Abstract：
BACKGROUND:The nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway is critical in inflammation, proliferation and carcinogenesis. There exist three main players in this pathway. The inhibitor of NF-κB (IκB), IκB kinase (IκK)- NF-κB essential modulator (NEMO) complex and NF-κB. The IkK-NEMO complex activates NF-κB via phosphorylation of Iκβ and, eventually, leads to its proteasomal degradation. This leads to nuclear translocation of NF-κB and activation of target genes, such as cyclooxygenases and interleukins. The identification of anti-inflammatory compounds might be an effective strategy to target inflammatory disorders and cancer. MATERIALS AND METHODS:In the present investigation, kaempferol was investigated in terms of its effect on NF-κB activity with a SEAP-driven reporter cell line, NF-κB DNA binding with electromobility shift assay (EMSA) and translocation of NF-κB-p65 from cytosol to the nucleus with western blot in Jurkat cells. RESULTS:Kaempferol revealed anti-inflammatory activity, as shown in vitro and in silico. Molecular docking studies of kaempferol revealed comparable binding energies and similar docking poses on target proteins such as MG-132, a known NF-κB inhibitor. CONCLUSION:We conclude that kaempferol possesses anti-inflammatory activity.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Kadioglu O,Nass J,Saeed ME,Schuler B,Efferth Tsubject
Has Abstractpub_date
2015-05-01 00:00:00pages
2645-50issue
5eissn
0250-7005issn
1791-7530pii
35/5/2645journal_volume
35pub_type
杂志文章abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) is one of the most important factors for angiogenesis in various tumors. However, its clinical significance in extrahepatic biliary tract carcinoma remains unclear. MATERIALS AND METHODS:To clarify the association of VEGF expression with the clinicopathological feat...
journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1999-05-01 00:00:00
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journal_title：Anticancer research
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journal_title：Anticancer research
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doi：
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journal_title：Anticancer research
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更新日期：2009-10-01 00:00:00
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journal_title：Anticancer research
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journal_title：Anticancer research
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更新日期：2007-07-01 00:00:00
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pub_type： 杂志文章
doi：
更新日期：2012-08-01 00:00:00
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journal_title：Anticancer research
pub_type： 杂志文章,多中心研究
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journal_title：Anticancer research
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doi：
更新日期：2006-01-01 00:00:00
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journal_title：Anticancer research
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doi：
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doi：
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journal_title：Anticancer research
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doi：
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doi：
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doi：
更新日期：2013-09-01 00:00:00
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pub_type： 杂志文章
doi：
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doi：
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doi：
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doi：
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doi：
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journal_title：Anticancer research
pub_type： 杂志文章
doi：
更新日期：1990-11-01 00:00:00
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更新日期：2014-09-01 00:00:00
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journal_title：Anticancer research
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doi：
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doi：
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