Evaluation of Global Histone Acetylation Levels in Bladder Cancer Patients.

abstract：UNLABELLED:BACKGROUD/AIM: We previously demonstrated that high protein expression of excision repair cross-complementation group-1 (ERCC1) was associated with poor disease-free survival in patients who received adjuvant cisplatin-based chemotherapy or chemoradiotherapy with cisplatin, and was shown to be an independent...

journal_title：Anticancer research

authors： Torii Y,Kato R,Minami Y,Hasegawa K,Fujii T,Udagawa Y

更新日期：2014-01-01 00:00:00

abstract：:The cytosol hormone receptors were extracted from rabbit uteri and human tumors with tris buffer systems for three consecutive homogenization and centrifugation processes to obtain three cytosols C-1, C-2, and C-3. The assay results evaluated revealed that minimal to tremendous amounts of receptor activities were pres...

journal_title：Anticancer research

authors： Chen YM,Rice RG,Vaughn CB

更新日期：1985-07-01 00:00:00

abstract：:Thalidomide was recently suggested to be angiogenesis-inhibitor following the demonstration of its activity in a rabbit cornea micropocket model. The purpose of the present study was to test its efficacy in solid tumors in mice. B16-F10 melanoma and CT-26 colon carcinoma cells were injected subcutaneously, intravenous...

journal_title：Anticancer research

authors： Gutman M,Szold A,Ravid A,Lazauskas T,Merimsky O,Klausner JM

更新日期：1996-11-01 00:00:00

abstract：:Experimental biochemical modulation of 1-hexylcarbamoyl-5-fluorouracil (HCFU) with l-leucovorin (LV) was carried out using human gastric (H-111) and colon (Co-4) carcinoma xenografts serially transplanted into nude mice. Thirty-five or 70 mg/kg HCFU dissolved in 0.2 ml of 1% hydroxymethyl cellulose was administered po...

journal_title：Anticancer research

authors： Kubota T,Kase S,Furukawa T,Tanino H,Kuo TH,Saikawa Y,Nishibori H,Ishibiki K,Kitajima M,Mabuchi K

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate whether tributyrin, a natural butyrate pro-drug, as well as butyrate itself could affect growth, differentiation and apoptosis in two human pancreatic cancer cell lines in culture. MATERIALS AND METHODS:Proliferation was studied by cell counting using crystal violet ...

journal_title：Anticancer research

authors： Gaschott T,Maassen CU,Stein J

更新日期：2001-07-01 00:00:00

abstract：AIM:To evaluate the role of radiotherapy alone or combined with chemotherapy in the treatment of recurrent vulvar cancer, emphasising the prognostic factors and outcomes. MATERIALS AND METHODS:Twenty women with loco-regional recurrence of vulvar carcinoma were retrospectively reviewed. Eleven patients were managed wit...

journal_title：Anticancer research

authors： Raffetto N,Tombolini V,Santarelli M,Valeriani M,Galla DA,Enrici RM

更新日期：2003-05-01 00:00:00

abstract：:Variations in dietary exposure to several minerals may alter the risk of acquiring colorectal cancer. These minerals include selenium, zinc, calcium, sodium, potassium, iron and fluoride. The mechanism by which each of these minerals alters cancer risk is not established. However, as both the epidemiologic and experim...

journal_title：Anticancer research

authors： Nelson RL

更新日期：1987-05-01 00:00:00

abstract：AIM:The aim of the present study was to investigate the prognostic impact of central nervous system metastases (CNS) after acquired resistance to epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI) in EGFR-mutant non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:We defined CNS-collapse as de...

journal_title：Anticancer research

authors： Hata A,Katakami N,Yoshioka H,Takeshita J,Tanaka K,Masago K,Fujita S,Kaji R,Imai Y,Monden K,Matsumoto T,Nagata K,Otsuka K,Tachikawa R,Tomii K,Kunimasa K,Iwasaku M,Nishiyama A,Ishida T,Nishimura Y

更新日期：2015-02-01 00:00:00

abstract：AIM:To determine depression in patients with choroidal melanoma (CM) treated with proton beam radiotherapy. PATIENTS AND METHODS:This was a cross-sectional study including 50 patients with CM (50% males, mean age=49.88±6.34 years) and 46 age- and sex-matched healthy controls (52% males, mean age=48.60±8.05 years). Par...

journal_title：Anticancer research

authors： Moschos MM,Moustafa GA,Lavaris A,Damaskos C,Laios K,Karathanou E,Ladas DS,Asproudis I,Garmpis N,Kalogeropoulos C

更新日期：2018-05-01 00:00:00

abstract：:Curcumin and its reduced derivative tetrahydrocurcumin have been shown to exhibit chemopreventive activity. Cyclooxygenase-2 (COX-2) inhibition in lipopolysaccharide (LPS)- or Porphyromonas gingivalis fimbria-stimulated RAW 264.7 cells was investigated using Northern blot analysis. The fimbria-stimulated expression of...

journal_title：Anticancer research

authors： Murakami Y,Ishii H,Takada N,Tanaka S,Machino M,Ito S,Fujisawa S

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:The effects of oxaliplatin (L-OHP) on cell cycle and apoptosis were examined. MATERIALS AND METHODS:The HT29, MCF7, Hela and A549 cell lines were treated and dual parameter flow cytometry BrdU/PI was then performed to monitor cell cycle modifications. Annexin V-FITC and PI probes were used for the detection...

journal_title：Anticancer research

authors： William-Faltaos S,Rouillard D,Lechat P,Bastian G

更新日期：2006-05-01 00:00:00

abstract：:Iceland has a total population of 300,000 inhabitants. All patients consulting for symptoms of the lower digestive tract during a four-year period (2003-2006) were subjected to a colonoscopic examination; all polyps were endoscopically removed. Out of the total 3,037 colorectal adenomas (CRAs), 308 (10.2%) were tradit...

journal_title：Anticancer research

authors： Rubio CA,Jónasson JG

更新日期：2015-09-01 00:00:00

abstract：:The growth inhibitory effect of trimetrexate (TMQ) is maintained in MCF-7 breast cancer but is decreased in Hs 824.T human bone marrow cells by a priming- and non-toxic 5-fluorouracil (5-FU) dose. Incubation of MCF-7 breast cells with 10 microM TMQ alone or in combination with 10 M 5-FU (TMQ 2 h prior to 5-FU [TMQ/5-F...

journal_title：Anticancer research

authors： Bowen D,Johnson DH,Southerland WM,Hughes DE,Hawkins M Jr

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:As a majority of ovarian cancer patients will ultimately develop recurrent disease, there is an urgent need for alternative or additional approaches in the treatment of this cancer. MATERIALS AND METHODS:The antitumour effect of i.p. administered cisplatin, liposomal muramyltripeptide phosphatidylethanulami...

journal_title：Anticancer research

authors： Klimp AH,De Vries EG,Scherphof GL,Daemen T

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:Previously we demonstrated that injection of Interleukin-alpha (IL-1) stimulated B16 melanoma tumour growth in vivo, associated with increased intercellular adhesion molecule-1 (ICAM-1) expression on the tumour cells (Photodermatol Photoimmunol Photomed 1994; 10: 74-79, ). METHODS:In the present study, we e...

journal_title：Anticancer research

authors： McKenzie RC,Oran A,Dinarello CA,Sauder DN

更新日期：1996-01-01 00:00:00

abstract：:The pattern of cytoplasmic membrane gangliosides and two cellular features which have been reported to be related to the expression of different membrane gangliosides, namely adhesion to solid substrates and susceptibility to the lytic activity of immune effector cells, have been investigated in drug sensitive A2780 h...

journal_title：Anticancer research

authors： Mazzoni A,Trave F,Fabbri M,Leto G,Ghidoni R

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND/AIM:Metabolomics is widely used for biomarker discovery, but conventional mass-spectrometry extraction procedures lose the spatial localization of metabolites. In this study, we directly analyzed breast carcinoma tissues embedded in frozen tissue microarrays (fTMAs) using MALDI mass-spectrometry imaging (MAL...

journal_title：Anticancer research

authors： Torata N,Kubo M,Miura D,Ohuchida K,Mizuuchi Y,Fujimura Y,Hayakawa E,Kai M,Oda Y,Mizumoto K,Hashizume M,Nakamura M

更新日期：2018-07-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) and v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations are common in non-small cell lung cancer (NSCLC) and colorectal cancer (CRC). The aim of the present study was to develop a simple and versatile tool to determine EGFR and KRAS mutations for pre-clinical r...

journal_title：Anticancer research

authors： Furugaki K,Yasuno H,Iwai T,Moriya Y,Harada N,Fujimoto-Ouchi K

更新日期：2014-02-01 00:00:00

abstract：:The objective of this study was to discover whether the peptides LRMK and LRMK-Ava linked to the N-terminus of peptides HER-2 (774-788) and HER-2 (776-788), respectively, help differentiation of E75-TCR(+)CD8(+) cells. Activation was quantified in terms of proliferation of E75-TCR(+)CD8(+) cells expressing high, mediu...

journal_title：Anticancer research

authors： Matsueda S,Gao H,Efferson CL,Tsuda N,Ishiyama S,Li Y,Ioannides MG,Fisk B,Peoples GE,Ioannides CG

更新日期：2009-07-01 00:00:00

abstract：:The incidence of breast cancer is increasing rapidly in Taiwan but is still low compared with western countries. The impact of body size factors in western countries inspired us to have a case-control study. A matched case-control study was done on 122 pairs of incident cases of female breast cancer and community cont...

journal_title：Anticancer research

authors： Chie WC,Chen CF,Lee WC,Chen CJ

更新日期：1996-09-01 00:00:00

abstract：:We generated a recombinant immunotoxin, named scFv(MGR6)-Cla, composed of the Fv region of an anti ErbB2 monoclonal antibody (MGR6) fused to clavin, a type 1 ribosome-inactivating protein (RIP) from Aspergillus clavatus. ErbB2 is a tyrosine kinase receptor which is overexpressed in most adenocarcinomas; clavin is a 17...

journal_title：Anticancer research

authors： D'Alatri L,Di Massimo AM,Anastasi AM,Pacilli A,Novelli S,Saccinto MP,De Santis R,Mele A,Parente D

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Patients with advanced pancreatic carcinoma have a risk of relapse after primary therapy, and the prognosis for these patients remains bleak. The effect of immuno-cell therapy in advanced pancreatic carcinoma, with or without other standard therapies, was examined. PATIENTS AND METHODS:Forty-six patients wi...

journal_title：Anticancer research

authors： Kaneko T,Goto S,Kato A,Akeyama A,Tomonaga M,Fujimoto K,Miyamoto Y,Eriguchi M,Egawa K

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND/AIM:Glioma-associated oncogene 1 (GLI1) is an important transcription factor in the hedgehog signalling pathway and tumour formation. We evaluated the clinical significance of GLI1 expression as a prognostic factor in patients with locally advanced gastric cancer (GC). PATIENTS AND METHODS:GLI1 expression l...

journal_title：Anticancer research

authors： Hashimoto I,Oue N,Kimura Y,Hiroshima Y,Hara K,Maezawa Y,Kano K,Fujikawa H,Aoyama T,Numata M,Yamada T,Tamagawa H,Yamamoto N,Ogata T,Shiozawa M,Morinaga S,Rino Y,Yasui W,Masuda M,Miyagi Y,Oshima T

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Various localized side effects which accompany head and neck irradiation [IR] have been widely reported. However, systemic side effects/have been only sparsely reported in the short-term period post-IR in an animal model. The potential modulatory role of zinc-desferrioxamine [Zn-DFO] on IR effects was examin...

journal_title：Anticancer research

authors： Nagler RM,Barak V,Nagler A

更新日期：2000-05-01 00:00:00

abstract：PURPOSE:To further evaluate lung cancer risk associated with rare Hras1 VNTR alleles and possible biological mechanisms. MATERIALS AND METHODS:The Hras1 VNTR was genotyped in 295 lung cancer patients and 500 healthy controls by PCR and high resolution electrophoresis. Microsatellite alterations were examined in 168 tu...

journal_title：Anticancer research

authors： Lindstedt BA,Ryberg D,Zienolddiny S,Khan H,Haugen A

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND:Solar ultraviolet-B (UVB) and vitamin D have been found inversely correlated with cancer incidence, mortality, and survival rates in many studies. MATERIALS AND METHODS:In this work, two sets of cancer data were used: age-adjusted cancer incidence and mortality rates in 2002 for 21 Western developed countri...

journal_title：Anticancer research

authors： Grant WB

更新日期：2006-07-01 00:00:00

abstract：:The significance of time interval for administration of a second drug after a first dose of cyclophosphamide (CTX) was studied for a human ovarian, lung, and colon carcinoma line growing as xenografts in nude mice. The effects of combination of two drugs were found to be dependent on the interval between the administr...

journal_title：Anticancer research

authors： Mattern J,Wauss K,Volm M

更新日期：1985-03-01 00:00:00

abstract：BACKGROUND/AIM:Ninjurin1 is a 17-kDa membrane protein that is highly expressed in circulating tumor cells (CTCs) obtained from locally-advanced prostate cancer patients. As CTCs are implicated in the initiation of distant metastasis, we examined the potential contribution of Ninjurin1 to the motility of prostate cancer...

journal_title：Anticancer research

authors： Park J,Joung JY,Hwang JE,Hong D,Park WS,Lee SJ,Lee KH

更新日期：2017-04-01 00:00:00

abstract：:We report two cases with small cell lung cancer (SCLC) receiving multicyclic dose-intensified chemotherapy (DI-CT) supported by autologous blood progenitor cell transplantation (ABPCT). Both cases were initially treated with cisplatin (CDDP), etoposide (ETP) and concurrent thoracic irradiation, however they had recurr...

journal_title：Anticancer research

authors： Fujimoto N,Ueoka H,Kiura K,Tabata M,Bessho A,Takata I,Sunami K,Hiramatsu Y,Ikeda K,Tanimoto M,Harada M

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:The presence of circulating tumor cells (CTCs) in the peripheral blood is a prerequisite for the formation of distant metastases. Transforming growth factor-βeta (TGF-β) and Chemokine (C-X-C Motif) Ligand-1 (CXCL1) are cytokines involved in the colonization of distant sites by CTCs in several pre-clinical an...

journal_title：Anticancer research

authors： Divella R,Daniele A,Savino E,Palma F,Bellizzi A,Giotta F,Simone G,Lioce M,Quaranta M,Paradiso A,Mazzocca A

更新日期：2013-04-01 00:00:00