Anti-tumor effect of lipopolysaccharide by intradermal administration as a novel drug delivery system.

Abstract:

:We examined the antitumor effect of lipopolysaccharide extracted from Pantoea agglomerans, a Gram-negative bacterium, using intradermal administration on murine syngeneic tumors, Meth A fibrosarcoma, MH134 hepatoma and Lewis lung (LL) carcinoma. The latter two tumors are known to be relatively low in immunogenicity, highly metastatic and to have low sensitivity to biological response modifiers. Although the intradermal administration of LPSp had a significantly suppressive effect on the growth of all tumors, including seventy-five percent of complete regression of mice bearing Meth A tumor, no complete regression was observed in MH134 or LL tumors. In combination with cyclophosphamide given once prior to the administration of LPS, however, the antitumor effects by intradermal administration of LPS were significantly augmented and there was complete regression in all types of tumors. Pretreatment by anti-tumor necrosis factor antibody reduced the effect exerted by LPS, suggesting that induced tumor necrosis factor might have a crucial role. Toxicity of intradermal administration of LPS was 230-380 times less than that by the intravenous route. Thus clinical application of LPS administered intradermally in combination with chemotherapeutics such as cyclophosphamide appears promising in terms of its antitumor effect as well as toxicity.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Inagawa H,Nishizawa T,Noguchi K,Minamimura M,Takagi K,Goto S,Soma G,Mizuno D

subject

Has Abstract

pub_date

1997-05-01 00:00:00

pages

2153-8

issue

3C

eissn

0250-7005

issn

1791-7530

journal_volume

17

pub_type

杂志文章
  • Treatment of unresectable glioblastoma multiforme.

    abstract::Uncertainty exists about the adequate treatment of adult patients with unresectable, primary, biopsy-proven glioblastoma multiforme (GBM), because the different options for this group of patients have not been evaluated in randomized clinical trials to date. Usually, these patients are lumped together in studies of ra...

    journal_title:Anticancer research

    pub_type: 杂志文章,评审

    doi:

    authors: Nieder C,Grosu AL,Astner S,Molls M

    更新日期:2005-11-01 00:00:00

  • Pegylated liposomal doxorubicin in the CHOP regimen for older patients with aggressive (stages III/IV) non-Hodgkin's lymphoma.

    abstract::Pegylated liposomal doxorubicin is associated with a lower risk of cardiotoxocity than conventional formulations of doxorubicin, allowing the use of higher cumulative doses. In this Phase II study, 25 patients aged over 70 years (median 79, range 75-82 years) with aggressive non-Hodgkin's lymphoma (NHL) (International...

    journal_title:Anticancer research

    pub_type: 临床试验,杂志文章,多中心研究

    doi:

    authors: Tsavaris N,Kosmas C,Vadiaka M,Giannouli S,Siakantaris MP,Vassilakopoulos T,Pangalis GA

    更新日期:2002-05-01 00:00:00

  • Intraperitoneal Chemotherapy in Patients Pretreated for Ovarian Cancer Matched with Patients Treated with Parenteral Chemotherapy.

    abstract:BACKGROUND:Our aim was to analyze the impact of intraperitoneal chemotherapy (IPC), administered with direct peritoneal puncture, on the survival of patients with pretreated ovarian cancer in a real-life setting. PATIENTS AND METHODS:This was a retrospective study comparing patients with advanced ovarian cancer treate...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.11256

    authors: Nicoletto MO,Casarin A,Baldoni A,Rulli E,Tasca G,Baretta Z,Artioli G,Lombardi G,Cappetta A,Floriani I,Randon G,Valpione S,Litta P,Conte P,Mocellin S,Aliberti C

    更新日期:2016-12-01 00:00:00

  • Tumor-specific cytotoxicity and type of cell death induced by beta-cyclodextrin benzaldehyde inclusion compound.

    abstract::The cytotoxicity of beta-cyclodextrin benzaldehyde inclusion compound (CDBA) against human normal and cancer cell lines was investigated. CDBA showed slightly higher cytotoxicity against human tumor cell lines, as compared to normal cells, with a tumor-specificity index of 2.2. Human myelogenous leukemia cell lines (H...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Liu Y,Sakagami H,Hashimoto K,Kikuchi H,Amano O,Ishihara M,Kanda Y,Kunii S,Kochi M,Zhang W,Yu G

    更新日期:2008-01-01 00:00:00

  • PCNA--a cell proliferation marker in vocal chord cancer. Part I: Premalignant laryngeal lesions.

    abstract::Laryngeal hyperkeratotic lesions can progress to fully developed malignant carcinoma in some cases. These premalignant lesions are proliferative disorders whose potential for further tumour progression is perhaps difficult to assess by mere histology. Immunostaining with PCNA, a protein correlated with cell proliferat...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Pignataro LD,Broich G,Lavezzi AM,Biondo B,Ottaviani F

    更新日期:1995-07-01 00:00:00

  • Parent of Origin and Prognosis in Familial Breast Cancer in Sweden.

    abstract:BACKGROUND:It has been suggested that prognosis in familial breast cancer could be influenced by the parent of origin, with a worse prognosis when inherited paternally. This study aimed to investigate the effect of the parent of origin on prognosis. PATIENTS AND METHODS:Index patients were divided into two study group...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.11442

    authors: Wendt C,Lindblom A,Arver B,VON Wachenfeldt A,Margolin S

    更新日期:2017-03-01 00:00:00

  • Effect of verapamil on the expression of EGFR and NM23 in A549 human lung cancer cells.

    abstract::Despite the advances in the detection and treatment of lung cancer, the overall 5-year survival is only 10-20%. Accumulating evidence suggests that verapamil, a calcium channel antagonist, is a potential anticancer agent. Epidermal growth factor receptor (EGFR) is a key therapeutic target in many types of cancer, wher...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Zhang C,Lv F,Zhou L,Li X,Wu XX,Hoffman RM

    更新日期:2009-01-01 00:00:00

  • [111In-DTPA-D-Phe1]-octreotide scintigraphy in patients with hormone-refractory prostatic adenocarcinoma can predict therapy outcome with octreotide treatment: a pilot study.

    abstract::A pilot study to evaluate the predictive value of Indium-111-labelled somatostatin analogue [DTPA-D-Phe1]-octreotide scintigraphy (OctreoScan111) in the Octreotide treatment of hormone-refractory prostatic adenocarcinoma was initiated. Ten patients were investigated with OctreoScan111 with regard to disease extension ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Kälkner KM,Nilsson S,Westlin JE

    更新日期:1998-01-01 00:00:00

  • Aberrant methylation of the Ras-related associated with diabetes gene in human primary esophageal cancer.

    abstract:BACKGROUND/AIM:Ras-related associated with diabetes (RRAD), a member of the Ras-related GTPase superfamily, is frequently methylated in several human cancers, though its methylation profile remains unclear in esophageal cancer. MATERIALS AND METHODS:We examined RRAD promoter hypermethylation using real-time quantitati...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Jin Z,Feng X,Jian Q,Cheng Y,Gao Y,Zhang X,Wang L,Zhang Y,Huang W,Fan X,Chen S,Yu H,Zhao Z,Dong M,Liu J,Mori Y,Meltzer SJ

    更新日期:2013-11-01 00:00:00

  • Enhancement of bleomycin activity by 3-aminobenzamide, a poly (ADP-ribose) synthesis inhibitor, in vitro and in vivo.

    abstract::A series of poly (ADP-ribose) synthesis inhibitors was evaluated for their ability to potentiate the cytotoxicity of bleomycin compared with their inhibition of poly(ADP-ribose) synthesis in L1210 cultured cells. Theophylline, nicotinamide, 3-aminobenzamide and thymidine inhibited 70 to 80% of poly(ADP-ribose) synthes...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Kato T,Suzumura Y,Fukushima M

    更新日期:1988-03-01 00:00:00

  • Surgical treatment of hepatocellular carcinoma in elderly cirrhotic patients: personal experience.

    abstract:BACKGROUND:Due to the longer life expectancy of the world's population, the number of elderly cirrhotic patients undergoing surgery for hepatocellular carcinoma (HCC) is increasing. Our study evaluates the benefits of hepatic resections for HCC in cirrhotic patients aged over 65, analysing the early and long-term surgi...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Mercantini P,Corigliano N,Lucandri G,Balducci G,Amodio PM,Ramacciato G,Ziparo V

    更新日期:2002-11-01 00:00:00

  • Effect of Fibroblast Growth Factor-2 and its Receptor Gene Polymorphisms on the Survival of Patients With Hepatitis B Virus-associated Hepatocellular Carcinoma.

    abstract:BACKGROUND/AIM:Fibroblast growth factor (FGF), vascular endothelial growth factor, and hepatocyte growth factor play a critical role in the pathogenesis of hepatocellular carcinoma (HCC). MATERIALS AND METHODS:We assessed nine single nucleotide polymorphisms (SNPs) in the FGF1, FGF2, FGF receptor (FGFR)-2, Flt-1, and ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.13337

    authors: Kim SS,Eun JW,Cho HJ,Lee HY,Seo CW,Noh CK,Shin SJ,Lee KM,Cho SW,Cheong JY

    更新日期:2019-04-01 00:00:00

  • Thyroid Hormones, Silencing Mediator for Retinoid and Thyroid Receptors and Prognosis in Primary Breast Cancer.

    abstract:BACKGROUND/AIM:Silencing mediator of retinoid and thyroid receptors (SMRT) is a nuclear corepressor in thyroid and estrogen hormones pathways. The aim was to evaluate SMRT expression in relation to thyroid hormone levels and prognostic markers in breast cancer (BC). PATIENTS AND METHODS:Serum and tumor tissues were ob...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.14663

    authors: Nisman B,Allweis TM,Carmon E,Kadouri L,Maly B,Maimon O,Meierovich A,Peretz T

    更新日期:2020-11-01 00:00:00

  • RBPJ and MAML3: Potential Therapeutic Targets for Small Cell Lung Cancer.

    abstract:BACKGROUND/AIM:Small cell lung cancer (SCLC) is still a deadly type of cancer for which there are few effective therapeutic strategies. Development of a new molecule targeting agent is urgently desired. Previously we showed that recombination signal binding protein for immunoglobulin-kappa-J region (RBPJ) and mastermin...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.12758

    authors: Onishi H,Ichimiya S,Yanai K,Umebayashi M,Nakamura K,Yamasaki A,Imaizumi A,Nagai S,Murahashi M,Ogata H,Morisaki T

    更新日期:2018-08-01 00:00:00

  • Toxic proteins from European mistletoe (Viscum album L.): increase of intracellular IL-4 but decrease of IFN-gamma in apoptotic cells.

    abstract:BACKGROUND:Mistletoe lectins (ML), the major biologically active components of mistletoe extracts, which are used for adjuvant cancer therapy, induce apoptosis in lymphocytes and tumor cells. In addition, ML at toxic concentrations induce the release of cytokines, but it remains unclear as to whether dying or activated...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Stein GM,Pfüller U,Schietzel M,Büssing A

    更新日期:2000-05-01 00:00:00

  • Genomic Sequencing of Cancer-related Genes in Sinonasal Squamous Cell Carcinoma and Coexisting Inverted Papilloma.

    abstract:BACKGROUND:The genetic basis of sinonasal inverted papilloma (SNIP)-derived squamous cell carcinoma (SCC) has not yet been well characterized. AIM:To characterize the genetic abnormalities of SNIP and SNIP-derived SCC and to uncover their differences. MATERIALS AND METHODS:Mutations of 409 genes were analyzed using a...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.14752

    authors: Uchi R,Jiromaru R,Yasumatsu R,Yamamoto H,Hongo T,Manako T,Sato K,Hashimoto K,Wakasaki T,Matsuo M,Nakagawa T

    更新日期:2021-01-01 00:00:00

  • The tyrosine kinase inhibitor AG490 inhibits growth of cancer cells and activates ERK in LS174T and HT-29 cells.

    abstract:BACKGROUND:The activity of tyrosine kinases, although strictly regulated in normal cells, is often disturbed in cancer cells. The inhibition of a tyrosine kinase could be a target for treating cancer. MATERIALS AND METHODS:The colon cancer cell lines LS174T and HT-29 and the lung cancer cell line NCI-H292 were used. T...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Saito K,Iwashita J,Murata J,Abe T

    更新日期:2006-03-01 00:00:00

  • Pyruvate kinase type tumor M2 plasma levels in patients afflicted with rheumatic diseases.

    abstract:BACKGROUND:Since tumor markers can be increased in the course of many benign diseases, the aim of this study was to verify if this also occurs in the course of rheumatic diseases. MATERIALS AND METHODS:We investigated the incidence and characteristics of Tumor M2-PK in the EDTA-plasma of 137 patients suffering from rh...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Oremek GM,Müller R,Sapoutzis N,Wigand R

    更新日期:2003-03-01 00:00:00

  • Expression of copper-transporting P-type adenosine triphosphatase (ATP7B) in human hepatocellular carcinoma.

    abstract::One of the major obstacles in the treatment of hepatocellular carcinoma (HCC) is the intrinsic/acquired resistance to cisplatin-based chemotherapy. Copper-transporting P-type adenosine triphosphate (ATP7B) has been reported to be associated with cisplatin resistance in vitro. However, the expression of ATP7B has not p...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Sugeno H,Takebayashi Y,Higashimoto M,Ogura Y,Shibukawa G,Kanzaki A,Terada K,Sugiyama T,Watanabe K,Katoh R,Nitta Y,Fukushima T,Koyama Y,Inoue N,Sekikawa K,Ogawa K,Sato Y,Takenoshita S

    更新日期:2004-03-01 00:00:00

  • Vitamin D and pancreatic cancer risk - no U-shaped curve.

    abstract::In a recent paper entitled "Circulating 25-Hydroxyvitamin D and the Risk of Pancreatic Cancer," Stolzenberg-Solomon et al. reported that the odds ratio for diagnosis of pancreatic cancer shows a "statistically significant" precipitous jump of more than a factor of 2 at the highest presented concentrations of >100 nmol...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Baggerly LL,Garland CF

    更新日期:2012-03-01 00:00:00

  • Clinical Significance of Serum p53 Antibody in the Early Detection and Poor Prognosis of Gastric Cancer.

    abstract:BACKGROUND:The aim of this retrospective study was to evaluate the clinical relevance of serum p53 antibody (S-p53Ab) as a biomarker and to investigate whether its diagnostic value could be improved when combined with other biomarkers of gastric cancer (GC). PATIENTS AND METHODS:Serum samples were obtained preoperativ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.11540

    authors: Kunizaki M,Fukuda A,Wakata K,Tominaga T,Nonaka T,Miyazaki T,Matsumoto K,Sumida Y,Hidaka S,Yasutake T,Sawai T,Hamamoto R,Nanashima A,Nagayasu T

    更新日期:2017-04-01 00:00:00

  • Detectable Wilms' tumor-1 transcription at treatment completion is associated with poor prognosis of acute myeloid leukemia: a single institution's experience.

    abstract:BACKGROUND/AIM:The present retrospective study was conducted to measure Wilms' tumor-1 (WT1) mRNA levels in the peripheral blood of patients with acute myeloid leukemia (AML) in order to examine any association with the clinical outcomes. PATIENTS AND METHODS:A total of 58 AML patients were evaluated retrospectively i...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Yamauchi T,Negoro E,Lee S,Takai M,Matsuda Y,Takagi K,Kishi S,Tai K,Hosono N,Tasaki T,Ikegaya S,Yoshida A,Urasaki Y,Iwasaki H,Ueda T

    更新日期:2013-08-01 00:00:00

  • Sonodynamic therapy with 5-aminolevulinic acid and focused ultrasound for deep-seated intracranial glioma in rat.

    abstract:BACKGROUND:5-Aminolevulinic acid (5-ALA) has already been applied clinically as a photosensitizer. In this study, sonodynamically induced selective antitumour effect of 5-ALA for deep-seated lesions was evaluated. MATERIALS AND METHODS:First, normal rat brains were sonicated via a transducer placed on the dural surfac...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Ohmura T,Fukushima T,Shibaguchi H,Yoshizawa S,Inoue T,Kuroki M,Sasaki K,Umemura S

    更新日期:2011-07-01 00:00:00

  • Methylation state of the prostate specific membrane antigen (PSMA) CpG island in prostate cancer cell lines.

    abstract:BACKGROUND:PSMA expression varies among prostate cell lines. We examined the role of CpG methylation and histone deacetylation in PSMA transcriptional repression in prostate cell lines. MATERIALS AND METHODS:The methylation status of a PSMA CpG island was investigated in LNCaP, DU145 and PC3 prostate cell lines. Cells...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Noss KR,Singal R,Grimes SR

    更新日期:2002-05-01 00:00:00

  • IL-6, IL-10 and HSP-90 expression in tissue microarrays from human prostate cancer assessed by computer-assisted image analysis.

    abstract::The interleukins (IL)-6 and -10 and heat shock proteins (HSP) have an important role in the host-tumor interaction and in tumor bulk. HSP-90 may have a regulatory role in cytokine biosynthesis and prognostic value in some tumors. To define the role of IL-6, IL-10 and HSP-90 in prostate cancer progression the immunohis...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Cardillo MR,Ippoliti F

    更新日期:2006-09-01 00:00:00

  • Breast preserving surgery decision making.

    abstract::Mammography, and in special cases MRT, allow the detection of DCIS and microcarcinomas. Breast preserving surgery needs intraoperative care for tumor free margins. Decision making under favourable and unfavourable conditions is discussed. Tumor grading is important with respect to locoregional recurrences. Improvement...

    journal_title:Anticancer research

    pub_type: 杂志文章,评审

    doi:

    authors: Schauer A,Marx D,Schauer M,Binder C,Kuhn W,Meden H

    更新日期:1998-05-01 00:00:00

  • Optimal Tumor Reduction Rate and Modalities for Predicting pCR in Women With Breast Cancer.

    abstract:BACKGROUND/AIM:To predict pCR during neoadjuvant chemotherapy is still difficult. The aim of this study was to evaluate the optimal tumor reduction rate and modalities for predicting pCR after two cycles of docetaxel. PATIENTS AND METHODS:We analyzed 52 patients with HER2-positive or triple-negative breast cancer. The...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:10.21873/anticanres.14196

    authors: Kuba S,Maeda S,Matsumoto M,Yamanouchi K,Iwata T,Morita M,Sakimura C,Otsubo R,Yano H,Sato S,Kanetaka K,Nagayasu T,Eguchi S

    更新日期:2020-04-01 00:00:00

  • Influence of culture media and multidrug resistance on the wheat germ agglutinin (WGA) glycocytochemical expression of two human glioblastoma cell lines.

    abstract::Over the last two decades, many studies carried out with the aid of lectins have firmly established that cell glycans usually change in the course of the normal processes of growth and development, as well as in pathological situations. We describe here the in vivo binding expression of wheat germ agglutinin (WGA) to ...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Camby I,Salmon I,Rombaut K,Pasteels JL,Kiss R,Danguy A

    更新日期:1996-07-01 00:00:00

  • Novel system for generating cytotoxic effector lymphocytes using carcinoembryonic antigen (CEA) peptide and cultured dendritic cells.

    abstract::We have established a practical system for generating antitumor effector lymphocytes using the tumor antigen peptide CEA and cultured dendritic cells (DCs), and have also characterized effector cells. DCs were induced from the adherent cell population of autologous peripheral blood mononuclear cells (PBMCs) obtained f...

    journal_title:Anticancer research

    pub_type: 杂志文章

    doi:

    authors: Ohta K,Yamaguchi Y,Shimizu K,Miyahara E,Toge T

    更新日期:2002-09-01 00:00:00

  • Tiazofurin effects on IMP-dehydrogenase activity and expression in the leukemia cells of patients with CML blast crisis.

    abstract::Tricot et al have reported that the nucleoside analog tiazofurin can induce hematologic remissions in patients with chronic myelogenous leukemia in blast crisis (CML-BC). These reports prompted us to begin a derivative, phase II trial of tiazofurin in CML-BC to determine if the promising findings reported by these inv...

    journal_title:Anticancer research

    pub_type: 临床试验,杂志文章,多中心研究

    doi:

    authors: Wright DG,Boosalis MS,Waraska K,Oshry LJ,Weintraub LR,Vosburgh E

    更新日期:1996-11-01 00:00:00