Abstract：
BACKGROUND:Carbon ion radiotherapy has precise dose distribution and high biological effectiveness and is likely a promising therapy for patients with sarcomas. We evaluated the outcomes of carbon ion radiotherapy in patients with unresectable chondrosarcomas. PATIENTS AND METHODS:A retrospective analysis of 75 tumors in 73 patients treated with carbon ion radiotherapy was performed. There were 26 spinal, 38 pelvic, and 11 other types of tumors. Seventy conventional and five dedifferentiated chondrosarcomas were treated in 69 and four patients, respectively. RESULTS:The median follow-up period was 49.4 (range=6.4-146.4) months. The 5-year local control, overall survival, and disease-free survival rates were 53%, 53%, and 34%, respectively. By multivariate analysis, tumor volume and histological grade were significantly related to overall and disease-free survival. Five patients required surgical intervention because of adverse events in the bones. CONCLUSION:Carbon ion radiotherapy might be a treatment option for unresectable chondrosarcoma.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Imai R,Kamada T,Araki N,WORKING GROUP FOR BONE and SOFT-TISSUE SARCOMAS.doi
10.21873/anticanres.12162subject
Has Abstractpub_date
2017-12-01 00:00:00pages
6959-6964issue
12eissn
0250-7005issn
1791-7530pii
37/12/6959journal_volume
37pub_type
杂志文章abstract：:Novel treatment strategies for cancer that are based on a more detailed understanding over the tumor biology are based on the latest new technology and are expected to improve the current treatment outcome for patients with cancer. However, many of these strategies still have one common and critical problem, being the...
journal_title：Anticancer research
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