Abstract:
PURPOSE:Circulating tumor cells (CTCs) can be detected in the peripheral blood of around 50% of patients with metastatic breast cancer. Their numbers are an independent predictor of the patient's progression-free survival (PFS) and of overall survival (OS). However, to date, none of the studies carried out with the most commonly used system of CTC determination (the CellSearch System, approved by the US Food and Drug Administration) has examined the intra-patient variation in CTC numbers, a variation that could impact on prognosis assessment. EXPERIMENTAL DESIGN:To evaluate possible circadian variations in the number of CTCs in patients with breast cancer a pilot study was conducted in which these cells were quantified 12 h apart (at 8:00 a.m. and 8:00 p.m. of the same day) in a cohort of hospitalized patients with metastatic breast cancer. RESULTS:Out of the 58 patients included in the study, 51 were evaluable. No statistically significant differences between day-time and night-time CTC numbers were observed (p=0.8427, Wilcoxon matched pair test). Only two of the patients were classified in different prognostic categories in the morning and night determinations (5 or more CTCs=poor prognosis group; <5 CTCs=good prognosis group). The prognostic classification of the remaining 49 patients was the same at 8:00 a.m. and 8:00 p.m. CONCLUSION:The number of peripheral blood CTCs in metastatic breast cancer patients is not significantly different at 8:00 a.m. from that at 8:00 p.m. and, as such, indicates a lack of circadian rhythm with respect to CTC numbers in these patients.
journal_name
Anticancer Resjournal_title
Anticancer researchauthors
Martín M,García-Sáenz JA,Maestro De las Casas ML,Vidaurreta M,Puente J,Veganzones S,Rodríguez-Lajusticia L,De la Orden V,Oliva B,De la Torre JC,López-Tarruella S,Casado A,Sastre J,Díaz-Rubio Esubject
Has Abstractpub_date
2009-10-01 00:00:00pages
4185-7issue
10eissn
0250-7005issn
1791-7530pii
29/10/4185journal_volume
29pub_type
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journal_title:Anticancer research
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pub_type: 临床试验,杂志文章
doi:
更新日期:1990-09-01 00:00:00
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更新日期:2000-05-01 00:00:00
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journal_title:Anticancer research
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journal_title:Anticancer research
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