Novel treatment strategies for cancer and their tumor-targeting approaches using antibodies against tumor-associated antigens.

abstract：BACKGROUND/AIM:Patients with metastatic head-and-neck cancer require individual therapies facilitated by prognostic tools. A tool to estimate the risk of recurrent or new cerebral metastases following whole-brain irradiation (WBI) is presented. PATIENTS AND METHODS:Age, gender, performance status, cancer site, number ...

journal_title：Anticancer research

authors： Staackmann C,Janssen S,Schild SE,Rades D

更新日期：2018-07-01 00:00:00

abstract：:Hormone refractory prostate cancer remains an incurable disease. Newer agents with more activity are required. Genistein is a flavone compound with anti-tumor activity against various tumor systems in vitro. This study is undertaken to assess the efficacy of genistein against hormone refractory prostate cancer. In vit...

journal_title：Anticancer research

authors： Naik HR,Lehr JE,Pienta KJ

更新日期：1994-11-01 00:00:00

abstract：:AIDS-related Epstein-Barr virus (EBV)-associated T cell lymphomas are emerging as a new, distinct histopathological entity. The pathway whereby EBV infects T cells as well as the initial EBV transcriptional program in T cells has not been established. In order to shed light on the early events of the EBV infection of ...

journal_title：Anticancer research

authors： Guan M,Romano G,Henderson EE

更新日期：1998-09-01 00:00:00

abstract：:A study on clinical and histological features of prognostic significance was performed in 45 patients with Ph1+ -CML who showed median survival of 36 months. The histological features were evaluated by morphometry of iliac crest biopsies. Among the variables correlated with prognosis, we eliminated those without prima...

journal_title：Anticancer research

authors： Thiele J,Fohlmeister I,Vonneguth B,Zankovich R,Fischer R

更新日期：1986-11-01 00:00:00

abstract：BACKGROUND:A 51-year-old woman experienced refractory chemotherapy-induced nausea and vomiting (CINV) in spite of extensive antiemetic therapy, including 5-HT3 antagonists, corticosteroids, dopamine antagonists and antihistamines. CASE REPORT:We administered the patient clonazepam. After taking clonazepam, the patient...

journal_title：Anticancer research

authors： Koga M,Nakadozono M,Nukariya K,Nogi H,Kobayashi T,Nakayama K

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Clofarabine is a second-generation nucleoside analogue. The aim of the study was the analysis of ex vivo activity of clofarabine and 14 other anticancer drugs in pediatric and adult acute lymphoblastic (ALL) and myeloid (AML) leukemia. PATIENTS AND METHODS:The ex vivo drug resistance profile was analyzed in...

journal_title：Anticancer research

authors： Styczynski J,Gil L,Derwich K,Wachowiak J,Balwierz W,Badowska W,Krawczuk-Rybak M,Matysiak M,Wieczorek M,Balcerska A,Sonta-Jakimczyk D,Stefaniak J,Kowalczyk J,Urasinski T,Sobol G,Komarnicki M,Wysocki M

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:High thymidine kinase (TK) activity in cancer cells could counteract adjuvant chemotherapy directed at the inhibition of de novo DNA synthesis. TK is an independent prognostic factor in breast cancer patients receiving adjuvant chemotherapy. MATERIAL AND METHODS:In this paper, we describe the effects of ext...

journal_title：Anticancer research

authors： Span P,Heuvel J,Romain S,Piffanelli A,Martin PM,Geurts-Moespot A,Sweep F

更新日期：2000-03-01 00:00:00

abstract：BACKGROUND:Experimental data at the molecular, cellular and organismal levels have implicated dietary components in cancer. Exposure to numerous growth factors, hormones and environmental agents, that can regulate signaling events, is involved in carcinogenesis. Research targets on gene-nutrient interactions may give u...

journal_title：Anticancer research

authors： Updike MS,Sawdy JC,Wang LS,Liu S,Huang YW,Ye W,Farrar WB,Lin YC,Wick M

更新日期：2007-01-01 00:00:00

abstract：:In the study of 65 matched pairs of lung tumor tissue and normal lung parenchyma, cathepsin B (CB) activity was found to be increased about 4.6-fold, when regarding median levels. CB activity was found to be insignificantly higher in adenocarcinoma compared to the other histologic cell types. CB levels did not correla...

journal_title：Anticancer research

authors： Ebert W,Knoch H,Werle B,Trefz G,Muley T,Spiess E

更新日期：1994-05-01 00:00:00

abstract：:Using the PM3 method, the interactions between chlorpromazine (CPZ) with 2'-deoxyguanosine-5'-monophosphate (dGMP) were examined. We obtained the optimized geometrical structure of each CPZ, dGMP and a CPZ-dGMP system in both aqueous-phase and gaseous-phase and investigated their geometric and electric changes and For...

journal_title：Anticancer research

authors： Kurihara T,Motohashi N,Kobayashi H,Yamanaka W,Dohyashiki S,Molnár J

更新日期：1998-09-01 00:00:00

abstract：:We assessed the prognostic value of the local tumor characteristics inflammatory stromal reaction (ISR) and vascular space invasion (VSI) together with established prognostic criteria, in cervical cancer patients. One hundred and forty-two patients with carcinoma of the cervix stage IB to IIB undergoing radical hyster...

journal_title：Anticancer research

authors： Kainz C,Gitsch G,Tempfer C,Heinzl H,Koelbl H,Breitecker G,Reinthaller A

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:Several types of human papilloma virus (HPV) have been associated with increased risk for epithelial malignancies. In light of a recently available vaccine that protects against persistent infection by certain HPV types (6, 11, 16, 18) and resulting neoplasias, the prevalence of HPV types was investigated in...

journal_title：Anticancer research

authors： Yapijakis C,Adamopoulou M,Antonopoulos G,Koufaliotis N,Vairaktaris E

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Pemetrexed and erlotinib represent novel agents for the treatment of non-small cell lung cancer (NSCLC). The role of sequential treatment in NSCLC has not been elucidated yet. We compared the efficacy of second-line pemetrexed followed by third-line erlotinib (P-E) to treatment with the reverse sequence (E-P...

journal_title：Anticancer research

authors： Fiala O,Pesek M,Finek J,Benesova L,Bortlicek Z,Minarik M

更新日期：2013-08-01 00:00:00

abstract：:When mouse resident peritoneal macrophages were cultured with PSK (Krestin), a protein-bound polysaccharide extracted from Coriolus versicolor, they became enlarged and elongated and expressed higher NBT-reducing activity. PSK stimulated the production of differentiation-inducing factor and cytotoxic factor by the mou...

journal_title：Anticancer research

authors： Kurakata Y,Sakagami H,Sato A,Kikuchi K,Takeda M,Asano K,Sato T

更新日期：1991-09-01 00:00:00

abstract：BACKGROUND:It has been demonstrated that 2-Methoxyestradiol (2-ME), one of the estrogen metabolites, induces apoptosis in many different tumor cell lines. In the present study, the effects of 2-ME on human cervical cancer HeLaS3 cells and on normal cervical epithelial cells were evaluated. MATERIALS AND METHODS:Acridi...

journal_title：Anticancer research

authors： Li L,Bu S,Bäckström T,Landström M,Ulmsten U,Fu X

更新日期：2004-03-01 00:00:00

abstract：AIM:Mitotane is used in adrenal cancer as adjuvant therapy, monotherapy or combined with other cytotoxic agents in advanced disease, but only 30% of patients respond. The aim of this study was to define the structural requirements for drug activity and to develop analogs with improved adrenalytic action. MATERIALS AND...

journal_title：Anticancer research

authors： Schteingart DE,Sinsheimer JE,Benitez RS,Homan DF,Johnson TD,Counsell RE

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Locally recurrent rate of advanced head and neck squamous cell carcinoma (HNSCC) still remains high and the treatment is controversial. PATIENTS AND METHODS:We retrospectively analyzed ninety-three patients with recurrent advanced oral cancer from 2009 to 2013. Sixty-four patients are in the docetaxel with ...

journal_title：Anticancer research

authors： Yang WC,Chen CH,Tang JY,Wu CF,Liu YC,Sun Y,Lin SF

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Combination chemotherapy of irinotecan and amrubicin for advanced non-small cell lung cancer (NSCLC) has not been fully evaluated. To determine the maximum-tolerated dose (MTD), a phase I study in patients with advanced NSCLC was conducted. MATERIALS AND METHODS:Patients with stage IIIB/IV NSCLC were enroll...

journal_title：Anticancer research

authors： Hotta K,Takigawa N,Kiura K,Tabata M,Umemura S,Ogino A,Uchida A,Bessho A,Segawa Y,Shinkai T,Nogami N,Harita S,Okimoto N,Ueoka H,Tanimoto M

更新日期：2005-05-01 00:00:00

abstract：AIM:The aim of the present study was to investigate the prognostic impact of central nervous system metastases (CNS) after acquired resistance to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) in EGFR-mutant non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:We defined CNS-collapse as de...

journal_title：Anticancer research

authors： Hata A,Katakami N,Yoshioka H,Takeshita J,Tanaka K,Masago K,Fujita S,Kaji R,Imai Y,Monden K,Matsumoto T,Nagata K,Otsuka K,Tachikawa R,Tomii K,Kunimasa K,Iwasaku M,Nishiyama A,Ishida T,Nishimura Y

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:To investigate the differences between two rat yolk sac tumor cell lines with different radiosensitivities and p53 status in sensitivity to high-LET heavy-ion beam and in sensitizing effect of etoposide or cisplatin in combination with heavy-ion beam. MATERIALS AND METHODS:NMT-1 (wild-type p53 cell) is a pa...

journal_title：Anticancer research

authors： Takahashi T,Fukawa T,Hirayama R,Yoshida Y,Musha A,Furusawa Y,Ando K,Nakano T

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:To investigate the role of body composition and oxidative stress measured by total thiol groups (TTG) levels in prostate specimens of patients affected by benign prostatic hyperplasia (BPH) or prostate cancer (PCa). PATIENTS AND METHODS:From January 2011 to January 2013, a cohort of 150 consecutive male pati...

journal_title：Anticancer research

authors： Cimino S,Favilla V,Russo GI,Galvano F,Li Volti G,Barbagallo I,Giofrè SV,D'Orazio N,DI Rosa A,Madonia M,Morgia G

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND/AIM:Soluble mesothelin-related peptide (SMRP) is regarded as a biomarker of malignant pleural mesothelioma (MPM). Herein, we compared the diagnostic performances of SMRP in matched pleural effusion (PE-SMRP) and serum (S-SMRP). MATERIALS AND METHODS:Diagnosis on pleural biopsies was performed for all patien...

journal_title：Anticancer research

authors： Ferro P,Canessa PA,Battolla E,Dessanti P,Franceschini MC,Chiaffi L,Morabito A,Fontana V,Pezzi R,Fedeli F,Pistillo MP,Roncella S

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND/AIM:Leiomyosarcoma is an extremely rare, small bowel neoplasm (2% of all gastrointestinal tumours). Early diagnosis is challenging due to the slow growth of the cancer. The biological behaviour of this group of tumours is aggressive, and the first-line treatment is surgical resection. PATIENTS AND METHODS:T...

journal_title：Anticancer research

authors： Ferrari C,DI Domenico S,Mascherini M,Santoliquido M,Mastracci L,DE Cian F

更新日期：2020-07-01 00:00:00

abstract：:We studied a consecutive series of 54 cases of lower lip squamous cell carcinoma (LLSCC) in order to identify any variables which might predict the development of lymph node metastases. The cases were divided into 38 tumors without metastases (group I) and 16 tumors with lymph node metastases (group II). The following...

journal_title：Anticancer research

authors： Rodolico V,Daniele E,Leonardi V,Marra G,Luciani A,Settineri G,Tralongo V

更新日期：1998-03-01 00:00:00

abstract：:Intratumoral (cervix uterine tumors) distribution of platinum was studied in ten patients after IV administration of CDDP. Sequential tumoral measurement of platinum was carried out 4, 24, and 48 h after the IV infusion. Platinum concentration in the tumor samples ranged from 0 to 29,5 ng/mg tissue. For all patients, ...

journal_title：Anticancer research

authors： Vennin P,Hecquet B,Fournier C,Demaille MC,Adenis L

更新日期：1985-07-01 00:00:00

abstract：BACKGROUND:S100(+) dendritic cells and CD57(+) lymphocytes are factors reflecting the immune system's ability to suppress the progress of tumor growth. CD57(+) cells include natural killer cells and late stages of T-effector lymphocytes. We evaluated the relationship between the known clinical and histological factors ...

journal_title：Anticancer research

authors： Liska V,Vycital O,Daum O,Novak P,Treska V,Bruha J,Pitule P,Holubec L

更新日期：2012-05-01 00:00:00

abstract：:We examined the antitumor effect of lipopolysaccharide extracted from Pantoea agglomerans, a Gram-negative bacterium, using intradermal administration on murine syngeneic tumors, Meth A fibrosarcoma, MH134 hepatoma and Lewis lung (LL) carcinoma. The latter two tumors are known to be relatively low in immunogenicity, h...

journal_title：Anticancer research

authors： Inagawa H,Nishizawa T,Noguchi K,Minamimura M,Takagi K,Goto S,Soma G,Mizuno D

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:F-Box protein 45 (FBXO45) is reported to be associated with cancer aggressiveness. We investigated the relationship between FBXO45 and clinicopathological factors in gastric cancer (GC). MATERIALS AND METHODS:We used immunohistochemistry to investigate FBXO45 expression in 104 GC samples; the prognostic val...

journal_title：Anticancer research

authors： Kogure N,Yokobori T,Ogata K,Altan B,Mochiki E,Ohno T,Toyomasu Y,Yanai M,Kimura A,Yanoma T,Suzuki M,Bai T,Asao T,Kuwano H

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:Matrix metalloproteinase-2 (MMP-2) and its tissue inhibitor (TIMP-2) are important regulators of cancer invasion and metastasis. Their associations to high-risk (HR) human papillomavirus (HPV) in cervical intra-epithelial neoplasia (CIN) and cervical cancer (CC) are unexplored and their prognostic significanc...

journal_title：Anticancer research

authors： Branca M,Ciotti M,Giorgi C,Santini D,Di Bonito L,Costa S,Benedetto A,Bonifacio D,Di Bonito P,Paba P,Accardi L,Syrjänen S,Favalli C,Syrjänen K,HPV-PathogenISS Study Group.

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Docetaxel is a very active drug against breast cancer, but at the standard dose causes severe myelosuppression. In order to reduce the toxicity while maintaining the activity, weekly docetaxel administration was tested. PATIENTS AND METHODS:We enrolled 30 patients with metastatic breast cancer, who had been...

journal_title：Anticancer research

authors： Maisano R,Mare M,Zavettieri M,Caristi N,Mesiti M,Scisca C,La Torre F

更新日期：2003-03-01 00:00:00