当前位置： SCI文献检索 > ANTICANCER RESEARCH期刊下所有文献 > Activation of resting T cells against the CA 72-4 tumor antigen with an anti-CD3/CA 72-4 bispecific antibody in combination with a costimulatory anti-CD28 antibody.

Activation of resting T cells against the CA 72-4 tumor antigen with an anti-CD3/CA 72-4 bispecific antibody in combination with a costimulatory anti-CD28 antibody.

Abstract：

:The poor prognosis of advanced gastric carcinoma requires new therapeutic approaches. Among these, the specific activation of resting lymphocytes by bispecific antibodies may be promising. Here we describe the generation and function of a bispecific monoclonal antibody (bi-mab) with specificity for CD3 and for the tumor antigen CA72-4 (TAG72) on various gastrointestinal tumors. We established a hybrid/hybridoma by somatic fusion of two hybridoma lines secreting antibodies against CA72-4 and CD3 respectively and characterized its bimab OKT3/B72.3. In combination with costimulatory anti-CD28 antibodies resting peripheral lymphocytes could be activated specifically by bi-mab OKT3/B72.3 with T cell proliferation and IL-2 secretion. The bi-mab OKT3/B72.3 could also trigger the cytotoxicity of these T cells toward, CA72-4+ cells in vitro. Our results indicate, that bi-mab OKT3/B72.3 in combination with an anti-CD28 mab can redirect T cell cytotoxicity specifically against CA72-4+ tumor cells implicating a novel strategy for the specific immunotherapy of CA72-4+ tumors.

journal_name

Anticancer Res

journal_title

Anticancer research

authors

Hombach A,Mathas S,Jensen M,Tillmann T,Menges M,Diehl V,Kruis W,Pohl C

subject

Has Abstract

pub_date

1997-05-01 00:00:00

pages

2025-32

issue

3C

eissn

0250-7005

issn

1791-7530

journal_volume

17

pub_type

杂志文章

相关文献

ANTICANCER RESEARCH文献大全
  • Pharmacokinetics of a new platinum compound, cis-(glycolato-O,O) [(4R,5R)-4,5-bis(aminomethyl)-1,3-dioxolane-2-spiro-1'-cyclohexane]plat inum (II) in dogs.

    abstract：:A pharmacokinetic study on cis-(glycolato-O,O)/ (4R,5R)-4,5-bis(aminomethyl)-1,3-dioxolane-2-spiro-1'- cyclohexane]platinum(II) (SKI 2032R) was performed in dogs. A single dose of 2.0 mg/kg of SKI 2032R was administered i.v. bolus to three beagle dogs. Plasma samples were analyzed for platinum by flameless atomic abso...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Kim DK,Cho YB,Kim HT,Kim TS,Kim KH,Hong WS

    更新日期：1996-05-01 00:00:00

  • New anticancer immunotherapies.

    abstract：:The quest for immunotherapies against cancer has been ongoing for many years, and a greater understanding of the normal mechanisms involved in developing immune responses has now led to clinically effective therapies. With the licensing of Ipilimumab and Sipuleucel-T, immunotherapeutic strategies are taking their plac...

    journal_title：Anticancer research

    pub_type： 杂志文章,评审

    doi：

    authors： Franks HA,Wang Q,Patel PM

    更新日期：2012-07-01 00:00:00

  • Detection of p53 mutations in Hong Kong colorectal carcinomas by conventional PCR-SSCP analysis versus p53 yeast functional assays.

    abstract：BACKGROUND:Previous reports indicate that the p53 yeast functional assay is a highly sensitive method of detection of p53 mutations in clinical specimens. Our earlier report (1) showed a 35.4% p53 mutation frequency in Hong Kong colorectal carcinoma (CRC) patients, when conventional molecular screening techniques were ...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Leung CS,Lung ML

    更新日期：1999-01-01 00:00:00

  • Circulating tumor cells in metastatic breast cancer: timing of blood extraction for analysis.

    abstract：PURPOSE:Circulating tumor cells (CTCs) can be detected in the peripheral blood of around 50% of patients with metastatic breast cancer. Their numbers are an independent predictor of the patient's progression-free survival (PFS) and of overall survival (OS). However, to date, none of the studies carried out with the mos...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Martín M,García-Sáenz JA,Maestro De las Casas ML,Vidaurreta M,Puente J,Veganzones S,Rodríguez-Lajusticia L,De la Orden V,Oliva B,De la Torre JC,López-Tarruella S,Casado A,Sastre J,Díaz-Rubio E

    更新日期：2009-10-01 00:00:00

  • Pre-transplant Quantitative Determination of NPM1 Mutation Significantly Predicts Outcome of AIlogeneic Hematopoietic Stem Cell Transplantation in Patients with Normal Karyotype AML in Complete Remission.

    abstract：BACKGROUND/AIM:Minimal residual disease (MRD) in patients with acute myeloid leukemia (AML) before allogeneic hematopoietic stem cell transplantation (alloHSCT) can influence the results of therapy. With the aim of evaluating the potential role of pre-transplant MRD, we studied the impact of pre-transplant MRD level on...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：10.21873/anticanres.11130

    authors： Karas M,Steinerova K,Lysak D,Hrabetova M,Jungova A,Sramek J,Jindra P,Polivka J,Holubec L

    更新日期：2016-10-01 00:00:00

  • Detectable Wilms' tumor-1 transcription at treatment completion is associated with poor prognosis of acute myeloid leukemia: a single institution's experience.

    abstract：BACKGROUND/AIM:The present retrospective study was conducted to measure Wilms' tumor-1 (WT1) mRNA levels in the peripheral blood of patients with acute myeloid leukemia (AML) in order to examine any association with the clinical outcomes. PATIENTS AND METHODS:A total of 58 AML patients were evaluated retrospectively i...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Yamauchi T,Negoro E,Lee S,Takai M,Matsuda Y,Takagi K,Kishi S,Tai K,Hosono N,Tasaki T,Ikegaya S,Yoshida A,Urasaki Y,Iwasaki H,Ueda T

    更新日期：2013-08-01 00:00:00

  • PTHrP regulates angiogenesis and bone resorption via VEGF expression.

    abstract：BACKGROUND:Parathyroid hormone-related protein (PTHrP) is a key regulator of osteolytic metastasis of breast cancer (BC) cells, but its targets and mechanisms of action are not fully understood. This study investigated whether/how PTHrP (1-34) signaling regulates expression of vascular endothelial growth factor (VEGF) ...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Isowa S,Shimo T,Ibaragi S,Kurio N,Okui T,Matsubara K,Hassan NM,Kishimoto K,Sasaki A

    更新日期：2010-07-01 00:00:00

  • Uncoupling of incorporation of ascorbic acid and apoptosis induction.

    abstract：:Exposure of human promyelocytic leukemic HL-60 cells to millimolar concentration of sodium ascorbate induced apoptotic cell death. The extent of apoptosis induction was a positive function of temperature at the time of exposure. The incorporation of [1-14C] ascorbic acid into the cytosolic fraction of HL-60 cells was ...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Amano Y,Sakagami H,Tanaka T,Yamanaka Y,Nishimoto Y,Yamaguchi M,Takeda M

    更新日期：1998-07-01 00:00:00

  • The amount and proteolytic content of vesicles shed by human cancer cell lines correlates with their in vitro invasiveness.

    abstract：:Cancer cells are known to shed extracellular membrane vesicles both in vitro and in vivo. To analyse their possible involvement in the metastatic behaviour of tumours, we measured the Matrigel invasion capability and amounts of vesicles shed by four human tumour cell lines (8701-BC, MCF-7, MDA-MB-231 and HT-1080), and...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Ginestra A,La Placa MD,Saladino F,Cassarà D,Nagase H,Vittorelli ML

    更新日期：1998-09-01 00:00:00

  • Elderly woman with triple-negative metastatic breast cancer successfully treated with metronomic capecitabine.

    abstract：:Triple-negative breast cancer phenotype (estrogen receptor-, progesterone receptor- and human epidermal growth receptor 2-negative) is one of the most aggressive molecular subtypes, accounting for 15-20% of all breast tumors. There is no standard treatment for this setting of patients except anthracyclines and taxanes...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： De Iuliis F,Salerno G,Taglieri L,Vicinanza R,Lanza R,Scarpa S

    更新日期：2014-08-01 00:00:00

  • Sunitinib First-line Treatment in Metastatic Renal Cell Carcinoma: Costs and Effects.

    abstract：BACKGROUND/AIM:Tyrosine kinase inhibitors are important in the treatment of metastatic renal cell cancer (mRCC). The aim of the study was to evaluate the costs and effects of sunitinib in mRCC. PATIENTS AND METHODS:A total of 81 mRCC patients who received first-line sunitinib therapy between 2010 and 2014 were recruit...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：10.21873/anticanres.13749

    authors： Vuorinen RL,Paunu N,Turpeenniemi-Hujanen T,Reunamo T,Jekunen A,Kataja V,Sintonen H,Purmonen T,Kellokumpu-Lehtinen PL

    更新日期：2019-10-01 00:00:00

  • Hypercalcemic-type of small cell carcinoma of the ovary: characterization of a new tumor line.

    abstract：BACKGROUND:The aim of this study was to develop and characterize a mouse xenograft model for the hypercalcemic-type of small cell carcinoma of the ovary (HTSCCO). PATIENTS AND METHODS:Tumor fragments were removed from a patient and cultured in six subsequent generations of nude mice. Histology, comparative genomic hyb...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Walt H,Hornung R,Fink D,Dobler-Girdziunaite D,Stallmach T,Spycher MA,Maly F,Haller U,Bürki N

    更新日期：2001-09-01 00:00:00

  • CEA as a prognostic factor in colorectal cancer.

    abstract：:We have measured serum CEA levels in 207 patients with colorectal cancer. CEA sensitivity was related to tumor stage in tumors located in the right colon, but not in tumors located in the left colon or the rectum. CEA had prognostic value in patients with tumors located in the right colon (p < 0.001) but not in the le...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Filella X,Molina R,Piqué JM,Grau JJ,Garcia-Valdecasas JC,Biete A,Novell F,Astudillo E,Bordas JM,Campo E

    更新日期：1994-03-01 00:00:00

  • Ninjurin1 Is Up-regulated in Circulating Prostate Tumor Cells and Plays a Critical Role in Prostate Cancer Cell Motility.

    abstract：BACKGROUND/AIM:Ninjurin1 is a 17-kDa membrane protein that is highly expressed in circulating tumor cells (CTCs) obtained from locally-advanced prostate cancer patients. As CTCs are implicated in the initiation of distant metastasis, we examined the potential contribution of Ninjurin1 to the motility of prostate cancer...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：10.21873/anticanres.11500

    authors： Park J,Joung JY,Hwang JE,Hong D,Park WS,Lee SJ,Lee KH

    更新日期：2017-04-01 00:00:00

  • A New-Generation Fecal Immunochemical Test (FIT) Is Superior to Quaiac-based Test in Detecting Colorectal Neoplasia Among Colonoscopy Referral Patients.

    abstract：AIM:To compare a new-generation fecal immunochemical test (FIT) with the leading guaiac-based test in detection of fecal occult blood (FOB) in colonoscopy-referral patients. PATIENTS AND METHODS:A cohort of 300 patients referred for colonoscopy was examined by two different tests for FOB: ColonView quick test (CV) (FI...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Vasilyev S,Smirnova E,Popov D,Semenov A,Eklund C,Hendolin P,Paloheimo L,Syrjänen K

    更新日期：2015-05-01 00:00:00

  • Role of DNA Methylation in Cabazitaxel Resistance in Prostate Cancer.

    abstract：BACKGROUND/AIM:Cabazitaxel is an approved second-line treatment for docetaxel-refractory metastatic castration-resistant prostate cancer. However, the median time to progression on cabazitaxel is 2.8 months. We aimed to determine whether DNA methylation plays a role in cabazitaxel resistance. MATERIALS AND METHODS:DU1...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Ramachandran K,Speer C,Nathanson L,Claros M,Singal R

    更新日期：2016-01-01 00:00:00

  • Detection of K-ras mutations by denaturing gradient gel electrophoresis (DGGE): a study on pancreatic cancer.

    abstract：:In pancreatic neoplasias mutations in the first exon (codon 12) of K-ras gene occur at high frequency and seem to have a diagnostic significance. We set up the DGGE conditions to search for these mutations in pancreatic tumor sample DNAs. All samples were directly classified by simply comparing their DGGE patterns wit...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Pellegata NS,Losekoot M,Fodde R,Pugliese V,Saccomanno S,Renault B,Bernini LF,Ranzani GN

    更新日期：1992-09-01 00:00:00

  • Adjuvant docetaxel, cisplatin and 5-fluorouracil (TPF) in locally advanced squamous cell carcinoma of the head and neck.

    abstract：BACKGROUND:In this phase II study, the efficacy and toxicity of a triple chemotherapy with docetaxel, cisplatin and 5- Fluorouracil (TPF) was evaluated in the adjuvant therapy of locoregionally advanced cancer of the head and neck. This represented the first use of polychemotherapy as single adjuvant therapy after surg...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Baghi M,Hambek M,May A,Radeloff A,Gstoettner W,Knecht R

    更新日期：2006-01-01 00:00:00

  • Induction of Th1 response by dendritic cells pulsed with autologous melanoma apoptotic bodies.

    abstract：BACKGROUND:We hypothesize that dendritic cells (DCs) can process antigens from autologous melanoma apoptotic bodies (MABs) and induce effector T cells in melanoma patients. MATERIALS AND METHODS:Peripheral blood mononuclear cells were obtained from three stage IV melanoma patients and adherent cells were cultured in c...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Chang JW,Peng M,Vaquerano JE,Zhou YM,Clinton RA,Hyun WC,Giedlin MA,Leong SP

    更新日期：2000-05-01 00:00:00

  • Kaempferol Is an Anti-Inflammatory Compound with Activity towards NF-κB Pathway Proteins.

    abstract：BACKGROUND:The nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway is critical in inflammation, proliferation and carcinogenesis. There exist three main players in this pathway. The inhibitor of NF-κB (IκB), IκB kinase (IκK)- NF-κB essential modulator (NEMO) complex and NF-κB. The IkK-NEMO co...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Kadioglu O,Nass J,Saeed ME,Schuler B,Efferth T

    更新日期：2015-05-01 00:00:00

  • A retrospective analysis of non-platinum-based first- and second-line chemotherapy in patients with advanced non-small cell lung cancer.

    abstract：BACKGROUND:Platinum-based chemotherapy represents the standard of care for advanced non-small cell lung cancer (NSCLC) while non-platinum-based regimens are frequently administered in patients with relapse. A retrospective analysis of the sequence administration of these regimens in the first- and second-line setting w...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Kotsakis A,Hatzidaki D,Vamvakas L,Vardakis N,Kalykaki A,Bozionelou V,Androulakis N,Kalbakis K,Saridaki Z,Georgoulias V,Agelaki S

    更新日期：2010-10-01 00:00:00

  • Non-pegylated liposomal doxorubicin plus ifosfamide in metastatic soft tissue sarcoma: results from a phase-II trial.

    abstract：BACKGROUND/AIM:Non-pegylated liposomal doxorubicin (NPLD) has demonstrated antitumour activity equivalent to conventional doxorubicin and a significantly lower risk of cardiotoxicity. This phase II trial was performed to evaluate the activity and the safety of NPLD and ifosfamide combination in patients with metastatic...

    journal_title：Anticancer research

    pub_type： 杂志文章,多中心研究

    doi：

    authors： De Sanctis R,Bertuzzi A,Basso U,Comandone A,Marchetti S,Marrari A,Colombo P,Lutman RF,Giordano L,Santoro A

    更新日期：2015-01-01 00:00:00

  • Mechanisms of the growth-inhibitory effect of the RNase-EGF fused protein against EGFR-overexpressing cells.

    abstract：BACKGROUND:We previously showed the usefulness of a fused protein of human pancreatic ribonuclease1 (hRNase1) with human epidermal growth factor (hEGF) for molecular targeting of EGF receptor (EGFR)-overexpressing cells. In this study, the mechanisms underlying the inhibition of cell growth by RNase-EGF fused proteins ...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Hoshimoto S,Ueda M,Jinno H,Kitajima M,Futami J,Seno M

    更新日期：2006-03-01 00:00:00

  • Prognostic value of serum CA9 in patients with metastatic clear cell renal cell carcinoma under targeted therapy.

    abstract：AIM:Carbonic anhydrase 9 (CA9) has been found to be one of most powerful biomarkers for clear-cell renal cell carcinoma (RCC). The serum CA9 is detectable. The aim of this study was to evaluate the potential prognostic role of serum CA9 in patients with metastatic clear-cell RCC patients under targeted therapy. PATIEN...

    journal_title：Anticancer research

    pub_type： 杂志文章,随机对照试验

    doi：

    authors： Gigante M,Li G,Ferlay C,Perol D,Blanc E,Paul S,Zhao A,Tostain J,Escudier B,Negrier S,Genin C

    更新日期：2012-12-01 00:00:00

  • Androgen receptor (AR) expression in normal and cancerous human endometrial tissues detected by RT-PCR and immunohistochemistry.

    abstract：OBJECTIVE:This study aimed at assessing the expression and cellular localisation of the androgen receptor (AR) in normal and malignant human endometrial tissues. MATERIALS AND METHODS:Twelve normal endometrial samples and 25 uterine cancers were studied using RT-PCR and immunohistochemistry (IHC). RESULTS:One of the ...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Brys M,Semczuk A,Baranowski W,Jakowicki J,Krajewska WM

    更新日期：2002-03-01 00:00:00

  • Correlation between the urinary dihydrouracil-uracil ratio and the 5-FU plasma concentration in patients treated with oral 5-FU analogs.

    abstract：BACKGROUND:The determination of dihydropyrimidine dehydrogenase (DPD) deficiency is important in avoiding severe 5-fluorouracil (FU) toxicity. The dihydrouracil (UH2)-uracil (Ura) ratio (UH2/Ura) in plasma might be an important indicator of the risk of 5-FU catabolic deficiency. In order to clarify this possibility, th...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Nakayama Y,Matsumoto K,Inoue Y,Katsuki T,Kadowaki K,Shibao K,Tsurudome Y,Hirata K,Sako T,Nagata N,Itoh H

    更新日期：2006-09-01 00:00:00

  • Prediction of the optimum clinical dosing schedule for menogaril from results with tumor-bearing mice.

    abstract：:Menogaril is an antitumor agent active after oral administration, and unlike other anthracyclines, extravasation cannot occur. When the IC90 values of menogaril were plotted versus exposure time on a double-logarithmic scale, the regression lines had slopes between -0.64 and -0.80. These results showed that the mode o...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Yoshida M,Kobunai T,Nakano K,Saito H,Toko T,Takeda S,Unemi N

    更新日期：1996-09-01 00:00:00

  • Effect of 5-fluorouracil on carcinoembryonic antigen expression and shedding at clonal level in colon cancer cells.

    abstract：BACKGROUND:The carcinoembryonic antigen (CEA) is a tumor marker largely utilized for the detection of minimal disease or as a target of immunotherapeutic approaches. In preclinical models CEA has been found to be up-regulated after exposure of cancer cells to 5-fluorouracil (5-FU). In the present study, the clonal dist...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Aquino A,Prete SP,Guadagni F,Greiner JW,Giuliani A,Orlando L,Masci G,De Santis S,Bonmassar E,Graziani G

    更新日期：2000-09-01 00:00:00

  • Simultaneous measurement of nucleolin and estrogen receptor in breast cancer cells by laser scanning cytometry.

    abstract：BACKGROUND:The purpose of the study was to test the feasibility of laser scanning cytometry (LSC) to simultaneously measure estrogen receptor (ER) and nucleolin (NU) expression in the nuclei of the same individual breast cancer cells. MATERIALS AND METHODS:Cancer cells from 64 breast tumors were labeled with anti-NU a...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：

    authors： Masiuk M,Urasinska E,Domagala W

    更新日期：2004-03-01 00:00:00

  • Current Status and Problems of T790M Detection, a Molecular Biomarker of Acquired Resistance to EGFR Tyrosine Kinase Inhibitors, with Liquid Biopsy and Re-biopsy.

    abstract：BACKGROUND/AIM:The purpose of this study was to consider appropriate application of liquid and re-biopsy through analysis of current status in practice. PATIENTS AND METHODS:We performed a retrospective analysis of 22 patients with epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer wh...

    journal_title：Anticancer research

    pub_type： 杂志文章

    doi：10.21873/anticanres.12628

    authors： Komiya K,Nakashima C,Nakamura T,Hirakawa H,Abe T,Ogusu S,Takahashi K,Takeda Y,Egashira Y,Kimura S,Sueoka-Aragane N

    更新日期：2018-06-01 00:00:00