fluorouracil Chemoradiotherapy for Unresectable Esophageal Cancer.

Phase II Study of Docetaxel, Cisplatin, and 5-Fluorouracil Chemoradiotherapy for Unresectable Esophageal Cancer.

Abstract：

BACKGROUND/AIM:We performed a phase II study of triple-drug combination chemoradiotherapy (DCF-R therapy), in which docetaxel was added to the standard chemoradiotherapy (cisplatin [CDDP]/5-fluorouracil [5-FU]) for unresectable advanced esophageal cancer. PATIENTS AND METHODS:Sixty-one patients with unresectable advanced esophageal cancer underwent the following DCF-R therapy: intravenous infusion of l60 mg/m2 docetaxel and 60 mg/m2 of CDDP (day 1), and 600 mg/m2 of 5-FU (days 1-5); 2 courses administered within a 4-week interval. Radiotherapy comprised 60 Gy in total. RESULTS:Response rates were 85.2% for the main lesion, 80.7% for metastasized lymph nodes, and 67.6% for distant organ metastases. Common adverse effects were leukopenia, anemia, and nausea, in 98.4%, 62.3%, and 60.7% of patients, respectively. Treatment completion rate was 90.2% and no treatment-associated deaths occurred. Median survival time was 406 days and 1-, 2-, and 5-year survival rates were 58.6%, 39.1%, and 22.8%, respectively. CONCLUSION:DCF-R therapy for unresectable advanced esophageal cancer demonstrated a high antitumor effect with sufficient safety.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Takahashi K,Osaka Y,Ota Y,Watanabe T,Iwasaki K,Tachibana S,Nagakawa Y,Katsumata K,Tsuchida A

doi

10.21873/anticanres.14256

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

2827-2832

issue

5

eissn

0250-7005

issn

1791-7530

pii

40/5/2827

journal_volume

40

pub_type

杂志文章

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